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Pulmonary Atypical Mycobacterial Infection
Lung Mycobacterium Infection Atypical

Presentation

Hot tub lung: an intriguing diffuse parenchymal lung disease Abstract In pulmonary medicine, identical pathogenesis due to varied etiological agents can present with indistinguishable clinical presentation, and produce similar laboratory and radiological [ajol.info]

Histologically, granulomatous inflammation, with or without necrosis, is present. [uscapknowledgehub.org]

Persons with HIV can present with intrathoracic adenopathy. [cancertherapyadvisor.com]

This is known as Lady Windermere syndrome. [ 6 ] MAC can also present as a hypersensitivity pneumonitis. [patient.info]

A retrospective study has been presented at the American Thoracic Society in this matter and was very well received. [kamelharpulmonary.com]

Entire Body System

  • Recurrent Infection

    Patients with NTM have recurrent lung infections and sometimes infections of the skin and other organs as well. They may also have curvature of the spine, barrel chest, and heart valve weakness. [clinicaltrials.gov]

    Antimycobacterial therapy is often beneficial, but recurrence is common and resection is required in some cases. [uscapknowledgehub.org]

    Infect Dis Clin Pract 1998;756- 60 Google Scholar Crossref 22. Toth ELBoychuk LRKirkland PA Recurrent infection of continuous subcutaneous insulin infusion sites with Mycobacterium fortuitum. Diabetes Care 1995;181284- 1285 PubMed Google Scholar 23. [jamanetwork.com]

    Immunoglobulins: Common variable immunodeficiency (CVID) may be associated with recurrent sinopulmonary infections, including NTM pulmonary disease. [infectiousdiseaseadvisor.com]

    Unfortunately, recurrent infection with new strains of mycobacteria or a relapse of infection caused by the original organism is not uncommon. [ncbi.nlm.nih.gov]

Respiratoric

  • Cough

    If your primary care provider cannot help your chronic cough, you might need to see a lung specialist. [lung.org]

    What Is Causing Your Chronic Cough? A chronic cough is a cough that persists over time. [medicinenet.com]

    At other times, they can cause lung symptoms similar to tuberculosis: Cough Weight loss Coughing up blood or mucus Weakness or fatigue Fever and chills Night sweats Lack of appetite and weight loss Medicines can treat these infections, but often more [icdlist.com]

    Episodes of fever and dyspnoea are common, as well as a more gradual onset of dyspnoea and cough. [err.ersjournals.com]

  • Hemoptysis

    The most common respiratory symptoms of NTM lung disease are: Cough that won't go away Coughing up blood (hemoptysis) Shortness of breath when active Other symptoms of NTM lung disease include: Fatigue Low-grade fever Night sweats Weight loss What Causes [lung.org]

    However, most have a combination of respiratory and systemic features similar to tuberculosis ; chronic cough shortness of breath on exertion hemoptysis low-grade fever night sweats fatigue weight loss As with M. tuberculosis NTMs commonly cause pulmonary [radiopaedia.org]

    The most common symptoms include a persistent cough, fatigue, weight loss, night sweats, and occasionally shortness of breath (dyspnea) and coughing up of blood (hemoptysis). [rarediseases.org]

    The classic symptoms include cough, hemoptysis, fatigue, weight loss, and night sweats, though atypical presentations are common. [cancertherapyadvisor.com]

    Respiratory insufficiency and persistent hemoptysis may develop. Fibronodular infiltrates on chest x-ray resemble those of pulmonary TB, but cavitation tends to be thin-walled, and pleural effusion is rare. [merckmanuals.com]

  • Chronic Cough

    Figure 2. 83 year old lady with a chronic cough. [massgeneral.org]

    If your primary care provider cannot help your chronic cough, you might need to see a lung specialist. [lung.org]

    However, most have a combination of respiratory and systemic features similar to tuberculosis ; chronic cough shortness of breath on exertion hemoptysis low-grade fever night sweats fatigue weight loss As with M. tuberculosis NTMs commonly cause pulmonary [radiopaedia.org]

    What Is Causing Your Chronic Cough? A chronic cough is a cough that persists over time. [medicinenet.com]

    It can be caused by many NTM species which depends on region, but most frequently MAC and M. kansasii. [14] Clinical symptoms vary in scope and intensity but commonly include chronic cough, often with purulent sputum. Hemoptysis may also be present. [en.wikipedia.org]

  • Dry Cough

    She was first to get sick, with shortness of breath and a dry cough that progressed to fevers as high as 104, chills, night sweats and weight loss. [nytimes.com]

    The most common symptom of NTM lung disease is a chronic or recurring dry cough, occasionally with sputum. [medicinenet.com]

