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Radiculomyelopathy

Myeloradiculopathy


Presentation

  • Tumoral calcinosis is a rare tumoral calcium pyrophosphate dihydrate crystal deposition disease which presents as periarticular soft tissue calcification.[ncbi.nlm.nih.gov]
  • Results: The patient had an NMO flare constituting Myeloradiculopathy, a rare presentation of NMOSD. She received Plasmapharesis with near complete resolution of her symptoms. Conclusions: Myeloradiculopathy is an uncommon presentation of NMO.[neurology.org]
  • We presented this case and reviewed the literature to acknowledge so-call "pseudogout syndrome."[ncbi.nlm.nih.gov]
  • A case of cervical radiculomyelopathy caused by multiple calcified nodules in the ligamenta flava is presented.[ncbi.nlm.nih.gov]
  • A 27-year-old woman with gait disturbance and shoulder pain radiating into the right upper arm and back presented for clinical evaluation.[ncbi.nlm.nih.gov]
Lower Extremity Pain
  • Pseudoclaudication, a characteristic symptom, is uni- or bilateral buttock or lower-extremity pain and/or numbness on walking, which may be relieved by resting, sitting, and bending forward.[consultant360.com]
Back Pain
  • pain and bilateral buttock and leg pain.[orthobullets.com]
  • Patients will frequently report moderate-to-severe back pain as a part of their initial symptomatology.[consultant360.com]
  • Most patients with vertebral involvement present with back pain, leg weakness and a gibbus deformity.[nature.com]
Lordosis
  • The mean sagittal lordosis of the C2-7 spine increased from -16.2 9.2 preoperatively to -18.5 11.9 at last follow-up.[ncbi.nlm.nih.gov]
  • Cervical lordosis, flexion-extension angles, range of motion (ROM), and the angulation and the extent of vertebral slippage at the affected nerve root levels were measured preoperatively and at last follow-up examination.[ncbi.nlm.nih.gov]
  • Loss of cervical lordosis is an early finding. Spinal cord narrowing correlates with myelopathy. Neurophysiologhical studies (EMG and nerve conduction studies) can be used when the diagnosis is in doubt.[thamburaj.com]
Sexual Dysfunction
  • Dysfunction 1203 Chapter 104 Womens Sexual Dysfunction 1210 Chapter 105 Sexuality Education for Young People 1221 A CultureBound Sex Related Disorder in Indian Subcontinent 1225 Chapter 107 Clinical Services for Sexually Transmitted Infections and HIV[books.google.ro]
  • In patients with diagnosed NMO/NMOSD, it is important to suspect conus lesions especially if presentation includes bowel, bladder, or sexual dysfunction.[neurology.org]
Unable to Walk
  • Positive serology for Campylobacter jejuni, cytomegalovirus (CMV), Epstein-Barr virus (EBV), or Mycoplasma pneumoniae is more frequently associated with the severe form of the disease (unable to walk at the nadir). 30 While the sequence of pathophysiologic[consultant360.com]
  • […] to walk without assistance Grade 5 Wheelchair or bedbound Based on gait and ambulatory function Ranawat Classification Class I Pain, no neurologic deficit Class II Subjective weakness, hyperreflexia, dyssthesias Class IIIA Objective weakness, long tract[orthobullets.com]
Involuntary Movements
  • It is likely that the late-onset myelopathy is linked to continuous torsion, compression and ‘wear and tear’ of the cervical spinal cord, induced by the involuntary movements.[karger.com]

Workup

Soft Tissue Calcification
  • Tumoral calcinosis is a rare tumoral calcium pyrophosphate dihydrate crystal deposition disease which presents as periarticular soft tissue calcification.[ncbi.nlm.nih.gov]
Mycobacterium Kansasii
  • We report two cases of disabling myelopathy in association with pulmonary infection by Mycobacterium kansasii and Mycobacterium malmoense; the myelopathy is presumed to be a para-infectious phenomenon. ID: 4108158[research.ed.ac.uk]
HLA-B27
  • Tests for rheumatoid factor and HLA-B27 antigen were both negative, also supporting the diagnosis. There was no evidence of malignancy.[neurology.org]

Treatment

  • This treatment protocol delivered rapid clinical benefits and long-term tumor control demonstrating the viability of SRS in the treatment of this difficult and rare condition.[ncbi.nlm.nih.gov]
  • Surgical excision is the treatment of choice, because this is completely curative without known recurrence.[ncbi.nlm.nih.gov]
  • No significant differences were observed between groups, up to two years following treatment.[ncbi.nlm.nih.gov]
  • No significant differences were observed between the groups up to 2 years after treatment.[ncbi.nlm.nih.gov]
  • One trial (68 patients with mild functional deficit associated with cervical myelopathy) found no significant differences between surgery and conservative treatment in three years following treatment.[cochrane.org]

