Gamboa et al. from the Clinical Neurosciences Center, University of Utah, Salt Lake City, present the case of a patient with RELA-fusion positive ependymoma of the frontal lobe in whom they used preoperative and intraoperative MR perfusion imaging. [operativeneurosurgery.com]

Some mitosis and necrosis were present. Endothelial proliferation and necrosis were also seen. [clinmedjournals.org]

In the case of RelA-C11orf95, the problem is that while the fusion presents a major therapeutic opportunity, it also presents some major challenges. [fredhutch.org]

The tumors frequently involved a single lobe in both the present cohort and literature series (P = 0.152). The rate of GTR for tumors in the present series was lower than that in the literature (P = 0.017). [frontiersin.org]

C11orf95-RELA fusion present in a primary supratentorial ependymoma and recurrent sarcoma. Brain Tumor Pathol. 2015. 32: 105-11 3. Delgado AF, Delgado AF. [surgicalneurologyint.com]

• Vomiting

  CASE REPORT A 10-year-old boy visited the pediatric neurosurgery outpatient clinic due to headache and vomiting for 1 week. On physical examination, grade IV+ motor weakness in the right upper extremity and limping gait of the right leg were noted. [ncbi.nlm.nih.gov]

  CASE REPORT History and examination A previously healthy 19-year-old man presented with a 6-week history of word-finding difficulty and a 3-week history of headaches, nausea, and vomiting, but he was otherwise neurologically intact. [surgicalneurologyint.com]

  Added right intraocular pain, besides nausea, vertigo, vomiting, diplopia, blurred vision, photophobia and right facial synesthesia. Physical examination revealed no abnormality, with a normal neurological examination. [clinmedjournals.org]

  15)a,b,c-a,b,c a Identified by FISH analysis. b Identified by RNA sequencing c Identified by WES. 2 Rec – – – – Cystic/solid, enhanced GTR Local 27 Gy + CSI 23.4 Gy Multiagent*1, (3rd and 4th courses), PBSCT RD (2.8 years) → DOD (3.5 years) – 3 1/M Vomit [onlinelibrary.wiley.com]

  The most common symptoms in the present series were those related to increased intracranial pressure such as headache or vomiting. Our institutional series showed higher rate of WHO grade II pathology in CEs. [frontiersin.org]

• Blurred Vision

  Added right intraocular pain, besides nausea, vertigo, vomiting, diplopia, blurred vision, photophobia and right facial synesthesia. Physical examination revealed no abnormality, with a normal neurological examination. [clinmedjournals.org]

• Aggressive Behavior

  For supratentorial (ST) ependymomas, RELA fusion-positive ependymomas show a more aggressive behavior than YAP1 fusion-positive ependymomas. Extracranial metastases of intra-axial neuroepithelial tumors are extremely rare. [snucm.elsevierpure.com]

  This tumor is a representative case of Ependymoma RELA fusion positive, showing aggressive behavior 7). [operativeneurosurgery.com]

  This tumor is a representative case of RELA fusion-positive ST ependymoma, showing aggressive behavior. [ncbi.nlm.nih.gov]

  behavior than low grade ependymomas Often require additional treatment after surgery and can recur The relevance of conventional grading (grade II versus grade III ependymomas) and the prognostic relevance of this approach is currently a matter of discussion [cern-foundation.org]

  Since ST EPN-RELA are tumors with aggressive behavior, such a correlation would be clinically relevant, particularly when there is limited access to molecular testing. References 1. Gajjar, A, Pfister, SM, Taylor, MD, Gilbertson, RJ. [journals.sagepub.com]

• Headache

  Abstract We report a case of 33-year-old Japanese male who presented with a headache and visual disturbances. [pubmed.ncbi.nlm.nih.gov]

  Common symptoms include headaches and feeling or being sick. What are ependymomas? Ependymomas develop from ependymal cell. These cells line the fluid filled areas of the brain (ventricles) and the spinal cord. [cancerresearchuk.org]

  Nine (30%) patients experienced seizures preoperatively, and the other common symptoms included headache (15, 50%) and weakness (4, 13.3%). [frontiersin.org]

