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Retinal Edema


Presentation

  • Presented are a series of case reports comparing retinal photography, FA, HRT, and ocular coherence tomography (Stratus OCT; Carl Zeiss Meditec, Jena, Germany) results on patients with DME.[ncbi.nlm.nih.gov]
  • Clinical presentation, age at presentation, detachment severity and visual recovery differed considerably in the three cases.[austinpublishinggroup.com]
Weight Loss
  • Neither TG100801 nor TG100572 were detectable in plasma following topical delivery of TG100801, and adverse safety signals (such as weight loss) were not observed even with prolonged dosing schedules.[ncbi.nlm.nih.gov]
Fishing
  • Fish for years. This place is always organized and very professional. Dr. Fish and everyone there is great.[houstonretina.com]
Anorexia
  • […] platelet-derived growth factor receptor (PDGFR) and KIT, and that it is effective for a variety of hematologic and nonhematologic malignancies. 1 A variety of adverse events including cytopenia, nausea, vomiting, edema, myalgia, diarrhea, rash, fatigue, and anorexia[nature.com]
Diarrhea
  • […] other than ABL, such as platelet-derived growth factor receptor (PDGFR) and KIT, and that it is effective for a variety of hematologic and nonhematologic malignancies. 1 A variety of adverse events including cytopenia, nausea, vomiting, edema, myalgia, diarrhea[nature.com]
Myalgia
  • […] kinases other than ABL, such as platelet-derived growth factor receptor (PDGFR) and KIT, and that it is effective for a variety of hematologic and nonhematologic malignancies. 1 A variety of adverse events including cytopenia, nausea, vomiting, edema, myalgia[nature.com]
Dermatitis
  • […] medicines for eye diseases, colorectal cancer, and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including hypercholesterolemia, oncology, rheumatoid arthritis, asthma, and atopic dermatitis[investor.regeneron.com]
Conjunctival Hyperemia
  • Conjunctival hyperemia, corneal infiltrates, ocular pain and headache have been reported. Also, NSAIDs have been shown to increase operative bleeding and have the potential for cross-sensitivity with acetylsalicylic acid.[retinalphysician.com]
Corneal Infiltrate
  • Conjunctival hyperemia, corneal infiltrates, ocular pain and headache have been reported. Also, NSAIDs have been shown to increase operative bleeding and have the potential for cross-sensitivity with acetylsalicylic acid.[retinalphysician.com]
Flame-shaped Hemorrhage
  • Central retinal vein occlusion sometimes has been described as a “blood and thunder” appearance due to extensive flame-shaped hemorrhages throughout 2 (hemiretinal) or 4 quadrants of the retina and causes sudden vision loss in one eye when venous flow[jamanetwork.com]
Periorbital Edema
  • Ocular manifestation of edema is a recognized problem associated with imatinib use. 6 However, periorbital edema and epiphora are the two most common complications, and retinal involvement has never been reported.[nature.com]
Papilledema
  • Cystoid macular edema and papilledema following cataract extraction. A fluorescein fundoscopic and angiographic study. Arch Ophthalmol. 1966;76:646-661. 4. Gass JD, Anderson DR, Davis EB.[retinalphysician.com]

Workup

  • As part of the preoperative workup, an OCT was repeated. To our surprise it showed what appeared to be edema of the outer plexiform layer.[eyeworld.org]
  • […] with diabetic nephropathy should be observed more closely Lipid and triglyceride levels: Elevated triglyceride and lipid levels increase the risk of retinopathy, while normalization of lipid levels reduces retinal leakage and deposition of exudates See Workup[emedicine.medscape.com]
Cytopenia
  • […] revealed that this agent also inhibits kinases other than ABL, such as platelet-derived growth factor receptor (PDGFR) and KIT, and that it is effective for a variety of hematologic and nonhematologic malignancies. 1 A variety of adverse events including cytopenia[nature.com]
Lymphocytic Infiltrate
  • There is a profound lymphocytic infiltration of the choroid, and there are confluent noncaseating epithelioid granulomata. Eosinophils are numerous, and some epithelioid cells contain melanin granules (H&E 10 original magnification).[nature.com]

Treatment

  • […] after the treatment, the situation of fundus got better without increased IOP; vision of 15 eyes (3.85%) decreased to some extent, and the symptoms eased slightly after symptomatic treatment.[ncbi.nlm.nih.gov]
  • Please click upon the name of the treatment to be redirected to a page with a more detailed description. Focal Macular Laser Treatment: This laser treatment is used to control bleeding and leakage caused by abnormal blood vessels.[calgaryretina.ca]
  • STEROID TREATMENT Off-label intravitreal triamcinolone acetonide (Kenalog, Bristol-Meyers Squibb) has become a common treatment for DME.[retinalphysician.com]

