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Reserpine


Presentation

  • Reserpine is a modulator of MDR in which these domains are present in a well-defined conformation.[ncbi.nlm.nih.gov]
  • The case is presented of a hypertensive patient on reserpine, who developed ventricular irritability after administration of alfentanil, a new ultra-short-acting narcotic used in anesthesia.[ncbi.nlm.nih.gov]
  • In the present article, a revision is made of the complicated process leading to the isolation and synthesis of reserpine, by the Swiss pharmaceutical company Ciba (Schlittler and Müller) and how its pharmacological properties (Bein) were discovered and[ncbi.nlm.nih.gov]
  • Parallels between the malformations present in this infant and those induced in rats through exposure to reserpine at analogous periods of gestation suggest that reserpine may pose specific risks for malformations in some pregnancies.[ncbi.nlm.nih.gov]
  • The present paper argues that, contrary to prevailing belief, reserpine is not depressogenic. The reason for perpetuation of this myth is reluctance to discard the monoamine hypothesis.[doi.org]
Fever
  • Aspirin also reduces fever. Rectal aspirin is used to reduce pain, inflammation, and fever. Aspirin is also used to treat the symptoms of arthritis and rheumatic fever. doxycycline (Vibramycin) Doxycycline is a tetracycline antibiotic.[emedicinehealth.com]
  • Reserpine was isolated in 1952 from the dried root of Rauwolfia serpentina (Indian snakeroot), which had been known as Sarpagandha and had been used for centuries in India for the treatment of insanity, as well as fever and snakebites — Mahatma Gandhi[en.wikipedia.org]
  • […] doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives ; itching; red, swollen, blistered, or peeling skin with or without fever[drugs.com]
  • Known in India as Sarpaganda, it was used for centuries to treat insanity as well as physical illnesses such as fevers and snakebites.[encyclopedia.com]
Hypotension
  • Side effects were mild to moderate in severity, and there were no cases of profound hypotension.[ncbi.nlm.nih.gov]
  • Surprisingly no or mild postural hypotension is seen. This is because centrally acting drugs do not produce postural hypotension. Baroreceptor sensitivity is increased even further (some spare baroreceptors).[howmed.net]
  • Gastrointestinal disturbances were reported in six patients, and hypotension in six. Toxicity occurred more frequently in those who received IM, and therefore high-dose, reserpine.[ncbi.nlm.nih.gov]
  • Dose dependent hypotension was observed with reserpine as well as with RMN. However, the vehicle (DMSO) also produced hypotension which was approximately 15 mm Hg from basal level.[biomedcentral.com]
  • Drug: Diuretics, other hypotensive agents compound hypotensive effects; cardiac glycosides (digoxin) may increase risk of arrhythmias; mao inhibitors may cause excitation and hypertension; cns depressants compound depression; may decrease response to[robholland.com]
Orthostatic Hypotension
  • Hypertension 0.02 mg/kg/day PO qDay or divided q12hr, not to exceed 0.25 mg/day Adverse CNS effects; may cause bradycardia and orthostatic hypotension; not recommended as routine treatment for hypertension (Beers criteria) 0.05 mg PO qDay; may increase[reference.medscape.com]
  • CV: Bradycardia, edema , orthostatic hypotension, increased AV conduction time (prolonged therapy); angina-like symptoms, arrhythmias, CHF (rare).[robholland.com]
  • Orthostatic hypotension in the nursing home setting. J Am Med Dir Assoc. 2006;7:163–7. PubMed Google Scholar 40. Luukinen H, Koski K, Laippala P, Kivela SL. Prognosis of diastolic and systolic orthostatic hypotension in older persons.[doi.org]
Suicidal Ideation
  • Suicidal ideation has been reported. Reserpine-induced depression is quickly reversible if therapy is withdrawn as soon as the syndrome is recognized, but can persist for several months after drug discontinuation if the syndrome fully develops.[drugs.com]
Psychiatric Symptoms
  • Conceivably, a parallel supersensitivity in the mesolimbic area could have occurred in this patient and accounted for the psychiatric symptoms.[ncbi.nlm.nih.gov]
Hemichorea
  • A 74-year-old woman developed a slowly progressive hemichorea starting 3 weeks after discontinuation of low-dose amitriptyline and perphenazine. The duration of neuroleptic exposure was 3 months.[ncbi.nlm.nih.gov]
Anuria
  • CHEBI:35674 antihypertensive agent Drug Use (View source of the data) scroll-- Disease Relation SNOMED_ID DOID Hypertensive disorder indication 38341003 DOID:10763 Psychotic disorder indication 69322001 Fluid volume disorder contraindication 1860003 Anuria[drugcentral.org]
Oliguria
  • […] contraindication 66999008 DOID:13543 Benign intracranial hypertension contraindication 68267002 DOID:11459 Hypochloremic alkalosis contraindication 70134007 Hepatic coma contraindication 72836002 DOID:12550 Diabetes mellitus contraindication 73211009 DOID:9351 Oliguria[drugcentral.org]

