Presentation
Tumoral calcinosis is a rare tumoral calcium pyrophosphate dihydrate crystal deposition disease which presents as periarticular soft tissue calcification. [ncbi.nlm.nih.gov]
Results: The patient had an NMO flare constituting Myeloradiculopathy, a rare presentation of NMOSD. She received Plasmapharesis with near complete resolution of her symptoms. Conclusions: Myeloradiculopathy is an uncommon presentation of NMO. [neurology.org]
Case Presentation A 66-year-old male patient, usually in good health, presented progressive paraparesis of three weeks’ duration. Three months prior to admission, he had worked hard for four to five hours a day for three months. [hindawi.com]
Entire Body System
- Lower Extremity Pain
Pseudoclaudication, a characteristic symptom, is uni- or bilateral buttock or lower-extremity pain and/or numbness on walking, which may be relieved by resting, sitting, and bending forward. [consultant360.com]
Gastrointestinal
- Abdominal Pain
Symptoms of Henoch-Schonlein Purpura The classic symptoms of HSP are rash, joint pain and swelling, abdominal pain, and/or related kidney disease, including blood in urine. [webmd.com]
Most adults experience symptoms including: nausea, poor appetite, abdominal pain, fatigue, jaundice (yellow eyes and skin), and dark urine. Although the symptoms resolve over several weeks, fatigue can be prolonged. [instagramwebs.com]
The symptoms of HSP usually begin suddenly and may include headache, fever, loss of appetite, cramping, abdominal pain, painful menstruation, hives, bloody diarrhea, and joint pain. Red or purple spots typically appear on the skin (petechiae). [rarediseases.org]
Henoch-Schonlein purpura can also cause abdominal pain and aching joints. Rarely, serious kidney damage can occur. Henoch-Schonlein purpura can affect anyone, but it's most common in children between the ages of 2 and 6. [mayoclinic.org]
If the clinical picture is suggestive of Henoch Schonlein purpura (purpura on the lower limbs and buttocks in a well child, with or without arthritis or abdominal pain), treat as per HSP guideline Petechiae in well children due to mechanical causes Children [rch.org.au]
Musculoskeletal
- Back Pain
pain and bilateral buttock and leg pain. [orthobullets.com]
Patients will frequently report moderate-to-severe back pain as a part of their initial symptomatology. [consultant360.com]
Most patients with vertebral involvement present with back pain, leg weakness and a gibbus deformity. [nature.com]
Neurologic
- Unable to Walk
Within a week she was readmitted with band-like thoracic pain associated with urinary incontinence, paraesthesiae in the legs, and worsening bilateral leg weakness such that she was unable to walk. [thorax.bmj.com]
Positive serology for Campylobacter jejuni, cytomegalovirus (CMV), Epstein-Barr virus (EBV), or Mycoplasma pneumoniae is more frequently associated with the severe form of the disease (unable to walk at the nadir). 30 While the sequence of pathophysiologic [consultant360.com]
[…] unassisted Grade 4 Unable to walk without assistance Grade 5 Wheelchair or bedbound Based on gait and ambulatory function Ranawat Classification Class I Pain, no neurologic deficit Class II Subjective weakness, hyperreflexia, dyssthesias Class IIIA Objective [orthobullets.com]
Workup
X-Ray
- Soft Tissue Calcification
Tumoral calcinosis is a rare tumoral calcium pyrophosphate dihydrate crystal deposition disease which presents as periarticular soft tissue calcification. [ncbi.nlm.nih.gov]
Treatment
This treatment protocol delivered rapid clinical benefits and long-term tumor control demonstrating the viability of SRS in the treatment of this difficult and rare condition. [ncbi.nlm.nih.gov]
One trial (68 patients with mild functional deficit associated with cervical myelopathy) found no significant differences between surgery and conservative treatment in three years following treatment. [cochrane.org]
Prognosis
However, most of the previous studies tend to justify patients, prognosis in a single dimension. [clinicaltrials.gov]
No evidence of any complications associated with irradiation was apparent, and the patient continued to demonstrate a positive prognosis. [ncbi.nlm.nih.gov]
Prognosis Gastrointestinal or pulmonary bleeding can be life-threatening. The long term prognosis depends on the extent of the renal involvement. [orpha.net]
