Renal metastases of thyroid carcinomas are rare and often present as a primitive unilateral renal mass. [ncbi.nlm.nih.gov]

Three years later before the patient was lost to follow-up, no evidence of recurrence was present. [scielo.br]

It is an unpredictable entity due to its atypical metastatic profile at presentation. [jcmtjournal.com]

We present a case of a 50-year-old male with RCC, metastasizing to the skin diagnosed on fine-needle aspiration cytology (FNAC). [ccij-online.org]

• Pathologist

  Pfizer (axitinib and sunitinib) Others Department of Health NHS England Welsh Government Patient carer groups Kidney Cancer Support Network Professional groups Association of Cancer Physicians Cancer Research UK Royal College of Nursing Royal College of Pathologists [nice.org.uk]

  A multidisciplinary approach with input from urologists, oncologists, radiologists and pathologists is needed to achieve the optimum outcomes for this specific patient population. © 2015 The Authors BJU International © 2015 BJU International Published [ncbi.nlm.nih.gov]

  In the end, communication between the urologist and pathologist is key to arriving at the correct diagnosis.” [renalandurologynews.com]

  Once removed, the tissue is then examined by a pathologist who will use a microscope to check for cancer cells. [physio-pedia.com]

• Intravenous Administration

  The fundamental principle of dynamic contrast-enhanced CT is the temporal changes in tissue attenuation after intravenous administration of iodinated contrast media. [pubs.rsna.org]

• Diarrhea

  The majority, 68 percent, experienced some adverse effects — fatigue, nausea and diarrhea — but nothing life-threatening. One patient died due to disease progression. [consultqd.clevelandclinic.org]

  Patients receiving lenvatinib had more proteinuria, hypertension, and diarrhea, whereas those who received everolimus had more anemia, dyspnea, hypertriglyceridemia, and hyperglycemia. [jhoponline.com]

  But, as these agents developed, these too appeared to have a class-effect of an adverse event profile, including diarrhea, nausea, hand-foot syndrome, fatigue, etc. [urotoday.com]

  Common axitinib toxicities observed in the study included diarrhea (55%), hypertension (40%), and fatigue (39%). [jhoonline.biomedcentral.com]

  Notably, there was a 20% incidence for grade 3 diarrhea in the combination arm, which highlights the need for recognition and management of this toxicity in the combination. [am.asco.org]

• Hypertension

  The overall survival for hypertensive patients with metastatic renal cell carcinoma receiving angiotensin system inhibitors was 27 months vs 17 months for non–angiotensin system inhibitor users. [ascopost.com]

  […] with and without hypertension. [intechopen.com]

  The adverse events with bevacizumab included proteinuria, hypertension, and bleeding. [jhoponline.com]

  March 06, 2018 ; 90 (10) Resident & Fellow Section Muhammad Taimur Malik, Syed Jaffar Kazmi, Scott Turner First published March 5, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005072 A 75-year-old man with hypertension presented with 2 weeks' history [n.neurology.org]

  Case Report A 74-year-old Caucasian man with a history of hypertension and stage I clear cell type renal cell cancer underwent right nephrectomy in 2004. [karger.com]

• Blister

  […] and may include any of the following: Palliative radiation therapy Metastasectomy [15] Bisphosphonates for bony metastasis [32] Special considerations Tyrosine kinase inhibitors have the potential to cause hand-foot syndrome, which usually consists of blisters [emedicine.medscape.com]

• Fracture

  Herein we describe a case of metastatic papillary thyroid microcarcinoma to the kidney in a patient with a pelvic fracture and pulmonary metastasis. [ncbi.nlm.nih.gov]

  Skeletal metastasis are very destructive in patients with renal cell carcinoma compromising bone integrity leading to skeletal related events including pains, impending fractures, nerve compressions, hypercalcemia and even pathological fractures which [mendeley.com]

  Patients with a pathologic fracture had a significantly shorter (p < 0.001) survival compared with patients without pathologic fracture (Figure 4 ). [bmcmusculoskeletdisord.biomedcentral.com]

  Forearm Bone Forearm bone adult forearm fractures lopt free. Forearm bone forearm fractures in children types and treatments orthoinfo aaos […] Muscles Lower Back Muscles lower back low back pain a guide for coaches and athletes on anatomy types. [healthday.info]

• Back Pain

  A 34-year-old man with an extensive medical history received a CT scan for chronic leg and back pain. Imaging revealed a single, enhancing 8-cm mass in the upper pole of the right kidney. [ncbi.nlm.nih.gov]