Prognosis

  • Treatment and Prognosis Depending on the cause of your cystoid macular edema (CME), treatment may include some of the following: • Anti-inflammatory medications, including steroid and/or non-steroidal anti-inflammatory medications in the form of eye drops[houstonretina.com]
  • As with other conditions, the visual prognosis depends on the severity of the underlying condition, its duration, the general health of the eye, and the degree to which vision has been affected.[asrs.org]
  • Long-term prognosis of cystoid macular edema after microsurgery of rhegmatogenous retinal detachment . J Fr Ophthalmol 1993; 16 (4): 259–263. 6. Lisle C , Mortensen KK , Sjolie AK . Pneumatic retinopexy. A long term follow-up study .[nature.com]
  • Noma H, Funatsu H, Mimura T, Eguchi S, Shimada K (2011) Visual prognosis and vitreous molecules after vitrectomy for macular edema with branch retinal vein occlusion. Clin Ophthalmol 5: 223-229.[esciencecentral.org]
  • Diagnosis and Prognosis: An ophthalmologist is usually the one to make this diagnosis following a complete examination of the retina. Several tests can be used to distinguish this condition from others which appear superficially similar.[disorders.eyes.arizona.edu]

Etiology

  • The unclear etiology of CME in this setting is explored by examining the clinical reports of the presented cases.[austinpublishinggroup.com]
  • Intravitreal steroids (IVS), such as triamcinolone acetonide, have been utilized to treat macular edema stemming from a variety of etiologies and may be a treatment option for CRVO-ME.[cochrane.org]
  • We were puzzled as to the etiology of the retinal findings and entertained the possibility of vitreomacular traction.[eyeworld.org]
  • We have hypothesized that structural causes of INL cystic changes may be the result of internal limiting membrane traction and that Müller cell death may be the underlying etiology.[retinalphysician.com]
  • Abnormal retinal capillary permeability or breakdown of the blood-retinal barrier is the underlying etiology. 1 This increased vascular permeability, in which the extracellular spaces expand, causes an accumulation of fluid, which overwhelms the mechanism[retinatoday.com]

Epidemiology

  • “I think the key here is that this study shows we have choices,” says Frederick Ferris, MD, clinical director and director of the Division of Epidemiology of Clinical Applications at the National Eye Institute.[diabetesforecast.org]
  • Arch Ophthalmol 114:1079-1084, 1996. 9) Klein R, Klein BEK, Moss SE, et al: The Wisconsin Epidemiologic Study of Diabetic Retinopathy, IV. Diabetic macular edema.[djo.harvard.edu]
  • Epidemiology CMO post-surgery : CMO occurs in only about 1% of cases of uncomplicated cataract surgery in a very mild form (in the past, with older techniques, up to 20% of patients developed CMO and the figure can be this high in more complex cases or[patient.info]
  • […] proliferative diabetic retinopathy . [5] A study suggests that the pathogenesis of diabetic macular edema is not only related to VEGF dependency but also to other inflammatory and angiogenic cytokine levels that can be suppressed by corticosteroids. [6] Epidemiology[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • Consideration of the pathophysiology of retinal edema may aid in the development of better strategies for managing retinal edema.[ncbi.nlm.nih.gov]
  • PATHOPHYSIOLOGY: UNDERSTANDING THE PROBLEM The defining feature of diabetic macular edema is, of course, edema of the retina.[djo.harvard.edu]
  • Age-related macular degeneration (AMD) [ 7 ] The pathophysiology of this condition is covered in the separate related article.[patient.info]
  • The pathophysiology of macular edema is complex, with a variety of processes involved in its development.[retinatoday.com]

Prevention

  • This prevents fluid from flowing through the tear and leading to retinal detachment. Treatment for a retinal tear is usually effective in relieving symptoms and preventing retinal detachment from occurring.[midhudsonretina.com]
  • Ripasudil significantly prevented deterioration, such as retinal edema, reduced the size of the nonperfusion area, and improved retinal blood flow. Ripasudil treatment inhibited disintegration of ZO-1 in HRMECs.[ncbi.nlm.nih.gov]
  • Hopefully, this research will lead to more exact prevention and treatment measures in the near future. Eye disease can strike at any age. Many disorders, like CME, do not always produce immediate symptoms.[retinaldiagnostic.com]
  • Gamache Article 211 Downloads 38 Citations Abstract The purpose of this study was to evaluate the ability of the nonsteroidal anti-inflammatory drug nepafenac to prevent development of mitogen-induced pan-retinal edema following topical ocular application[link.springer.com]

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