Presentation
Dictionary of Food Compounds, Second Edition is presented in a user-friendly format in both hard copy and fully searchable CD-ROM. [books.google.com]
1 We have reviewed the clinical features and management of 44 consecutive patients presenting to hospital over a 5 week period during an outbreak of ingestion of psilocybin containing mushrooms. 2 Patients presented to hospital usually because of dysphoric [ncbi.nlm.nih.gov]
Paper presented at the Second International Conference on the Use of LSD in Psychotherapy, Amityville, New York, May 1965. This paper discusses the treatment of drug addicts. [doi.org]
Method: Two male patients are presented who developed relapsing and short-lasting psychotic episodes after chewing kath leaves. [tandfonline.com]
Entire Body System
-
Crying
It's a far cry from the military ambitions of would be brainwashers. As for me, well it was an interesting experience. But not one I will be repeating. [bbc.co.uk]
Before the treatment, some of the participants would cry and shake when they talked about their cancer. But “the moment they get psilocybin, their distress comes down. [theatlantic.com]
The HD-HS group differed from the HD-SS group only on guide ratings of tearing/crying, which were higher in the HD-HS group. Figure 2. [doi.org]
Psychiatrical
-
Depersonalization
Prolonged depersonalization after marijuana use. Am J Psychiatry 1981 Feb; 138(2): 231–3 PubMed Google Scholar 19. Keshaven MS, Lishman WA. Prolonged depersonalization following cannabis abuse. [doi.org]
[…] fewer than half showed other sympathomimetic features--tachycardia, hypertension or hyperreflexia. 4 Twenty-three patients experienced nausea and vomiting. 5 Distortions of perception chiefly visual were frequent as were paraesthesiae and feelings of depersonalization [ncbi.nlm.nih.gov]
[…] fewer than half showed other sympathomimetic features - tachycardia, hypertension or hyperreflexia. 4 Twenty-three patients experienced nausea and vomiting. 5 Distortions of perception chiefly visual were frequent as were paraesthesiae and feelings of depersonalization [dx.doi.org]
-
Visual Hallucination
In addition, although visual hallucinations are more common, auditory hallucinations can also occur. Hallucinations typically do not last longer than four or five hours.4 References Ross S, Bossis A, Guss J, et al. [sites.google.com]
After both drugs, abnormal mental states characterized by feelings of strangeness, difficulty in thinking, anxiety, altered sensory perception (particularly visual), elementary and true visual hallucinations, and alterations of body image were reported [dx.doi.org]
[…] lightness and feelings of floating Psychological effects include: Heightened sensory experiences and perceptual distortions (i.e. brighter colors, sharper visual definition, increased hearing acuity, more distinguished taste) Auditory, tactile, and visual [cesar.umd.edu]
Neurologic
-
Excitement
"General inactivation", "emotional excitability", and "dreaminess" were the only domains of the AMRS showing increased scores following MD and HD PY. [ncbi.nlm.nih.gov]
While the findings are exciting, this is a very preliminary study on a small number of people and with no control sample. More importantly, this study doesn’t mean magic mushrooms cure depression. [iflscience.com]
We are excited to be taking this work forward with our clinical trial on psilocybin therapy for treatment-resistant depression. [compasspathways.com]
"It's very exciting from a scientific point of view. [wired.com]
This finding was exciting because it synched with the idea that psychedelics cause temporary “ego dissolution”, in other words – diminishing one’s sense of having a firm and enduring personality. [scienceandnonduality.com]
-
Confusion
The adverse reactions we noted were transient anxiety during drug onset (all patients), transient confusion or thought disorder (nine patients), mild and transient nausea (four patients), and transient headache (four patients). [ncbi.nlm.nih.gov]
Symptoms of mushroom poisoning may include muscle spasms, confusion, and delirium. Visit an emergency room immediately if these symptoms occur. [medicalnewstoday.com]
Signs of a bad trip include anxiety, confused or disordered thinking and panic. At doses of 13 mg or more, users' perceptions become altered, and they develop the same symptoms as an LSD user. [brown.edu]
At the time, the volunteers reported mystical experiences – typically described as a "sense of unity" – in which the confusion of the world and of competing value systems came together in a coherent whole. [wired.com]
If anxiety or confusion arose, the monitors provided reassurance to the participants. [hopkinsmedicine.org]
-
Hyperactivity
Autonomic hyperactivity (eg, sweating or pulse rate greater than 100) 2. Increased hand tremor 3. Insomnia 4. Nausea or vomiting 5. Transient visual, tactile, or auditory hallucinations or illusions 6. Psychomotor agitation 7. Anxiety 8. [books.google.com]
The ego becomes hyperactive, even tyrannical, enforcing rigid habits of thought and behavior—habits that the psychedelic experience, by loosening the ego’s grip, could help us to break. [michaelpollan.com]
It turns out that this network is hyperactive in depression. Interestingly, in meditation it becomes quiescent, and also with psilocybin it becomes quiescent. This may correlate with the experience of clarity of coming into the present moment. [scientificamerican.com]
