Pulmonary lymphomatoid granulomatosis is a rare diagnosis that frequently presents with a constellation of seemingly unrelated signs and symptoms. [ncbi.nlm.nih.gov]

• Fever

  In a 49 year old woman presenting with fever, malaise and pulmonary masses the diagnosis of lymphomatoid granulomatosis was established histologically by open lung biopsy. [ncbi.nlm.nih.gov]

  Herein, we describe LYG in a 56-year-old renal allograft recipient 11 years after transplantation, on azathioprine and prednisolone maintenance immunosuppression, presenting to us with fever, weight loss, and nodular and patchy opacities in both lung [ingentaconnect.com]

  Patients may be asymptomatic at the time of diagnosis, but up to 60% can present non-specific symptoms such as cough, fever, rash, subcutaneous nodules, asthenia and anorexia, dyspnea, chest pain, ataxia or peripheral neuropathy. [archbronconeumol.org]

• Weight Loss

  Herein, we describe LYG in a 56-year-old renal allograft recipient 11 years after transplantation, on azathioprine and prednisolone maintenance immunosuppression, presenting to us with fever, weight loss, and nodular and patchy opacities in both lung [ingentaconnect.com]

  The commonest presenting picture includes fever, cough, rash/nodules, malaise, weight loss, neurologic abnormalities, dyspnoea, and chest pain (Katzenstein et al. 1979 ). [springerplus.springeropen.com]

  Other symptoms such as weight loss, sweating, acute respiratory distress may be present 1, 2, 5. Extrapulmonary site of involvement mainly affect the skin, nervous system, and kidneys 1. [synapse.koreamed.org]

  The symptoms associated with LYG depend on the site of disease involvement but mainly include cough, dyspnea or chest pain (in those with pulmonary involvement) and constitutional symptoms such as weight loss and fever. [orpha.net]

  We present a 60-year-old woman with worsening fatigue, night sweats, unintentional weight loss, and dyspnea of 2 weeks’ duration. [mdedge.com]

• Intermittent Fever

  An 87-year-old male had a week-long history of intermittent fever and general weakness. A chest radiograph showed multifocal patchy consolidations with nodular lesions. [ncbi.nlm.nih.gov]

• Collapse

  Nevertheless, after 8 months her respiratory symptoms recurred and computed tomography (CT) findings revealed LUL total collapse and follow-up bronchoscopy revealed total obstruction of LUL lingula segment ( Figure 4 ). [synapse.koreamed.org]

• Splenomegaly

  A computerized tomography (CT) scan demonstrated bilateral pulmonary nodules and splenomegaly. [ncbi.nlm.nih.gov]

  The child redeveloped splenomegaly and fever, and then suffered an acute decompensation with hypoxemia, tachypnea, splenomegaly, and cardiac gallop. Open-lung biopsy revealed lymphomatoid granulomatosis. [baillement.com]

  Splenomegaly was observed and the SUVmax was 12.4 in the PET/CT image. The CT-guided transthoracic biopsy revealed inflammatory cells and large coagulated necrotic tissue. [spandidos-publications.com]

• Inguinal Lymphadenopathy

  CT scan revealed mediastinal (complex confluent subcarinal lymph node mass measuring 5.6 cm), aortopulmonary, paratracheal, right tracheobronchial, axillary, upper abdominal (1.5 cm), external ileac and right inguinal lymphadenopathy (largest 10.7 mm) [springerplus.springeropen.com]

• Cough

  On clinical examination, this dog presented with nonproductive dry cough, serous nasal discharge, dyspnea, and lack of appetite. Radiography showed a consolidated lesion in the left cranial lung lobe. [ncbi.nlm.nih.gov]

  It most often affects the lungs, causing chest pains, cough, and shortness of breath. [medical-dictionary.thefreedictionary.com]

  The commonest presenting picture includes fever, cough, rash/nodules, malaise, weight loss, neurologic abnormalities, dyspnoea, and chest pain (Katzenstein et al. 1979 ). [springerplus.springeropen.com]

• Rales

  General physical examination revealed bilateral crackles and rales on both lung fields. There was no evidence of cardiac murmur, lymphadenopathy, hepatosplenomegaly, or skin lesion. [journals.lww.com]

  This was slowly tapered, but on August 22, 1995, she suffered an acute decompensation with hypoxemia, tachypnea, poor color, splenomegaly, diffuse rales, and cardiac gallop. [baillement.com]

  On lung auscultation, breath sounds were diminished over the lower left lung, and there were no crackles or rales on either side. A neurological examination revealed no focal defect. [spandidos-publications.com]