Workup

  • A free-radical cyclisation with tributylstannane in refluxing t-butanol and subsequent workup led to an epimeric mixture that was equilibrated with base to the desired isomer 9.6G .[chem.libretexts.org]
  • A free-radical cyclisation with tributylstannane in refluxing t-butanol and subsequent workup led to an epimeric mixture that was equilibrated with base to the desired isomer 9.6G.[chemwiki.ucdavis.edu]
Hypercholesterolemia
  • […] indication 38341003 DOID:10763 Psychotic disorder indication 69322001 Fluid volume disorder contraindication 1860003 Anuria contraindication 2472002 DOID:2983 Suicidal thoughts contraindication 6471006 Peptic ulcer contraindication 13200003 DOID:750 Hypercholesterolemia[drugcentral.org]
Hypertriglyceridemia
  • 6713 Disease of liver contraindication 235856003 DOID:409 Lupus erythematosus and erythema multiforme-like syndrome contraindication 238926009 Calculus in biliary tract contraindication 266474003 Neonatal hyperbilirubinemia contraindication 281610001 Hypertriglyceridemia[drugcentral.org]
Staphylococcus Aureus
  • Abstract Overexpression of efflux pump genes conferring multidrug resistance (MDR) in Staphylococcus aureus results in reduced susceptibility to select biocides, dyes and fluoroquinolones.[ncbi.nlm.nih.gov]

Treatment

  • These findings suggest that treatment with a combination of different antihypertensives with different modes of action in low doses is a rational alternative to conventional monotherapy in the first-line treatment of hypertension.[ncbi.nlm.nih.gov]
  • […] refractory to at least six previous drug treatments.[ncbi.nlm.nih.gov]
  • She also had a remission in 3 months and the treatment was continued for one year, requiring no further treatment.[ncbi.nlm.nih.gov]
  • The circadian rhythm of plasma cortisol was normal in one patient when the basal glucocorticoid level became normal with reserpine treatment.[ncbi.nlm.nih.gov]
  • Active treatment included hydrochlorothiazide, reserpine, and hydralazine hydrochloride.[web.archive.org]

Prognosis

  • Prognosis of diastolic and systolic orthostatic hypotension in older persons. Arch Intern Med. 1999;159:273–80. PubMed Google Scholar 41. Beckett NS, Connor M, Sadler JD, et al.[doi.org]

Etiology

  • This bias can arise in case-control studies if patients with a particularly high (or low) rate of prior exposure to the alleged etiologic agent are excluded from the selection of either cases or controls, but not from both.[ncbi.nlm.nih.gov]

Epidemiology

  • Postprandial hypotension: epidemiology, pathophysiology, and clinical management. Ann Intern Med. 1995;122:286–95. PubMed Google Scholar 48. Morley JE. Postprandial hypotension—the ultimate Big Mac attack.[doi.org]
  • EPIDEMIOLOGY AND RISK FACTORS The reported incidence rates of LID show a wide range, from 9–80%. 2, 3 This is unsurprising as the risk of developing LID depends on age of onset and severity of Parkinson's disease, dose and duration of levodopa therapy[ncbi.nlm.nih.gov]
  • Blood pressure, stroke, and coronary heart disease: Part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet. 1990;335:827-838. Google Scholar 46.[doi.org]
  • Blood pressure, stroke, and coronary heart disease: Part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet. 1990;335:827-838. FULL TEXT WEB OF SCIENCE PUBMED 46.[web.archive.org]
Sex distribution
Age distribution

Pathophysiology

  • Although its underlying pathophysiology remains obscure, peripheral vasospasm appears to accompany acute embolic arterial occlusion.[ncbi.nlm.nih.gov]
  • Abstract The administration of reserpine to rodents was one of the first models used to investigate the pathophysiology and screening for potential treatments of Parkinson's disease (PD).[ncbi.nlm.nih.gov]
  • Pathophysiology of the anorexia of aging. Curr Opin Clin Nutr Metab Care. 2013;16:27–32. PubMed Google Scholar 77. Bibbins-Domingo K.[doi.org]
  • Certain types of genetic polymorphism of the dopamine receptor D 2 gene have been associated with a reduced the risk of developing peak‐dose dyskinesias. 13 PATHOPHYSIOLOGY OF LID Despite significant advances, the pathogenesis of LID remains incompletely[ncbi.nlm.nih.gov]
  • Pathophysiology and treatment implications of hypertension in the African-American population. Endocrinol Metab Clin North Am. 1997;26:125-144. Google Scholar 51. Cushman WC, Reda DJ, Perry HM. et al.[doi.org]

Prevention

  • Reserpine-induced orofacial dyskinesia and catalepsy (P 0.05) were prevented by FO (P 0.05).[ncbi.nlm.nih.gov]
  • By using the fluorescent indicator quin-2 we have demonstrated that preincubation with reserpine prevented the increase of cytosolic free calcium, which accompanies PHA-induced proliferative responses of human T lymphocytes.[ncbi.nlm.nih.gov]
  • Combined therapy with reserpine, chewing gum, lemon candies, and hydration is suggested for the prevention of sialadenitis and xerostomia due to large doses of radioiodine.[ncbi.nlm.nih.gov]
  • Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures. Alendronate is used to treat or prevent postmenopausal osteoporosis and steroid-induced osteoporosis.[emedicinehealth.com]

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