Presentation
By presenting this case we aim to not only highlight one of the rare presentations of Sjogren's syndrome but also the favourable response of our patient to potassium replacement alone. [ncbi.nlm.nih.gov]
Gastrointestinal
- Failure to Thrive
We suggest that RTA be considered a diagnostic possibility in all children with failure to thrive and nephrocalcinosis. [ncbi.nlm.nih.gov]
- Vomiting
Since causes of nausea and vomiting among HIV/AIDS patients are very diverse, awareness of this phenomenon is useful in diagnosing and managing the problem. [ncbi.nlm.nih.gov]
- Nausea
Since causes of nausea and vomiting among HIV/AIDS patients are very diverse, awareness of this phenomenon is useful in diagnosing and managing the problem. [ncbi.nlm.nih.gov]
The patient denied associated fever, nausea, vomiting, diarrhea, or recent illness prior to this admission. She noted recent polyuria prior to presentation, but denied dysuria or hematuria. [shmabstracts.com]
For some kids, the first symptom of RTA is kidney stones, which can cause symptoms like: pain in the back or side that spreads to the lower abdomen pain while urinating pee that is red, brown, or cloudy frequent urge to urinate nausea and vomiting Over [kidshealth.org]
Confusion Nausea Fatigue Vomiting ( 10 ). If your child experiences pain during urination, needs to urinate frequently, has cloudy or red/brown urine then these could be signs of kidney stones and hence RTA. [momjunction.com]
Nausea, vomiting and anorexia are frequently present, particularly in children. Metabolic acidosis occurring in children is very rarely due to an inborn error of metabolism (conditions such as moderately severe gastroenteritis being more common). [patient.info]
Musculoskeletal
- Proximal Muscle Weakness
Hypokalemic paralysis, proximal muscle weakness and voiding difficulty were the common modes of presentation. Doubling of serum creatinine during the study period was noted in 13 out of 27 patients who had GFR 60 mL/min (P [ncbi.nlm.nih.gov]
Face, Head & Neck
- Prominent Cheeks
Their facial features are unique with prominent cheeks, well-defined philtrum, large bulbous nose, V-shaped upper lip border, full lower lip, open mouth with protruded tongue, and pits on the ear lobule. [ncbi.nlm.nih.gov]
Urogenital
- Nocturia
Symptoms of renal failure such as nocturia, polyuria, oliguria, pruritus and anorexia. Recent history of urinary problems such as nephrolithiasis may indicate RTA. Recent history of severe or prolonged diarrhoea. Recent nutritional status. [patient.info]
Workup
Should blood gas analysis be part of the diagnostic workup of short children? Auxological data and blood gas analysis in children with renal tubular acidosis. [medigraphic.com]
[…] incomplete and only develop in the presence of an acid load occurs despite a normal or only mildly reduced glomerular filtration rate (GFR) causes are numerous poorly understood by many physicians RTA is often detected incidentally through an abnormal blood workup [lifeinthefastlane.com]
Should gas analysis be part of the diagnostic workup of short children? Auxological data and blood gas analysis in children with renal tubular acidosis. Horm Res Paediatr. 2010;74(5):351-357. DOI: http://dx.doi.org/10.1159/000314967. [revistaalergia.mx]
X-Ray
- Nephrolithiasis
This is the first demonstration of renal acidification defects and nephrolithiasis in heterozygous carriers of a mutant B1 subunit that cannot be attributable to negative dominance. [ncbi.nlm.nih.gov]
Nephrolithiasis, which may occur in any of the subsets of type I renal tubular acidosis, accounts for most of the morbidity in adults and adolescents. Major risk factors for nephrolithiasis include alkaline urine, hypercalciuria and hypocitraturia. [doi.org]
QT, RR, ST Intervals
- Prolonged QT Interval
Electrocardiogram showed rate 140/min, electrical alternans, multifocal ventricular ectopics, ventricular reentrant beats, ventricular couplets, and prolonged qT interval (corrected qT = 512 ms). Echocardiogram was normal. [ijccm.org]
