Edit concept Question Editor Create issue ticket

Pulmonary Lymphoma

Primary Pulmonary Lymphoma


Presentation

  • It is suggested that primary pulmonary lymphoma arises from centrocyte-like cells normally present in bronchus-associated lymphoid tissue.[ncbi.nlm.nih.gov]
  • There is no report about synchronous primary pulmonary adenocarcinoma presenting with lung lymphoma. It can be easily misdiagnosed or missed.[ncbi.nlm.nih.gov]
  • Abstract A case of lobar primary pulmonary lymphoma is presented.[ncbi.nlm.nih.gov]
  • Abstract A 55-year-old woman with primary pulmonary lymphoma is presented. Contrast enhanced CT through the right lower lobe mass demonstrated the "CT angiogram sign" previously reported to be highly specific for bronchioloalveolar carcinoma.[ncbi.nlm.nih.gov]
  • Abstract A case of primary pulmonary lymphoma presenting as a nodular lesion on the chest radiograph in a patient with the acquired immune deficiency syndrome is described.[ncbi.nlm.nih.gov]
Weight Loss
  • They are: Fevers Unexplained weight loss Respiratory problems Treatment and prognosis of pulmonary lymphoma Because this cancer is so rare, the optimal treatment for pulmonary lymphoma remains in dispute.[lymphomainfo.net]
  • loss are uncommon Signs: -Lymphadenopathy usually absent Complications: -Transformation to high-grade NHL (in Treatment Asymptomatic: may not require treatment Symptomatic: surgical resection is preferred for resectable disease -XRT: for unresectable[mdnxs.com]
  • Case 1 A 27-year-old previously healthy male presented with nonproductive cough, night sweats, and a 15-pound unintentional weight loss over 7 months. Extensive infectious workup was negative.[ijpmonline.org]
  • Constitutional symptoms include weight loss, fever and night sweats. Previous or synchronous MALT lymphoma at other extranodal sites may be present.[histopathology-india.net]
  • […] lymphoma Nodular lymphocyte predominant Hodgkin disease (NLPHD) Distinct entity -- unique clinical features, different treatment Clinical Findings Most patients with disease above diaphragm are asymptomatic “B” symptoms are present in 40% Unexplained weight[learningradiology.com]
Hodgkin's Disease
  • We report the case of a patient with Hodgkin's disease who demonstrated multiple cavitating lung lesions with aberrant immunophenotypic expression of T-cell antigens.[ncbi.nlm.nih.gov]
  • Fourteen patients had mucosa-associated lymphoid tissue (MALT) lymphoma, 2 had large cell transformation of sheet cells in MALT lymphoma, and 1 each had Hodgkin's disease and follicular lymphoma.[ncbi.nlm.nih.gov]
  • Primary Hodgkin’s disease of the lung. Report of 4 cases and review of the literature. Cancer 1961;14:1151-1165. Cartier Y, Johkoh T, Honda O, Muller NL. Primary Pulmonary Hodgkin’s disease: CT findings in three patients.[casereports.in]
  • Diffuse lung involvement, on the other hand, carries a graver prognosis Five-year Survival Rates for Hodgkin Lymphoma Stages I and II 90% Stage III 84% Stage IV 65% Hodgkin Disease.[learningradiology.com]
  • Primary pulmonary lymphomais rare non Hodgkin lymphoma usually secondary pulmonary lymphoma includes Hodgkin disease and non Hodgkin lymphoma. Diagnosis and determining treatment is often difficult in lymphomatous involvement of the lungs.[omicsonline.org]
Cough
  • The infiltrate increased slowly in size accompanied by coughing and sputum and a gradual increase in serum IgM throughout the 5-yr period.[ncbi.nlm.nih.gov]
