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Rabies Virus


Presentation

  • Rabies, one of the oldest infectious diseases, still presents a public health threat in most parts of the world today.[ncbi.nlm.nih.gov]
  • Numerous antigenic masses, which apparently corresponded to the matrices and cylindrical particles in neurites revealed by electron microscopy, were present in the neuropil remote from neuronal perikarya.[ncbi.nlm.nih.gov]
  • RVG-29-functionalized DDSs present themselves with modifications of the RVG-29 peptide sequence and different physicochemical properties compared to the rabies virus.[ncbi.nlm.nih.gov]
  • The ability to silence genes associated with disease progression by using short interfering RNA (siRNA) presents the potential to develop safe and effective therapies.[ncbi.nlm.nih.gov]
  • Thus, the ATS fusion approach presented here is easily implemented and can be used as a new strategy to improve the stability and half-life of engineered antibody proteins for practical applications.[ncbi.nlm.nih.gov]
Movement Disorder
  • Disorders, UCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom. 4 From Gene Therapy, Centre for Neuroinflammation and Neurodegeneration, Division of Brain Sciences, Department of Medicine, Imperial College[ncbi.nlm.nih.gov]
Intravenous Administration
  • Following intravenous administration, the pseudovirus effectively infected the mice, with dynamic viral distributions being sequentially observed in spleen, liver and brain.[ncbi.nlm.nih.gov]
Agitated Delirium
  • Encephalitis developed in all four recipients within 30 days after transplantation and was accompanied by rapid neurologic deterioration characterized by agitated delirium, seizures, respiratory failure, and coma.[ncbi.nlm.nih.gov]

Workup

Cytoplasmic Inclusion Bodies
  • Histopathology indicated that eosinophilic and cytoplasmic inclusion bodies, Negri bodies, were seen in neuronal cells of the CNS. Inflammatory cell reactions were scarce, and no apoptosis in the CNS was detected.[ncbi.nlm.nih.gov]

Treatment

  • These findings suggest that the rhuIFN α-2a might have some anti-viral activity, which can be used for the treatment of rabies infection.[ncbi.nlm.nih.gov]
  • This paper introduces the role of the BBB in rabies infections and protection of the CNS and provides insight into future treatments for patients with clinical rabies.[ncbi.nlm.nih.gov]
  • Of these protein changes, 45 were upregulated and 14 were downregulated following RABV infection relative to non-infected (mock) synaptosomes. 28 proteins were unique to mock treatment and 12 were unique to RABV treatment.[ncbi.nlm.nih.gov]
  • Once symptoms appear, there is no effective treatment to prevent death.[ncbi.nlm.nih.gov]
  • Raccoon-variant rabies was confirmed in 7 pet rabbits and 1 pet guinea pig in New York State, and postexposure treatment was required in several adults and children.[ncbi.nlm.nih.gov]

Prognosis

  • Moreover, although the disease is rarer than other human infections such as influenza, the prognosis following a bite from a rabid animal is poor: There is currently no effective treatment that will save the life of a symptomatic rabies patient.[ncbi.nlm.nih.gov]

Etiology

  • However its epidemiology remains largely unappreciated in much of these regions, such as in Nepal, where limited information is available about the spatiotemporal dynamics of the main etiological agent, the rabies virus (RABV).[ncbi.nlm.nih.gov]
  • Rabies should be considered in patients with acute progressive encephalitis of unexplained etiology, especially for potential organ donors.[ncbi.nlm.nih.gov]
  • Adelchi Negri reported the identification of what he believed to be the etiologic agent of rabies, the Negri body.[whonamedit.com]
  • The etiology of rabies and the work of Adelchi Negri (1876–1912). In: Camillo Golgi (1843–1926), Santiago Ramón y Cajal (1852–1934), Adelchi Negri (1876–1912).[dx.doi.org]

Epidemiology

  • METHODS: Data pertaining to human rabies cases in Fujian Province during the period from 2002 through 2012 were collected, and the epidemiological profiles were described.[ncbi.nlm.nih.gov]
  • Epidemiological investigation revealed that the dog was not vaccinated and had been attacked by a crab-eating fox, "zorro" (Cerdocyon thous).[ncbi.nlm.nih.gov]
  • KEYWORDS: Canada; United States; phylogeography; rabies; raccoon rabies virus; spatial epidemiology; transboundary outbreaks; viruses; whole-genome sequencing; wildlife disease; zoonoses[ncbi.nlm.nih.gov]
  • According to the current epidemiologic data, there is only one TFBV strain in Taiwan. TFBV is still sequestered to the mountainous regions.[ncbi.nlm.nih.gov]
  • Epidemiologic study determined a respiratory mode of transmission. After a fulminant encephalitic illness, formed rabies virions were identified in the synaptic zones of the olfactory glomeruli.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • ., 2010 ), but may also reveal hitherto unknown connections or a re-organization of wiring diagrams under physiological and pathophysiological conditions (Figure 3A ).[doi.org]

Prevention

  • Disease Control and Prevention, Beijing, 102206, China.[ncbi.nlm.nih.gov]
  • Author information 1 Celltrion, INC, Department of Research and Development, Incheon, Republic of Korea. 2 Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America. 3 Chinese Center for Disease Control and Prevention, Beijing[ncbi.nlm.nih.gov]
  • Inhibition of PKR expression significantly prevents RABV-SG formation and favors viral replication by increasing viral translation.[ncbi.nlm.nih.gov]
  • This study demonstrates the feasibility of a non-replicating mRNA rabies vaccine in small and large animals and highlights the promises of mRNA vaccines for the prevention of infectious diseases.[ncbi.nlm.nih.gov]
  • Once symptoms appear, there is no effective treatment to prevent death.[ncbi.nlm.nih.gov]

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