Presentation
SpaceNext50 Britannica presents SpaceNext50, From the race to the Moon to space stewardship, we explore a wide range of subjects that feed our curiosity about space! [britannica.com]
Most commonly, symptoms in dyskeratosis congenita do not present until later in life, but severe mutations may present in infancy. [oncohemakey.com]
Accurate physical examination and appropriate laboratory tests are of great value for evaluating a patient presenting with bleeding due to congenital platelet disorders. [cureus.com]
(s): Stormorken syndrome Thrombocytopathy-asplenia-miosis syndrome Prevalence: Inheritance: Autosomal dominant Age of onset: All ages ICD-10: D69.8 OMIM: 185070 UMLS: C1861451 MeSH: - GARD: 5188 MedDRA: - The documents contained in this web site are presented [orpha.net]
In this article, we have a detailed literature review of these rare thrombocytopathies, their presentation and treatment. Find Full Text Links for this Article Trending Papers [read.qxmd.com]
Entire Body System
- Fatigue
Homepage Rare diseases Search Search for a rare disease Stormorken-Sjaastad-Langslet syndrome Disease definition Stormorken-Sjaastad-Langslet syndrome is characterized by thrombocytopathy, asplenia, miosis, muscle fatigue, migraine, dyslexia, and ichthyosis [orpha.net]
Cardiovascular
- Chest Pain
Platelet hyperagregability in patients with chest pain and angiographically normal coronary arteries. Am J Cardiol 1986;57:657. [ Links ] 103. Mammen EF, Barnhart MI, Selik NR, et al. [scielo.org.mx]
- Hypertension
Effects of diltiazem hydrochloride on cardiovascular response, platelet aggregation and coagulation activity during exercise testing in systemic hypertension. Am J Cardiol 1986;57:609. [ Links ] 84. Hines R, Barash PG. [scielo.org.mx]
Skin
- Dermatitis
Camppell: Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea. Pediatrics 13, 133 (1954). PubMed CAS Google Scholar Alexander, B., and R. [link.springer.com]
Workup
These evaluations are readily available and can suggest the diagnosis and inform the subsequent workup. [oncohemakey.com]
Treatment
Article / Publication Details First-Page Preview Abstract Increased bleeding risk or impaired platelet function in donors have to be considered under treatment with ASS. [karger.com]
Treatment Glanzmann thrombasthenia patients require symptomatic treatment. All patients should be counseled about the cautious use of NSAIDs and aspirin and to avoid contact sports. [cureus.com]
The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]
In this article, we have a detailed literature review of these rare thrombocytopathies, their presentation and treatment. Find Full Text Links for this Article Trending Papers [read.qxmd.com]
[…] avoiding drugs that cause bleeding Treating the underlying associated disease, for example, dialysis for a person with kidney failure Sometimes drugs or platelet transfusion If platelet dysfunction is caused by a drug, stopping the drug usually is the only treatment [msdmanuals.com]
Epidemiology
Epidemiological investigation of the prevalence of von Willebrand's disease. Blood 1987;69:454-460. [ Links ] 46. Werner E, Broxson E, Tucker E, et al. Prevalence of von Willebrand's disease in children: a multiethnic study. [scielo.org.mx]
Epidemiologic and outcome studies of patients who received platelet transfusions in the neonatal intensive care unit. J Perinatol 2001;21(7):415–20.Google ScholarPubMed Noris, P, Pecci, A. Hereditary thrombocytopenias: A growing list of disorders. [cambridge.org]
Pathophysiology
Although recently and remarkable advances in our understanding of platelet mechanisms and their role in the hemostatic process, in the majority of cases a defined pathophysiological molecular basis still remains now to be determined. [bloodtransfusion.it]
Clinical manifestations and pathophysiological mechanisms of the Wiskott–Aldrich syndrome. J Clin Immunol 2018;38(1):13–27.CrossRefGoogle ScholarPubMed Bastida, JM, Del Rey, M, Revilla, N, et al. [cambridge.org]
Clinical spectrum, pathophysiology and treatment of the Wiskott-Aldrich syndrome. Curr Opin Hematol. 2011; 18: 42-48. -MINELLI A, et al. [revistaseletronicas.fmu.br]
En: Platelets: Pathophysiology and antiplatelet drug therapy. New York: Alan R. Liss, 1982:45. [ Links ] 77. Triplett DA. Appendix C: Miscellaneous lists and forms. En: Triplett DA, Ed. [scielo.org.mx]
Prevention
Aspirin and NSAIDs prevent cyclooxygenase-mediated production of thromboxane A2. This effect can last 5 to 7 days. [merckmanuals.com]
Due to the associated immunodeficiency, transfused blood products including platelets should be irradiated to prevent transfusion-associated graft vs. host disease. [oncohemakey.com]