• Dry Cough

  On clinical examination, this dog presented with nonproductive dry cough, serous nasal discharge, dyspnea, and lack of appetite. Radiography showed a consolidated lesion in the left cranial lung lobe. [ncbi.nlm.nih.gov]

  Review of systems was positive only for a dry cough for two months. She denied fever, shortness of breath or weight loss. She was diagnosed with HIV 14 years prior but never sought medical care. [ijcasereportsandimages.com]

  Case Presentation A 66-year-old Caucasian man with no significant past medical history presented with flu-like symptoms, progressively worsening shortness of breath, difficulty in breathing (NYHA class III) and dry cough over the past 2 weeks prior to [jhoonline.biomedcentral.com]

  Case report A 19-year-old male was presented to the pulmonary clinic of the People’s hospital of Shenzhen University (Shenzhen, China) with chills, a fever, mild intermittent dry coughing, night sweating and fatigue that had lasted 7 days. [spandidos-publications.com]

• Pulmonary Disorder

  Cutaneous lesions may appear before the pulmonary disorder,[ 10 ] as in our case. Dermatologic manifestations are diverse, but most typically appear as nodules. The clinical pattern of the cutaneous lesions correlates with histological grade. [mjhid.org]

• Nasal Discharge

  On clinical examination, this dog presented with nonproductive dry cough, serous nasal discharge, dyspnea, and lack of appetite. Radiography showed a consolidated lesion in the left cranial lung lobe. [ncbi.nlm.nih.gov]

• Janeway Lesion

  Page 551 2016/03 Janeway Lesions in Eosinophilic Granulomatosis with Polyangiitis Oiwa H, Nishioka K Internal Medicine Vol.55 No. [city-hosp.naka.hiroshima.jp]

  No Osler nodes, Janeway lesions or splinter hemorrhages were observed. [journals.lww.com]

• Splinter Hemorrhage

  No Osler nodes, Janeway lesions or splinter hemorrhages were observed. [journals.lww.com]

Broad infectious workup was negative. Given the time course of presentation and anterior accentuation of the lung infiltrates, the greatest clinical concern was radiation pneumonitis followed by drug toxicity. [mdedge.com]

Additional workup showed negative antinuclear antibodies and antineutrophil cytoplasmic antibodies (ANCA). Two skin biopsies were performed, showing a dense T-cell lymphoid infiltrate, EBV-ISH negative. [mjhid.org]

• Pulmonary Infiltrate

  Given the persistence of the nodular pulmonary infiltrates, emperic itraconazole was started. Over the next several weeks, continued improvement and resolution of the pulmonary infiltrates was noted (Fig 2). [baillement.com]

  A 54-year-old female was admitted with a 1-month history of dyspnea, cough and pulmonary infiltrates. She was a never smoker and had no preexisting lung disease. [synapse.koreamed.org]

  A 48-year-old woman with peripheral neuropathy, hypercalcemia, and pulmonary infiltrates. Chest 1998 ; 114 : 1205 –1209. Lymphomatoid granulomatosis. In : Travis WD, Colby TV, Corrin B, Shimosato Y, Brambilla E. [erj.ersjournals.com]

  A crucial factor contributing to the frequent delay in diagnosis of LYG is its ability to mimic various infectious diseases, vasculitides, and malignancies. [5] [10] Bilateral pulmonary infiltrates or nodules are usually seen. [ijcasereportsandimages.com]

• Right Pleural Effusion

  A small right pleural effusion and little pleural thickening/pleural reaction was reported in dependent parts of the left lower lobe (Figure 1 ). Figure 1 CT scan chest. [springerplus.springeropen.com]

  A chest radiograph and computed tomography (CT) scan showed multifocal patchy consolidations with nodular lesions of variable sizes and irregular margins combined with right pleural effusion, but there was no hilar or mediastinal lymphadenopathy (Fig. [journals.lww.com]

• Air Bronchogram

  Imaging tests showed the presence of bilateral pulmonary nodules, predominantly in the lower lobes ( Fig. 1 ), some with air bronchogram sign and occasional central cavities. [archbronconeumol.org]

• Kerley A Lines

  Chest x-ray revealed increased coarse, linear shadowing in the mid- and lower zones, prominent hila, bilateral Kerley B lines, and a pleural reaction on the left. Nodular shadows were present bilaterally, the largest measuring 18 mm. [springerplus.springeropen.com]

