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Pulmonary Metastasis

Metastasis to Lung


Presentation

  • PATIENT SUMMARY: We reviewed outcomes among kidney cancer patients who presented with small lung nodules and developed a clinical tool to predict risk of developing lung metastases. Copyright 2015 European Association of Urology.[ncbi.nlm.nih.gov]
  • We present a case of an 18-year-old man who presented with chest pain, cough and haemosputum with markedly raised serum α-fetoprotein (AFP) levels above 112,000 ng/mL. Chest roentgenogram and CT showed a giant anterior mediastinal mass.[ncbi.nlm.nih.gov]
  • In the present report, we describe the first case of pulmonary metastasis from renal epithelioid angiomyolipoma in the setting of breast cancer.[ncbi.nlm.nih.gov]
  • The present case suggests that CMV-PTC with a high Ki-67 labeling index may cause visceral metastasis.[ncbi.nlm.nih.gov]
  • To the best of our knowledge, cases of pulmonary metastases presenting as a pulmonary arteriovenous malformation have not been reported.[ncbi.nlm.nih.gov]
Weight Loss
  • Herein a previously healthy patient was admitted for dysphagia and fatigue, without significant weight loss. The pathological and molecular tests revealed his diagnosis of BRAF-mutant, advanced PMME with localized pulmonary metastasis.[ncbi.nlm.nih.gov]
  • She had no history of weight loss/body pain or any respiratory symptoms. She was not a diabetic or hypertensive.[thetrp.net]
  • She had abdominal pain, occasional fever and weight loss for 3 months. Progressive breathlessness was present for 15 days. Her physical examination was unremarkable.[err.ersjournals.com]
  • loss Not all cancers can be prevented.[medlineplus.gov]
  • The symptoms of metastatic lung cancer can include: a persistent cough coughing up blood or bloody phlegm chest pain shortness of breath wheezing weakness sudden weight loss For cancer cells to metastasize, they must go through several changes.[healthline.com]
Fever
  • This 13-year-old girl admitted with 1-year history of cough, intermittent fever, and recurrent hemoptysis.[ncbi.nlm.nih.gov]
  • -1 Idaigaoka, Yufu-city, Oita, 879-5593 Japan Received: March 17, 2014; Accepted: March 18, 2014; Published: March 19, 2015 Keywords Infiltrative shadow; Lung; Metastasis; Pancreas Clinical Image A 61-year-old female was admitted due to a persistent fever[austinpublishinggroup.com]
  • She had abdominal pain, occasional fever and weight loss for 3 months. Progressive breathlessness was present for 15 days. Her physical examination was unremarkable.[err.ersjournals.com]
  • At the clinical exam, we note fever at 38 C.[latunisiemedicale.com]
  • […] worse in the developing world. [20] Signs and symptoms [ edit ] Signs and symptoms which may suggest lung cancer include: [1] Respiratory symptoms: coughing, coughing up blood, wheezing, or shortness of breath Systemic symptoms: weight loss, weakness, fever[en.wikipedia.org]
Intermittent Fever
  • This 13-year-old girl admitted with 1-year history of cough, intermittent fever, and recurrent hemoptysis.[ncbi.nlm.nih.gov]
Cough
  • This 13-year-old girl admitted with 1-year history of cough, intermittent fever, and recurrent hemoptysis.[ncbi.nlm.nih.gov]
  • We present a case of an 18-year-old man who presented with chest pain, cough and haemosputum with markedly raised serum α-fetoprotein (AFP) levels above 112,000 ng/mL. Chest roentgenogram and CT showed a giant anterior mediastinal mass.[ncbi.nlm.nih.gov]
  • […] up blood Persistent cough Shortness of breath Unexplained weight loss Not all cancers can be prevented.[medlineplus.gov]
  • The symptoms of metastatic lung cancer can include: a persistent cough coughing up blood or bloody phlegm chest pain shortness of breath wheezing weakness sudden weight loss For cancer cells to metastasize, they must go through several changes.[healthline.com]
  • In 2012, seven years after the initial surgery, the patient complained several times of a persistent cough. Antitussives were prescribed without any improvement of the symptoms.[pagepress.org]
Hemoptysis
  • Three cases of choriocarcinoma with pulmonary metastasis who had the primary symptom of hemoptysis are described.[ncbi.nlm.nih.gov]
  • This 13-year-old girl admitted with 1-year history of cough, intermittent fever, and recurrent hemoptysis.[ncbi.nlm.nih.gov]
  • He presented at our emergency unit within 4 years of completion of the chemotherapy, with sudden massive hemoptysis.[ncbi.nlm.nih.gov]
  • A 39-year-old Japanese woman presented with hemoptysis, dyspnea, and a well-defined tumor measuring 3.0 cm in greatest diameter in the right lower lobe on chest computed tomography (CT).[ncbi.nlm.nih.gov]
  • Hemoptysis and pneumothorax are sometimes the presenting symptom. Tumor cells reach the lungs via the pulmonary circulation, where they lodge in small distal vessels.[radiopaedia.org]
Pneumonia
  • Twenty-two months after completion of radiation therapy, the patient developed a lower left lobe pneumonia.[ecancer.org]
  • Physicians have long noted an association between lung inflammation – seen in smokers or in people with lung diseases such as asthma, COPD and emphysema, and pneumonia – and the development of lung tumors.[news.cornell.edu]
  • Crackles can be heard in patients with pneumonia, atelectasis, pulmonary fibrosis, acute bronchitis, bronchiectasis, interstitial lung disease or post thoracotomy or metastasis ablation.[dbpedia.org]
  • […] include 3 : malignant melanoma skeletal sarcoma testicular carcinoma adenocarcinomas in general Adenocarcinoma metastases, rather than displace or destroy adjacent lung parenchyma, may grow in a lepidic fashion (spread along alveolar walls) resulting in pneumonia-like[radiopaedia.org]
  • The differential diagnosis for this air-space pattern includes infections, edema, hemorrhage, organizing pneumonia, eosinophilic pneumonia, minimally invasive adenocarcinoma, lymphoma, and sarcoidosis, among other entities.[emedicine.medscape.com]
Rales
  • The word "rales" derives from the French word râle meaning "rattle".[dbpedia.org]
Rhinorrhea
  • A 29-year-old woman presented with nasal congestion and rhinorrhea for 6 months. CT scanning showed a large mass in the right maxillary sinus, which had infiltrated the surrounding tissues.[ncbi.nlm.nih.gov]
Dysphagia
  • Herein a previously healthy patient was admitted for dysphagia and fatigue, without significant weight loss. The pathological and molecular tests revealed his diagnosis of BRAF-mutant, advanced PMME with localized pulmonary metastasis.[ncbi.nlm.nih.gov]
  • Acute toxicities (eg, cough, dyspnea, dysphagia, nausea, and fatigue) were reported in half of the patients treated with whole-lung irradiation.[ascopost.com]
  • Acute (0 to 6 months) EBRT side effects include esophagitis, dysphagia, erythema, and a need for tracheostomy, while late complications (6 months to 2 years) include xerostomia, esophageal stenosis, tracheal constriction, carotid stenosis, and brachial[thyroid.org]
Liver Dysfunction
  • A 77-year-old man was admitted to our hospital due to exertional dyspnea and liver dysfunction. Computed tomography showed widespread infiltration and a ground-glass opacity in the lung and dilation of the intrahepatic bile duct.[ncbi.nlm.nih.gov]