  Forearm bone forearm fractures in children types and treatments orthoinfo aaos […] Muscles Lower Back Muscles lower back low back pain a guide for coaches and athletes on anatomy types. [healthday.info]

  A pain in the back that doesn't go away. Extreme tiredness. Weight loss with no known reason. Painful or frequent urination. [cancer.gov]

  Review Topic QID: 951 3 Proximal femoral locking plate 5 Proximal femoral replacement ML 1 Select Answer to see Preferred Response PREFERRED RESPONSE 2 (OBQ07.111) A 70-year-old female has unrelenting lower back pain and severe left anterior thigh pain [orthobullets.com]

• Seizure

  Symptoms may include headaches, seizures, lack of energy, confusion, high blood pressure, loss of speech, blindness or changes in vision, and problems thinking. [us.votrient.com]

• Hematuria

  The most common presenting symptom of bladder metastasis is hematuria. In a patient with synchronous bladder metastasis, hematuria may be wrongly attributed to collecting system infiltration of RCC. [jcmtjournal.com]

  The man underwent radical nephrectomy (to prevent hematuria), splenectomy and biopsies in liver and small intestine. After surgery the patient refused adjuvant chemotherapy. [ncbi.nlm.nih.gov]

• Flank Pain

  Abstract A 50-year-old man, with a history of right lower lobectomy for pulmonary adenocystic carcinoma, presented with chronic flank pain due to a large mass in the right kidney. [ncbi.nlm.nih.gov]

  Renal abscess is usually a complication of acute pyelonephritis and patients present with urinary tract infection, flank pain and fever. [radiologyassistant.nl]

The patient was referred to a urologist and had a complete workup, which included a CT scan of his chest, abdomen, and pelvis, appropriate blood work and a urinalysis, and he underwent a left radical nephrectomy. [targetedonc.com]

Metastatic workup was done: contrast-enhanced computed tomography of whole abdomen and pelvis was within normal limits. [jcmtjournal.com]

Further, staging workup showed bilateral pulmonary metastasis. She was given palliative Radiotherapy 30 Gy in 10 fractions followed by Sunitinib 50 mg oral daily, but patient died of progressive disease 4 months of palliative radiotherapy. [omicsonline.org]

CNB has a higher sensitivity and a lower false negative rate than FNA, and was less likely to require a further diagnostic workup, especially for metastatic thyroid nodules [ 15 ]. [e-ultrasonography.org]

With respect to the diagnostic workup, brain imaging was done routinely in the Munich centre, whereas in the two Swedish centres brain imaging was done only if clinical signs suspicious of brain involvement were present. [tandfonline.com]

• Neutrophilia

  Table 1 Baseline characteristics & first-line therapy in metastatic chrRCC Baseline characteristics Metastatic chrRCC patient &first-line therapy group ( N = 109) Gender 59/109 Male, 50/109 Female Anemia 50% (50/100) Thrombocytosis 15% (15/101) Neutrophilia [content.iospress.com]

• Polyps

  Godfrey GJ, Moore G, Alatassi H (2010) Presentation of renal cell carcinoma as cervical polyp metastasis. J Low Genit Tract Dis 14: 387-389. Modi PR, John PJ, Joshi DP, Rohit NJ (2004) Vaginal metastasis from renal cell carcinoma - a case report. [omicsonline.org]

  Macroscopic types were varied and included polyp-like lesions, ulcerative lesions, and minor erosion. Ulcerative lesions, which can be called “volcano-like lesions,” were the most frequent. [journals.sagepub.com]

Cryoablation is successfully performed as a treatment for small renal cancers. The occurrence of a solitary renal metastasis from lung cancer is an uncommon finding entailing a limited knowledge on the choice of its optimal treatment. [ncbi.nlm.nih.gov]

Treatment The patient rejected all treatments for metastases except the steroid therapy. [wjgnet.com]

Advancement in targeted therapy in recent decades had made some improvement in treatment of SREs and has helped in improving patent's quality of life but still we are in need of further improvement in treatment modalities to cure disease thereby decreasing [mendeley.com]

Here, We focused on 2 published microarray data to select our anchored miRNA which was downregulated after Sunitinib treatment while upregulated in metastasis RCC tissues. [biorxiv.org]

Outcome with local treatment for LM The characteristics of the 9 patients who underwent local treatment for LM are summarized in Table V. [spandidos-publications.com]

This study suggests that the patients with decreased E-CD expression may be associated with metastasis, resulting in poor prognosis. [nature.com]