  • Cough and slowly progressive dyspnea were the most common pulmonary symptoms, and chest roentgenographic findings varied.[ncbi.nlm.nih.gov]
  • In other cases, it may be manifested by: irritated breathing (dyspnea); coughing; chest pain; the presence of blood in the sputum (hemoptysis).[health.ccm.net]
  • The most common clinical presentation is dry cough. Due to the non-specific presentation of the disease, non-invasive tests are often noncontributory.[casereports.in]
  • Common presenting symptoms were cough and dyspnea.[ijpmonline.org]
Pleural Effusion
  • This technique can also be applied to determine the clonality of lymphocytes obtained by bronchoalveolar lavage or needle biopsy, or from a pleural effusion.[ncbi.nlm.nih.gov]
  • The presence of lymphadenopathy and pleural effusion was also documented. RESULTS: Five patients with pulmonary lymphoma were identified.[ncbi.nlm.nih.gov]
  • effusion, patients with SS have a high risk of developing non-Hodgkin's lymphoma that may affect the lungs.[ncbi.nlm.nih.gov]
  • No lymph node enlargement or specific pleural effusion was detected. Transthoracic needle biopsies were performed in 10 patients and avoided open-lung biopsy for the diagnosis of lymphoma in five patients.[ncbi.nlm.nih.gov]
  • A chest x-ray showed increased opacities and pleural effusion in the right inferior lobe.[archbronconeumol.org]
Dyspnea
  • Cough and slowly progressive dyspnea were the most common pulmonary symptoms, and chest roentgenographic findings varied.[ncbi.nlm.nih.gov]
  • RESULTS: The symptoms of the 19 cases were dyspnea, fever, hemoptysis, chest pain or physical findings without obvious symptoms.[ncbi.nlm.nih.gov]
  • In other cases, it may be manifested by: irritated breathing (dyspnea); coughing; chest pain; the presence of blood in the sputum (hemoptysis).[health.ccm.net]
  • Nodules may cavitate 4) Pleural Effusion: PET Scan: positive -Useful to follow after therapy (as scan should revert to PET-negative): recurrence may be manifested by return to being PET-positive Clinical Symptoms (many patients are asymptomatic): -Cough/dyspnea[mdnxs.com]
  • When present, symptoms are various, such as cough, mild dyspnea, chest pain, and occasionally hemoptysis.[pubs.sciepub.com]
Dry Cough
  • The most common clinical presentation is dry cough. Due to the non-specific presentation of the disease, non-invasive tests are often noncontributory.[casereports.in]
  • Case 2 A 35-year-old healthy male presented with a 5-month history of dry cough, fevers, night sweats, and a 20-pound unintentional weight loss. He was previously treated with antibiotics at an outside hospital with no relief of symptoms.[ijpmonline.org]
  • Initial assessment, investigation and treatment in primary care [ 6 ] Studies have shown a low frequency of serious pulmonary conditions in patients who have an isolated chronic dry cough and normal physical examination, CXR and spirogram [ 7 ].[patient.info]
Chronic Cough
  • Unexplained chronic cough causes significant impairments in quality of life [ 2 ]. Epidemiology Chronic cough lasting for more than eight weeks is common in the community [ 1 ]. Chronic cough is reported by 10-20% of adults [ 3 ].[patient.info]
Purpura
  • , Thrombocytopenic, Idiopathic/complications Purpura, Thrombocytopenic, Idiopathic/diagnosis Purpura, Thrombocytopenic, Idiopathic/surgery* Spirometry Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed[ncbi.nlm.nih.gov]

