If you like this presentation, please let the Tanapat Palaga know! If you want to be able to download a copy of this presentation to facilitate classroom use, please contact Eric Martz, specifying the title and author of the presentation. [umass.edu]

Abstract We present a review of recent investigations of anticancer drug bexarotene in this article. [ncbi.nlm.nih.gov]

• Hepatosplenomegaly

  Anorexia, skin lesions, hair loss, hepatosplenomegaly, papilloedema, bleeding, general malaise, pseudotumor cerebri, and death may also occur. [en.wikipedia.org]

• Alopecia

  Moreover, he was conspicuous for the presence of total alopecia of the scalp and eyebrows. Histopathologically, the lesional skin showed dense follicular and perifollicular infiltrates of atypical lymphocytes. [ncbi.nlm.nih.gov]

  Other non-FDA approved indications that have been reported in the literature include treatment of verruca vulgaris, molluscum contagiosum, Darier disease, photoaging, pigmentary disorders, actinic keratoses and alopecia areata.[4] A study has concluded [en.wikipedia.org]

  Severely impaired liver or kidney function Chronic abnormally elevated blood lipid values Toxicity Cheilitis Alopecia Xerosis, pruritus Xerophthalmia, night blindness Dry mouth Paronychia Paresthesias Headache, pseudotumor cerebri Nausea, abdominal pain [aad.org]

  PubMed Citation (Extensive review of the pharmacology, clinical efficacy, and toxicity of acitretin; vitamin A like side effects are common such as dry skin, lips, eyes and nose, skin desquamation, alopecia, fatigue and pruritus; ALT elevations occur [livertox.nih.gov]

Treatment options for acne vulgaris have expanded considerably in the past decade. The main goals of treatment continue to be reducing acne lesions while maintaining patient satisfaction and adherence to treatment. [ncbi.nlm.nih.gov]

The Role of Topical Retinoids in Prevention and Treatment of Atrophic Acne Scarring: Understanding the Importance of Early Effective Treatment. J Drugs Dermatol. 2019 Mar 1;18(3):255-260. PubMed PMID: 30909329. Journal. [dermnetnz.org]

Uses[edit] Retinoids are used in the treatment of many diverse diseases and are effective in the treatment of a number of dermatological conditions such as inflammatory skin disorders,[citation needed] skin cancers,[citation needed] disorders of increased [en.wikipedia.org]

On the basis of their data, the authors recommended at least two to three months of treatment for significant improvement to be noted. The literature shows that retinol has potentially beneficial effects in the treatment of aged skin. [doi.org]

Kaplan-Meier method and Cox's regression analyses were performed to evaluate the prognosis of 60 patients with EC. RESULTS: RXRα was elevated in EC tissues comparing with normal esophageal tissues at both mRNA and protein levels. [ncbi.nlm.nih.gov]

[…] are prescribed isotretinoin should be warned about this potential pathologic condition at the initiation of treatment and that physicians who are treating patients with a history of Accutane use should be suspicious of underlying enthesopathies as the etiology [ncbi.nlm.nih.gov]

Sherman SI (2003) Etiology, diagnosis, and treatment recommendations for central hypothyroidism associated with bexarotene therapy for cutaneous T-cell lymphoma. Clin Lymphoma 3:249–252 PubMed CrossRef Google Scholar 55. [link.springer.com]

On the basis of epidemiologic data, an increased risk seems to exist at a daily intake of 10000-25000 IU. An average liver meal can contain 10- to 30-fold higher amounts of vitamin A than the recommended daily intake. [digibib.tu-bs.de]

Epidemiology, clinical manifestations, and diagnosis of psoriasis. http://www.uptodate.com/home. Accessed Dec. 6, 2013. Armstrong AW, et al. [web.archive.org]

There is a wealth of epidemiological and molecular evidence suggesting that retinoids repress HIV-1 expression. [jvi.asm.org]

Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris. J Am Acad Dermatol. 1998;39(2 pt 3):S34–7. ... 2. Krowchuk DP, Stancin T, Keskinen R, Walker R, Bass J, Anglin TM. [aafp.org]

Targeting all the pathophysiologic processes in acne development, Iso has been considered to be an unique drug, however it has several side effects. [ncbi.nlm.nih.gov]

Louis, MO 63110, USA. 4 Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain. * Corresponding author. Email: [email protected] 要約 レチノイドX受容体α（RXRA）は、さまざまな血液学的過程に関与している。 [cosmobio.co.jp]

Retinol for acne is a great way to both minimise active breakouts and prevent future breakouts from occurring. [adorebeauty.com.au]

Summary: A prescription retinoid is very beneficial for age-prevention and can work on some types of acne but not all because every type of acne can be different. [blog.reneerouleau.com]

and confirmed that an update of measures for pregnancy prevention is needed. [ema.europa.eu]

We previously showed that expression of CYP26 in BM stromal cells maintains a retinoic acid-low (RA-low) microenvironment that prevents the differentiation of normal and malignant hematopoietic cells. [ncbi.nlm.nih.gov]

Retinoid/Retinol stimulates collagen and increases cell turnover, which in turn helps plump and firm skin, but can both treat and prevent many fine lines and reduce deeper wrinkles. It's also an effective tool for preventative measures. [beautylish.com]