Presentation
Renal metastases of thyroid carcinomas are rare and often present as a primitive unilateral renal mass. [ncbi.nlm.nih.gov]
Three years later before the patient was lost to follow-up, no evidence of recurrence was present. [scielo.br]
We present a case of a 50-year-old male with RCC, metastasizing to the skin diagnosed on fine-needle aspiration cytology (FNAC). [ccij-online.org]
Here we present a case of postmenopausal lady with cervix uteri metastasis as initial metastatic manifestation of RCC. Case Presentation A 70 year old Saudi female presented in our clinic with vaginal bleeding and significant weight loss. [omicsonline.org]
Entire Body System
- Hunting
Rykken JB, Diehn FE, Hunt CH, Schwartz KM, Eckel LJ, Wood CP, Kaufmann TJ, Lingineni RK, Carter RE, Wald JT. Intramedullary spinal cord metastases: MRI and relevant clinical features from a 13-year institutional case series. [wjgnet.com]
Respiratoric
- Sputum
Case presentation A 53-year-old Chinese woman presented symptoms of cough, bloody sputum at the first visit. [mrmjournal.biomedcentral.com]
In the present study, a case of lung squamous cell carcinoma causing isolated unilateral renal metastasis is reported. 2 Case presentation A 74-year-old Chinese male complained of coughing and bloody sputum at the first visit. [journals.lww.com]
Gastrointestinal
- Left Flank Pain
A 62-year-old man who had undergone hepatectomy for HCC presented 6 years after initial diagnosis with left flank pain and was found on CT and MRI to have a tumor in the left kidney. [ncbi.nlm.nih.gov]
- Pelvic Mass
Abstract A 44-year-old woman presented with a large pelvic mass. Pathology revealed a granulosa cell tumour of the left ovary. The patient was followed after surgery with inhibin B levels and interval imaging. [ncbi.nlm.nih.gov]
Cardiovascular
- Hypertension
The overall survival for hypertensive patients with metastatic renal cell carcinoma receiving angiotensin system inhibitors was 27 months vs 17 months for non–angiotensin system inhibitor users. [ascopost.com]
[…] with and without hypertension. [intechopen.com]
March 06, 2018 ; 90 (10) Resident & Fellow Section Muhammad Taimur Malik, Syed Jaffar Kazmi, Scott Turner First published March 5, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005072 A 75-year-old man with hypertension presented with 2 weeks' history [n.neurology.org]
Case Report A 74-year-old Caucasian man with a history of hypertension and stage I clear cell type renal cell cancer underwent right nephrectomy in 2004. [karger.com]
The adverse events with bevacizumab included proteinuria, hypertension, and bleeding. [jhoponline.com]
- Palpitations
While patients with cardiac metastases are often asymptomatic, they can present with nonspecific symptoms, such as palpitations, chest pain, shortness of breath, and even syncope [ 6 ]. Hypertension is the most common cardiac presentation of RCC. [karger.com]
Musculoskeletal
- Back Pain
A 34-year-old man with an extensive medical history received a CT scan for chronic leg and back pain. Imaging revealed a single, enhancing 8-cm mass in the upper pole of the right kidney. [ncbi.nlm.nih.gov]
Forearm bone forearm fractures in children types and treatments orthoinfo aaos […] Muscles Lower Back Muscles lower back low back pain a guide for coaches and athletes on anatomy types. [healthday.info]
A pain in the back that doesn't go away. Extreme tiredness. Weight loss with no known reason. Painful or frequent urination. [cancer.gov]
Review Topic QID: 951 3 Proximal femoral locking plate 5 Proximal femoral replacement ML 1 Select Answer to see Preferred Response PREFERRED RESPONSE 2 (OBQ07.111) A 70-year-old female has unrelenting lower back pain and severe left anterior thigh pain [orthobullets.com]
- Leg Weakness
Most cases of ISCM might have additional metastases with various clinical features that cause unique symptoms such as gait disturbance or leg weakness; however, Rykken et al [ 1 ] reported that the clinical presentation of the ISCM preceded the primary [wjgnet.com]
Urogenital
- Hematuria
The most common presenting symptom of bladder metastasis is hematuria. In a patient with synchronous bladder metastasis, hematuria may be wrongly attributed to collecting system infiltration of RCC. [jcmtjournal.com]
The man underwent radical nephrectomy (to prevent hematuria), splenectomy and biopsies in liver and small intestine. After surgery the patient refused adjuvant chemotherapy. [ncbi.nlm.nih.gov]
Renal metastases frequently do not present clinical symptoms and many patients have no hematuria or hyperazotemia. [mrmjournal.biomedcentral.com]
- Flank Pain
Abstract A 50-year-old man, with a history of right lower lobectomy for pulmonary adenocystic carcinoma, presented with chronic flank pain due to a large mass in the right kidney. [ncbi.nlm.nih.gov]
Renal abscess is usually a complication of acute pyelonephritis and patients present with urinary tract infection, flank pain and fever. [radiologyassistant.nl]
Workup
The patient was referred to a urologist and had a complete workup, which included a CT scan of his chest, abdomen, and pelvis, appropriate blood work and a urinalysis, and he underwent a left radical nephrectomy. [targetedonc.com]
Metastatic workup was done: contrast-enhanced computed tomography of whole abdomen and pelvis was within normal limits. [jcmtjournal.com]
Further, staging workup showed bilateral pulmonary metastasis. She was given palliative Radiotherapy 30 Gy in 10 fractions followed by Sunitinib 50 mg oral daily, but patient died of progressive disease 4 months of palliative radiotherapy. [omicsonline.org]
CNB has a higher sensitivity and a lower false negative rate than FNA, and was less likely to require a further diagnostic workup, especially for metastatic thyroid nodules [ 15 ]. [e-ultrasonography.org]
