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2.1
Renal Fibrosis

Presentation

Both Julie and Ana gave an excellent presentation. The RF-lab presented 3 very interesting posters at the local Occitanie Cardiovascular Disease meeting. [renalfibrosis.fr]

Kidney/Renal Fibrosis Treatment market Analysis report is an up-to-date granular analysis of the present industry conditions, market demands, reveals facts on the Kidney/Renal Fibrosis Treatment market size, revenues and provides forecasts through 2025 [aeresearch.net]

Free Preview Systemically presenting the latest research on renal fibrosis Covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD) Elaborating [springer.com]

Methods: In the present study, human renal glomerular endothelial cells (HRGECs) were treated with various concentrations of silibinin. Then, cell viability and apoptosis were measured by MTT assay and flow cytometry, respectively. [dovepress.com]

Session Information Session Time: 6:00pm-7:00pm Presentation Time: 6:00pm-7:00pm Location: Halls C&D Ischemia-reperfusion injury (IRI) leads to an irreversible damage to the tubular epithelium and promotes acute kidney injury (AKI) that is associated [atcmeetingabstracts.com]

Entire Body System

  • Inflammation

    Thomson & Jeremy Hughes Review Article | 01 July 2014 Renal fibrosis is caused by renal inflammation, although the underlying mechanisms are unclear. [nature.com]

    Fibrosis is a reactive process that develops in response to excessive epithelial injury and inflammation, leading to myofibroblast activation and an accumulation of extracellular matrix. [semanticscholar.org]

    This results in local inflammation that, over time, can impair the kidneys’ ability to filter waste from blood. [pipelinereview.com]

    Overview Pancreatitis is inflammation in the pancreas. The pancreas is a long, flat gland that sits tucked behind the stomach in the upper abdomen. [mayoclinic.org]

Gastrointestinal

  • Nausea

    Acute pancreatitis signs and symptoms include: Upper abdominal pain Abdominal pain that radiates to your back Abdominal pain that feels worse after eating Fever Rapid pulse Nausea Vomiting Tenderness when touching the abdomen Chronic pancreatitis signs [mayoclinic.org]

    In all of those studies, adverse effects that were attributable to the drug were relatively minimal and were mostly gastrointestinal ( e.g., dyspepsia, nausea), sedation or fatigue, and a photosensitivity dermatitis. [cjasn.asnjournals.org]

    […] aim to inhibit the growth of new blood vessels in the tumors, hence slowing growth and in some cases reducing the size of the tumors. [97] Side effects unfortunately are quite common with these treatments and include: [98] Gastrointestinal effects – nausea [en.wikipedia.org]

  • Vomiting

    Acute pancreatitis signs and symptoms include: Upper abdominal pain Abdominal pain that radiates to your back Abdominal pain that feels worse after eating Fever Rapid pulse Nausea Vomiting Tenderness when touching the abdomen Chronic pancreatitis signs [mayoclinic.org]

    […] inhibit the growth of new blood vessels in the tumors, hence slowing growth and in some cases reducing the size of the tumors. [97] Side effects unfortunately are quite common with these treatments and include: [98] Gastrointestinal effects – nausea, vomiting [en.wikipedia.org]

Cardiovascular

  • Hypertension

    Montford Division of Renal Diseases and Hypertension, University of Colorado-Anschutz Medical Campus, Denver, Colorado Department of Medicine, University of Colorado-Anschutz Medical Campus, Denver, Colorado Eastern Colorado Veterans Affairs Hospital, [physiology.org]

    The prevalence of hypertension in African Americans in the United States is among the highest in the world. Onset of hypertension in African Americans generally occurs at an earlier age than Caucasians. [pipelinereview.com]

    Sep 14, 2018 0 115 Oncology & Cancer Diagnostic mutations ID'd in chronic kidney disease patients (HealthDay)—About one-quarter of adults with chronic kidney disease (CKD) of unknown cause or familial nephropathy or hypertension have diagnostic mutations [medicalxpress.com]

    Current Opinion for Hypertension in Renal Fibrosis Pages 37-47 Sun, Hai-Jian A Glimpse of the Mechanisms Related to Renal Fibrosis in Diabetic Nephropathy Pages 49-79 Zeng, Ling-Feng (et al.) [springer.com]

