The disease should be suspected in intact bitches and queens presenting with illness, and particularly if within 4 months after estrus. [ncbi.nlm.nih.gov]

Surgical ovariohysterectomy is the safest and most effective treatment. For breeding animals with less severe illness, purely medical treatments alternatives are possible. Copyright 2018 Elsevier Inc. All rights reserved. [ncbi.nlm.nih.gov]