  CASE REPORT A 10-year-old boy visited the pediatric neurosurgery outpatient clinic due to headache and vomiting for 1 week. On physical examination, grade IV+ motor weakness in the right upper extremity and limping gait of the right leg were noted. [ncbi.nlm.nih.gov]

  CASE REPORT History and examination A previously healthy 19-year-old man presented with a 6-week history of word-finding difficulty and a 3-week history of headaches, nausea, and vomiting, but he was otherwise neurologically intact. [surgicalneurologyint.com]

• Limb Weakness

  Numbness of the right arm and myoclonic movement accompanied by limb weakness and sensory change in taste developed. F/U MRI showed increased enhancing mass and increased edema compared with the MRI findings a month ago. [ncbi.nlm.nih.gov]

• Liver Biopsy

  Results of the liver biopsy revealed metastatic anaplastic ependymoma, which showed robust GFAP positivity and high Ki-67 index of 92.47% (Fig. 3A–C). [ncbi.nlm.nih.gov]

As part of your treatment, your doctor might ask you to take part in a clinical trial. This might be to test a new treatment or look at different combinations of existing treatments. [cancerresearchuk.org]

Treatment of no residual disease, no disseminated disease. Treatment of residual disease, no disseminated disease. Treatment of central nervous system (CNS) disseminated disease. Treatment of children younger than 1 year. [uofmhealth.org]

Standard Treatment Options for Childhood Ependymoma Treatment Group Standard Treatment Options Newly diagnosed childhood myxopapillary ependymoma (WHO grade I) Surgery with or without adjuvant radiation therapy Newly diagnosed childhood ependymoma (WHO [cancer.gov]

Our ALSF supported project on the identification of non-mutated cancer dependency genes has led to new therapeutic leads for treatment of ependymoma. [alexslemonade.org]

“These data show that surgery and radiation therapy are the backbone of ependymoma treatment,” Dr. Merchant said. [ascopost.com]

It was a predictive factor of poor prognosis with vulvar cancer, endometrial cancer, gastric cancer, etc. [1]. [hindawi.com]

In cases of ST ependymomas, RELA fusion-positive ependymomas have worse prognosis than YAP1 fusion-positive ependymomas [8]. [ncbi.nlm.nih.gov]

Subtotal resection confers a very poor prognosis.[16,24]; [21][Level of evidence: 2A] Lower doses of radiation. [uofmhealth.org]

Subtotal resection confers a very poor prognosis.[17,25]; [22][Level of evidence: 2A] Lower doses of radiation. [cancer.gov]

Tumor Location has been identified as an important prognosis factor. The supratentorial site is associated with a better prognosis than posterior fossa neoplasm. EPs are considered conferring to their locations and genetic abnormalities. [clinmedjournals.org]

Etiology To theorize the "cell of origin" of ependymomas and related tumors, one needs only to look back through the stages of normal ependymal cell development. [emedicine.medscape.com]

Predictors of survival among pediatric and adult ependymoma cases: a study using Surveillance, Epidemiology, and End Results data from 1973 to 2007. [frontiersin.org]

References: Villano JL, Parker CK, Dolecek TA: Descriptive epidemiology of ependymal tumours in the United States. Br J Cancer 108 (11): 2367-71, 2013. [uofmhealth.org]

Primary spinal myxopapillary ependymoma in the pediatric population: a study from the Surveillance, Epidemiology, and End Results (SEER) database. J Neurooncol. 2016 Oct. 130 (1):133-140. [Medline]. [emedicine.medscape.com]

References Villano JL, Parker CK, Dolecek TA: Descriptive epidemiology of ependymal tumours in the United States. Br J Cancer 108 (11): 2367-71, 2013. [cancer.gov]

McGuire CS, Sainani KL, Fisher PG (2009) Incidence patterns for ependymoma: a surveillance, epidemiology, and end results study. J Neurosurg 110:725–729. https://doi.org/10.3171/2008.9.JNS08117 Article PubMed Google Scholar 14. [link.springer.com]

However, an author would be permitted to write a sentence such as "NCI's PDQ cancer information summary about breast cancer prevention states the risks succinctly: [include excerpt from the summary]." [uofmhealth.org]

However, an author would be permitted to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks succinctly: [include excerpt from the summary].” [cancer.gov]