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Radiation Stomatitis


Presentation

  • Hak Choy Springer Science & Business Media, ٠٤‏/١٢‏/٢٠٠٢ - 420 من الصفحات Internationally recognized experts in cancer biology and clinical research review the present status of the multimodality approach to the management of solid tumors and speculate[books.google.com]
  • Genetic and Environmental Risk Factors 1233 1700 Tumor Classification Histopathology and Molecular Genetics 1703 Cholangiocarcinomas 1157 1712 Natural History and Patterns of Failure 1000 1713 Emerging Therapeutic Options 1718 Incidence 1186 1720 Clinical Presentation[books.google.de]
  • Seven abstracts were retrieved; 2 discussed stomatitis prevention (1 as a “trial-in-progress” and 1 presented results of the trial); the other 5 abstracts presented meta-analyses or reviews of previous clinical studies to assess the risk, incidence, management[mdedge.com]
  • Differential Diagnosis and Treatment Mucositis is distinguishable from other forms of inflammatory disorders in terms of: – causality – clinical presentation/lab findings – severity – treatment The presence and severity of radiation- or chemotherapy[slideshare.net]
  • A genetic predisposition is present, and there is a positive family history in about one third of patients with RAS.[nature.com]
Xerostomia
  • Glycerol Spray for Management of Psychotropic Drug-Induced Xerostomia Xerostomia (mouth dryness) often occurs as an unwanted effect of psychotropic drugs.[medlife.pharmacy]
  • Pilocarpine Troches for Xerostomia Pilocarpine is indicated for the treatment of xerostomia secondary to radiation therapy of the head and neck. Pilocarpine is a cholinergic agent that stimulates residual-functioning exocrine glands.[orrongpharmacy.com]
  • Aust Dent J 2002 Sep;47(3):249-53 An investigation into the use of pilocarpine as a sialagogue in patients with radiation induced xerostomia. Frydrych AM, Davies GR, Slack-Smith LM, Heywood J.[laspalmaspharmacy.com]
Sore Mouth
  • Thorough, regular mouth care can help prevent a sore mouth and reduce infection. The healthcare team will give instructions about how often to clean and rinse the mouth and what to use.[cancer.ca]
  • In a double-blind, placebo-controlled study that compared a commercially produced pilocarpine tablet, a compounded pilocarpine lozenge, and placebo, patients who received the compounded lozenge reported the most improvement in oral dryness, sore mouth[medlife.pharmacy]
  • More than a sore mouth: patients experience oforal mucositis. Oncol Nurs Forum. 2002;29:1051-1057, and Bellm et al. 2000.**Bellm et al. 2000 10.[slideshare.net]
  • It can range in severity from a red, sore mouth and/or gums to open sores that can cause a patient to be unable to eat.[oncolink.org]
Aphthous Stomatitis
  • Both herpes and aphthous stomatitis have lesions that are unique in appearance.[encyclopedia.com]
  • Most ulcers are due to local causes such as trauma or burns, but recurrent aphthous stomatitis and cancer must always be considered.[nature.com]
  • stomatitis (most commonly, minor aphthae) Head and neck radiation *Rare.[merckmanuals.com]
Halitosis
  • […] adverse consequences, including difficulty tasting, chewing, and swallowing, which results in compromised nutrition; impaired sleep; esophageal dysfunction; intolerance to medications; increased incidence of glossitis, angular chelitiss, candidiasis, and halitosis[dimensionsofdentalhygiene.com]
  • Bad breath (halitosis) may also accompany the condition. Stomatitis affects all age groups, from the infant to the elderly.[medical-dictionary.thefreedictionary.com]
Oral Bleeding
  • Although rarely serious, oral bleeds can be of concern to the patient and family.[cancer.gov]
Cutaneous Manifestation
  • Manifestations of Cancer 2349 Colon Cancer 240 2352 Approach to the Patient with Paraneoplastic Neurologic Disease 2359 Gastrointestinal Cancers 664 2376 HepaticoBiliary System 713 2381 Summary 668 2384 Diagnosis 1237 2389 Treatment 2396 HOWLEY DON GANEM[books.google.de]

Workup

  • 1859 Infectious Agents and Cancer 549 1860 Cancer of the Skin 1863 Melanoma 1889 Diagnostic Studies and Pretreatment Staging 1001 1908 Principles of Isolation Perfusion 701 1923 Intraocular Melanomas 1951 Invasion and Metastasis 117 1952 Metastatic WorkUp[books.google.de]
  • Accurate and early diagnostic workup. Effective preventative and therapeutic strategies. An individual approach geared to unique patient characteristics.[cancer.gov]
Helicobacter Pylori
  • Pylori 554 2100 Principles of the World Health Organization Classification of Lymphoid Neoplasms 2106 Specific Disease Entities 2115 Special Clinical Situations 2136 Cutaneous TCell Lymphomas 2143 Principles of Therapy of Mycosis Fungoides and the Sézary[books.google.de]
Hepatocellular Carcinoma
  • Carcinoma 1139 1644 Cancer of the Endocrine System 1655 Thyroid Tumors 1663 Parathyroid Cancer 1682 Adrenal Tumors 1690 Pheochromocytomas 1697 Von HippelLindau 1315 1698 Genetic and Environmental Risk Factors 1233 1700 Tumor Classification Histopathology[books.google.de]
  • carcinoma) Antiangiogenic Inhibition of angiogenesis by blocking VEGF tyrosine kinase Yes, when combined with antiresorptives With the approval of a new antiresorptive medication, denosumab, a fully humanized monoclonal antibody that targets RANKL and[cancer.gov]

