A 15-year-old boy presented with long-term ocular symptoms of foreign body sensation, burning, irritation, tearing, and transient photophobia. One year's treatment with steroidal agents had led to only partial improvement. [ncbi.nlm.nih.gov]

Case presentation A 15-year-old boy presented with long-term ocular symptoms of foreign body sensation, burning, irritation, tearing, and transient photophobia. One year's treatment with steroidal agents had led to only partial improvement. [doi.org]

Clinical features: Symptoms: Patients usually present with bilateral keratitis Characteristic remissions and exacerbations of tearing, foreign body sensation, and photophobia over several years. [dro.hs.columbia.edu]

Symptoms Typically, the patient is young, usually under 40 years of age, and complains of foreign body sensation, photophobia (aversion to light), and tearing. [healthcentral.com]

A 29-year-old woman with a 5-year history of decreased visual acuity in both eyes had bilateral honeycomb-shaped corneal opacities, located mainly in the superficial central cornea. [ncbi.nlm.nih.gov]

Clinically it appears as multiple, punctate or circular, gray, superficial corneal opacities that may or may not be ulcerated (Figure 11.22 ). The condition is bilateral and lesions are frequently symmetric. [aibolita.com]

Every attempt to taper the cyclosporin A treatment resulted in a reappearance of symptoms and of corneal opacities. At the most recent follow-up visit, 4.5 years after presentation, the patient was still applying cyclosporin A drops 3 times daily. [doi.org]

The most common causes of loss of corneal transparency are: Corneal Oedema Drying of Cornea Depositions on Cornea Inflammations of Cornea Corneal Degenerations Dystrophies of cornea Vascularization of cornea Scarring of Cornea Corneal Opacities [ edit [en.wikibooks.org]

There was only trace conjunctival injection. On slit-lamp examination, discrete, centrally located, slightly elevated, grayish-white corneal subepithelial opacities were detected, with a granular texture bilaterally (Figure 1 ). [doi.org]

Upon gross inspection, the affected eye appears normal, with little or no evidence of eyelid swelling, conjunctival injection or corneal edema. [web.archive.org]

Examination revealed severe conjunctival injection as well as punctate stains on the corneas. [avehjournal.org]

Slitlamp examination found improvement in the superficial punctate keratitis and conjunctival injection (Figures 8 and 9). The papillary conjunctivitis and corneal infiltrate appeared unchanged. [siliconehydrogels.org]

Diagnosis Symptoms: Ocular irritation, burning, itching, pain, foreign-body sensation, photophobia, and blurred vision Examination: Conjunctival injection/inflammation, decreased tear meniscus, decreased tear break-up time, increased debris in the tear [biotissue.com]

SPK in 5 corneal regions, conjunctival hyperemia, tear breakup time (TBUT), and intraocular pressure (IOP) were examined in a masked manner at baseline, 1 month, and 3 months. [ncbi.nlm.nih.gov]

In phase 3 clinical trials of 0.05% and 0.1% ophthalmic emulsions of cyclosporin for the treatment of dry eye disease, the most common treatment-related adverse events were burning eye, stinging eye, and conjunctival hyperemia. [doi.org]

In phase 3 clinical trials of 0.05% and 0.1% ophthalmic emulsions of cyclosporin for the treatment of dry eye disease, the most common treatment-related adverse events were burning eye, stinging eye, and conjunctival hyperemia. [doi.org]

Recessive Mutations in ELOVL4 Cause Ichthyosis, Intellectual Disability, and Spastic Quadriplegia. Am J Hum Genet. 2011 Nov 16. [disorders.eyes.arizona.edu]

Recessive Mutations in ELOVL4 Cause Ichthyosis, Intellectual Disability, and Spastic Quadriplegia. Am J Hum Genet. 2011 Nov 16. [disorders.eyes.arizona.edu]

Although its exact etiology is controversial, TSPK has a genetic association with HLA-DR3, an antigen associated with immunogenic responses. [ncbi.nlm.nih.gov]

Although TSPK has a genetic association with HLA-DR3, controversy exists regarding its exact etiology. [emedicine.medscape.com]

Br J Ophthalmol. 2007;91(8):1038-41. 7.0 7.1 7.2 Darrell RW: Thygeson's superficial punctate keratitis: natural history and association with HLA-DR3, Trans Am Ophthalmol Soc 79:486, 1981. 8.0 8.1 8. [eyewiki.aao.org]

[…] is suggested by the presence of white blood cells in the conjunctiva and corneal epithelium, "by the extended course of the disease, by the therapeutic efficacy of topical corticosteroids," and by the presence in some individuals of an antigen called HLA-DR3 [webeye.ophth.uiowa.edu]