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Renal Carcinoma

Carcinoma of Kidney


Presentation

  • We present the case of a 56 year-old male with a pulsating lesion in the temporal region of the left orbit as presenting sign of a renal cell carcinoma.[ncbi.nlm.nih.gov]
Goiter
  • Ultrasonography showed the presence of a multinodular goiter, all nodules being "cold" at scintiscan. Total thyroidectomy was performed; histology of all nodules revealed a metastatic thyroid cancer from renal cell carcinoma.[ncbi.nlm.nih.gov]
Thyroid Nodule
  • History of patients with thyroid nodules should include inquiring about extra-thyroid malignancies, especially renal cell carcinoma, that may have been diagnosed even many years earlier.[ncbi.nlm.nih.gov]
Stridor
  • CASE PRESENTATION: We report a case of a 73-year-old man with a painful neck mass, dyspnoea, stridor and dysphonia that was evaluated in emergency. A right radical nephrectomy for renal cell carcinoma was performed 8 years previously.[ncbi.nlm.nih.gov]
Heart Disease
  • INTRODUCTION: Recent advances in surgical and anesthesiology techniques allow simultaneous thoracic and abdominal operations to be performed for severe heart disease and benignant or malignant abdominal diseases.[ncbi.nlm.nih.gov]
Neck Mass
  • CASE PRESENTATION: We report a case of a 73-year-old man with a painful neck mass, dyspnoea, stridor and dysphonia that was evaluated in emergency. A right radical nephrectomy for renal cell carcinoma was performed 8 years previously.[ncbi.nlm.nih.gov]
Sciatica
  • We report on a sciatica leading to the discovery of a tumour of the right thigh which proved to be an endoneural metastasis of the sciatic nerve from a renal carcinoma surgically removed 4 years before.[ncbi.nlm.nih.gov]
Limb Weakness
  • At 5 months, the patient was pain-free and his right limb weakness had completely resolved. A tumoral recurrence could be observed on the control MRI 5 months after surgery.[ncbi.nlm.nih.gov]

Workup

  • During the staging workup, she was found to have a synchronous early-stage clear cell renal carcinoma. The patient underwent an esophagogastrectomy and radical nephrectomy and remains disease-free at a 12-month follow-up visit.[ncbi.nlm.nih.gov]
  • […] aminotransferase [AST] and alanine aminotransferase [ALT]) Serum calcium Imaging studies used to evaluate and stage renal masses may include the following: Excretory urography CT scanning PET scanning Ultrasonography Arteriography Venography MRI See Workup[emedicine.medscape.com]

Treatment

  • In contrast, combined treatment with osthole and TRAIL did not induce apoptosis in normal human skin fibroblast cells.[ncbi.nlm.nih.gov]

Prognosis

  • We believe that studies involving more patients are needed for the long-term prognosis assessment in these patients.[ncbi.nlm.nih.gov]
  • Prognosis can be variable depending both on histological subtype and stage.[radiopaedia.org]

Etiology

  • Etiology A specific factor in the etiology of RCC is not known at the moment, although a number of dietary, environmental factors, hormonal, celllular and genetic factors associated with increased risk.[atlasgeneticsoncology.org]
  • "Etiology of Renal Cell Carcinoma: Incidence, Demographics, and Environmental Factors". Renal Cell Carcinoma Clinical Management. Humana Pr Inc. pp. 3–22. ISBN 978-1-62703-061-8. Lane, Brian R. (2013).[en.wikipedia.org]

Epidemiology

  • […] middle-aged or older people of either gender (although more common in men). renal cell carcinoma renal cell carcinoma Adenocarcinoma of renal cells, hypernephroma, kidney cancer, renal cancer, renal cell cancer, renal adenocarcinoma Oncology A renal tubule CA Epidemiology[medical-dictionary.thefreedictionary.com]
  • Epidemiology They are the most common renal carcinoma in adults. They rarely present before the age of 40, and the average age of onset is 65-75 Twice as common in men as women.[almostadoctor.co.uk]
  • Epidemiology of renal cell carcinoma. Scand J Surg 2004;93(2):88-96 4 Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012.[ipsen-pharma.de]
  • Epidemiology Renal cell carcinomas (RCCs) of all subtypes and variations are dispersed nationwide. The incidence and number of kidney cancer cases is not geographically specific.[pharmacytimes.com]
  • "Epidemiologic characteristics and risk factors for renal cell cancer". Clinical Epidemiology. 1: 33–43. doi:10.2147/clep.s4759. PMC 2943168. PMID 20865085. Pavlovich, Christian P.; Schmidt, Laura S. (2004).[en.wikipedia.org]
Sex distribution
Age distribution

Pathophysiology

  • Renal cell carcinoma: a review of biology and pathophysiology [version 1; referees: 2 approved] .[f1000research.com]
  • The pathophysiology of RCC is still far from understood, and there is a clear need to identify key mechanisms of tumour progression and metastasis to open up novel therapeutic avenues targeting different aspects of RCC biology.[u1029.u-bordeaux.fr]
  • Targeted Adjuvant Therapy The treatment of metastatic RCC has been revolutionized by an improved understanding of the molecular pathophysiology of RCC.[hematologyandoncology.net]
  • Pathophysiology The tissue of origin for renal cell carcinoma (RCC) is the proximal renal tubular epithelium.[emedicine.medscape.com]

Prevention

  • Cordycepin downregulated GADD45B and c-FLIPL, but upregulated MKK7 and phospho-JNK, by preventing nuclear mobilization of NF-κB.[ncbi.nlm.nih.gov]
  • They can slow bone damage, prevent fractures, and lower the amount of calcium in your blood. Denosumab (Xgeva). Like bisphosphonates, it helps prevent bone breakdown and fractures.[webmd.com]

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