Case presentation A 26-year-old Caucasian woman presented with acute renal failure as an initial manifestation of sarcoidosis. [jmedicalcasereports.biomedcentral.com]

Case Presentation A 30-year-old male with no past medical history was instructed by his nephrologist to present to the emergency department (ED). [cureus.com]

Most common mode of presentation was acute renal failure (11) during spring/summer (14). Evidence for systemic disease was present in all patients. Mean plasma creatinine on presentation was 0.52 mmol/L and calcium 3.01 mmol/L. [ncbi.nlm.nih.gov]

Case Presentation: A 26 year old African-American male with past medical history of pancytopenia and hepatosplenomegaly was transferred to our facility for evaluation of his acute kidney injury. [shmabstracts.com]

• Communicating Hydrocephalus

  The dementia was explained by communicating hydrocephalus, which the patient developed because of neurosarcoidosis (28). The diagnosis was established by the biopsy of several lymph nodes, including one in the mediastinum. [jasn.asnjournals.org]

• Nocturia

  A 66-year-old woman presented with a 1-year history of lethargy, polyuria and nocturia. Clinical examination was unremarkable and she had impaired renal function (urea 18 mmol/l (108 mg%) and creatinine 380 mumol/l (4.3 mg%)). [ncbi.nlm.nih.gov]

  Patients frequently have nocturia (decreased concentrating ability), sterile pyuria, and HTN. Anaemia is frequently seen. 32. [slideshare.net]

Contralateral progression and workup for further symptoms finally established the diagnosis of extrapulmonary sarcoidosis. With corticosteroid and azathioprine treatment, renal function was preserved in the long term. [ncbi.nlm.nih.gov]

Because histopathological analysis of renal biopsy specimens can reveal various entities, a diagnostic workup is necessary in every patient with sarcoidosis. [journals.lww.com]

The chronic kidney disease workup was negative. Imaging indicated nephromegaly and a normal CT of the chest. Bone marrow and kidney biopsies were obtained. The bone marrow biopsy showed extensive noncaseating granulomatous inflammation. [shmabstracts.com]

• X-Ray Abnormal

  I n more than 90% of the patient's chest x-ray film is abnormal. 49. Does sarcoidosis cause a lot of anxiety and insomnia? Any illness, particularly in individuals who were previously healthy, can cause anxiety and insomnia. [sarcoid-network.org]

• Abnormal Renal Function

  Case Report A 43-year-old African-American male with no prior medical history was referred to outpatient nephrology clinic for evaluation of abnormal renal function found on routine health exam. Serum creatinine level was 2.4 mg/dL. [ispub.com]

• HLA-B12

  Negative associations were identified for HLA-B12 and DR4. HLA-B27 was associated with pulmonary sarcoidosis. [jasn.asnjournals.org]

The specific treatment is aimed at treatment of the underlying disorder. [academic.oup.com]

Treatment with corticosteroids is successful in improving renal function, but relapse is common on steroid withdrawal and prolonged treatment is necessary for disease control. [ncbi.nlm.nih.gov]

Prognosis of Sarcoidosis and the Kidney The prognosis of this condition, like the natural history, is variable. The presence of scarring within the kidney carries a less favourable prognosis. [myvmc.com]

In the same way, familial sarcoidosis does not imply a worse prognosis, with several reported cases in whom treatment is not required but spontaneous remission happens. [erj.ersjournals.com]

Prognosis Mortality associated with sarcoidosis is estimated at between 0.5-5%. [orpha.net]

The prognosis of sarcoidosis is usually good with spontaneous remission but the chronic aspect can be seen in one third of cases and may be associated then with one or more organ dysfunctions [ 1, 7, 9, 10 ]. [panafrican-med-journal.com]

Introduction: Sarcoidosis is a systemic inflammatory disease of unknown etiology, characterized by the presence of non-caseating granulomas in several organs; renal impairment alone is a rare condition. [scielo.br]

Although uncommon, renal sarcoidosis should be considered in the differential diagnosis of acute or chronic renal failure of uncertain etiology, as early diagnosis and treatment can lead to recovery of renal function and prevent interstitial fibrosis. [ncbi.nlm.nih.gov]

Our experience indicates that the previously unreported etiology of acute renal failure in sarcoidosis, acute interstitial nephritis, can be successfully treated with prednisone. Author information Affiliations New York Univ. [nature.com]

References [ 1 ] Löffler, U., Tuleweit, A., Waldherr, R., Uppenkamp, M. and Bergner, R. (2015) Renal Sarcoidosis: Epidemiological and Follow-Up Data in a Cohort of 27 Patients. [scirp.org]

Renal Sarcoidosis: epidemiological and follow-up data in a cohort of 27 patients. Sarcoidosis Vasc Diffuse Lung Dis. 2015;31(4):306-15. PubMed | Google Scholar Manjunath V, Moeckel G, Dahl NK. [panafrican-med-journal.com]

Experts in the field provide chapters on epidemiology, genetics, pathology, ocular sarcoidosis, renal sarcoidosis, rare manifestations, diagnostic approaches, therapy, transplantation and more. Voransicht des Buches » [books.google.de]

Experts in the field provide chapters on epidemiology, genetics, pathology, ocular sarcoidosis, renal sarcoidosis, rare manifestations, diagnostic approaches, therapy, transplantation and more. Vista previa del libro » [books.google.es]

Acute Kidney Injury: Definition, Pathophysiology and Clinical Phenotypes. Clin Biochem Rev. 2016 May;37(2):85-98. PMID: 28303073; PMCID: PMC5198510. 25. Rajakariar R, Sharples E, Raftery M, Sheaff M, Yaqoob M. [mattioli1885journals.com]

Ackermann D (2007) Hypercalcemia in sarcoidosis–case report, prevalence, pathophysiology and therapeutic options. [link.springer.com]

We discuss the atypical presentation, pathophysiology and highlight the importance of performing a renal biopsy. [ispub.com]

Curr Opin Rheumatol12 : 71-76,2000 ↵ Mentzer SJ: Dendritic cells in the pathophysiology of sarcoidal reactions. [jasn.asnjournals.org]

This review will summarize the epidemiologic, pathophysiologic, diagnostic, clinical, and therapeutic aspects of RS. [peertechz.com]

Although uncommon, renal sarcoidosis should be considered in the differential diagnosis of acute or chronic renal failure of uncertain etiology, as early diagnosis and treatment can lead to recovery of renal function and prevent interstitial fibrosis. [ncbi.nlm.nih.gov]

High levels of calcium in the blood also cause blood vessels in the kidney to constrict, preventing proper clearance of waste from the blood and leading to dehydration. [sarcoidosisnews.com]