Pulmonary lymphomatoid granulomatosis is a rare diagnosis that frequently presents with a constellation of seemingly unrelated signs and symptoms. [ncbi.nlm.nih.gov]

Nodular shadows were present bilaterally, the largest measuring 18 mm. Methotrexate and Azathioprine were discontinued. [springerplus.springeropen.com]

Here, we present a case of low grade pulmonary LYG with multiple lung lesions and endobronchial mass which is a rare presentation. A 54-year-old female was admitted with a 1-month history of dyspnea, cough and pulmonary infiltrates. [synapse.koreamed.org]

• Splenomegaly

  A computerized tomography (CT) scan demonstrated bilateral pulmonary nodules and splenomegaly. [ncbi.nlm.nih.gov]

  The child redeveloped splenomegaly and fever, and then suffered an acute decompensation with hypoxemia, tachypnea, splenomegaly, and cardiac gallop. Open-lung biopsy revealed lymphomatoid granulomatosis. [baillement.com]

  Splenomegaly was observed and the SUVmax was 12.4 in the PET/CT image. The CT-guided transthoracic biopsy revealed inflammatory cells and large coagulated necrotic tissue. [spandidos-publications.com]

• Fever

  In a 49 year old woman presenting with fever, malaise and pulmonary masses the diagnosis of lymphomatoid granulomatosis was established histologically by open lung biopsy. [ncbi.nlm.nih.gov]

  Herein, we describe LYG in a 56-year-old renal allograft recipient 11 years after transplantation, on azathioprine and prednisolone maintenance immunosuppression, presenting to us with fever, weight loss, and nodular and patchy opacities in both lung [ingentaconnect.com]

  CASE REPORT A 33-yr-old female was hospitalised with a 3-month history of cough, dyspnoea, fever and skin rash. [erj.ersjournals.com]

• Weight Loss

  Herein, we describe LYG in a 56-year-old renal allograft recipient 11 years after transplantation, on azathioprine and prednisolone maintenance immunosuppression, presenting to us with fever, weight loss, and nodular and patchy opacities in both lung [ingentaconnect.com]

  The commonest presenting picture includes fever, cough, rash/nodules, malaise, weight loss, neurologic abnormalities, dyspnoea, and chest pain (Katzenstein et al. 1979 ). [springerplus.springeropen.com]

  The symptoms associated with LYG depend on the site of disease involvement but mainly include cough, dyspnea or chest pain (in those with pulmonary involvement) and constitutional symptoms such as weight loss and fever. [orpha.net]

  We present a 60-year-old woman with worsening fatigue, night sweats, unintentional weight loss, and dyspnea of 2 weeks’ duration. [mdedge.com]

  Cough, fever and weight loss in a young male. Eur Respir J 2002 ; 19 : 1210 –1213. ↵ Lemieux J, Bernier V, Martel N, Delage R. Autologous hematopoietic stem cell transplantation for refractory lymphomatoid granulomatosis. [erj.ersjournals.com]

• Cough

  On clinical examination, this dog presented with nonproductive dry cough, serous nasal discharge, dyspnea, and lack of appetite. Radiography showed a consolidated lesion in the left cranial lung lobe. [ncbi.nlm.nih.gov]

  It most often affects the lungs, causing chest pains, cough, and shortness of breath. [medical-dictionary.thefreedictionary.com]

  Conchillo Armend{\'a}riz and Francisco Vega Vazquez and {\'O}scar Beloqui Ruiz}, journal={Anales De Medicina Interna}, year={1998}, volume={15}, pages={487-489} } We present an AIDs patient who was admitted to our hospital because of dry cough, pleuritic [semanticscholar.org]

• Rales

  This was slowly tapered, but on August 22, 1995, she suffered an acute decompensation with hypoxemia, tachypnea, poor color, splenomegaly, diffuse rales, and cardiac gallop. [baillement.com]

  General physical examination revealed bilateral crackles and rales on both lung fields. There was no evidence of cardiac murmur, lymphadenopathy, hepatosplenomegaly, or skin lesion. [journals.lww.com]

  On lung auscultation, breath sounds were diminished over the lower left lung, and there were no crackles or rales on either side. A neurological examination revealed no focal defect. [spandidos-publications.com]

• Dry Cough

  On clinical examination, this dog presented with nonproductive dry cough, serous nasal discharge, dyspnea, and lack of appetite. Radiography showed a consolidated lesion in the left cranial lung lobe. [ncbi.nlm.nih.gov]

