Of these patients, 28 (10.8%) and 55 (9.8%) randomized to alteplase and reteplase, respectively, presented with shock. [ncbi.nlm.nih.gov]

Continuous variables are presented as mean±SD values. Patency data are presented with 95% CIs in parentheses. Results Patient Characteristics A total of 324 patients were enrolled between November 11, 1993, and October 26, 1994. [ahajournals.org]

Continuous variables were presented as means and SDs and categorical variables were expressed as frequencies and percentages. [journals.lww.com]

• Intravenous Administration

  All patients received catheter-directed infusion of reteplase (0.5 U/h) in combination with intravenous administration of abciximab (0.25-mg/kg bolus followed by 0.125 microg/kg/min infusion) for 12 hours without systemic heparinization. [ncbi.nlm.nih.gov]

  Prior to administration, the product should be visually inspected for particulate matter and discoloration. DOSING (Adult): Retavase® (Reteplase) is for intravenous administration only. [globalrph.com]

  Reteplase is for intravenous administration only. Reteplase is administered as two bolus injections of 10 units each. Each bolus is administered over 2 minutes. The second bolus is given 30 minutes after the first bolus injection. [mims.com]

  Reteplase dosage sponsored Reteplase® (Reteplase) is for intravenous administration only. Reteplase® is administered as a 10 + 10 unit double-bolus injection. Two 10 unit bolus injections are required for a complete treatment. [ndrugs.com]

• Gangrene of the Toe

  […] digits/purple toe syndrome, hypertension, pancreatitis, MI, cerebral infarction, spinal cord infarction, retinal artery occlusion, bowel infarction, and rhabdomyolysis. 1 Arrhythmias Possible reperfusion-related arrhythmias (e.g., sinus bradycardia, [drugs.com]

• Oral Bleeding

  Two patients had minor bleeding episodes in form of mild hematuria and oral bleeding. No other clinically relevant events were observed during thrombolytic treatment. [journals.lww.com]

• Heart Block

  block, ventricular tachycardia, ventricular fibrillation) Contraindications: Patient must be screened for possible contraindications to prevent critical complications like cerebral hemorrhage! [shadwige.sites.truman.edu]

• Sinus Arrest

  […] bradycardia, sinus arrest, heart block, ventricular tachycardia, ventricular fibrillation) Contraindications: Patient must be screened for possible contraindications to prevent critical complications like cerebral hemorrhage! [shadwige.sites.truman.edu]

• P Pulmonale

  Other findings were atrial arrhythmias (35%), right axis deviation (35%), QR pattern in V1 (30%), P-pulmonale (25%), and clockwise rotation 10% patients. ECG findings are depicted in Table 2. [journals.lww.com]

[…] with a shorter time to treatment than bolus anistreplase or infusion of streptokinase. [ncbi.nlm.nih.gov]

which reduces the time to treatment, a critical factor in improving long-term survival. [pubmed.ncbi.nlm.nih.gov]

ST Segment Elevation 1 3 Recruiting Treatment Catheter Occlusion / Thrombosis 1 3 Withdrawn Treatment Restoration of Function to CVADs 1 2 Completed Treatment Cerebrovascular Accident 1 Manufacturers Not Available Packagers EKR Therapeutics Inc. [go.drugbank.com]

ST-segment recovery and prognosis in patients with ST-elevation myocardial infarction reperfused by prehospital combination fibrinolysis, prehospital initiated facilitated percutaneous coronary intervention, or primary percutaneous coronary intervention [pubmed.ncbi.nlm.nih.gov]

On the other hand, a small inferior infarct has a much better prognosis. Evaluate your “bleeding risk,” and compare it to the risk of withholding thrombolytics. [cprworks.com]

[…] more than just restoration of epicardial flow.11 Therefore, "facilitated PCI" should be considered in a broader and more appropriate context as a PCI performed after pretreatment with antithrombotic drugs able to reduce final infarct size and improve prognosis [jamanetwork.com]

Tian C., Li Z., Yang Z., Huang Q., Liu J. and Hong B. (2016) Plasma microRNA-16 is a biomarker for diagnosis, stratification, and prognosis of hyperacute cerebral infarction. [ncbi.nlm.nih.gov]

Complications Summary of Experience with Agents Recommendation for Clinical Gene Therapy in Vascular Disease Vector Design and Current Challenges Neutrophil Localization and the Role of Adhesion Molecules A Cell Biological Approach to Therapeutic Interventions Epidemiologic [books.google.de]

Abstract Pathophysiological aspects of acute myocardial infarction include altered hemostatic and fibrinolytic systems as well as platelet activation. [ncbi.nlm.nih.gov]

[…] plasminogen activators (Alteplase, Reteplase and Tenecteplase) and the non fibrin-specific activators (Streptokinase or Urokinase plasminogen activator), the former are anticipated to be more efficacious and safer than nonspecific agents because of their pathophysiologically [jpma.org.pk]

These artefactual changes of PA or plasmin activities have been prevented by arginine stabilization of blood samples of myocardial infarction patients treated with plasminogen activators. [ncbi.nlm.nih.gov]

Use extra care to prevent bleeding while shaving or brushing your teeth. [drugs.com]