• Kerley B Lines

  Chest x-ray revealed increased coarse, linear shadowing in the mid- and lower zones, prominent hila, bilateral Kerley B lines, and a pleural reaction on the left. Nodular shadows were present bilaterally, the largest measuring 18 mm. [springerplus.springeropen.com]

• Granulomatous Tissue

  Kradin-RL; Mark-EJ; Belley-G; Norris-PJ; Ton-F A 48-year-old man with a cough and bloody sputum - Wegener's granulomatosis, with microabscesses, capillaritis, granulomatous vasculitis, diffuse granulomatous tissue, and palisading granuloma. [malattierare.regione.veneto.it]

Open lung biopsy and total excision is mandatory for the appropriate diagnosis and treatment. [ncbi.nlm.nih.gov]

The clinical response to treatment was very good, and a post-treatment CT chest shows complete resolution of lung changes. [springerplus.springeropen.com]

PLG is even harder to cure because of the lack of an established treatment strategy. [journals.lww.com]

Lymphoma diagnosed in this way was associated with a better prognosis than lymphoma diagnosed on the basis of conventional histopathologic findings. In three patients, solid tumors eventually developed. [ncbi.nlm.nih.gov]

Prognosis 64% mortality, median survival of 14 months; death is due to pulmonary destruction accompanied by sepsis; severe T-cell impairment may explain the malignant evolution of this condition. [medical-dictionary.thefreedictionary.com]

Keywords EBV Immunohistochemistry Grading Rare Lymphoproliferative disorder Pulmonary involvement Prognosis This is a preview of subscription content, log in to check access. Notes Acknowledgment None. [link.springer.com]

Extensive work-up for neoplastic, infectious, inflammatory, and autoimmune etiologies needs to be done in such cases. A prompt diagnosis of LYG is necessary for optimal management and improved patient outcomes. [ncbi.nlm.nih.gov]

Lymphomatoid granulomatosis (LYG) is a rare tumor with unknown etiology. [spandidos-publications.com]

Differential diagnosis at this time was extensive with an infectious etiology considered most likely, but malignancy also a serious consideration. [ijcasereportsandimages.com]

Etiology: - L ymphomatoid granulomatosis is closely associated with EBV. - P atients may have underlying defects in their cell-mediated immunity. [histopathology-india.net]

The etiology is not known, but there is an association collagen vascular diseases, AIDS, and immunodeficiency. [icnet.uk]

Abstract We reviewed the epidemiologic, laboratory, roentgenographic, pulmonary function, and survival data from 28 patients who had a histologic diagnosis of lymphomatoid granulomatosis (LG) with involvement of the lungs. [ncbi.nlm.nih.gov]

The epidemiologic, ultrastructural, immunologic, and clinicopathologic features of well-known viral pathogens and newer emergent infectious agents are discussed in detail. [books.google.de]

Methods Statistics Trigonometry Medical & Nursing Anatomy Anesthesiology Audiology Bacteriology Biochemistry Bioethics Biomedical Science Cardiology Cardiovascular Childbirth Chiropractic Dentistry Dermatology Diagnostic Imaging Drugs Endocrinology Epidemiology [brainscape.com]

Epidemiology This is a rare condition, usually presenting in adults 9, but also seen in children with immunodeficiency. The male to female ratio is 2:1 6,9. [e-immunohistochemistry.info]

While the epidemiology of neurological complications has changed considerably since the introduction of highly active antiretroviral therapy (HAART), a wide spectrum of neurological complications in HIV-infection individuals continues to be seen. [ijcasereportsandimages.com]

[…] infection and immunosuppression through immunosuppressive drugs (with case reports of methotrexate [6] [7] [8] [9] [10] [11] [12] [13] [14] and azathioprine [15] [16] ), infections such as HIV or chronic viral hepatitis or endogenous T cell defects. [17] Pathophysiology [en.wikipedia.org]

Etiology Pathophysiology LYG is an EBV-associated lymphoproliferative disorder. LYG may be more common in patients with immunodeficiency due to incomplete clearance of EBV and the resulting clonal proliferation of atypical EBV-infected B-cells. [dermatologyadvisor.com]

Prevention Little can be done to prevent this disease; however, avoiding the Epstein-Barr Virus (human herpesvirus 4) is one preventative measure. [knowcancer.com]

How can Lymphomatoid Granulomatosis be Prevented? Presently, the cause of Lymphomatoid Granulomatosis is unknown; hence, there are no known methods to prevent its occurrence. [dovemed.com]

Radiotherapy was delivered to the whole brain, however, this treatment did not prevent progression of the disease and the patient succumbed three months after initial presentation. [spandidos-publications.com]