Workup

  • In the second case, patient was placed on prolonged antibiotic treatment despite negative microbiologic workup.[ijpmonline.org]
Pulmonary Infiltrate
  • Abstract We performed bronchoalveolar lavage in a patient with pulmonary lymphoma and IgM lambda monoclonal serum gammopathy previously not diagnosed accurately by histologic examination and not treated for 5 yr after detection of a pulmonary infiltrate[ncbi.nlm.nih.gov]
  • Abstract A 63-yr-old-woman presented with pulmonary infiltrates and macroglobinemia. Open lung biopsy revealed an interstitial plasma cell infiltrate.[ncbi.nlm.nih.gov]
  • Pulmonary infiltration in mediastinal malignant lymphoma (A repot of 25 cases). J Pract Radiol (Chinese), 2005, 21: 247–249. Google Scholar 7. Song W, Wang L, Yan HZ. The radiographic findings in diagnosis of pulmonary lymphoma.[link.springer.com]
  • The radiological manifestation of PPL consists of unilateral and bilateral nodes or of a subpleural pulmonary infiltrate or mass that may cavitate. 3,6 Although pleural effusions have been described in 15% of immunocompetent patients with PPL, 4,7 such[archbronconeumol.org]
  • Página 54 - Ward HN: Pulmonary infiltrates associated with leukoagglutinin transfusion reactions. Ann Intern Med 73:689-694. 1970. 234. Thompson JSA.[books.google.es]
Pulmonary Infiltrate
  • Abstract We performed bronchoalveolar lavage in a patient with pulmonary lymphoma and IgM lambda monoclonal serum gammopathy previously not diagnosed accurately by histologic examination and not treated for 5 yr after detection of a pulmonary infiltrate[ncbi.nlm.nih.gov]
  • Abstract A 63-yr-old-woman presented with pulmonary infiltrates and macroglobinemia. Open lung biopsy revealed an interstitial plasma cell infiltrate.[ncbi.nlm.nih.gov]
  • Pulmonary infiltration in mediastinal malignant lymphoma (A repot of 25 cases). J Pract Radiol (Chinese), 2005, 21: 247–249. Google Scholar 7. Song W, Wang L, Yan HZ. The radiographic findings in diagnosis of pulmonary lymphoma.[link.springer.com]
  • The radiological manifestation of PPL consists of unilateral and bilateral nodes or of a subpleural pulmonary infiltrate or mass that may cavitate. 3,6 Although pleural effusions have been described in 15% of immunocompetent patients with PPL, 4,7 such[archbronconeumol.org]
  • Página 54 - Ward HN: Pulmonary infiltrates associated with leukoagglutinin transfusion reactions. Ann Intern Med 73:689-694. 1970. 234. Thompson JSA.[books.google.es]
Atelectasis
  • […] secondary to endobronchial obstruction (rare) Atelectasis is very uncommon and almost always due to an endobronchial lesion Cavitation secondary to necrosis (rare) Subpleural form Circumscribed subpleural masses Pleural effusion from lymphatic obstruction[learningradiology.com]
  • […] consolidation greater than 1 cm with or without cavitations or bronchograms - most common finding according to one study 2 masses of pleural origin nodules alveolar or interstitial infiltrates peribronchial or perivascular thickening with or without atelectasis[radiopaedia.org]
  • The radiographic findings are nonspecific also and include solitary nodule, multiple ill-defined nodules, consolidated mass with air bronchograms, pleura effusions, atelectasis, and cavities.[pubs.sciepub.com]
Pleural Effusion on Chest X-Ray
  • A chest x-ray showed increased opacities and pleural effusion in the right inferior lobe.[archbronconeumol.org]
Cavitary Lesion
  • CT scan showed a cavitary lesion in five patients. No lymph node enlargement or specific pleural effusion was detected.[ncbi.nlm.nih.gov]
Pleural Effusion
  • This technique can also be applied to determine the clonality of lymphocytes obtained by bronchoalveolar lavage or needle biopsy, or from a pleural effusion.[ncbi.nlm.nih.gov]
  • The presence of lymphadenopathy and pleural effusion was also documented. RESULTS: Five patients with pulmonary lymphoma were identified.[ncbi.nlm.nih.gov]
  • effusion, patients with SS have a high risk of developing non-Hodgkin's lymphoma that may affect the lungs.[ncbi.nlm.nih.gov]
  • No lymph node enlargement or specific pleural effusion was detected. Transthoracic needle biopsies were performed in 10 patients and avoided open-lung biopsy for the diagnosis of lymphoma in five patients.[ncbi.nlm.nih.gov]
  • A chest x-ray showed increased opacities and pleural effusion in the right inferior lobe.[archbronconeumol.org]

Treatment

  • Abstract Because of the rarity of its occurrence, there is no established treatment for early stage primary pulmonary lymphoma.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: A wide range of treatments were used for patients with generally MALT lymphoma, resulting in good outcomes, and recurrent disease was well controlled.[ncbi.nlm.nih.gov]
  • Over the following 5 years, she suffered at least 2 recurrences involving the lung and breast for which she received additional treatment.[ncbi.nlm.nih.gov]
  • This review summarizes the present knowledge of histopathology, molecular biology, diagnosis, prognosis, and treatment of this heterogeneous entity.[ncbi.nlm.nih.gov]
  • Physicians should be aware that Epstein-Barr virus-associated lymphoproliferative disorders that occur during treatment with methotrexate are not specific to patients with RA.[ncbi.nlm.nih.gov]