Serum level of potassium was 1.5 meq/l and electrocardiogram showed prolonged QT interval, ST depression, T wave flattening in V1-V4, and the presence of 'U' waves. Child was given potassium replacement therapy and recovered from paralysis. [indianjnephrol.org]
Treatment
Treatment to correct the acidosis and hyperkalemia should be promptly initiated, and the tacrolimus dose adjusted when possible. [ncbi.nlm.nih.gov]
Management and treatment Alkali therapy is the standard treatment (to achieve normal serum bicarbonate levels). Patients are usually given sodium bicarbonate or sodium citrate. [orpha.net]
Treatment in the initial phase consists of alkalising agents such as bicarbonate or citrate and correction of the hypokalaemia. [revistanefrologia.com]
Prognosis
[…] distal renal tubular acidosis (dRTA) presents itself with variable clinical manifestations and often with late expressions that impact on prognosis. [ncbi.nlm.nih.gov]
Prognosis Hereditary dRTA is a permanent circumstance, with an excellent prognosis if therapy is established as soon as possible. Complications Chronic renal failure can be a complication of untreated nephrocalcinosis. [renaltube.com]
Etiology
Of these stone 1,093 patients were included in study who had an available etiological diagnosis and stones containing at least 70% of calcium phosphate without struvite. [ncbi.nlm.nih.gov]
Etiology Genetic Disease Carbonic Anhydrase I (CA-I) Deficiency/Alteration Ehlers-Danlos Syndrome (see Ehlers-Danlos Syndrome, [[Ehlers-Danlos Syndrome]]) Familial Type 1 Distal Renal Tubular Acidosis Autosomal Dominant Autosomal Recessive Hereditary [mdnxs.com]
Epidemiology
Rotterdam, The Netherlands. 4 Division of Clinical Immunology, Department of Internal Medicine, PO Box 2040, Room D-419, 3000 CA, Rotterdam, The Netherlands. 5 Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands. 6 Department of Epidemiology [ncbi.nlm.nih.gov]
Summary Epidemiology Prevalence of dRTA is unknown but is often underreported. [orpha.net]
References: [6] [7] Bartter syndrome Definition : : a group of rare genetic disorders ; ( autosomal recessive or dominant ) that affect chloride reabsorption in the ascending limb of the loop of Henle Epidemiology Prevalence : 1/1,000,000 Etiology Type [amboss.com]
Renal tubular acidosis Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Renal tubular acidosis from other Diseases Epidemiology and Demographics Risk Factors Screening Natural [wikidoc.org]
Pathophysiology
Multiple pathophysiologic mechanisms, each associated with various etiologies, can lead to dRTA. The most important consequence of dRTA is (recurrent) nephrolithiasis. The diagnosis is based on a urinary acidification test. [ncbi.nlm.nih.gov]
Acidosis Renal Tubular Kidney Calculi Nephrolithiasis The pathophysiology of renal tubular acidosis (RTA) seems well worked out. [cjasn.asnjournals.org]
References: [1] [2] [3] [4] Type 1 renal tubular acidosis Pathophysiology : inability of the intercalated cells of the distal tubu le to secrete H + Etiology Sporadic type 1 RTA ( idiopathic ) Familial type 1 RTA (inherited genetic defects) Autosomal [amboss.com]
In dRTA, the potassium level can be low, normal, or even high depending upon the pathophysiologic abnormality. Early recognition and prompt treatment is imperative to avoid the serious consequences of severe electrolyte and metabolic disturbances. [sciencedomain.org]
Prevention
To prevent the nephrocalcinosis from deteriorating, she was given potassium-sodium citrate. Since administration, she has not experienced spontaneous stone passage or renal colic. [ncbi.nlm.nih.gov]
Get medical help right away if you develop emergency symptoms such as: Decreased consciousness Seizures Prevention There is no prevention for this disorder. Images References Krapf R, Seldin DW, Alpern RJ. Clinical syndromes of metabolic acidosis. [ufhealth.org]
Correcting acidosis and low potassium levels restores normal growth patterns, allowing bone to mature while preventing further renal disease. Vitamin D supplements may also be needed to help prevent bone problems. [niddk.nih.gov]