  Conchillo Armend{\'a}riz and Francisco Vega Vazquez and {\'O}scar Beloqui Ruiz}, journal={Anales De Medicina Interna}, year={1998}, volume={15}, pages={487-489} } We present an AIDs patient who was admitted to our hospital because of dry cough, pleuritic [semanticscholar.org]

  Review of systems was positive only for a dry cough for two months. She denied fever, shortness of breath or weight loss. She was diagnosed with HIV 14 years prior but never sought medical care. [ijcasereportsandimages.com]

  Case report A 19-year-old male was presented to the pulmonary clinic of the People’s hospital of Shenzhen University (Shenzhen, China) with chills, a fever, mild intermittent dry coughing, night sweating and fatigue that had lasted 7 days. [spandidos-publications.com]

  Case Presentation A 66-year-old Caucasian man with no significant past medical history presented with flu-like symptoms, progressively worsening shortness of breath, difficulty in breathing (NYHA class III) and dry cough over the past 2 weeks prior to [jhoonline.biomedcentral.com]

• Pulmonary Disorder

  […] lymphomatoid granulomatosis (PLG), which has been defined as a clinicopathological entity is a rare Epstein–Barr virus (EBV)-driven lymphoproliferative pulmonary disorder. [journals.lww.com]

  Pulmonary involvement is almost always present, while other common sites include central nervous system (CNS) and skin.[ 2 ] Currently, LYG is considered an EBV related B-lymphoproliferative disorder,[ 3 ] similar to other lymphoproliferative disorders [mjhid.org]

• Splinter Hemorrhage

  No Osler nodes, Janeway lesions or splinter hemorrhages were observed. [journals.lww.com]

Broad infectious workup was negative. Given the time course of presentation and anterior accentuation of the lung infiltrates, the greatest clinical concern was radiation pneumonitis followed by drug toxicity. [mdedge.com]

Additional workup showed negative antinuclear antibodies and antineutrophil cytoplasmic antibodies (ANCA). Two skin biopsies were performed, showing a dense T-cell lymphoid infiltrate, EBV-ISH negative. [mjhid.org]

• Pulmonary Infiltrate

  Given the persistence of the nodular pulmonary infiltrates, emperic itraconazole was started. Over the next several weeks, continued improvement and resolution of the pulmonary infiltrates was noted (Fig 2). [baillement.com]

  Here, we present a case of low grade pulmonary LYG with multiple lung lesions and endobronchial mass which is a rare presentation. A 54-year-old female was admitted with a 1-month history of dyspnea, cough and pulmonary infiltrates. [synapse.koreamed.org]

  A 48-year-old woman with peripheral neuropathy, hypercalcemia, and pulmonary infiltrates. Chest 1998 ; 114 : 1205 –1209. ↵ Lymphomatoid granulomatosis. In : Travis WD, Colby TV, Corrin B, Shimosato Y, Brambilla E. [erj.ersjournals.com]

  On hospital day-3, a biopsy of the pulmonary lesions via video-assisted thoracoscopy (VATS) was obtained. Pathology of the pulmonary nodule revealed an angiocentric infiltrate of lymphocytes with large areas of necrosis. [ijcasereportsandimages.com]

• Right Pleural Effusion

  A small right pleural effusion and little pleural thickening/pleural reaction was reported in dependent parts of the left lower lobe (Figure 1 ). Figure 1 CT scan chest. [springerplus.springeropen.com]

  A chest radiograph and computed tomography (CT) scan showed multifocal patchy consolidations with nodular lesions of variable sizes and irregular margins combined with right pleural effusion, but there was no hilar or mediastinal lymphadenopathy (Fig. [journals.lww.com]

• Kerley A Lines

  Chest x-ray revealed increased coarse, linear shadowing in the mid- and lower zones, prominent hila, bilateral Kerley B lines, and a pleural reaction on the left. Nodular shadows were present bilaterally, the largest measuring 18 mm. [springerplus.springeropen.com]

• Kerley B Lines

  Chest x-ray revealed increased coarse, linear shadowing in the mid- and lower zones, prominent hila, bilateral Kerley B lines, and a pleural reaction on the left. Nodular shadows were present bilaterally, the largest measuring 18 mm. [springerplus.springeropen.com]