Prognosis

  • No evidence of any complications associated with irradiation was apparent, and the patient continued to demonstrate a positive prognosis.[ncbi.nlm.nih.gov]
  • Spinal lesions in SAPHO syndrome are described in 50[percnt] of the cases but generally show a good prognosis and rarely cause neurological deterioration.[neurology.org]
  • ., Natural history and prognosis of cervical spondylosis. Brit. Med. J. 2 (1963), 1607–1610. Google Scholar 19. Martins, A. N., Anterior cervical disectomy with and without interbody bone graft. J. Neurosurg. 44 (1976), 290–295.[link.springer.com]
  • This cautious approach is understandable, given the prognosis of the illness and the devastation that being given the diagnosis may cause to a person's life.[patient.info]

Etiology

  • It brings together information on all aspects of OPLL - epidemiology, etiology, diagnosis, and treatment - with contributions by Japanese researchers and surgeons, including members of the Ministry of Health and Welfare Investigation Committee, and by[books.google.com]
  • Work up for other etiologies was negative. Results: The patient had an NMO flare constituting Myeloradiculopathy, a rare presentation of NMOSD. She received Plasmapharesis with near complete resolution of her symptoms.[neurology.org]
  • As previously discussed, the etiology of OTAL may be of multiple origins, such as injury, and acquired or congenital abnormalities.[fluoridealert.org]
  • Etiology and pathophysiology: The primary event is a progressive decrease in the degree of hydration resulting in loss of disc height, disc fibrosis and annular weakening.[thamburaj.com]
  • Pathophysiology etiology neurologic injury mechanism of injury can be direct cord compression ischemic injury secondary to compression of anterior spinal artery Associated conditions Prognosis natural history tends to be slowly progressive and rarely[orthobullets.com]

Epidemiology

  • The characteristics of the virus, its epidemiology and the diag nosis and management of the various forms of infection are all considered.[books.google.ro]
  • Each chapter begins with a shot historical account of the disease, followed by a critical evaluation of the epidemiological and/or hospital based data. This is then compared with the data of other global populations.[books.google.ro]
  • It brings together information on all aspects of OPLL - epidemiology, etiology, diagnosis, and treatment - with contributions by Japanese researchers and surgeons, including members of the Ministry of Health and Welfare Investigation Committee, and by[books.google.com]
  • Authors’ Affiliations (1) Department of Neurosurgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands (2) Department of Biostatistics and Epidemiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands References[bmcmusculoskeletdisord.biomedcentral.com]
Sex distribution
Age distribution

Pathophysiology

  • View Article PubMed Google Scholar Baptiste DC, Fehlings MG: Pathophysiology of cervical myelopathy. Spine J. 2006, 6: 190S-197S. 10.1016/j.spinee.2006.04.024.[bmcmusculoskeletdisord.biomedcentral.com]
  • Pathophysiology Cervical spondylosis is the result of disk degeneration. As disks age, they fragment, lose water, and collapse. Initially, this starts in the nucleus pulposus.[emedicine.medscape.com]
  • Etiology and pathophysiology: The primary event is a progressive decrease in the degree of hydration resulting in loss of disc height, disc fibrosis and annular weakening.[thamburaj.com]
  • Pathophysiology This is a degenerative condition that affects motor neurons, namely the anterior horn cells of the spinal cord and the motor cranial nuclei.[patient.info]
  • Pathophysiology etiology neurologic injury mechanism of injury can be direct cord compression ischemic injury secondary to compression of anterior spinal artery Associated conditions Prognosis natural history tends to be slowly progressive and rarely[orthobullets.com]

Prevention

  • Chapter 69 Surrogate Markers of Antiretroviral Efficacy 826 Overcoming Barriers to Providing ARV Therapy in ResourceLimited Settings 831 Chapter 71 Antiretroviral Drugs for HIV Prevention 836 Chapter 72 Acute HIV Infection 843 Chapter 73 Opportunistic[books.google.ro]
  • In order to prevent damage to the spinal cord, the instrumentation should be completed before the laminectomy.[bmcmusculoskeletdisord.biomedcentral.com]
  • When root pain is the predominant symptom a fusion to prevent narrowing of the intervertebral foramen is recommended.[thamburaj.com]
  • , treatment of concurrent infections, and monitoring for arrhythmias help prevent much of the morbidity associated with GBS.[consultant360.com]

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