Reserpine is a modulator of MDR in which these domains are present in a well-defined conformation. [ncbi.nlm.nih.gov]

• Weight Gain

  gain, deafness, optic atrophy, glaucoma, uveitis, conjunctival injection, purpura, rash, pruritus; rare: parkinsonian syndrome and other extrapyramidal symptoms. [empr.com]

  • Miscellaneous : Shortness of breath, swelling of ankles/feet, unexplained/sudden weight gain, enlarged breasts (in males) and unusual breast discharge (in females). Store it at room temperature. [medindia.net]

  gain Thrombocytopenia purpura Gynecomastia Rash Nightmare Nervousness Paradoxical anxiety Tardive dyskinesia GI hypersecretion Impotence Blurred vision Optic atrophy Decreased libido Nasal congestion Warnings Contraindications Hypersensitivity, active [reference.medscape.com]

  Check for edema and record weight daily to help make a distinction between weight gain from edema and that from increased appetite. Consult physician about gain of 1–2 kg (3–5 lb) in 1 wk. [robholland.com]

• Fever

  Aspirin also reduces fever. Rectal aspirin is used to reduce pain, inflammation, and fever. Aspirin is also used to treat the symptoms of arthritis and rheumatic fever. doxycycline (Vibramycin) Doxycycline is a tetracycline antibiotic. [emedicinehealth.com]

  […] doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives ; itching; red, swollen, blistered, or peeling skin with or without fever [drugs.com]

  Known in India as Sarpaganda, it was used for centuries to treat insanity as well as physical illnesses such as fevers and snakebites. [encyclopedia.com]

• Nightmare

  Adverse Reactions: GI upset, dry mouth, hypersecretion, arrhythmias, syncope, angina-like symptoms, bradycardia, edema, dyspnea, epistaxis, nasal congestion, dizziness, headache, paradoxical anxiety, depression, nervousness, nightmares, dull sensorium [empr.com]

  Adverse effects CNS sedation depression ( producing suicidal tendencies, one reason why use discontinued) extra pyramidal effects decreasing the levels of biogenic amines in nigrostriatal pathway (due to decrease in dopamine, parkinsonism like symptoms) nightmares [howmed.net]

  Reserpine causes many toxic side effects including nightmares, Parkinsonism (see Parkinson's disease ), and gastrointestinal disturbances. Cite this article Pick a style below, and copy the text for your bibliography. [encyclopedia.com]

• Disability

  We report that low dose reserpine treatment (0.25 mg/day for 7 days) improves the dystonic-dyskinetic disability score in patients affected by idiopathic dystonias, iatrogenic dystonic-dyskinetic syndromes and Sydenham's chorea. [ncbi.nlm.nih.gov]

  (via alkaloid ) Application(s): first generation antipsychotic Antipsychotic drugs which can have different modes of action but which tend to be more likely than second generation antipsychotics to cause extrapyramidal motor control disabilities such [ebi.ac.uk]

  | Login Aaltodoc → Browsing by Keyword JavaScript is disabled for your browser. Some features of this site may not work without it. [aaltodoc.aalto.fi]

• Antipsychotic Agent

  MeSH PA D018759 Adrenergic Uptake Inhibitors MeSH PA D000959 Antihypertensive Agents MeSH PA D014150 Antipsychotic Agents MeSH PA D002317 Cardiovascular Agents MeSH PA D002491 Central Nervous System Agents MeSH PA D002492 Central Nervous System Depressants [drugcentral.org]

  Agents Antipsychotic Agents Tranquilizing Agents Psychotropic Drugs Adrenergic Uptake Inhibitors Adrenergic Agents [clinicaltrials.gov]

• Muscle Rigidity

  rigidity; respiratory depression, convulsions, hypothermia. [robholland.com]

• Hypertension

  […] could reduce risk for hypertension-related complications. [web.archive.org]

  Abstract A retrospective chart analysis was conducted on all new elderly hypertensive patients referred to a community hypertension clinic who were being treated with either reserpine or alpha-methyldopa plus a diuretic. [ncbi.nlm.nih.gov]

• Hypotension

  Surprisingly no or mild postural hypotension is seen. This is because centrally acting drugs do not produce postural hypotension. Baroreceptor sensitivity is increased even further (some spare baroreceptors). [howmed.net]

  Drug: Diuretics, other hypotensive agents compound hypotensive effects; cardiac glycosides (digoxin) may increase risk of arrhythmias; mao inhibitors may cause excitation and hypertension; cns depressants compound depression; may decrease response to [robholland.com]

  Side effects were mild to moderate in severity, and there were no cases of profound hypotension. [ncbi.nlm.nih.gov]

• Orthostatic Hypotension

  […] depression or other adverse reactions may increase Pediatric 0.02 mg/kg/day orally once daily or divided every 12 hours, not to exceed 0.25 mg/day Geriatric: Adverse central nervous system (CNS) effects; may cause slow heart rate and dizziness on standing (orthostatic [rxlist.com]

  Hypertension 0.02 mg/kg/day PO qDay or divided q12hr, not to exceed 0.25 mg/day Adverse CNS effects; may cause bradycardia and orthostatic hypotension; not recommended as routine treatment for hypertension (Beers criteria) 0.05 mg PO qDay; may increase [reference.medscape.com]

  CV: Bradycardia, edema, orthostatic hypotension, increased AV conduction time (prolonged therapy); angina-like symptoms, arrhythmias, CHF (rare). [robholland.com]

