We present the first reported case of an immunocompromised patient with cervical carcinoma and pulmonary lymphangitic metastasis with a prospective diagnosis made by transbronchial biopsy. [ncbi.nlm.nih.gov]

All articles but 3 were full case reports with variable information on the clinical presentation and outcome of the described patients. [journals.sagepub.com]

Localised parenchymal involvement may be present as nodular amyloidosis or as amyloid deposits associated with localised lymphomas. [err.ersjournals.com]

Acute brucellosis presenting with erythema nodosum. Eur J Epidemiol 2003; 18:913–915. CrossRef PubMed Google Scholar Barnett JH, Estes SA, Wirman JA et al. Erysipeloid. J Am Acad Dermatol 1983; 9:116–123. [link.springer.com]

• Collapse

  Narrowing of airways can cause wheezing, distal atelectasis, recurrent pneumonia or lobar collapse, and solitary nodules may be mistaken for endobronchial neoplasia [78, 79]. [err.ersjournals.com]

  END OF TRIAL Expand All Collapse All A. [clinicaltrialsregister.eu]

• Pain

  Pleuritic chest pain will be present if the neoplasm obstructs the subpleural lymphatics. [ncbi.nlm.nih.gov]

• Pleural Effusion

  Additional HRCT findings include 2,4: subpleural nodules, and thickening of the interlobar fissures pleural effusion(s): pleural carcinomatosis hilar and mediastinal nodal enlargement (40-50%) relatively little destruction of overall lung architecture [radiopaedia.org]

  The visceral pleura may be affected and pleural effusion is common. [err.ersjournals.com]

  Hilar/mediastinal adenopathy (in 20 to 40% of cases & are usually asymmetric) with associated pleural effusions (in one third to half of the patients) are observed. [ncbi.nlm.nih.gov]

  The CT angiography of the chest revealed no pulmonary embolism, no significant lung parenchyma abnormalities, no pleural effusions, and no mediastinal lymphadenopathy. [journals.sagepub.com]

• Dyspnea

  Most patients (69% [22/32]) had a history of progressive dyspnea over a few weeks. [journals.sagepub.com]

  Some patients experience dyspnea and abnormal pulmonary function tests early in the course of the disease, well before any radiographic abnormalities are evident, whereas others remain asymptomatic until much later 4. [radiopaedia.org]

  History and Physical Unexplained progressive dyspnea, which evolves over days to weeks, is the commonest presentation in almost 60 % of patients. [ncbi.nlm.nih.gov]

• Cough

  Cough, hemoptysis, weight loss, and lethargy are usually uncommon though a report of pulmonary lymphangitic carcinomatosis presenting with isolated chronic cough is reported in the literature.[12] Asymptomatic presentations do exist where the diagnosis [ncbi.nlm.nih.gov]

  Patients present with cough and haemoptysis, which may occasionally be abundant. As is often the case in patients with subglottic stenosis of any origin, dyspnoea may for a long time be falsely diagnosed as asthma [77]. [err.ersjournals.com]

• Chest Pain

  Pleuritic chest pain will be present if the neoplasm obstructs the subpleural lymphatics. [ncbi.nlm.nih.gov]

Because the treatment options for amyloidosis are dependent on the fibril protein type, the workup of all new cases should include accurate determination of the amyloid protein. Most cases are asymptomatic and need only a careful follow-up. [err.ersjournals.com]

• Pulmonary Infiltrate

  METHODS: Bronchoscopy with bronchoalveolar lavage (BAL) was used to assess pulmonary infiltrates in 14 patients with infiltrating ductal breast cancer. All patients had received prior cytotoxic or hormonal therapy. [ncbi.nlm.nih.gov]

• Kerley A Lines

  When abnormal, the most common finding is a reticulonodular pattern, with thickening of the interlobular septa which may resemble septal (Kerley B) lines. CT CT, especially HRCT, is excellent at demonstrating both peripheral and central changes. [radiopaedia.org]

• Pericardial Effusion

  Prolonged Survival in Colon Cancer with Malignant Pericardial Effusion and Pulmonary Lymphangitic Carcinomatosis: A Case for Monoclonal Antibodies? Conn Med. 2016 Sep;80(8):483-485. [PubMed: 29782785] 26. [ncbi.nlm.nih.gov]

• Pleural Effusion

  Additional HRCT findings include 2,4: subpleural nodules, and thickening of the interlobar fissures pleural effusion(s): pleural carcinomatosis hilar and mediastinal nodal enlargement (40-50%) relatively little destruction of overall lung architecture [radiopaedia.org]

  The visceral pleura may be affected and pleural effusion is common. [err.ersjournals.com]

  Hilar/mediastinal adenopathy (in 20 to 40% of cases & are usually asymmetric) with associated pleural effusions (in one third to half of the patients) are observed. [ncbi.nlm.nih.gov]

  The CT angiography of the chest revealed no pulmonary embolism, no significant lung parenchyma abnormalities, no pleural effusions, and no mediastinal lymphadenopathy. [journals.sagepub.com]

The clinical and pathologic features of this disease process are reviewed, as are potential treatment options. [ncbi.nlm.nih.gov]

Current treatment approaches derive from chemotherapy schemes developed for multiple myeloma. [err.ersjournals.com]

Treatment and prognosis Treatment is determined by the histology of the primary tumor, but in general, relies on systemic chemotherapy. [radiopaedia.org]

Intake of CYP3A4 inhibitors (see Attachment 3) less than 2 weeks before start of study treatment 5. Other investigational drug therapies less than 4 weeks or at least 5 half lives before start of study treatment 6. [clinicaltrialsregister.eu]

Given that this condition carries a uniformly fatal prognosis, unwanted therapy may result from a missed diagnosis. A prospective pathologic diagnosis by transbronchial biopsy may guide appropriate therapy in these patients. [ncbi.nlm.nih.gov]

Treatment and prognosis Treatment is determined by the histology of the primary tumor, but in general, relies on systemic chemotherapy. [radiopaedia.org]

In general, nodular amyloidosis is treated satisfactorily by conservative excision, and the long-term prognosis is excellent. [err.ersjournals.com]

Etiology Only about 6 -8 % of pulmonary metastasis is caused by lymphangitic carcinomatosis. 80 % of pulmonary lymphangitic carcinomatosis is caused by adenocarcinomas. [ncbi.nlm.nih.gov]

Tularemia: current epidemiology and disease management. Infect Dis Clin North Am 2006; 20: 289–311. CrossRef PubMed Google Scholar Cerny Z. Skin manifestations of tularaemia. Int J Dermatol 1994; 33:468–470. [link.springer.com]

[…] resection of the primary renal tumor is available in the literature.[6][7] Though pulmonary lymphangitic carcinomatosis is rare in children, cases have been reported in renal cell carcinoma, chondrosarcoma, skin, colon, and cancer of unknown primary.[5] Epidemiology [ncbi.nlm.nih.gov]

Two different studies by Bruce et al. and Ikezoe et al. also found carcinoma breast as the commonest cause of pulmonary lymphangitic carcinomatosis.[9] Pathophysiology Pulmonary lymphangitic carcinomatosis & pulmonary tumor embolism represents end-stage [ncbi.nlm.nih.gov]