Factors affecting prognosis We next attempted to identify the clinical factors affecting the prognosis of RCC patients with LM. [spandidos-publications.com]

Most of these diseases exhibit slow progression and have a favorable prognosis. Distant metastasis caused by thyroid microcarcinoma is uncommon, and is usually found in the lung or bone. [ncbi.nlm.nih.gov]

An oral metastasis implies a serious prognosis, as in the majority of patients there is multiple organ involvement at the time of diagnosis. [roderic.uv.es]

P Keywords: renal cell cancer, sorafenib, targeted therapy, prognosis This work is published and licensed by Dove Medical Press Limited. [dovepress.com]

Therapy was initially complicated by a hospital admission for fever and confusion of uncertain etiology, but sunitinib was subsequently resumed and was well tolerated. [ncbi.nlm.nih.gov]

Etiology/Causes If a patient is diagnosed with renal cancer, their first question might be “how did this happen?” [physio-pedia.com]

"Etiology of Renal Cell Carcinoma: Incidence, Demographics, and Environmental Factors". Renal Cell Carcinoma Clinical Management. Humana Pr Inc. pp. 3–22. ISBN 978-1-62703-061-8. ^ Lane, Brian R. (2013). [en.wikipedia.org]

Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies Medical Subject Headings::Diseases::Endocrine System Diseases::Thyroid Diseases Medical Subject Headings::Diseases:: [repositoriosalud.es]

It provides an overview of new information concerning epidemiology, molecular and immunologic characteristics, as well as surgical therapy. Particular focus is given to the latest diagnostic tests and genetic counseling. [books.google.de]

[…] in Renal Cell Carcinoma Edited by Robert Amato Next chapter Prognostic Factors in Renal Cell Carcinoma: An Evaluation of T-Stage, Histopathological Grade, p53, Ki-67, COX-2, and Her-2 Expressions By Minna Kankuri-Tammilehto Related Book First chapter Epidemiology [intechopen.com]

These updated ESMO guidelines cover incidence and epidemiology, diagnosis and pathology/molecular biology, staging and risk assessment, management of local and metastatic disease, response evaluation and follow-up, long-term implications and survivorship [esmo.org]

The authors are an international group of acknowledged experts in kidney cancer epidemiology, molecular biology, pathology, diagnosis, clinical features, staging, prognostic and predictive factors, surgery, systemic therapy, and emerging investigational [books.google.ro]

Objective: In this review we discuss pathophysiology of tumor metastasis, diagnosis, management and Case examples of metastatic renal cell carcinoma. Conclusion: Incidence of metastatic renal carcinoma is increasing. [mendeley.com]

Effective strategies to prevent and treat AD remain elusive despite major efforts to understand its basic biology and clinical pathophysiology. Significant investments in therapeutic ... [annualreviews.org]

↵ Coleman RE Metastatic bone disease: clinical features, pathophysiology and treatment strategies. [clincancerres.aacrjournals.org]

[…] sickle cell disease. [23] The most significant disease affecting risk however is not genetically linked – patients with acquired cystic disease of the kidney requiring dialysis are 30 times more likely than the general population to develop RCC. [24] Pathophysiology [en.wikipedia.org]

Tumor angiogenesis: pathophysiology and implications for contrast-enhanced MRI and CT assessment. Abdom Imaging 2006 ;31(2):188–193. Crossref, Medline, Google Scholar 54 Verma S, Rajesh A, Fütterer JJ et al.. [pubs.rsna.org]

The man underwent radical nephrectomy (to prevent hematuria), splenectomy and biopsies in liver and small intestine. After surgery the patient refused adjuvant chemotherapy. [ncbi.nlm.nih.gov]

This case suggests that retrograde venous dissemination may be at the origin of vaginal metastasis of renal cell carcinoma and emphasized the preventive value of early ligature of renal vein. [panafrican-med-journal.com]

Because you’re trying to prevent the first skeletal-related event. Dr. Yang: These data are very scant. [clincancerres.aacrjournals.org]

Clinical Trial Resources ESMO Clinical Trial Resources are designed to support you with designing, participating in and reviewing clinical trials Educational Slides Educational slides on Cancer Prevention, Clinical Trials, Colorectal Cancer and Molecular [oncologypro.esmo.org]

Practitioners should consider metastases from solid tumors in the differential diagnosis of renal masses, especially since differentiating primary versus metastatic renal tumors will alter management and prognosis and may prevent unnecessary nephrectomies [kidney-international.org]