We present the case of a 36-year-old woman with a primary alveolar hypoventilation syndrome. [archbronconeumol.org]

• Fatigue

  She began presenting symptoms at infancy, with cyanosis during the sleep, being diagnosed of cyanotic congenital malformation of the heart; she subsequently developed diurnal cyanosis, fatigue, purpura, and lower limbs edema. [archbronconeumol.org]

The primary aim of treatment is to reverse the toxic effects of opiates so that patients are no longer at risk of respiratory arrest, airways loss or other complications. [handbook.ggcmedicines.org.uk]

Treatment [ edit ] Respiratory stimulants such as nikethamide were traditionally used to counteract respiratory depression from CNS depressant overdose, but offered limited effectiveness. [en.wikipedia.org]

In summary, neurokinin-1 receptor-expressing preBötzinger complex neurons constitute the critical site mediating opioid-induced respiratory rate depression, and the key therapeutic target for its prevention or reversal. View Full Text [jneurosci.org]

To prevent lapse back into sedation and respiratory depression following the initial treatment. Naloxone has a shorter plasma half-life than that of all opioid analgesics. The following administration advice is from TOXBASE – www.toxbase.org. [handbook.ggcmedicines.org.uk]

Randomised trial of preventive nasal ventilation in Duchenne muscular dystrophy. French Multicentre Cooperative Group on Home Mechanical Ventilation Assistance in Duchenne de Boulogne Muscular Dystrophy. Lancet 1994;343(8913):1600-4. [revistas.asoneumocito.org]