PATIENT SUMMARY: We reviewed outcomes among kidney cancer patients who presented with small lung nodules and developed a clinical tool to predict risk of developing lung metastases. Copyright © 2015 European Association of Urology. [ncbi.nlm.nih.gov]

• Weight Loss

  Herein a previously healthy patient was admitted for dysphagia and fatigue, without significant weight loss. The pathological and molecular tests revealed his diagnosis of BRAF-mutant, advanced PMME with localized pulmonary metastasis. [ncbi.nlm.nih.gov]

  She had abdominal pain, occasional fever and weight loss for 3 months. Progressive breathlessness was present for 15 days. Her physical examination was unremarkable. [err.ersjournals.com]

  Clinical signs of nematodiasis were vague but generally consisted of weight loss, anorexia, and lethargy. Frequent antemortem fecal examinations were negative for spirurid eggs. [bioone.org]

  loss Not all cancers can be prevented. [medlineplus.gov]

  She had no history of weight loss/body pain or any respiratory symptoms. She was not a diabetic or hypertensive. [thetrp.net]

• Fever

  This 13-year-old girl admitted with 1-year history of cough, intermittent fever, and recurrent hemoptysis. [ncbi.nlm.nih.gov]

  She had abdominal pain, occasional fever and weight loss for 3 months. Progressive breathlessness was present for 15 days. Her physical examination was unremarkable. [err.ersjournals.com]

  1 Idaigaoka, Yufu-city, Oita, 879-5593 Japan Received: March 17, 2014; Accepted: March 18, 2014; Published: March 19, 2015 Keywords Infiltrative shadow; Lung; Metastasis; Pancreas Clinical Image A 61-year-old female was admitted due to a persistent fever [austinpublishinggroup.com]

  At the clinical exam, we note fever at 38°C. [latunisiemedicale.com]

  […] does not go away or gets worse weight loss dyspnea (shortness of breath or difficulty breathing) chest pain, which may be aggravated by deep breathing, coughing, or laughing hemoptysis (coughing up blood or rust-colored phlegm)[7] bone pain clubbing fever [en.wikipedia.org]

• Cough

  This 13-year-old girl admitted with 1-year history of cough, intermittent fever, and recurrent hemoptysis. [ncbi.nlm.nih.gov]

  If a lung metastasis does cause symptoms, they may include: pain or discomfort in the lung shortness of breath wheezing persistent cough coughing up blood and mucus It can be difficult to tell the difference between symptoms of lung metastasis and symptoms [breastcancer.org]

  Very rarely are patients symptomatic with cough, pain, hemoptysis, or dyspnea. Helical, thin-sliced computed tomography is the gold standard for detecting pulmonary metastases. [accesssurgery.mhmedical.com]

  […] up blood Persistent cough Shortness of breath Unexplained weight loss Not all cancers can be prevented. [medlineplus.gov]

• Hemoptysis

  Three cases of choriocarcinoma with pulmonary metastasis who had the primary symptom of hemoptysis are described. [ncbi.nlm.nih.gov]

  Very rarely are patients symptomatic with cough, pain, hemoptysis, or dyspnea. Helical, thin-sliced computed tomography is the gold standard for detecting pulmonary metastases. [accesssurgery.mhmedical.com]

• Pneumonia

  Pneumonia-like consolidation  Adenocarcinoma metastases may destroy adjacent lung parenchyma, resulting in pneumonia-like consolidation. 15. [slideshare.net]

  (mnemonic) acute interstitial pneumonia (AIP) cryptogenic organizing pneumonia (COP) reversed halo / atoll sign desquamative interstitial pneumonia (DIP) idiopathic non-specific interstitial pneumonia (NSIP) fibrotic non-specific interstitial pneumonia [radiopaedia.org]

  Twenty-two months after completion of radiation therapy, the patient developed a lower left lobe pneumonia. [ecancer.org]

  Crackles can be heard in patients with pneumonia, atelectasis, pulmonary fibrosis, acute bronchitis, bronchiectasis, interstitial lung disease or post thoracotomy or metastasis ablation. [dbpedia.org]

• Rales

  The word "rales" derives from the French word râle meaning "rattle". [dbpedia.org]

  Pulmonary auscultation showed decreased breath sounds, principally in the left lung, with wheezing, diffuse rales and crackles in the lung bases. [scielo.br]

• Dysphagia

  Herein a previously healthy patient was admitted for dysphagia and fatigue, without significant weight loss. The pathological and molecular tests revealed his diagnosis of BRAF-mutant, advanced PMME with localized pulmonary metastasis. [ncbi.nlm.nih.gov]

  Acute toxicities (eg, cough, dyspnea, dysphagia, nausea, and fatigue) were reported in half of the patients treated with whole-lung irradiation. [ascopost.com]