Prognosis

  • Abstract Primary pulmonary lymphoma (PPL) is a rare disease with a favorable prognosis compared with lung cancer.[ncbi.nlm.nih.gov]
  • The prognosis is excellent, but treatment is controversial (simple monitoring, surgery or single-agent chemotherapy).[ncbi.nlm.nih.gov]
  • In a single patient with T-cell lymphoma, the radiographic and pathologic features of the tumor were indistinguishable from those in the first group, but the patient had an unfavorable prognosis.[ncbi.nlm.nih.gov]
  • Prognostically, mediastinal node enlargement worsens prognosis but only minimally.[learningradiology.com]
  • They are: Fevers Unexplained weight loss Respiratory problems Treatment and prognosis of pulmonary lymphoma Because this cancer is so rare, the optimal treatment for pulmonary lymphoma remains in dispute.[lymphomainfo.net]

Etiology

  • Etiology Primary pulmonary lymphomas Only gold members can continue reading. Log In or Register to continue Jan 14, 2016 Posted by in RESPIRATORY IMAGING Comments Off on 82 Primary Pulmonary Lymphoma[radiologykey.com]
  • Etiology: Unlike gastric lymphomas where there is a clinical association with previous Helicobacter pylori infection, there is no consistent clinical association with pulmonary counterparts.[histopathology-india.net]
  • The etiology is not known, but there is an association collagen vascular diseases, AIDS , and immunodeficiency.[icnet.uk]

Epidemiology

  • (aka Mucosa-Associated Lymphoid Tissue, MALT-Associated Lymphoma) Epidemiology: accounts for Increased incidence in AIDS (although AIDS-related NHL are intrathoracic in Pathogenesis NHL arising from mucosa-associated lymphoid tissue in the lung Usually[mdnxs.com]
  • Epidemiology Hyponatraemia is the most common electrolyte abnormality encountered in clinical practice. An accurate incidence of mild hyponatraemia managed in the community is impossible, as it is rarely reported.[patient.info]
  • Epidemiology Marginal zone lymphoma accounts for less than 0.5% of all lung neoplasms and of all lymphomas, but constitutes 70-90% of all lung lymphomas. It is not uncommon for patients to have extranodal MALT lymphoma at other sites.[e-immunohistochemistry.info]
  • Epidemiology Chronic cough lasting for more than eight weeks is common in the community [ 1 ]. Chronic cough is reported by 10-20% of adults [ 3 ]. Risk factors include atopy and smoking.[patient.info]
Sex distribution
Age distribution

Pathophysiology

  • The recent delineation of new pathologic entities such as low-grade malignant lymphoma of mucosa-associated lymphoid tissue (MALT type) has aided in the understanding of the pathophysiology, clinical course, and management of patients with pulmonary lymphoma[ncbi.nlm.nih.gov]
  • The aim of this review is to describe the pathophysiological, diagnostic, prognostic and therapeutic aspects of these three entities. Low-grade pulmonary B-cell lymphoma is the most frequent form of primary pulmonary clonal lymphoid proliferation.[ncbi.nlm.nih.gov]
  • A good deal of progress has been made in understanding the pathophysiology of primary pulmonary lymphoma.[pubs.sciepub.com]

Prevention

  • Conclusion A preoperative diagnosis of pulmonary Hodgkin’s disease with an immunohistochemistry panel in combination with imaging offers a chance to the patient to be given specific treatment thus improving prognosis and preventing spread of the disease[casereports.in]
  • Whether you are on our soothing Doreen Koenig Blessed Beginnings Maternity Unit, where babies bond with their new families, coming in for routine outpatient or diagnostic procedures, seeking emergency or preventive care, we are here to be a transforming[holy-cross.com]
  • If you have any suicidal thoughts do not hesitate to call the National Suicide Prevention Hotline. This number is 1-800-273-8255. 6.[davidwolfe.com]
  • World trends for H. pylori eradication therapy and gastric cancer prevention strategy by H. pylori test-and-treat.[jshem.or.jp]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!