A similar association was present in children with wheeze cOR = 0.4 (95% CI 0.1-1.2). The number of siblings was not associated with atopy in any group. [ncbi.nlm.nih.gov]

Many of the children who present with RRTI are immunologically normal children but it is important to recognise the features of a possible immune deficit or other serious underlying disorder. [repository.up.ac.za]

• Fatigue

  [4] Common (dry cough, can be severe) Headache Uncommon Rare Common Fever Never Rare in adults, possible in children [4] Very common 100–102 °F (or higher in young children), lasting 3–4 days; may have chills Malaise Sometimes Sometimes Very common Fatigue [en.wikipedia.org]

• Splenectomy

  Immunological consequences of splenectomy. Prog Pediatr Surg 1985; 18:139. [PubMed] 1 7. Faist E. Schinkel C. Zimmer S. Update on the mechanisms of immune suppression of injury and immune modulation. World J Surg 1996; 20:454. [PubMed] 1 8. [antimicrobe.org]

• Headache

  Check if you have an RTI Symptoms of an RTI include: a cough – you may bring up mucus (phlegm) sneezing a stuffy or runny nose a sore throat headaches muscle aches breathlessness, tight chest or wheezing a high temperature (fever) feeling generally unwell [nhs.uk]

  Symptoms of URTIs commonly include cough, sore throat, runny nose, nasal congestion, headache, low-grade fever, facial pressure and sneezing. Symptoms of rhinovirus in children usually begin 1–3 days after exposure. [en.wikipedia.org]

  Other symptoms include: headaches stuffed or runny nose sore throat sneezing muscle aches and pain The symptoms of an upper respiratory tract infection usually pass within one to two weeks. [hse.ie]

  Finally, late adverse reactions may include headache, which may have migraine-like features and may be associated with nausea and fever. [theasthmacenter.org]

  Commonly reported symptoms include chills, rigors, hypotension, lightheadedness, myalgias, low grade fever, headache, and occasionally shortness of breath and/or dyspnea ( 5, 38, 44, 51 ). [antimicrobe.org]

Diagnostic workup in a 2-year-old girl with acute foreign body impaction into the esophagus and frequent respiratory tract infections revealed right descending aortic arch with ligamentum arteriosum as the cause of extrinsic esophageal-tracheal compression [ncbi.nlm.nih.gov]

• HLA-B8

  Abstract HLA-A, B, C and DR typing was performed in healthy IgA deficient donors and in IgA deficient patients with recurrent respiratory tract infections. In healthy donors, a strong association with HLA B8 and DR3 was observed. [ncbi.nlm.nih.gov]

There were no clinical relevant changes in laboratory parameters after treatment. [ncbi.nlm.nih.gov]

Immune deficiency is not frequent but could influence the prognosis. Therefore immune explorations should be well codified. KEYWORDS: Immune deficiency; Pediatrics; Recurrent respiratory infections [ncbi.nlm.nih.gov]

Prognosis Although HIES is associated with significant morbidity and mortality, adequate care, close monitoring, and patient compliance improve the prognosis and can lead to survival of 50 years of age or over. [orpha.net]

In addition, treatment before the age of 3 months is also associated with better prognosis. [antimicrobe.org]

A HRQOL assessment may identify unexpected functional disability, monitor disease progression, and improve patient prognosis. [journals.plos.org]

The prognosis is poor, with most children dying early. Defective neutrophil chemotaxis, phagocytosis and intracellular killing results from defects in micro-tubules and an inability of enzymes to release their granules. h. [theasthmacenter.org]

The results suggest that TTP is effective drug in the treatment of recurrent respiratory tract infections with undefined infectious etiology. In the period of the treatment as well as during 6 months observation no side effects were noticed. [ncbi.nlm.nih.gov]

Etiology In 70% of patients, the phenotype is associated with heterozygous mutations of the signal transducer and activator of transcription 3 gene ( STAT3 ; 17q21.31). [orpha.net]

I would suggest a CT scan of the sinuses to see if the child has chronic rhinosinusitis as the etiology or a factor in her condition. She may never be clearing chronic sinus disease. 2. [aaaai.org]

Timing, location, and prodromes to recurrence can all provide important clues to the etiology of infection. [immunoloji.uludag.edu.tr]

Available evidence suggests that defining recurrent RTIs as >or=3 infections per fall-winter semester is both medically and epidemiologically justified. Therefore, this criterion was chosen as a primary endpoint. [ncbi.nlm.nih.gov]

The epidemiology of acute respiratory infections in children and adults: a global perspective. Epidemiol Rev. 1990;12:149-78. Teele DW, Klein JO, Rosner B. [ijpediatrics.com]

Keywords: disease management, epidemiology, general practice, immunity, therapeutics This work is published and licensed by Dove Medical Press Limited. [dovepress.com]

Epidemiology of otitis media. Otolaryngol Clin North Am 1991; 24: 775–86 PubMed Google Scholar 4. Wald ER, Dashefsky B, Beyers C, et al. Frequency and severity of infections in day care. J Pediatr 1986; 112: 4540–6 Google Scholar 5. Appelbaum PC. [link.springer.com]

Epidemiology, natural history, and risk factors: panel report from the Ninth International Research Conference on Otitis Media. Int J Pediatr Otorhinolaryngol 2010; 74:231. 2. James KM, Peebles RS Jr, Hartert TV. [aaaai.org]

Cause [ edit ] In terms of pathophysiology, rhino virus infection resembles the immune response. The viruses do not cause damage to the cells of the upper respiratory tract but rather cause changes in the tight junctions of epithelial cells. [en.wikipedia.org]

The pathophysiology of this ‘post-bronchiolitis syndrome’ is complex, involving abnormalities of both immune function and airway growth. [academic.oup.com]

Antibacterial treatments can temporarily restore the equilibrium between host and bacterial load, but do not prevent recurrence of infection. [ncbi.nlm.nih.gov]

These infections are still treated with antibiotics but the rise in resistant bacterial strains has prompted investigation of novel preventative strategies. [moh-it.pure.elsevier.com]