  Acute (0 to 6 months) EBRT side effects include esophagitis, dysphagia, erythema, and a need for tracheostomy, while late complications (6 months to 2 years) include xerostomia, esophageal stenosis, tracheal constriction, carotid stenosis, and brachial [thyroid.org]

  This is caused by compression of vasculature by the lung tumor that restricts blood return from the upper body.[4] dysphagia (trouble swallowing or the sensation that something is caught in the throat) and hoarseness new onset of wheezing without history [en.wikipedia.org]

• Liver Dysfunction

  A 77-year-old man was admitted to our hospital due to exertional dyspnea and liver dysfunction. Computed tomography showed widespread infiltration and a ground-glass opacity in the lung and dilation of the intrahepatic bile duct. [ncbi.nlm.nih.gov]

Isolated pulmonary metastasis was defined as limited to presumable pulmonary metastasis according to the follow-up radiologic workup. RESULTS: Thirty-five patients were identified to have repeat pulmonary metastasis. [ncbi.nlm.nih.gov]

[…] an underlying lung cancer at younger ages.[5] Importantly, many of these signs are commonly due to other causes which are not cancer.[6] A detailed medical history should be obtained from each patient to determine the relevance of further diagnostic workup [en.wikipedia.org]

• Pulmonary Infiltrate

  Adem et al. [12] described seven patients with metastatic angiosarcoma presenting with diffuse pulmonary hemorrhage. In four of those patients, chest radiographs showed diffuse pulmonary infiltrates in both lungs. [ajronline.org]

Therefore, early detection, adequate treatment of the primary bone lesion, conservative treatment of lung metastases, and regular long-term follow-up are recommended. Copyright 2016, SLACK Incorporated. [ncbi.nlm.nih.gov]

Lymph-node sampling or dissection is therefore warranted to predict patient prognosis. © The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. [ncbi.nlm.nih.gov]

Surgery is the recommended option for a good prognosis for limited stage IVb patients if the thymomas with lung metastases appear completely resectable. [wjso.biomedcentral.com]

Etiology Pulmonary cavities may be the result of malignancy, infection, inflammation, or be congenital: cavitating malignancy primary bronchogenic carcinoma (especially squamous cell carcinoma) cavitating pulmonary metastases squamous cell carcinoma adenocarcinoma [radiopaedia.org]

In contrast to in the situation for breast carcinoma involving women, the etiology of male breast carcinoma remains little understood. [scielo.br]

[…] bone, muscle, skin, and breast, 3–7 but it most commonly arises in the lungs, in which the incidence ranges from 1% to 9%. 7–11 Pulmonary metastases usually have the same histological features as the benign primary tumor. 5,7,10,12 There are several etiologies [healio.com]

The solitary pulmonary nodule in this case was indistinguishable from pulmonary metastases of the adamantinoma based on clinical symptoms, epidemiology, chest radiography, CT, and FDG-PET/CT. [ncbi.nlm.nih.gov]

Objectives: To review the available data on epidemiology and management of foodborne nematodiasis in the European Union, detect any trends and determine the possible causes of the observed changes. [tandfonline.com]

Gestational trophoblastic neoplasia Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Gestational trophoblastic neoplasia from other Diseases Epidemiology and Demographics Risk [wikidoc.org]

The epidemiology will match that of the underlying malignancy (see below), but as malignancies increase in incidence with increasing age, so does the presence of pulmonary metastases. [radiopaedia.org]

A review of the epidemiology of lung adenocarcinoma". International Journal of Epidemiology. 26 (1): 14–23. doi : 10.1093/ije/26.1.14. PMID 9126499. Archived from the original on 5 December 2008. ^ Kadara H, Kabbout M, Wistuba II (January 2012). [en.wikipedia.org]

In this study, we explored the impact of autophagy on the pathophysiology of breast cancer cells using a novel hypoxia-dependent, reversible dominant-negative strategy to regulate autophagy at the cellular level within the TME. [ncbi.nlm.nih.gov]

Gestational trophoblastic neoplasia Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Gestational trophoblastic neoplasia from other Diseases Epidemiology and Demographics Risk [wikidoc.org]

The presumed underlying pathophysiologic mechanism is excessive vascular production of vasodilators (particularly, nitric oxide). [pubs.rsna.org]

Pathophysiology[edit] The respiratory tract can be divided into two main components: the conducting airways and the gas exchange airways. [en.wikipedia.org]

Bcl-3 could bind to Smad3 and prevent the ubiquitination and degradation of Smad3 protein. These results indicate that Bcl-3 serves as a promising target to prevent breast tumor lung metastasis. [ncbi.nlm.nih.gov]