Urogenital

  • Renal Injury

    The researchers found that SSR treatment significantly attenuated renal injury and fibrosis in the remnant kidneys. [nexusnewsfeed.com]

    renal disease which causes the original kidney injury. [ncbi.nlm.nih.gov]

Workup

Acute Kidney Injury Workup. Medscape Reference. Available online at http://emedicine.medscape.com/article/243492-workup#c13. Accessed May 2016. (April 2014) Seaborg E. New Biomarkers Offer Hope for Identifying Acute Kidney Injury Risk. [labtestsonline.it]

[…] clinical proteomics focusing on amniotic fluid peptides, she showed that high definition, omics based, medicine allows accurate prediction of postnatal renal survival in developmental renal disease, not attainable by the currently available clinical workup [renalfibrosis.fr]

Treatment

Treatment Kidney/Renal Fibrosis Treatment Market forecasts for a minimum of 6 years of all the mentioned segments, sub segments and the regional Kidney/Renal Fibrosis Treatment markets Kidney/Renal Fibrosis Treatment Market Trends (Drivers, Constraints [aeresearch.net]

Current treatments can slow the progression of chronic kidney disease but there is no treatment that can halt the progression of the disease, or reverse damage that has already occurred. [biomodels.com]

Mycophenolate inhibits inosine monophosphate dehydrogenase and is a standard treatment for LN. The mammalian or mechanistic target of rapamycin (mTOR) pathway is activated in LN. [portlandpress.com]

DiaMedica Therapeutics Inc. is a clinical stage biopharmaceutical company focused on developing novel treatments for chronic kidney diseases and neurological disorders. [pipelinereview.com]

The Network is comprised of clinicians and scientists involved in research into the diagnosis, mechanisms, biomarkers and treatment of renal fibrosis. There is no fixed membership and anyone interested in this field is welcome to join the network. [kidneyresearchuk.org]

Prognosis

A very stiff, fibrotic kidney would potentially: (1) suggest that little could be done to improve renal function, and (2) portend a poor renal prognosis. [ukidney.com]

[…] is discussed in the “Diagnosis” and “Prognosis” section. [en.wikipedia.org]

Etiology

Discussion Etiology of renal disease Kidney disease consists of a diverse range of etiologies, including immunological, mechanical, metabolic and toxic insults amongst others. [fibrogenesis.biomedcentral.com]

"Etiology of Renal Cell Carcinoma: Incidence, Demographics, and Environmental Factors". Renal Cell Carcinoma Clinical Management. Humana Pr Inc. pp. 3–22. ISBN 978-1-62703-061-8. ^ Lane, Brian R. (2013). [en.wikipedia.org]

Epidemiology

"Epidemiologic characteristics and risk factors for renal cell cancer". Clinical Epidemiology. 1 : 33–43. doi : 10.2147/clep.s4759. PMC 2943168. PMID 20865085. ^ Pavlovich, Christian P.; Schmidt, Laura S. (2004). [en.wikipedia.org]

Pathophysiology

Open Access Article Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai 200032, China * Author to whom correspondence should be addressed. [mdpi.com]

Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. [springer.com]

In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. http://www.clinicalkey.com. Accessed July 26, 2016. Complementary pancreatitis therapies. [mayoclinic.org]

[…] sickle cell disease. [23] The most significant disease affecting risk however is not genetically linked – patients with acquired cystic disease of the kidney requiring dialysis are 30 times more likely than the general population to develop RCC. [24] Pathophysiology [en.wikipedia.org]

Prevention

Jun 14, 2019 0 0 Diseases, Conditions, Syndromes Scientists report new approach to reduce or prevent renal fibrosis Renal fibrosis, the abnormal accumulation of fibrotic material within the kidney, hinders kidney function and may lead to eventual renal [medicalxpress.com]

As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. [springer.com]

Rapamycin inhibits mTOR and is effective in preventing kidney transplant rejection, with the additional merits of reduced incidence of malignancies and viral infections. [portlandpress.com]

Our results show that metformin prevents renal fibrosis, possibly through the inhibition of ERK signaling, and may be a novel strategy for the treatment of renal fibrosis. [mdpi.com]

They discuss the therapeutic methods that might prevent the transition of precursors to a myofibroblast phenotype, thereby inhibiting fibrosis. Lucas L. Falke, Shima Gholizadeh, Roel Goldschmeding, Robbert J. Kok & Tri Q. [nature.com]

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