Author/year Number of cases Age/sex Presenting symptom/signs Location Diagnostic modality Treatment Prognosis follow-up period Associated condition Takano et al., 1992 1 72/m Spastic paraparesis, 1 yr bilat. [hindawi.com]
Etiology
Such characteristic similarities in both clinical and radiologic features are important in considering the etiology of calcification of the cervical ligamenta flawa. [ncbi.nlm.nih.gov]
It brings together information on all aspects of OPLL - epidemiology, etiology, diagnosis, and treatment - with contributions by Japanese researchers and surgeons, including members of the Ministry of Health and Welfare Investigation Committee, and by [books.google.com]
Source: The Veterinary record 2001 v.148 no.13 pp. 403-407 ISSN: 0042-4900 Subject: etiology, blood serum, dogs, German Shepherd, alpha-tocopherol, chronic diseases Agid: 1537403 http://dx.doi.org/10.1136/vr.148.13.403 Links DOI: 10.1136/vr.148.13.403 [pubag.nal.usda.gov]
Etiology SHP is associated with deposition of IgA-dominant immune complexes in arterioles, capillaries, and venules, but the exact etiology remains unknown. [orpha.net]
Work up for other etiologies was negative. Results: The patient had an NMO flare constituting Myeloradiculopathy, a rare presentation of NMOSD. She received Plasmapharesis with near complete resolution of her symptoms. [neurology.org]
Epidemiology
The characteristics of the virus, its epidemiology and the diag nosis and management of the various forms of infection are all considered. [books.google.ro]
It brings together information on all aspects of OPLL - epidemiology, etiology, diagnosis, and treatment - with contributions by Japanese researchers and surgeons, including members of the Ministry of Health and Welfare Investigation Committee, and by [books.google.com]
Each chapter begins with a shot historical account of the disease, followed by a critical evaluation of the epidemiological and/or hospital based data. This is then compared with the data of other global populations. [books.google.de]
Summary Epidemiology SHP usually affects children and is rare in adults. Annual incidence in children is estimated at between 1/6,660 and 1/4,880, whereas it is estimated at around 1/1,000,000 in adults. The male-to-female ratio is 1.5:1. [orpha.net]
Pathophysiology
View Article PubMed Google Scholar Baptiste DC, Fehlings MG: Pathophysiology of cervical myelopathy. Spine J. 2006, 6: 190S-197S. 10.1016/j.spinee.2006.04.024. [bmcmusculoskeletdisord.biomedcentral.com]
Pathophysiology Cervical spondylosis is the result of disk degeneration. As disks age, they fragment, lose water, and collapse. Initially, this starts in the nucleus pulposus. [emedicine.medscape.com]
The characteristic bilateral occurrence and associated cervical subluxation at the involved segment supported the degenerative pathophysiology in the cyst. Conflicts of Interest The authors declare no conflicts of interest regarding this manuscript. [hindawi.com]
Etiology and pathophysiology: The primary event is a progressive decrease in the degree of hydration resulting in loss of disc height, disc fibrosis and annular weakening. [thamburaj.com]
Schönlein-henoch purpura in children and adults: diagnosis, pathophysiology and management. Biodrugs. 2001;15:99-138. Saulsbury FT. Henoch-Schönlein purpura. Curr Opin Rheumatol. 2001;13:35-40. INTERNET Clowse MEB. Henoch-Schönlein purpura. [rarediseases.org]
Prevention
Getting prompt treatment will help prevent any potential complications. [healthline.com]
Chapter 69 Surrogate Markers of Antiretroviral Efficacy 826 Overcoming Barriers to Providing ARV Therapy in ResourceLimited Settings 831 Chapter 71 Antiretroviral Drugs for HIV Prevention 836 Chapter 72 Acute HIV Infection 843 Chapter 73 Opportunistic [books.google.com]
[…] in 19% of 84 cases of post-traumatic cerebrospinal fluid (CSF) rhinorrhea in one series.1 In the less common "spontaneous" CSF leaks, the incidence of meningitis is uncertain, since only a few isolated cases have been reported.2,3 Consequently, the prevention [jamanetwork.com]
In order to prevent damage to the spinal cord, the instrumentation should be completed before the laminectomy. [bmcmusculoskeletdisord.biomedcentral.com]