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Refractory Anemia with Excess Blasts in Transformation

RAEB-t


Presentation

  • The duplicated product had not been observed at presentation in malignant disease, as far as we are aware; thus, the findings are discussed with regard to this case and other possible smoldering leukemias.[ncbi.nlm.nih.gov]
  • Blasts are commonly present. RAEB-1 is defined by 2-4% blasts in the peripheral blood. RAEB-2 is defined by 5-19% blasts in the peirpheral blood.[imagebank.hematology.org]
  • […] consider Chronic Myelomonocytic Leukemia ) Lack of neutrophilia (if present consider BCR-ABL1 CML or atypical CML) Elevated blasts, but not to leukemic levels in either: Peripheral blood blasts 2-19%, based on 200 leukocyte differential, OR Bone marrow[surgpathcriteria.stanford.edu]
  • Promyelocytes and myelocytes and 2 myeloblasts on right Large neutrophil (upper right) is hypogranular with marked nuclear hyperlobulation, also single myeloblast with prominent nucleolus and 2 neutrophils with markedly hypogranular cytoplasm RAEB-2: Auer rod present[pathologyoutlines.com]
  • (Outcomes/Resolutions) The severity of Refractory Anemia with Excess Blasts depends on the degree to which blast cell levels are elevated, and if Auer rods are present.[dovemed.com]
Suggestibility
  • Our data suggest that the propriety of administering AML Rx to patients with RAEB or RAEB-t who have poor prognosis without treatment is identical to the propriety of treating AML in this fashion.[ncbi.nlm.nih.gov]
  • The data suggest that RAEB-T is more likely to be an advanced stage of MDS and biologically different from AML.[ncbi.nlm.nih.gov]
  • It is suggested that imbalance in immunoregulatory T cells, which has a crucial role in the control of hemopoiesis, may be a primary event in the pathogenesis of myelodysplastic syndrome which eventually develops into an overt leukemia.[mdanderson.influuent.utsystem.edu]
  • Here we present data suggesting that the biology of RAEB-T more resembles that of refractory anemia (RA), refractory anemia with ringed sideroblasts (RARS), and RAEB (“other MDS”) than that of AML.[bloodjournal.org]
  • Access full-color images and more than 90 online-only topics at Expert Consult, as well as EBMs, Suggested Reading, Patient Teaching Guides, and additional algorithms.[books.google.com]
Stroke
  • Collaborative overview of randomised trials of antiplatelet therapy, I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. ‎[books.google.com]

Workup

Poikilocytosis
  • Dyserythropoeisis Peripheral blood erythrocyte abnormalities Normocytic, normochromic anemia Macrocytosis Dimorphic red blood cells (RBC) Mixture of normal RBC and hypochromic microcytic RBC Often seen in Sideroblastic Anemia (RARS) Basophilic stippling Poikilocytosis[surgpathcriteria.stanford.edu]

Treatment

  • Our data suggest that the propriety of administering AML Rx to patients with RAEB or RAEB-t who have poor prognosis without treatment is identical to the propriety of treating AML in this fashion.[ncbi.nlm.nih.gov]
  • […] service, product or treatment in your circumstances.[leukaemia.org.au]
  • Censoring at allogeneic hematopoietic stem cell transplantation, the OS difference between the treatment groups increased, particularly among patients aged 60-74 years (HR 0.48, 95 % CI 0.26-0.89).[ncbi.nlm.nih.gov]
  • الصفحة 295 - Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). ‏[books.google.com]
  • Yi JH, Huh J, Kim HJ et al (2013) Genome-wide single-nucleotide polymorphism array-based karyotyping in myelodysplastic syndrome and chronic myelomonocytic leukemia and its impact on treatment outcomes following decitabine treatment.[link.springer.com]

Prognosis

  • Our data suggest that the propriety of administering AML Rx to patients with RAEB or RAEB-t who have poor prognosis without treatment is identical to the propriety of treating AML in this fashion.[ncbi.nlm.nih.gov]
  • (Type 2 RAEB), the prognosis is around 10 months survival Proper care should be taken to treat and control complications from MDS.[dovemed.com]
  • While we were among the first to point out that response to chemotherapy was independent of the distinction between AML, RAEB-T, and refractory anemia with excess blasts (RAEB), 2 after accounting for features such as poor prognosis cytogenetics and older[bloodjournal.org]
  • CAG as the induction therapy seems promising for the treatment of various categories of poor-prognosis AML.[ncbi.nlm.nih.gov]
  • PMID 2319806 International scoring system for evaluating prognosis in myelodysplastic syndromes.[atlasgeneticsoncology.org]

Etiology

  • (Etiology) Refractory Anemia with Excess Blasts is caused by genetic mutations.[dovemed.com]

Epidemiology

  • Epidemiology There are few data on the epidemiology of RAEB, which may account for 20-30% of all MDS cases. MDS is predominantly diagnosed in the elderly population.[atlasgeneticsoncology.org]
  • Thrombocytopenia Weakness or feeling tired Diagnostic Exams FISH (flourescence in situ hybridzation) Flow cytometry Immunocytochemistry Immunophenotyping Peripheral blood smear Progression and Transformation 25% of RAEB-1 and 33% of RAEB-2 transform to AML Epidemiology[seer.cancer.gov]
  • Age-related incidence and other epidemiological aspects of myelodysplastic syndromes. Br J Haematol. 1992;82:358-67. INTERNET Besa EC, Woermann UJ. Myelodysplastic Syndrome. Medscape. Last Update September 28, 2016. Accessed February 1, 2017.[rarediseases.org]
  • Epidemiology and Clinical Features Epidemiology As with other types of myelodysplastic syndromes (MDS), MDS with excess blasts-1 (MDS-EB1) and MDS-EB2 tend to occur in older adults with a male predominance.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • Bone marrow fibrosis: pathophysiology and clinical significance of increased bone marrow stromal fibres. Br J Haematol 2007;139:351–62. Web of Science Google Scholar 5. Farolino DL, Rustagi PK, Currie MS, Doeblin TD, Logue GL.[degruyter.com]

Prevention

  • Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets[books.google.com]
  • Collaborative overview of randomised trials of antiplatelet therapy, I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. ‎[books.google.com]
  • Antibiotics can prevent a simple infection becoming life-threatening.[leukaemia.org.au]
  • Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma Completed NCT00003187 Phase 2, Phase 3 cyclophosphamide;cyclosporine;cytarabine;methotrexate;methylprednisolone 14 Treatment of Bone Marrow to Prevent[malacards.org]

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