Workup

  • Isolated pulmonary metastasis was defined as limited to presumable pulmonary metastasis according to the follow-up radiologic workup. RESULTS: Thirty-five patients were identified to have repeat pulmonary metastasis.[ncbi.nlm.nih.gov]
Anterior Mediastinal Mass
  • Chest roentgenogram and CT showed a giant anterior mediastinal mass. CT guided biopsy revealed a diagnosis of endodermal sinus tumour.[ncbi.nlm.nih.gov]
  • An anterior mediastinal mass had been incidentally noticed on chest computed tomography (CT) approximately 10 years previously (patient age, 64 years). The patient refused surgery, and he was conservatively followed-up by annual CT scan.[wjso.biomedcentral.com]
Ground Glass Appearance
  • Here we present a rare case of biopsy-proven PCa pulmonary metastasis with a ground-glass appearance.[ncbi.nlm.nih.gov]

Treatment

  • Therefore, early detection, adequate treatment of the primary bone lesion, conservative treatment of lung metastases, and regular long-term follow-up are recommended. Copyright 2016, SLACK Incorporated.[ncbi.nlm.nih.gov]
  • The type of DTC is the only factor that affects the response to treatment.[ncbi.nlm.nih.gov]
  • Aims of this study were to retrospectively analyze treatment outcomes and to find prognostic factors for survivals.[ncbi.nlm.nih.gov]
  • These findings demonstrate co-targeting of DNA, RNA and protein molecules as a novel therapeutic strategy for the treatment of metastasis.[ncbi.nlm.nih.gov]
  • In vivo, animal experiments showed that THF treatment resulted in significant reduction in syngeneic tumor growth, microvascular density and lung metastasis rate.[ncbi.nlm.nih.gov]