    Case A 56-year-old Caucasian man with past medical history of COPD secondary to tobacco abuse (40 packs per year of smoking) and chronic alcohol abuse presented to the Emergency Department with several months of increasing dyspnea, dry cough, fatigue, [pulmonarychronicles.com]

    Case 1: This patient, a 46-year-old woman, was in excellent health until early June, when she noted the onset of shortness of breath and a dry cough. A chest radiograph at that time was consistent with early right lower lobe bronchial pneumonia. [wwwnc.cdc.gov]

  • Productive Cough

    Over the course of a week, fevers with temperatures up to 102.4°F, night sweats, progressive dyspnea, and a worsening, now productive cough developed. [uscapknowledgehub.org]

    Case 2: The 44-year-old husband of Patient 1 was well until mid-August when he had onset of productive cough, fever, and night sweats. Over the next month, he had an 8-pound weight loss. [wwwnc.cdc.gov]

    Respiratory symptoms may consist of cough, sputum production, haemoptysis, or dyspnoea and can be secondary to various respiratory tract or parenchymal diseases [ 4, 47 ]. [karger.com]

    Pu lmonary Disease Pulmonary disease usually presents with chronic productive cough in the absence of hemoptysis. Diagnosis can be delayed due to underlying lung disease. [antimicrobe.org]

Gastrointestinal

  • Loss of Appetite

    Some people may have mild symptoms, while others have severe problems: Cough, sometimes with blood Fatigue Fever Large amount of mucus Loss of appetite or weight Night sweats Shortness of breath Other symptoms include wheezing, chest pain, and repeat [webmd.com]

    They are: Coughing Fever Fatigue Loss of Appetite Trouble Breathing Weight Loss Night Sweats Because these symptoms are so common, hot tub lung is often misdiagnosed as anything from bronchitis to asthma to tuberculosis. [swimuniversity.com]

    […] of appetite or weight, fevers, or night sweats. [medicinenet.com]

    Two weeks prior to presentation, he had intermittent fever associated with sweating and loss of appetite but no rigors or weight loss. [alliedacademies.org]

    Such symptoms include cough, fatigue, shortness of breath (dyspnea), coughing up of blood (hemoptysis), excessive mucus (sputum) production, fever, night sweats, loss of appetite, and unintended weight loss. Wheezing and chest pain may also occur. [rarediseases.org]

  • Failure to Thrive

    Symptoms may include chronic cough, hemoptysis, weight loss and ‘failure to thrive’. Some patients present with a history of recurrent chest infections. [academic.oup.com]

Workup

In cases of lung infection, a diagnostic workup will include a chest x ray and tests on discharges from the respiratory passages (sputum). [medical-dictionary.thefreedictionary.com]

The patient was transferred for further workup and treatment of combined MTB and MAC infection. Two months later, the patient was diagnosed with IL-12 deficiency. [alliedacademies.org]

Microbiology

  • Mycobacterium Kansasii

    Rifampin-resistant Mycobacterium kansasii Clin Infect Dis 1994 ; 18 : 1736-1743 Varadi R.G., Marras T.K. [em-consulte.com]

    kansasii infection Infection due to mycobacterium avium-intracellulare group Mycobacterial infection, disseminated, kansasii Mycobacterial pneumonia, non tb (tuberculosis) Mycobacterium avium complex Mycobacterium avium intracellulare, localized Non-tuberculous [icd10data.com]

    Slow-growing NTM include Mycobacterium avium, Mycobacterium intracellulare ( Mycobacterium avium-intracellulare complex) and Mycobacterium kansasii, whereas fast-growing NTM include Mycobacterium abscessus, Mycobacterium fortuitum and Mycobacterium chelonae [scielo.br]

    Some of those causing atypical mycobacterial infections include: Mycobacterium avium-intracellulare Mycobacterium kansasii Mycobacterium marinum Mycobacterium ulcerans Mycobacterium chelonae Mycobacterium fortuitum Mycobacterium abscessus Mycobacterium [dermnetnz.org]

    Mycobacterium avium-intracellulare Mycobacterium kansasii Mycobacterium marinum Mycobacterium ulcerans Mycobacterium chelonae Mycobacterium fortuitum Mycobacterium abscessus Any individual may develop Atypical Mycobacterial Infections; although, the [dovemed.com]

  • Mycobacterium Chelonae

    Objective To compare the demographics, clinical features, susceptibility patterns, and treatment for skin and soft tissue infections due to Mycobacterium fortuitum and Mycobacterium chelonae or Mycobacterium abscessus. [jamanetwork.com]

    […] parascrofulaceum Mycobacterium xenopi Mycobacterium chelonae : pulmonary Mycobacterium chelonae infection Mycobacterium simiae Mycobacterium abscesssus : pulmonary Mycobacterium abscessus infection 2 Risk factors The organisms have a predilection for [radiopaedia.org]