With respect to the diagnostic workup, brain imaging was done routinely in the Munich centre, whereas in the two Swedish centres brain imaging was done only if clinical signs suspicious of brain involvement were present. [tandfonline.com]
X-Ray
- Pericardial Effusion
Complications of therapy, such as tumor necrosis, extracardiac spread, and pericardial effusion, can be identified with cardiac MRI. [karger.com]
Treatment
Cryoablation is successfully performed as a treatment for small renal cancers. The occurrence of a solitary renal metastasis from lung cancer is an uncommon finding entailing a limited knowledge on the choice of its optimal treatment. [ncbi.nlm.nih.gov]
Treatment The patient rejected all treatments for metastases except the steroid therapy. [wjgnet.com]
Physicians who attempt this treatment in the future need to be aware of the possibility of cardiac wall perforation from treatment-induced necrosis. [karger.com]
Outcome with local treatment for LM The characteristics of the 9 patients who underwent local treatment for LM are summarized in Table V. [spandidos-publications.com]
Here, We focused on 2 published microarray data to select our anchored miRNA which was downregulated after Sunitinib treatment while upregulated in metastasis RCC tissues. [biorxiv.org]
Prognosis
Factors affecting prognosis We next attempted to identify the clinical factors affecting the prognosis of RCC patients with LM. [spandidos-publications.com]
This study suggests that the patients with decreased E-CD expression may be associated with metastasis, resulting in poor prognosis. [nature.com]
An oral metastasis implies a serious prognosis, as in the majority of patients there is multiple organ involvement at the time of diagnosis. [roderic.uv.es]
Most of these diseases exhibit slow progression and have a favorable prognosis. Distant metastasis caused by thyroid microcarcinoma is uncommon, and is usually found in the lung or bone. [ncbi.nlm.nih.gov]
However, a favorable prognosis cannot be expected for patients whose tumors are classified as rapid-growing type. [journals.sagepub.com]
Etiology
Therapy was initially complicated by a hospital admission for fever and confusion of uncertain etiology, but sunitinib was subsequently resumed and was well tolerated. [ncbi.nlm.nih.gov]
Etiology/Causes If a patient is diagnosed with renal cancer, their first question might be “how did this happen?” [physio-pedia.com]
"Etiology of Renal Cell Carcinoma: Incidence, Demographics, and Environmental Factors". Renal Cell Carcinoma Clinical Management. Humana Pr Inc. pp. 3–22. ISBN 978-1-62703-061-8. ^ Lane, Brian R. (2013). [en.wikipedia.org]
Epidemiology
[…] in Renal Cell Carcinoma Edited by Robert Amato Next chapter Prognostic Factors in Renal Cell Carcinoma: An Evaluation of T-Stage, Histopathological Grade, p53, Ki-67, COX-2, and Her-2 Expressions By Minna Kankuri-Tammilehto Related Book First chapter Epidemiology [intechopen.com]
The book begins with a review of the epidemiology, pathology, and biology of renal cell carcinoma followed by chapters on specific targeted therapies and managing complications. [books.google.ro]
Renal Cell Carcinoma Epidemiology Renal Cell Carcinoma Symptoms Renal Cell Carcinoma Diagnosis [news-medical.net]
Demographic and epidemiological perspectives. Hematol Oncol Clin North Am 2000; 14 (1): 17–23). [siog.org]
The researchers conducted a retrospective cohort study using Surveillance, Epidemiology, and End Results (SEER)-Medicare data from 2000 to 2013 to examine overall survival and estimated overall survival improvements in over 1,100 patients with stage IV [medicalxpress.com]
Pathophysiology
Objective: In this review we discuss pathophysiology of tumor metastasis, diagnosis, management and Case examples of metastatic renal cell carcinoma. Conclusion: Incidence of metastatic renal carcinoma is increasing. [mendeley.com]
Effective strategies to prevent and treat AD remain elusive despite major efforts to understand its basic biology and clinical pathophysiology. Significant investments in therapeutic ... [annualreviews.org]
↵ Coleman RE Metastatic bone disease: clinical features, pathophysiology and treatment strategies. [clincancerres.aacrjournals.org]
[…] sickle cell disease. [23] The most significant disease affecting risk however is not genetically linked – patients with acquired cystic disease of the kidney requiring dialysis are 30 times more likely than the general population to develop RCC. [24] Pathophysiology [en.wikipedia.org]
Tumor angiogenesis: pathophysiology and implications for contrast-enhanced MRI and CT assessment. Abdom Imaging 2006 ;31(2):188–193. Crossref, Medline, Google Scholar 54 Verma S, Rajesh A, Fütterer JJ et al.. [pubs.rsna.org]
Prevention
The man underwent radical nephrectomy (to prevent hematuria), splenectomy and biopsies in liver and small intestine. After surgery the patient refused adjuvant chemotherapy. [ncbi.nlm.nih.gov]
This case suggests that retrograde venous dissemination may be at the origin of vaginal metastasis of renal cell carcinoma and emphasized the preventive value of early ligature of renal vein. [panafrican-med-journal.com]
Because you’re trying to prevent the first skeletal-related event. Dr. Yang: These data are very scant. [clincancerres.aacrjournals.org]
Clinical Trial Resources ESMO Clinical Trial Resources are designed to support you with designing, participating in and reviewing clinical trials Educational Slides Educational slides on Cancer Prevention, Clinical Trials, Colorectal Cancer and Molecular [oncologypro.esmo.org]
The sponges block the blood flow to the kidney and prevent the cancer cells from getting oxygen and other substances they need to grow. [cancer.gov]