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Renal Glycosuria

Renal Glucosuria


Presentation

  • All the affected members present autoantibodies against various antigens. In nine patients immunofluorescence revealed antibody coated bacteria in urine specimens.[ncbi.nlm.nih.gov]
  • A pregnant woman presented at gestational week 28 with loss of consciousness and profound polyuria. Further characterization revealed osmotic diuresis due to massive glycosuria without hyperglycemia.[ncbi.nlm.nih.gov]
  • Such a presentation is very rare in adults and has not been previously reported. These findings confirm that AIN with acute renal failure can cause an isolated tubular defect with benign reversible glycosuria in an adult.[ncbi.nlm.nih.gov]
  • In addition, most subjects presented with hypophosphataemia and hyperphosphaturia.[ncbi.nlm.nih.gov]
  • Here we present data on a large pedigree with renal glycosuria due to two mutations (c.300-303 2del and p.A343V) in the SLC5A2 gene.[ncbi.nlm.nih.gov]
Asymptomatic
  • In most affected individuals, the condition causes no apparent symptoms (asymptomatic) or serious effects.[en.wikipedia.org]
  • 'renal' glycosuria A common–1:500 AR condition in which glycosuria occurs without hyperglycemia, unrelated to diet; subjects are asymptomatic, have a normal glucose tolerance test and utilization and storage of carbohydrates, but may become transiently[medical-dictionary.thefreedictionary.com]
  • It is usually asymptomatic. In most affected individuals, no treatment is required. However, some individuals with renal glycosuria may develop diabetes mellitus.[patient.info]
Turkish
  • The Na /glucose cotransporter gene SGLT2 ( SLC5A2 ) was analyzed in a Turkish patient with congenital isolated renal glucosuria.[doi.org]

Workup

Glycosuria
  • Etiologically, renal glycosuria is of 3 types-benign renal glycosuria, glycosuria with diabetes mellitus (including gestational diabetes) and tubular defects (Fanconi syndrome). Prognosis of benign renal glycosuria is excellent and reversible.[ncbi.nlm.nih.gov]
  • SLC5A2 and HNF1A mutations are associated with renal glycosuria, but their contributions to renal glycosuria in patients with T2DM are not well understood.[ncbi.nlm.nih.gov]
  • Several drugs have been introduced as means to lower glucose in patients with type 2 diabetes targeting SGLT2 resulting in renal glycosuria, but no studies have addressed the potential effects of decreased renal glucose reabsorption and chronic glycosuria[ncbi.nlm.nih.gov]
  • Further characterization revealed osmotic diuresis due to massive glycosuria without hyperglycemia. Glycosuria reduced substantially postpartum, from approximately 100 to approximately 30 g/1.73 m2 per day.[ncbi.nlm.nih.gov]
Candida
  • One individual, who was compound heterozygous for mutations in the SLC5A2 gene suffered from severe urogenital candida infections and postprandial hypoglycemia.[ncbi.nlm.nih.gov]

Treatment

  • Though renal glycosuria is a benign condition, mistaken diagnosis for diabetes mellitus puts patients at risk of hypoglycaemia due to treatment.[ncbi.nlm.nih.gov]
  • Treatment is directed at the underlying tubular disease condition.[doctor.ndtv.com]
  • CLOSE Medical Disclaimer The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes.[diseaseinfosearch.org]
  • You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments.[rarediseases.info.nih.gov]
  • Seite 935 - In utero surgical treatment of fetal obstructive uropathy: a new comprehensive approach to identify appropriate candidates for vesicoamniotic shunt therapy. Am J Obstet Gynecol 170: 1770-6. ‎[books.google.de]

Prognosis

  • Prognosis of benign renal glycosuria is excellent and reversible. Acute interstitial nephritis (AIN) is one of the main causes of acute renal failure and may often result in tubular dysfunction.[ncbi.nlm.nih.gov]
  • Primary renal glucosuria has been considered a ‘non-disease’ with an excellent prognosis.[doi.org]

Etiology

  • Our data provide the first direct evidence of an etiologic role for the sodium/glucose cotransporter type 2 in the pathogenesis of renal glucosuria.[doi.org]
  • Etiologically, renal glycosuria is of 3 types-benign renal glycosuria, glycosuria with diabetes mellitus (including gestational diabetes) and tubular defects (Fanconi syndrome). Prognosis of benign renal glycosuria is excellent and reversible.[ncbi.nlm.nih.gov]
  • Practically all categories in the chapter could be designated 'not otherwise specified', 'unknown etiology' or 'transient'.[icd10data.com]

Epidemiology

  • It gives compreensive coverage of the epidemiology, aetiology, and mechanism of disease, as well as clear, unambiguous coverage of the diagnosis, practical management and prevention of the entire spectrum of medical disorders.[books.google.de]
Sex distribution
Age distribution

Pathophysiology

  • From basic science and pathophysiology to clinical best practices, Brenner & Rector’s The Kidney is your go-to resource for any stage of your career.[books.google.de]
  • There are major introductory sections on the scientific basis of disease; and in the system-based clinical sections genetic predisposition, pathophysiology, pathogenesis, molecular mechanisms, and cell biology are covered in depth for all significant[books.google.de]
  • Hanley ME, Bone RC: Acute respiratory failure: Pathophysiology, causes and clinical management. Postgrad Med 1986;79:166–176.[doi.org]
  • Pathophysiology Blood is filtered by millions of nephrons , the functional units that comprise the kidneys. In each nephron, blood flows from the arteriole into the glomerulus , a tuft of leaky capillaries .[dictionnaire.sensagent.leparisien.fr]
  • The pathophysiological mechanisms and the long-term outcome in the latter two diseases, however, differ from renal glucosuria type 0.[doi.org]

Prevention

  • Abstract Under physiological conditions, the kidneys contribute to glucose homoeostasis by producing glucose by gluconeogenesis and preventing glucose loss in urine.[ncbi.nlm.nih.gov]
  • […] have been introduced as means to lower glucose in patients with type 2 diabetes targeting SGLT2 resulting in renal glycosuria, but no studies have addressed the potential effects of decreased renal glucose reabsorption and chronic glycosuria on the prevention[ncbi.nlm.nih.gov]
  • It gives compreensive coverage of the epidemiology, aetiology, and mechanism of disease, as well as clear, unambiguous coverage of the diagnosis, practical management and prevention of the entire spectrum of medical disorders.[books.google.de]
  • How to use an article about therapy or prevention. B. What were the results and will they help me in caring for my patients? Evidence-Based Medicine Working Group. JAMA 1994;271:59-63. 79.[books.google.de]
  • […] sudden cardiac death - guidance (IPG603) Source: National Institute for Health and Care Excellence - NICE - 20 December 2017 Evidence-based recommendations on subcutaneous implantable cardioverter defibrillator insertion for preventing sudden cardiac[evidence.nhs.uk]

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