Abstract Retinoschisis can be found in the fovea or the retinal periphery, either of which may be present in isolation, or in conjunction with each other. [onlinelibrary.wiley.com]

Acquired retinoschisis is most commonly peripheral, unilateral, asymptomatic, and present in an older demographic. XLRS is usually bilateral, central, symptomatic, and present in a younger male demographic (Table 1). [journal.opted.org]

CONCLUSION: We present a case of atypical retinoschisis with clinical findings of retinitis pigmentosa.tinoschisis with clinical findings of retinitis pigmentosa. [cegat.de]

The retinal pigment epithelium (RPE) presents focal atrophic changes. The OCT findings of 12 year old brother show early cystoid development in the foveal center in the right eye. [iovs.arvojournals.org]

Peripheral bullous retinoschisis (seen in the current patient’s left eye) is present in approximately 50% of cases at presentation and may flatten spontaneously as the disease progresses. 1 The current case suggests that the likely mechanism for this [healio.com]

Fortunately, this complication is rare, occurring in only 0.05% of patients with retinoschisis. 1 Treatment of progressive RRD associated with retinoschisis follows the same principles as treatment of any RRD, but with a few special considerations. [retinatoday.com]

Additionally, no treatment, including laser, has been shown to halt the progression of retinoschisis. [eyewiki.aao.org]

Although treatment with oral CAIs has been shown to produce equal visual acuity outcomes, it is associated with a significantly greater side-effect profile when compared with topical treatment.8,17,19 Acute onset macular edema is more responsive to treatment [journal.opted.org]

Carbonic anhydrase inhibitor sub-study Subjects with maculoschisis may be offered topical treatment with CAIs. These subjects will be asked to visit the study site at 1 month and 3 months after starting topical treatment. [clinicaltrials.gov]

Researchers are testing new treatments for retinoschisis. One of these replaces the damaged gene with a copy of a healthy gene. Stem cell treatments are also being studied. [webmd.com]

Patient’s perspective Medical counselling helped me and my family members to have better understanding of the disease nature, its inheritance pattern and prognosis. [casereports.bmj.com]

There are many useful considerations and tools for evaluation and monitoring that can be used to determine the aetiology and prognosis of these retinal findings. [onlinelibrary.wiley.com]

Prognosis Visual prognosis is highly variable, depending on the XLRS phenotypic variability. With prompt identification and management of the disease, the vision could be preserved adequately. [institut-vision.org]

This does not change the prognosis. If there are both inner and outer layer holes, then liquid vitreous can work its way under both retinal layers and cause a retinal detachment. Fortunately double layer holes occur very rarely. [retinalmd.com]

Prognosis The natural history is that this disease almost never progresses from where it's first observed. Most people with senile retinoschisis do well and can be followed without intervention. [eyewiki.aao.org]

Etiology and pathogenesis The gene responsible for XLRS, RS1 (also known as XLRS1), was identified in 1997. So far, more than 160 inactivating mutations have been found. [institut-vision.org]

Epidemiology, onset & clinical features Epidemiology Based on data from Finland (where the highest prevalence has been reported, due to 3 founder mutations) and The Netherlands, the prevalence is estimated to be 1 in 15,000 to 1 in 30,000. [institut-vision.org]

There is a lack of contemporary epidemiological data for PSRDR, and further studies are required. [nature.com]

Retinal holes or tears can be treated with laser therapy or cryotherapy to prevent their progression to a full-scale detachment. Vitreous hemorrhage when not associated with retinal detachment may resolve spontaneously. [institut-vision.org]

This work was funded by the Core Grant for Vision Research (P30 EY01931), an unrestricted grant from Research to Prevent Blindness, and a Milwaukee donor fund supporting Macular Degeneration. References 1. [ncbi.nlm.nih.gov]

At the same time, it enables scientists to search the “de-identified” (i.e., anonymous) patient information to study conditions and identify targets for treatments, preventions and cures. [fightingblindness.org]

Advances in eISSN: 2377-4290 Case Report Volume 2 Issue 1 Miguel Paciuc Beja, Regret for the inconvenience: we are taking measures to prevent fraudulent form submissions by extractors and page crawlers. [medcraveonline.com]

This prophylactic treatment will not re-establish the neuronal integrity of the split retina; therefore, it does not reverse the absolute visual field defect caused by acquired retinoschisis.24 The goal is to help prevent a retinal detachment by creating [journal.opted.org]