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Pulmonary Plasma Cell Granuloma

Inflammatory Pseudotumors Pulmonary


Presentation

  • A large pulmonary plasma-cell granuloma (PCG) mimicking a mediastinal germinal-cell tumor in a 9-year-old boy is presented. The nonspecificity of the tumoral calcifications and of the radiographic and CT findings in pulmonary PCG is demonstrated.[ncbi.nlm.nih.gov]
  • Chemotherapy presents varying results, with few studies and unfavorable results alone.[archbronconeumol.org]
  • Squamous cell carcinomas often present with hemoptysis within 4 to 6 months of symptom onset, due to mucosal irritation and ulceration.[clinicaladvisor.com]
  • The case presented represents the only published account of IMT with intralesional histoplasma organisms isolated.[humpath.com]
  • We reported [2] a 44-year-old male, who presented to us with cough and minimal expectoration for five months, along with chest pain, hemoptysis and fever for a fortnight.[lungindia.com]
Fever of Unknown Origin
  • Pulmonary inflammatory pseudotumor presenting as fever of unknown origin. Kor J Infect Dis. 31:435–438. 1999. [ Google Scholar ] 16. Kim JG, Jeong NY, Kim KH, Kim HS, Lee WY, Yong SJ, Shin KC, Yang SW, Jeong SH.[e-sciencecentral.org]
Constitutional Symptom
  • Pulmonary vasculitis, especially Wegener granulomatosis, may present with nodular pulmonary disease with or without constitutional symptoms.[clinicaladvisor.com]
Aspiration
  • CT-guided transthoracic needle biopsy: a comparison between automated biopsy gun and fine needle aspiration. Clin Radiol. 51:503–506. 1996. [ CrossRef ] [ Google Scholar ] 30. Shirakusa T, Kusano T, Motonaga R, Eimoto T.[e-sciencecentral.org]
Irritability
  • Squamous cell carcinomas often present with hemoptysis within 4 to 6 months of symptom onset, due to mucosal irritation and ulceration.[clinicaladvisor.com]

Workup

Liver Biopsy
  • Inflammatory pseudotumor of the liver diagnosed by needle liver biopsy under ultrasonographic tomography guidance. J Gastroenterol 2000;35:641-5. 6. Katoh M, Imamura H, Yoshino M, Aoki T, Abumiya T, Aida T.[lungindia.com]

Treatment

  • As middle-dosage corticosteroid therapy is not cytotoxic, it is useful for the treatment of pulmonary plasma cell granuloma, especially in multifocal, unresectable, and/or relapsing cases.[ncbi.nlm.nih.gov]
  • Complications, such as fluid in the lungs or a partial lung collapse, are known to occur occasionally The mainstay of treatment is a surgical excision that can be curative.[dovemed.com]
  • With antibiotic treatment and respiratory physiotherapy, the patient improved.[archbronconeumol.org]
  • Surgical treatment and course of pulmonary pseudotumor (plasma cell granuloma). J Thorac Cardiovasc Surg 1981;82:77-82. [ PUBMED ] 4. Bush A, Sheppard MN, Wahn U, Warner JO. Spontaneous arrest of growth of a plasma cell granuloma.[lungindia.com]
  • Surgical treatment of benign lung tumor. Kor J Thorac Cardiovasc Surg. 25:258–270. 1992. [ Google Scholar ] 11. Bang SH, Kim CH, Kwon SS, Kim YK, Kim KH, Moon HS, Song JS, Park SH.[e-sciencecentral.org]

Prognosis

  • , risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE .[dovemed.com]
  • In addition, early diagnosis benefits patients as the prognosis worsens with the progression of symptoms.[archbronconeumol.org]
  • […] pituitary stalk and other sites, [8] and kidney and other organs. [9] Overall, prevalence of IPT is estimated to be 0.7% in tumors of lung and bronchi. [10] It displays local aggression and hence it has been christened 'tumor' but it has an encouraging prognosis[lungindia.com]
  • Plasma cell granuloma of the lung: difficulties in diagnosis and prognosis. Ann Thorac Surg. 61:1477–1482. 1996. [ CrossRef ] [ Google Scholar ] 24. Doski JJ, Priebe CJ Jr, Driessnack M, Smith T, Kane P, Romero J.[e-sciencecentral.org]
  • The long-term prognosis is unpredictable, and late and fatal recurrences are possible.[ncbi.nlm.nih.gov]

Etiology

  • The etiology of these ‘tumors’ is not certain and often difficult to ascertain.[humpath.com]
  • It is important to distinguish the different etiologies because treatment varies widely, from observation for granulomas or hamartomas to surgery for malignancies like carcinoid tumor and solitary metastasis.[clinicaladvisor.com]
  • Abstract Inflammatory pseudotumors are a relatively uncommon pathology of uncertain etiology, generally considered to be reactive in origin. They may be observed in different locations as single or multiple masses.[archbronconeumol.org]
  • Plasma cell granuloma is a rare benign lesion but its exact etiology, behavior and prognosis is still controversial.[jicdro.org]
  • […] pseudotumor, inflammatory myofibrohistiocytic proliferation Epidemiology Incidence unclear since terminology / definition varies M F, broad age range but usually 30 if IMT 3% bilateral Sites Typically parenchymal, but may involve pleura Rarely intrabronchial Etiology[pathologyoutlines.com]

Epidemiology

  • Summary Epidemiology Approximately 140 cases have been reported worldwide, with a higher prevalence for male adults of Asian origin and subjects affected by systemic diseases such as rheumatoid arthritis.[orpha.net]
  • […] myofibroblastic tumor means neoplastic, fibrohistiocytic, associated with ALK rearrangement Other names used in nonneoplastic lesions: plasma cell granuloma, hyalinizing granuloma, plasma cell pseudotumor, inflammatory myofibrohistiocytic proliferation Epidemiology[pathologyoutlines.com]
  • Epidemiology Occurring at any age, inflammatory myofibroblastic tumour is most common before the age of 40 years.[e-immunohistochemistry.info]
Sex distribution
Age distribution

Prevention

  • […] known to recur and rarely they can even metastasize Please find comprehensive information on Inflammatory Myofibroblastic Tumor of Lung regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention[dovemed.com]
  • 69 الصفحة 62 صفحة العنوان جدول المحتويات المحتويات Quantitation of Morphologic Changes 6 Abnormal Structural Development 12 Available SpaceCompression 18 References 24 Nasopharynx 30 Pathology of Hyaline Membrane Disease and Acute 101 Morphometry 114 Prevention[books.google.com]

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