• Granulomatous Tissue

  Kradin-RL; Mark-EJ; Belley-G; Norris-PJ; Ton-F A 48-year-old man with a cough and bloody sputum - Wegener's granulomatosis, with microabscesses, capillaritis, granulomatous vasculitis, diffuse granulomatous tissue, and palisading granuloma. [malattierare.regione.veneto.it]

The clinical response to treatment was very good, and a post-treatment CT chest shows complete resolution of lung changes. [springerplus.springeropen.com]

PLG is even harder to cure because of the lack of an established treatment strategy. [journals.lww.com]

Half of all cases of lymphomatoid granulomatosis develop during the treatment of leukemia. Herein, we describe a case of lymphomatoid granulomatosis in a previously healthy child without leukemia. [unboundmedicine.com]

Open lung biopsy and total excision is mandatory for the appropriate diagnosis and treatment. [ncbi.nlm.nih.gov]

Prognosis 64% mortality, median survival of 14 months; death is due to pulmonary destruction accompanied by sepsis; severe T-cell impairment may explain the malignant evolution of this condition. [medical-dictionary.thefreedictionary.com]

Lymphoma diagnosed in this way was associated with a better prognosis than lymphoma diagnosed on the basis of conventional histopathologic findings. In three patients, solid tumors eventually developed. [ncbi.nlm.nih.gov]

[…] confined to site of origin, the prognosis is usually excellent with appropriate therapy. [dovemed.com]

Prognosis: The prognosis is poor, the median survival being only fourteen months after diagnosis. [histopathology-india.net]

Extensive work-up for neoplastic, infectious, inflammatory, and autoimmune etiologies needs to be done in such cases. A prompt diagnosis of LYG is necessary for optimal management and improved patient outcomes. [ncbi.nlm.nih.gov]

Lymphomatoid granulomatosis (LYG) is a rare tumor with unknown etiology. [spandidos-publications.com]

Differential diagnosis at this time was extensive with an infectious etiology considered most likely, but malignancy also a serious consideration. [ijcasereportsandimages.com]

Etiology: - L ymphomatoid granulomatosis is closely associated with EBV. - P atients may have underlying defects in their cell-mediated immunity. [histopathology-india.net]

The etiology is not known, but there is an association collagen vascular diseases, AIDS, and immunodeficiency. [icnet.uk]

Abstract We reviewed the epidemiologic, laboratory, roentgenographic, pulmonary function, and survival data from 28 patients who had a histologic diagnosis of lymphomatoid granulomatosis (LG) with involvement of the lungs. [ncbi.nlm.nih.gov]

The epidemiologic, ultrastructural, immunologic, and clinicopathologic features of well-known viral pathogens and newer emergent infectious agents are discussed in detail. [books.google.de]

Methods Statistics Trigonometry Medical & Nursing Anatomy Anesthesiology Audiology Bacteriology Biochemistry Bioethics Biomedical Science Cardiology Cardiovascular Childbirth Chiropractic Dentistry Dermatology Diagnostic Imaging Drugs Endocrinology Epidemiology [brainscape.com]

Epidemiology This is a rare condition, usually presenting in adults 9, but also seen in children with immunodeficiency. The male to female ratio is 2:1 6,9. [e-immunohistochemistry.info]

While the epidemiology of neurological complications has changed considerably since the introduction of highly active antiretroviral therapy (HAART), a wide spectrum of neurological complications in HIV-infection individuals continues to be seen. [ijcasereportsandimages.com]

Etiology Pathophysiology LYG is an EBV-associated lymphoproliferative disorder. LYG may be more common in patients with immunodeficiency due to incomplete clearance of EBV and the resulting clonal proliferation of atypical EBV-infected B-cells. [dermatologyadvisor.com]

[…] infection and immunosuppression through immunosuppressive drugs (with case reports of methotrexate [6] [7] [8] [9] [10] [11] [12] [13] [14] and azathioprine [15] [16] ), infections such as HIV or chronic viral hepatitis or endogenous T cell defects. [17] Pathophysiology [en.wikipedia.org]

Prevention Little can be done to prevent this disease; however, avoiding the Epstein-Barr Virus (human herpesvirus 4) is one preventative measure. [knowcancer.com]

How can Lymphomatoid Granulomatosis be Prevented? Presently, the cause of Lymphomatoid Granulomatosis is unknown; hence, there are no known methods to prevent its occurrence. [dovemed.com]

Radiotherapy was delivered to the whole brain, however, this treatment did not prevent progression of the disease and the patient succumbed three months after initial presentation. [spandidos-publications.com]