Google Scholar 160 Solanto MV: Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration. Behav. Brain Res. 94,127–152 ( 1998 ). [doi.org]
-
Agitation
Psychomotor agitation 7. Anxiety 8. Grand mal seizures C. The symptoms in... [books.google.com]
Misidentification of poisonous mushrooms resembling psilocybin could lead to unintentional, potentially fatal poisoning Peyote Increased body temperature and heart rate Uncoordinated movements (ataxia) Profound sweating Flushing DMT Increased heart rate Agitation [drugabuse.gov]
[…] present Feelings of unity with the environment Feelings of involvement with intense spiritual experiences Tension, anxiety, and restlessness Highly adverse reactions ("bad trip"), including frightening hallucinations, confusion, disorientation, paranoia, agitation [cesar.umd.edu]
-
Giddiness
Effects: Produces vivid hallucinations similar (though reportedly less intense) to LSD—beginning within a half hour and lasting three to six hours — muscular relaxation, and giddiness. [drugtimes.org]
The effects range from mild feelings of relaxation, giddiness, euphoria, visual enhancement (seeing colours brighter), visual disturbances (moving surfaces, waves), to delusions, altered perception of real events, images and faces, or real hallucinations [emcdda.europa.eu]
[…] fundamental factors in determining the outcome of experiments that tested the effects of psychedelic drugs on artists' creativity.After ingesting psilocybin, a wide range of subjective effects may be experienced: feelings of disorientation, lethargy, giddiness [en.wikipedia.org]
Workup
Sample workup included protection of the unstable PI with ascorbic acid, freeze-drying, and extraction with methanol. Peak PI concentrations up to 870 microg/l were measured in urine samples from the 2-4 h collection interval. [ncbi.nlm.nih.gov]
Treatment
[…] post-Treatment treatment (two-tailed, 5000 permutations). [dx.doi.org]
The study, published in Scientific Reports, focused on 19 patients, all of which experienced treatment-resistant depression. Each patient showed less depressive symptoms at the one week post-treatment mark. [iflscience.com]
Human Psychopharmacology: Clinical and Experimental 25 January 2017 The fibrinolytic system: A new target for treatment of depression with psychedelics Idell, R. D., Florova, G., Komissarov, A. A., Shetty, S., Girard, R. B. S., & Idell, S. [stichtingopen.nl]
Prognosis
Ekbom K, Bahra A: Diagnosis, differential diagnosis, and prognosis of cluster headaches. In The Headaches. Edited by Olesen J, Goadsby PJ, Ramadan NM, et al. Philadelphia: Lippincott Williams & Wilkins; 2006:797–800. Google Scholar 13. [dx.doi.org]
Patients with an active cancer (e.g. stage III or IV with a poor prognosis) or disease progression or recurrence are eligible. [clinicaltrials.gov]
Etiology
Ekbom K, Hardebo JE: Cluster headache: etiology, diagnosis, and management. Drugs 2002, 62 :61–69. PubMed CrossRef Google Scholar 14. Carter DM: Cluster headache mimics. Curr Pain Headache Rep 2004, 8 :133–139. [dx.doi.org]
Etiology and phenomenology: II. clinical syndromes. J Ment Sci 1954; 100: 838–72 Google Scholar 43. Vallar G, Perani D. The anatomy of unilateral neglect after right-hemisphere stroke lesions: a clinical/CT-scan correlation study in man. [doi.org]
There is considerable evidence from family, twin, and adoptive studies that genetic factors make a robust contribution to the etiology of schizophrenia, with genetic factors established as relevant to some, perhaps all cases ( Buchanan and Carpenter, [ncbi.nlm.nih.gov]
Epidemiology
Warner AJ, Kessler R: Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: basic findings from the National Comorbidity Survey. Exp Clin Psychopharmacol 1994;2:244–268. [doi.org]
A thorough, scholarly, evidence-based review of the pathophysiology, natural history, epidemiology, and treatment of cluster headache and the other trigeminal autonomic cephalalgias. [dx.doi.org]
Very careful epidemiological researches showed that this mostly experimental use of mushrooms with its objectively mild side-effects, if any, will not cause a significant danger to the society (Siegel, 1985; Francis et al., 1983; Gartz, 1996; Thompson [web.archive.org]
International Consortium in Psychiatric Epidemiology (2005) Appendix for “New Scales to Screen for Serious Mental Illness in the General Population”. Available: . Accessed 2013 Apr 30. 26. [ncbi.nlm.nih.gov]
Pathophysiology
Thus, serotonin-2A overactivity may be involved in the pathophysiology of schizophrenia and serotonin-2A antagonism may contribute to therapeutic effects of antipsychotics. [dx.doi.org]
Prevention
Experts stumped as to what to do in kids both to prevent and treat it. [medscape.com]
Page 55 - To disseminate knowledge concerning the symptoms, diagnosis, treatment and prevention of cancer, to investigate the conditions under which cancer is found and to compile statistics in regard thereto. [books.google.com]
Pagina 55 - To disseminate knowledge concerning the symptoms, diagnosis, treatment and prevention of cancer, to investigate the conditions under which cancer is found and to compile statistics in regard thereto. [books.google.ro]
However, the status of psychoactive mushrooms in most countries as illegal hallucinogens has prevented full investigation of their biochemical properties. [doi.org]