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Pseudovascular Skin Squamous Cell Carcinoma

Presentation

ABSTRACT The adenoid form of squamous cell carcinoma is a neoplasm that is characterized by the fact that it presents a pseudoglandular pattern in the histological study. [pesquisa.bvsalud.org]

[…] ulcers Chronic inflammation Sinus tract Human papillomavirus infection Tars / oils Xeroderma pigmentosa (J Am Acad Dermatol 2018;78:237) Clinical features Thin squamous cell carcinoma: erythematous scaly thin papule or plaque Thicker tumors typically present [pathologyoutlines.com]

Treatment

(Clin Exp Dermatol 2012;37:505) 88 year old woman with a recurrence on left lower leg (JAAD Case Rep 2019;5:491) Rare case of poorly differentiated squamous cell carcinoma with osteoclastic giant cell-like proliferation (J Cutan Pathol 2007;34:930) Treatment [pathologyoutlines.com]

Prognosis

Most cases of pseudovascular squamous cell carcinoma of the skin have a poor prognosis [pesquisa.bvsalud.org]

less often associated with a poor prognosis following exposure to ionizing radiation, trauma or burn Desmoplastic squamous cell carcinoma: poorly differentiated, pleomorphic spindle cells with a dense stromal response Adenosquamous carcinoma: mixed [pathologyoutlines.com]

Etiology

[…] mutations involving genes (such as TP53, CDKN2A, NOTCH1 and NOTCH2, EGFR and TERT) and molecular pathways (RAS / RAF / MEK / ERK and PI3K / AKT / mTOR) have been shown to play an important role in the pathogenesis (J Eur Acad Dermatol Venereol 2020;34:932) Etiology [pathologyoutlines.com]

Pathophysiology

(cSCC) Squamous cell carcinoma (SCC) Squamous cell carcinoma in situ (SCCIS) Bowen disease (BD) ICD coding ICD-O: 8070/3 - squamous cell carcinoma, NOS Sites Most often in sun exposed areas Scalp, ear, lip, nose, eyelid are high risk anatomic sites Pathophysiology [pathologyoutlines.com]

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