Prognosis

  • In this study, by assessing the metastasis pattern, we aimed to identify the factors that may affect prognosis and response to treatment in patients with differentiated thyroid carcinoma (DTC) with pulmonary metastasis.[ncbi.nlm.nih.gov]
  • Abstract Objective This retrospective analysis aimed to determine the factors influencing prognosis in adult patients who presented to our thoracic surgery service with lung metastases and were eligible for pulmonary metastasectomy.[ncbi.nlm.nih.gov]
  • Lymph-node sampling or dissection is therefore warranted to predict patient prognosis. The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.[ncbi.nlm.nih.gov]
  • PURPOSE: Prognosis of synchronous hepatocellular carcinoma (HCC) patients with pulmonary metastasis (PM) was poor, while aggressive intrahepatic therapies remained controversial.[ncbi.nlm.nih.gov]
  • This study indicated that most DTC patients with pulmonary metastases can obtain partial or complete remission after RIT, while older patients with higher Tg levels at diagnosis and extrapulmonary distant metastases more likely show poor prognosis.[ncbi.nlm.nih.gov]

Etiology

  • Calcification, although uncommon and more frequently a feature of benign etiology (e.g. granuloma or hamartoma) is also seen with metastases, particularly those from papillary thyroid carcinoma and adenocarcinomas.[radiopaedia.org]
  • […] bone, muscle, skin, and breast, 3–7 but it most commonly arises in the lungs, in which the incidence ranges from 1% to 9%. 7–11 Pulmonary metastases usually have the same histological features as the benign primary tumor. 5,7,10,12 There are several etiologies[healio.com]
  • "Lung cancer: epidemiology, etiology, and prevention". Clinics in Chest Medicine. 32 (4): 605–44. doi : 10.1016/j.ccm.2011.09.001. PMC 3864624. PMID 22054876. Goodman GE (November 2002). "Lung cancer. 1: prevention of lung cancer".[en.wikipedia.org]

Epidemiology

  • The solitary pulmonary nodule in this case was indistinguishable from pulmonary metastases of the adamantinoma based on clinical symptoms, epidemiology, chest radiography, CT, and FDG-PET/CT.[ncbi.nlm.nih.gov]
  • The epidemiology will match that of the underlying malignancy (see below), but as malignancies increase in incidence with increasing age, so does the presence of pulmonary metastases.[radiopaedia.org]
  • A review of the epidemiology of lung adenocarcinoma". International Journal of Epidemiology. 26 (1): 14–23. doi : 10.1093/ije/26.1.14. PMID 9126499. Archived from the original on 5 December 2008. Kadara H, Kabbout M, Wistuba II (January 2012).[en.wikipedia.org]
  • Pulmonary adenocarcinomas of the fetal lung type: a clinicopathologic study indicating differences in histology, epidemiology, and natural history of low-grade and high-grade forms. Am. J. Surg.[twmu.ac.jp]
  • Meerbeek JP, Gosselin R, Duyck PH (2007) Lung metastases: epidemiology, clinical presentation and imaging. lung metastases and isolated lung perfusion. Nova Science Publishers Inc, New York. Dail DH (2008) Metastases to and from the lung.[omicsonline.org]
Sex distribution
Age distribution

Pathophysiology

  • In this study, we explored the impact of autophagy on the pathophysiology of breast cancer cells using a novel hypoxia-dependent, reversible dominant-negative strategy to regulate autophagy at the cellular level within the TME.[ncbi.nlm.nih.gov]

Prevention

  • Bcl-3 could bind to Smad3 and prevent the ubiquitination and degradation of Smad3 protein. These results indicate that Bcl-3 serves as a promising target to prevent breast tumor lung metastasis.[ncbi.nlm.nih.gov]
  • We performed endotracheal intubation to prevent suffocation and bronchoscopic examination revealed that a tumor and blood clots had obstructed the left main bronchus.[ncbi.nlm.nih.gov]
  • TPVB may represent an easy, safe, and effective strategy to prevent or treat postoperative pain after pulmonary RFA.[ncbi.nlm.nih.gov]
  • We have previously demonstrated that naringenin significantly reduced TGF-β1 levels in bleomycin-induced lung fibrosis and effectively prevented pulmonary metastases of tumors.[ncbi.nlm.nih.gov]
  • Cessation of smoking should be recommended to prevent pulmonary metastasis, although further basic and clinical studies are required. Colorectal Disease 2017 The Association of Coloproctology of Great Britain and Ireland.[ncbi.nlm.nih.gov]

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