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Retinoid


Presentation

  • Abstract We present a review of recent investigations of anticancer drug bexarotene in this article.[ncbi.nlm.nih.gov]
  • This is corroborated in the present immunocytochemical investigation using antibodies against another photoreceptor-cell marker, the interphotoreceptor retinoid-binding protein (IRBP).[ncbi.nlm.nih.gov]
  • Whether VDR, RXR or PPARγ are expressed in BRCA1 mutated breast cancer or may even be present in case of triple negativity is not known.[ncbi.nlm.nih.gov]
  • Together, these data suggest that natural RXRA ligands are present and dynamically increased in abundance in mouse hematopoietic cells in vivo.[ncbi.nlm.nih.gov]
  • If you like this presentation, please let the Tanapat Palaga know! If you want to be able to download a copy of this presentation to facilitate classroom use, please contact Eric Martz , specifying the title and author of the presentation.[umass.edu]
Developmental Disabilities
  • Gov't MeSH terms Adult Child Chromosome Breakpoints Chromosome Deletion Codon, Nonsense Developmental Disabilities/diagnosis Developmental Disabilities/genetics* Epilepsy, Generalized/diagnosis Epilepsy, Generalized/genetics* Exome Exons Female Humans[ncbi.nlm.nih.gov]
Periodontitis
  • The combination of retinoid therapy and periodontal treatment improved the dermatologic and periodontal conditions.[ncbi.nlm.nih.gov]
Alopecia
  • Moreover, he was conspicuous for the presence of total alopecia of the scalp and eyebrows. Histopathologically, the lesional skin showed dense follicular and perifollicular infiltrates of atypical lymphocytes.[ncbi.nlm.nih.gov]
  • Severely impaired liver or kidney function Chronic abnormally elevated blood lipid values Toxicity Cheilitis Alopecia Xerosis, pruritus Xerophthalmia, night blindness Dry mouth Paronychia Paresthesias Headache, pseudotumor cerebri Nausea, abdominal pain[aad.org]
Tonic-Clonic Seizure
  • GGE are clinically characterized by absence, myoclonic, or generalized tonic-clonic seizures with electroencephalographic pattern of bilateral, synchronous, and symmetrical spike-and-wave discharges.[ncbi.nlm.nih.gov]

Treatment

  • Most importantly, this topical vitamin A treatment caused the reversal of squamous metaplasia as evidenced by impression cytology.[ncbi.nlm.nih.gov]
  • Analysis was made of (a) T6 and HLA-DR Langerhans cells (LCs) by immunoperoxidase staining in lesional and clinically normal skin before and during retinoid treatment, (b) the effect of retinoid treatment on CMI in vivo and in vitro, and (c) cytogenetic[ncbi.nlm.nih.gov]
  • Although retinoids were developed to avoid toxicity associated with vitamin A, skeletal lesions and rheumatologic consequences are possible hazards of isotretinoin treatment.[ncbi.nlm.nih.gov]
  • The Role of Topical Retinoids in Prevention and Treatment of Atrophic Acne Scarring: Understanding the Importance of Early Effective Treatment. J Drugs Dermatol. 2019 Mar 1;18(3):255-260. PubMed PMID: 30909329. Journal.[dermnetnz.org]
  • These findings revealed a number of combination treatments likely to improve clinical response to retinoid therapy, including co-treatment with retinoids and KGN, which may prove valuable in the treatment of high-risk MYCN-amplified neuroblastoma.[ncbi.nlm.nih.gov]

Prognosis

  • Kaplan-Meier method and Cox's regression analyses were performed to evaluate the prognosis of 60 patients with EC. RESULTS: RXRα was elevated in EC tissues comparing with normal esophageal tissues at both mRNA and protein levels.[ncbi.nlm.nih.gov]
  • It is usually resistant to treatment with reduction in immunosuppression or chemotherapy and carries a poor prognosis.[ncbi.nlm.nih.gov]
  • […] second decade of life, no extraocular signs or symptoms, diffuse retinal capillary leakage on fluorescein angiography but without apparent fundus changes, many vitreous cells but no snowbank-like vitreous opacity, responsiveness to steroid, and good prognosis[ncbi.nlm.nih.gov]
  • Treatment strategies are inefficient resulting in poor prognosis of PEL patients, stressing the need for new effective therapy.[ncbi.nlm.nih.gov]
  • We recently highlighted thyroid hormone receptors (TRs) to predict prognosis in breast cancer patients that had been diagnosed a BRCA1 germline mutation.[ncbi.nlm.nih.gov]

