Presentation
Choroidal neovascularization may be associated with radiation retinopathy and, when present, may require indocyanine green angiography for its diagnosis. [ncbi.nlm.nih.gov]
Retinal nonperfusion was also present, leading the diagnosis of radiation retinopathy. The right eye developed cataract 32 months later followed by cataract surgery. [okayama.pure.elsevier.com]
Entire Body System
- Fever
The trial was in a Deltasonne indication and a delay in starting meant that it now straddled the hay-fever season. [channel2012.ru]
Cardiovascular
- Hypertension
In the multivariate model, the predictive factors were a younger age (hazard ratio [HR] 0.98, p < 0.03), diabetes (HR 2.17, p < 0.007), and hypertension (HR 2.17, p < 0.004). [ncbi.nlm.nih.gov]
Anterior Chamber Brain and Optical Pathway Choroid Congenital Syndromes, Malformations and Abnomalities Conjunctiva Cornea Glaucomas, Ocular Hypertension Hypertensive Retinopathy Iris and Ciliary Body Lacrimal System Lens Lids Neuro-Ophthalmology Optic [atlasophthalmology.net]
Key features of acute hypertensive retinopathy are as follows: ● Retinal arteriolar spasm ● Retinal hemorrhages ● Cotton wool spots ● Retinal exudates ● Serous retinal detachment ● Optic nerve edema Acute hypertensive retinopathy is often complicated [neuro-ophthalmology.stanford.edu]
Eyes
- Retinal Damage
The usual threshold dose for retinal damage is approximately 30 Gy to 35 Gy, but the lowest reported dose of radiation that caused radiation retinopathy is 11 Gy. 1 Photoreceptors are more resistant to radiation than inner retinal layers and retinal vascular [reviewofoptometry.com]
Electroretinographic (ERG) responses are depressed following acute retinal radiation—pattern ERG and visual evoked response abnormalities confirm inner retinal damage or the presence of a maculopathy. [medtextfree.wordpress.com]
They concluded that radiation damage enhanced by chemotherapy may have damaged the retinal vasculature and pigment epithelium with a secondary loss of photoreceptors. They noted that rods seemed to be more affected than cones. [doctorlib.info]
- Vitreous Floaters
1 vitreous haemorrhage, 3 retinal haemorrhage, 3 retinal detachment, 1 vision blurred, 1 endophthalmitis, 1 vitreous floaters, 2 postoperative uveitis. [cochranelibrary.com]
Skin
- Flushing
Most patients report flushing during this injection. Oft tritt eine Uveitis symptoms of norvasc bei allgemeinen oder immunologi- schen Erkrankungen auf. [luxbar-starway.ru]
Workup
Current Stan dard Workup for R adiation Maculopathy Radiation retinopathy is typically detected on ophthalmoscopic examination and confirmed with fluorescein angiography (FA) revealing retinal vascular abnormalities such as retinal hemorrhage and exudation [eyecareupdate.com]
In these cases, vascular risk factors need to be aggressively controlled, but very little workup is obtained. [neuro-ophthalmology.stanford.edu]
Treatment
SUMMARY: Currently, there are no proven treatments for radiation retinopathy or maculopathy. The current treatment methods require frequent administration with variable improvement in visual acuity. [ncbi.nlm.nih.gov]
Secondary macular edema and visual acuity improved following a single treatment session with minimal scarring. [karger.com]
Prognosis
Within the retina, the posterior pole is particularly sensitive to this pathology, 13 with grave implications for visual prognosis. [clinicalgate.com]
CONCLUSIONS: The presence of macular edema and proliferation indicates more severe retinopathy and worse visual prognosis than for eyes without macular edema and proliferation. [ncbi.nlm.nih.gov]
What is the prognosis of the ocular ischemic syndrome? The prognosis of the ocular ischemic syndrome is poor. Laser panphotocoagulation of the ischemic retina may reduce neovascularization as with proliferative diabetic retinopathy. 17. [neuro-ophthalmology.stanford.edu]
Prognosis: Patients with Non- proliferative retinopathy retain a visual acuity of 6/15(20/50) for at least 4 yrs. Proliferative retinopathy has a very poor prognosis with 86% patients having visual acuity of 20/200 or worse after 6 years. [djo.org.in]
Etiology
Sections and Some Topics Include: • Basic Principles o Cancer etiology; cancer genetics, principles of laser therapy, and more • Eyelid Tumors o Benign epidermal tumors; melanoma of the eyelid, systemic associations, and more • Conjunctival and Corneal [books.google.com]
Etiology Exposure to any radiation source including external beam and plaque brachytherapy. [eyewiki.aao.org]
[…] patientвs level of knowledge about the disease and the modes nasla disease transmission is evaluated. 2 Nas al Retinochoroidal Atrophy Mobic and nasal polyps retinochoroidal atrophy is a non- progressive, regional chorioretinal atrophy mobicc unknown etiology [luxbar-starway.ru]
Epidemiology
EPIDEMIOLOGY AND PATHOGENESIS Radiation Dose The key determinants in the development of radiation retinopathy are the total dose of radiation administered to the retina and the fraction size in the case of teletherapy. [medtextfree.wordpress.com]
Pathophysiology
BACKGROUND: to review the currently available therapeutic modalities for radiation retinopathy (RR), including newer investigational interventions directed towards specific aspects of the pathophysiology of this refractory complication. [ncbi.nlm.nih.gov]
Clinical picture can be identical to that of diabetic retinopathy suggesting a common pathophysiologic mechanism of the damage to capillary endothelial cells, and the importance of clinical examination, anamnesis and fluorescein angiography. [ingentaconnect.com]
Staging of radiation retinopathy has been proposed. [3] Pathophysiology [ edit ] Radiation retinopathy is very similar to other vascular diseases. Diabetes and radiation primarily damage the retinal capillaries. [en.wikipedia.org]
Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any [books.google.com]
Pathophysiology Although it is not entirely clear how ionizing radiation causes radiation retinopathy, the primary site of damage appears to be the endothelial cells of the retinal and optic nerve vasculature. 2, 3, 4, 5, 6 Although the neural retina, [entokey.com]
Prevention
Recent work has been directed towards prevention of radiation retinopathy prior to its development. This has been done with preventive scatter laser and intravitreal bevacizumab therapy. [ncbi.nlm.nih.gov]
Finger, MD Radiation Retinopathy: Prevention and Suppression Benjamin Franklin once wrote, “an ounce of prevention is worth a pound of cure.” 1 Although he was referring to fire prevention, this adage also applies to radiation maculopathy. [eyecancer.com]