  Orthostatic hypotension in the nursing home setting. J Am Med Dir Assoc. 2006;7:163–7. PubMed Google Scholar 40. Luukinen H, Koski K, Laippala P, Kivela SL. Prognosis of diastolic and systolic orthostatic hypotension in older persons. [doi.org]

• Suicidal Ideation

  Suicidal ideation has been reported. Reserpine-induced depression is quickly reversible if therapy is withdrawn as soon as the syndrome is recognized, but can persist for several months after drug discontinuation if the syndrome fully develops. [drugs.com]

• Agitation

  […] re·ser·pine | \ ri-ˈsər-ˌpēn, -pən \ : an alkaloid C 33 H 40 N 2 O 9 that is extracted especially from the root of rauwolfias and is used chiefly in the treatment of hypertension and sometimes in the treatment of agitation associated with mental illness [merriam-webster.com]

  How Supplied: Tabs—100, 1000, 5000 Psychosis: Indications for: Reserpine Relief of symptoms in agitated psychotic states (eg, schizophrenia), primarily in those unable to tolerate phenothiazine derivatives or in those who require antihypertensive medication [empr.com]

  It is also used to treat severe agitation in patients with mental disorders. It works by decreasing the amounts of certain chemicals in the brain. [medindia.net]

  It also is used to treat severe agitation in patients with mental disorders. Reserpine is in a class of medications called rauwolfia alkaloids. [nlm.nih.gov]

• Lethargy

  From California's Modesto State Hospital came enthusiastic reports of success in using reserpine (TIME, June 21) to calm down the most disturbed patients in the back wards, and to lift the most depressed out of their lethargy, thus making both types more [time.com]

  SIDE-EFFECTS AND SPECIAL PRECAUTIONS: Side-effects commonly occurring include nasal congestion, lethargy, drowsiness, gastro-intestinal upsets, diarrhoea and vertigo; weight increase is sometimes experienced. [home.intekom.com]

  Found Interactions Found Serious - Use Alternative Significant - Monitor Closely All Interactions Sort By: Adverse Effects Frequency Not Defined Angina Bradycardia Anorexia Peripheral edema Syncope Premature ventricular contractions Dizziness Depression Lethargy [reference.medscape.com]

  CNS: Drowsiness, sedation, lethargy, mental depression, nervousness, anxiety, nightmares, increased dreaming, headache, dizziness, increased appetite, dull sensorium; prolonged use of large doses: CNS stimulation (parkinsonian syndrome): tremors, muscle [robholland.com]

• Anuria

  CHEBI:35674 antihypertensive agent Drug Use (View source of the data) scroll--> Disease Relation SNOMED_ID DOID Hypertensive disorder indication 38341003 DOID:10763 Psychotic disorder indication 69322001 Fluid volume disorder contraindication 1860003 Anuria [drugcentral.org]

A free-radical cyclisation with tributylstannane in refluxing t-butanol and subsequent workup led to an epimeric mixture that was equilibrated with base to the desired isomer 9.6G. [chemwiki.ucdavis.edu]

These findings suggest that treatment with a combination of different antihypertensives with different modes of action in low doses is a rational alternative to conventional monotherapy in the first-line treatment of hypertension. [ncbi.nlm.nih.gov]

Active treatment included hydrochlorothiazide, reserpine, and hydralazine hydrochloride. [web.archive.org]

Prognosis of diastolic and systolic orthostatic hypotension in older persons. Arch Intern Med. 1999;159:273–80. PubMed Google Scholar 41. Beckett NS, Connor M, Sadler JD, et al. [doi.org]

This bias can arise in case-control studies if patients with a particularly high (or low) rate of prior exposure to the alleged etiologic agent are excluded from the selection of either cases or controls, but not from both. [ncbi.nlm.nih.gov]

Postprandial hypotension: epidemiology, pathophysiology, and clinical management. Ann Intern Med. 1995;122:286–95. PubMed Google Scholar 48. Morley JE. Postprandial hypotension—the ultimate Big Mac attack. [doi.org]

EPIDEMIOLOGY AND RISK FACTORS The reported incidence rates of LID show a wide range, from 9–80%. 2, 3 This is unsurprising as the risk of developing LID depends on age of onset and severity of Parkinson's disease, dose and duration of levodopa therapy [ncbi.nlm.nih.gov]

Blood pressure, stroke, and coronary heart disease: Part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet. 1990;335:827-838. Google Scholar 46. [jama.ama-assn.org]

Blood pressure, stroke, and coronary heart disease: Part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet. 1990;335:827-838. FULL TEXT | WEB OF SCIENCE | PUBMED 46. [web.archive.org]

Although its underlying pathophysiology remains obscure, peripheral vasospasm appears to accompany acute embolic arterial occlusion. [ncbi.nlm.nih.gov]

Pathophysiology of the anorexia of aging. Curr Opin Clin Nutr Metab Care. 2013;16:27–32. PubMed Google Scholar 77. Bibbins-Domingo K. [doi.org]

Reserpine-induced orofacial dyskinesia and catalepsy (P < 0.05) were prevented by FO (P < 0.05). [ncbi.nlm.nih.gov]

Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures. Alendronate is used to treat or prevent postmenopausal osteoporosis and steroid-induced osteoporosis. [emedicinehealth.com]

[…] of High Blood Pressure" provides a new guideline for hypertension prevention and management. [doi.org]