Etiology

  • Liver Neoplasms/prevention & control* Male Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease/etiology Non-alcoholic Fatty Liver Disease/prevention & control* RNA Interference Retinoids/pharmacology* Substances Atg16l1 protein, mouse Carrier Proteins[ncbi.nlm.nih.gov]
  • […] are prescribed isotretinoin should be warned about this potential pathologic condition at the initiation of treatment and that physicians who are treating patients with a history of Accutane use should be suspicious of underlying enthesopathies as the etiology[ncbi.nlm.nih.gov]
  • However, the detailed cellular and molecular mechanisms underpinning the etiology and pathogenesis of CA remain elusive.[ncbi.nlm.nih.gov]
  • Abstract Genetic generalized epilepsy (GGE), formerly known as idiopathic generalized epilepsy, is the most common form of epilepsy and is thought to have predominant genetic etiology.[ncbi.nlm.nih.gov]
  • Sherman SI (2003) Etiology, diagnosis, and treatment recommendations for central hypothyroidism associated with bexarotene therapy for cutaneous T-cell lymphoma. Clin Lymphoma 3:249–252 PubMed CrossRef Google Scholar 55.[link.springer.com]

Epidemiology

  • On the basis of epidemiologic data, an increased risk seems to exist at a daily intake of 10000-25000 IU. An average liver meal can contain 10- to 30-fold higher amounts of vitamin A than the recommended daily intake.[digibib.tu-bs.de]
  • Epidemiology, clinical manifestations, and diagnosis of psoriasis. . Accessed Dec. 6, 2013. Armstrong AW, et al. The association between psoriasis and obesity: A systematic review and meta-analysis of observational studies.[web.archive.org]
  • There is a wealth of epidemiological and molecular evidence suggesting that retinoids repress HIV-1 expression.[jvi.asm.org]
  • Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris. J Am Acad Dermatol . 1998;39(2 pt 3):S34–7. ... 2. Krowchuk DP, Stancin T, Keskinen R, Walker R, Bass J, Anglin TM.[aafp.org]
Sex distribution
Age distribution

Pathophysiology

  • Targeting all the pathophysiologic processes in acne development, Iso has been considered to be an unique drug, however it has several side effects.[ncbi.nlm.nih.gov]
  • Along with the understanding of the neurodegenerative disease progression and its pathophysiological mechanisms, development of anti-Aβ targeted effective therapeutics is essential for AD management.[ncbi.nlm.nih.gov]
  • Although accelerated disease progression among alcohol abusers infected with HCV is clinically well recognized, the molecular pathophysiology behind this manifestation has not been well elucidated.[ncbi.nlm.nih.gov]
  • Author information 1 Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli 35053, Taiwan. 2 Department of Physiology and Pathophysiology, Basic Medical College, Peking University, Beijing 100871, China. 3 Department of[ncbi.nlm.nih.gov]
  • Fisher GJWang ZQDatta SCVarani JKang SVoorhees JJ Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med 1997;3371419- 1428 PubMed Google Scholar Crossref 3. Weiss JSEllis CNHeadington JT et al.[doi.org]

Prevention

  • Abstract The pathogenesis of non-alcoholic steatohepatitis (NASH) is still unclear and the prevention of the development of hepatocellular carcinoma (HCC) has not been established.[ncbi.nlm.nih.gov]
  • We previously showed that expression of CYP26 in BM stromal cells maintains a retinoic acid-low (RA-low) microenvironment that prevents the differentiation of normal and malignant hematopoietic cells.[ncbi.nlm.nih.gov]
  • Acyclic retinoid (ACR) is a synthetic vitamin A-like compound capable of preventing the recurrence of HCC.[ncbi.nlm.nih.gov]
  • Similarly, these agents have been applied towards preventing second primary malignancies from developing following curative therapy for upper aerodigestive cancers.[ncbi.nlm.nih.gov]
  • Retinoids have been implicated as pharmacological agents for the prevention and treatment of various types of cancers, including breast cancers.[ncbi.nlm.nih.gov]

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