Treatment

  • Classification Histopathology and Molecular Genetics 1703 Cholangiocarcinomas 1157 1712 Natural History and Patterns of Failure 1000 1713 Emerging Therapeutic Options 1718 Incidence 1186 1720 Clinical Presentation 1001 1723 Anatomy of the Colon 1236 1724 Treatment[books.google.de]
  • They also show how radiation interacts with such chemotherapeutic agents as the platinum complexes, taxanes, and gemcitabine in the treatment of malignant gliomas, and head and neck cancer.[books.google.com]
  • Radiation to the head and neck and chemotherapy for any malignancy can cause oral side effects so debilitating that patients may tolerate only lower, less effective doses of cancer treatment, may postpone scheduled treatments, or may discontinue treatment[colgate.com]
  • This includes oral care and patient education prior to and following oncology treatment. Once cancer is diagnosed, patients and their families are presented with many treatment options.[dimensionsofdentalhygiene.com]

Prognosis

  • Prognosis The prognosis for the resolution of stomatitis is based upon the cause of the problem. Many mouth ulcers are benign and resolve without specific treatment.[encyclopedia.com]
  • Prognosis The prognosis for the resolution of stomatitis is based on the cause of the problem. Many local factors can be modified, treated, or avoided.[medical-dictionary.thefreedictionary.com]
  • Dentition that exhibits poor prognosis and is within high-dose fields should be extracted before radiation therapy begins.[cancer.gov]

Etiology

  • […] for treating mouth ulcers and pain from oral mucositis Learn More INDICATIONS GELCLAIR has a mechanical action indicated for the management of pain and relief of pain by adhering to the mucosal surface of the mouth, soothing oral lesions of various etiologies[gelclair.com]
  • . V58.0, Encounter or admission for radiotherapy; and V58.1, Encounter or admission for chemotherapy 528.0, Stomatitis  Stomatitis coding is non-specific and does not permit differentiation based on – NOS etiology (viral, fungal, etc.). – ulcerative[slideshare.net]
  • Principal symptoms include vesicles, erosion, ulcers, erythema, purpura, angioedema, burning, and itching. recurrent aphthous stomatitis a recurrent disease of unknown etiology, characterized by one or more small round or oval ulcer(s) on the oral mucosa[medical-dictionary.thefreedictionary.com]
  • Biopsy at the periphery of normal and abnormal tissue can be done for persistent lesions that do not have an obvious etiology.[merckmanuals.com]

Epidemiology

  • Carcinoma of the Vulva 1528 Cancer of the Uterine Body 1543 Chemoprevention 609 1545 Uterine Sarcomas 1557 Gestational Trophoblastic Diseases 1564 Colon Cancer 1232 1574 Epothilones 455 1586 Genetic Predisposition 1390 1595 Epidemiology 1232 1604 Malignant[books.google.de]
  • Epidemiology  40% of patients receiving standard-dose chemotherapy  80% of patients receiving radiation therapy for head and neck cancer  75% of all patients undergoing BMT Mucositis Frequency: BMT withMucositis Frequency: Mucositis Frequency: Radiation[slideshare.net]
  • Sonis ST, Elting LS, Keefe D, et al.: Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100 (9 Suppl): 1995-2025, 2004.[cancer.gov]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology of mIAS The pathophysiology mIAS is incompletely understood.[mdedge.com]
  • Released on August 08, 2017 Context: Despite numerous proposed mechanisms, no definitive pathophysiology underlying radiotherapy-induced fatigue (RIF) has been established.[biomodels.com]
  • Therefore, oral mucositis can be a dose-limiting condition, disrupting a patient’s optimal cancer treatment plan and consequentially decreasing their chances of survival. [4] Pathophysiology [ edit ] The pathophysiology of mucositis is complex and multifactorial[en.wikipedia.org]
  • The ulcers may occur on the lip, buccal mucosa, palate, or tongue. 3 The pathophysiology of mucositis includes initial inflammation with disruption of the epithelial cells followed by damage to the subepithelial layers of mucosa caused by free radicals[practicalpainmanagement.com]
  • Oral complications from cancer therapy: Part 1SAMPLE Pathophysiology and secondary complications. Oncology Nursing Forum, 23(5):801-806, 1996. National Cancer Institute. CancerNet PDQ Cancer Information Summaries.[colgate.com]

Prevention

  • Early recognition of mIAS facilitates early intervention and can prevent dose modification and interruption. Third, implement the preventive and treatment measures described.[mdedge.com]
  • Phase Learn More » Gabapentin Compared to Standard of Care in Preventing Mucositis in Patients With Stage III-IV Head and Neck Cancer Undergoing Primary or Adjuvant Chemoradiation Therapy PRIMARY OBJECTIVES: I.[centerwatch.com]
  • It is known that a good oral care regimen can help prevent or decrease the severity of mucositis and, just as important, help prevent the development of infection through open mouth sores.[oralcancerfoundation.org]
  • […] could lead to potentially fatal systemic infections Prevent or minimize complications that can compromise nutrition Prevent, eliminate or control oral pain Prevent or reduce the incidence of bone necrosis in patients receiving radiation therapy to the[colgate.com]
  • It is known that a good oral care regimen can help in preventing or decreasing the severity of mucositis and can help prevent the development of infection through open mouth sores.[oncolink.org]

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