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Reticulate Acropigmentation of Kitamura

Kitamura Retic Acropigmentat


Presentation

  • A 25-year-old male presented with asymptomatic dark-colored lesions on his hands and feet with light-colored skin lesions involving the trunk since three years.[ncbi.nlm.nih.gov]
Axillary Lesion
  • Histopathology axillary lesion was also similar except for features of follicular plugging [Figure 3] a and b.[doi.org]
  • lesion demonstrating filiform elongation of the rete ridges, hyperpigmentation of basilar keratinocytes, and clusters of melanocytes at the tip of the rete ridges along with follicular plugging (H and E, 10) (b) High-power view of the same (H and E,[slideplayer.com]
Partial Alopecia
  • Other features include breaks in the epidermal ridges on the palms and fingers, palmoplantar pits, occasionally plantar keratoderma, and partial alopecia.[uniprot.org]
Facial Swelling
  • Periorbital and facial swelling due to dermatomyositis. CMAJ. 2007;176:1580--1. 9. Dwivedi N, Michael C, Lew DB, Arnold S, Igarashi… CONTINUE READING[pdfs.semanticscholar.org]
Dysesthesia
  • […] cutaneous diseases Arne Kanig and Rudolf Happle Ichthyoses erythrokeratodermas and related disorders Keratodermas Kro Dariers disease and HaileyHailey disease Daniel Hohl Theodora Mauro and leanPhilippe Gorog Mosaicism and linear lesions Pruritus and dysesthesia[books.google.com]

Treatment

  • Treatment Options 1. Observation and reassurance 2.[dermatologyadvisor.com]
  • The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.[orpha.net]
  • The treatment is symptomatic and involves skin therapy using topical applications and laser therapy, if necessary The prognosis is typically good for most individuals, since Dowling-Degos Disease is not a life-threatening condition.[dovemed.com]
  • Stay at the forefront of your field with updated treatment methods throughout, as well as an increased focus on patients with skin of color.[books.google.com]

Prognosis

  • The treatment is symptomatic and involves skin therapy using topical applications and laser therapy, if necessary The prognosis is typically good for most individuals, since Dowling-Degos Disease is not a life-threatening condition.[dovemed.com]
  • 1998 45 Co-existence of leukoderma with features of Dowling-Degos disease: reticulate acropigmentation of Kitamura spectrum in five unrelated patients. ( 9529553 ) Lestringant G.G....Galadari I.H. 1997 46 New protein and PCR markers RAK for diagnosis, prognosis[malacards.org]
  • Treatment and prognosis The disorder has a a poor prognosis and death is the rule, often in the third decade.[ijdvl.com]
  • A Chinese newborn with reticulate pigmented anomaly of the flexures was recently described. [21] Prognosis Dowling-Degos disease (reticulate pigmented anomaly) is slowly progressive but not life threatening.[emedicine.medscape.com]

Etiology

  • Grover disease (GD) is a sporadic papular condition of uncertain etiology that presents most often in sun-damaged skin. Intractable pruritus is common.[accessmedicine.mhmedical.com]
  • Prurigo pigmentosa  Rare inflammatory disease of skin of uncertain etiology commonly reported from Japan  Recurrent eruptions of itchy urticarial macules, papules, vesicopapules, and plaques with a reticular arrangement  Quickly resolve leaving a net-like[slideshare.net]
  • Reviews addressing the etiology of vitiligo suggest that vitiligo is probably a heterogeneous disease encompassing multiple etiologies.47,48 An immune-mediated pathogenesis is the most popular theory.[what-when-how.com]
  • Although, the precise etiology of this disorder is not yet known, the dyschromatosis universalis hereditaria in an autosomal dominant disease but some cases are autosomal rescessive and the locus has been mapped to chromosome 6q24.2eq25.2 [ 3 ] and 12q21eq23[clinical-pediatrics-dermatology.imedpub.com]
  • (Etiology) Dowling-Degos Disease is most commonly inherited from a single parent (in an autosomal dominant manner); however, the condition may also develop sporadically.[dovemed.com]

Epidemiology

  • Each condition is organised into epidemiology, clinical evaluations, treatment and management. This new edition provides the most up-to-date information on each disorder.[books.google.com]
  • This chapter covers the epidemiology, pathophysiology, clinical presentation, histopathology, differential diagnosis, and treatment of both common and rare genetic hyperpigmentation disorders.[link.springer.com]
  • Epidemiology  Rare group of disorders  Incidence and prevalence: Not known  Most cases: Japan  Paucity of literature might be due to underreporting of cases  Mostly autosomal dominant with variable degrees of penetrance 6.[slideshare.net]
  • Epidemiology Frequency Dowling-Degos disease (reticulate pigmented anomaly) is a rare condition worldwide. Sex Dowling-Degos disease (reticulate pigmented anomaly) affects both sexes.[emedicine.medscape.com]
  • Epidemiology Vitiligo affects 1% to 2% of the population. Onset may begin at any age, but peak incidence is in the second or third decade of life.[what-when-how.com]
Sex distribution
Age distribution

Pathophysiology

  • This chapter covers the epidemiology, pathophysiology, clinical presentation, histopathology, differential diagnosis, and treatment of both common and rare genetic hyperpigmentation disorders.[link.springer.com]
  • Etiology See Pathophysiology. Dowling-Degos disease (reticulate pigmented anomaly) may coexist with hidradenitis suppurativa.[emedicine.medscape.com]
  • It can be considered an acantholytic variant of Dowling-Degos disease. [ 8 ] The pathophysiology of Dowling-Degos disease is related to a genetic defect.[derm101.com]
  • The pigmentary system: physiology and pathophysiology. 2 nd ed. United States: Blackwell Science; 2006. p. 780-808. 8. Chang MW. Disorders of Hyperpigmentation. In: Rapini Ronald P, Bolognia Jean L, Jorizzo, Joseph L, editors. Dermatology. 2 nd ed.[ijdvl.com]

Prevention

  • […] cause severe cosmetic issues leading to emotional distress and depression Please find comprehensive information on Dowling-Degos Disease regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention[dovemed.com]
  • The patient's clinical photograph prevented us from making an embarrassing and uninformed diagnosis. Thanks to the referring dermatologist for providing such a beautiful clinical photograph.[dermpathmd.com]
  • Author Robert A Schwartz, MD, MPH Professor and Head of Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, Rutgers New Jersey Medical School; Visiting Professor, Rutgers University School of Public[emedicine.medscape.com]
  • Treatment  Exposure to heat should be limited, and sufficient hydration is recommended  Sports-related exercise should be restricted  Tooth care is required to prevent early dental caries 52.[slideshare.net]

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