    Treatment of mycobacterium avium and mycobacterium chelonae is difficult. Effective treatment requires three to four antibiotics given at once, sometimes intravenously. [sciencedaily.com]

    Some of those causing atypical mycobacterial infections include: Mycobacterium avium-intracellulare Mycobacterium kansasii Mycobacterium marinum Mycobacterium ulcerans Mycobacterium chelonae Mycobacterium fortuitum Mycobacterium abscessus Mycobacterium [dermnetnz.org]

    Mycobacterium avium-intracellulare Mycobacterium kansasii Mycobacterium marinum Mycobacterium ulcerans Mycobacterium chelonae Mycobacterium fortuitum Mycobacterium abscessus Any individual may develop Atypical Mycobacterial Infections; although, the [dovemed.com]

Treatment

Treatment Treatment of NTM pulmonary infection varies depending on the species of mycobacterium. [academic.oup.com]

Prognosis

Treatment and prognosis Detailed guidelines on the management approach are available 12. [radiopaedia.org]

Focal nodular disease has the best prognosis and tends to be fairly benign. [patient.info]

Etiology

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

Hot tub lung: an intriguing diffuse parenchymal lung disease Abstract In pulmonary medicine, identical pathogenesis due to varied etiological agents can present with indistinguishable clinical presentation, and produce similar laboratory and radiological [ajol.info]

The pericardial effusion was suggestive of tuberculous origin, however, lack of response to conventional anti-tuberculous therapy raised suspicion about the etiology of the effusion being non-tuberculous. [ispub.com]

Nontuberculous Mycobacteria Lymph node disease Common etiological agents MAC M. kansasii M. malmoense M. haemophilum Uncommon etiological agents M. scrofulaceum M.fortuitum/ peregrinum M.abscessus/ chelonae 62. [de.slideshare.net]

The etiology of these infections is unknown, but it is most likely due to direct implantation or contamination of surgical instruments. [ncbi.nlm.nih.gov]

Epidemiology

O'Brien RJ, Geiter LJ, Snider DE., Jr The epidemiology of nontuberculous mycobacterial diseases in the United States. Results from a national survey. [ncbi.nlm.nih.gov]

Based on our review, we suggest two sets of modifications for epidemiologic and clinical studies. [journals.plos.org]

For several NTM species, environmental sources have been linked epidemiologically to cases of disease ( 15 - 20 ). [wwwnc.cdc.gov]

To identify imaging and epidemiological features that can help to distinguish ATB infection from Mycobacterium tuberculosis (MTB) infection. Epidemiology Mycobacteria that cause human disease can be divided into two broad groups. [epos.myesr.org]

Epidemiology of infection by nontuberculous mycobacteria. VI. Identification and use of epidemiologic markers for studies of Mycobacterium avium, M. intracellular, and M. scrofulaceum. Am Rev Respir Dis 1986;134:39–43. PubMed Google Scholar 24. [link.springer.com]

Pathophysiology

Childhood lymphadenitis due to MAC is very rare but appears to be on the increase in developed countries. [ 3 ] Pathophysiology M. avium causes 95% of AIDS-related MAC infections. [ 4 ] M. intracellulare causes 40% of MAC infections in the immunocompetent [patient.info]

In contrast, most patients could be easily classified as having primary or secondary disease, and these categories are more likely to facilitate better understanding of pathophysiology. [journals.plos.org]

The pathophysiology of disseminated Mycobacterium avium complex disease in AIDS. J Infect Dis. 1999; 179: S461-465. Vankayalapati R, Wizel B, Samten B, et al. Cytokine profiles in immunocompetent persons infected with Mycobacterium avium complex. [alliedacademies.org]

Mycobacterium peregrinum can result in skin infections. [2] Pathophysiology Infections with atypical mycobacteria usually occur in immunocompromised hosts due to host immunity and resistance factors. [emedicine.medscape.com]

Prevention

The great thing about this disease is that it is very easy to prevent. All it takes is a little work from you. The main way to prevent these types of infections is to properly clean your hot tub and its filters on a regular basis. [swimuniversity.com]

Currently, there no consensus on prevention among NTM experts. [medicinenet.com]

(November 6, 2017) Centers for Disease Control and Prevention. CDC Features: Pneumonia can be prevented—vaccines can help. Available online at https://www.cdc.gov/Features/Pneumonia/. Accessed on September 8, 2018. [labtestsonline.it]

Can People Prevent Atypical Mycobacterial Infections? Because mycobacteria are common in the environment, these infections are difficult to prevent, especially in people with weakened immune systems. [encyclopedia.com]

Prevention People with HIV infection can prevent or delay the onset of MAC by taking disease-preventing drugs such as rifabutin. [medical-dictionary.thefreedictionary.com]

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