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Retroperitoneal Sarcoma

Sarcoma of Retroperitoneum


Presentation

  • RESULTS: Forty-three out of 78 patients (55%) presented with primary RS. Infiltrated organs were resected in 42 patients (54%).[ncbi.nlm.nih.gov]
Inguinal Mass
  • CT scan showing the left inguinal mass. Surgical specimen which includes the right and left iliac fossa masses. 3.[ncbi.nlm.nih.gov]
Abdominal Mass
  • A huge left renal capsular leiomyoma mimicking retroperitoneal sarcoma presented in a patient as an abdominal mass.[ncbi.nlm.nih.gov]
  • Retroperitoneal leiomyosarcoma in a young adult presenting as a huge abdominal mass Department of Pathology, Dr. D. Y.[ccij-online.org]
  • Clinical findings Often asymptomatic abdominal mass; average age, 50. Prognosis 65% to 80% of cases achieve complete resection; 5-year local recurrence, 50%; 5-year survival, 50%.[medical-dictionary.thefreedictionary.com]
Lower Abdominal Pain
  • Abstract A 42-year-old man presented with lower abdominal pain and a vague abdominal mass. He underwent resection of a well-differentiated liposarcoma arising from his retroperitoneum measuring 50 cm and weighing 11.7 kg (25.8 lb).[ncbi.nlm.nih.gov]
  • A 73-year-old man had sudden, intermittent lower abdominal pain, and he noted that his abdominal girth was increasing.[nejm.org]
  • A 65 year old male presented with lower abdominal pain and fullness of one year duration, which was progressive in nature. On examination, there was a palpable mass in the lumbar region and revealed a retroperitoneal mass on ultrasonography.[ijpmonline.org]
Thrombosis
  • Early clinically relevant complications (grade 3) were detected in one patient (7%) (symptomatic graft thrombosis). No reoperations were needed. No late relevant complications (grade 3) were observed. Overall graft patency was 60%.[ncbi.nlm.nih.gov]
  • Palliation Equipment Laparotomy tray Helgerud's retractor Self-retaining retractor, Bookwalter or similar Depending on the localization of the tumor: Ligasure, staple instruments (GIA, TA) Preparation Preoperative colon emptying Antiobiotic prophylaxis Thrombosis[oncolex.org]
  • […] associated with tumor resection were the kidney (70%), the right or left colon (44%) and other for 18% of the cases (spleen in 4 patients, psoas muscle in 6 patients, inferior vena cava in one patient who did not require reconstruction from previous thrombosis[elsevier.es]
  • Doppler/duplex ultrasound may offer additional information on the patency of the femoral and iliac vessels and of the inferior caval vein (ICV), especially in case of suspicion of partial or complete deep venous thrombosis due to vascular compression.[frontiersin.org]
Back Pain
  • Possible symptoms include abdominal pain, abdominal rigidity, back pain, swelling of lower limbs, intestinal obstruction, and an early feeling of satiation.[tasmc.org.il]
  • She started getting really bad back pains which she thought at the time was a water infection..[community.macmillan.org.uk]
  • A 20-year-old male was admitted in our institution with a 3-month history of back pain, hematuria, lower urinary tract symptoms, and weight loss of 12 kg. Past medical history was non-significant.[scielo.br]
  • His dr. ordered an MRI(last AUG) and diagnosed the back pain as inflammed discs. He gave him an anti-depressant for the fatigue and the sweating was never treated.[cancercompass.com]
Foot Drop
  • We report the case of a 59-year-old woman presenting left-sided foot drop as her initial symptom.[ncbi.nlm.nih.gov]
Kidney Failure
  • Post-operatively, she developed kidney failure and biopsy showed minimal change disease. With steroid therapy, patient's symptoms went into remission.[ncbi.nlm.nih.gov]
  • These tumors may also compress the kidney or ureter, leading to kidney failure.[en.wikipedia.org]
  • Precautions must be taken for kidney failure, heart failure, lung failure, large fluid and electrolyte loss, diabetes mellitus and liver failure.[oncolex.org]
Renal Impairment
  • The GFR decreased by an average of 33.4 mL/min/1.73 m 2 with 66% of patients demonstrating mild progression of their renal impairment. Only three (6%) patients progressed to CKD stage 4 or 5, one of which required life-long dialysis.[ncbi.nlm.nih.gov]

Workup

  • The discovery of intestinal perforation during workup necessitates initiation of empirical antibiotic coverage and prompt surgical intervention. INTRODUCTION Retroperitoneal sarcomas are uncommon malignancies with indolent presentations.[jscr.oxfordjournals.org]
  • Further workup should include detailed physical examination (including testicular examination and ultrasound) and measurement of serum beta human chorionic gonadotropin and alpha-fetoprotein if testicular mass is suspected or found.[ijam-web.org]
  • The patient should undergo dedicated imaging and workup of the retroperitoneal mass. Surgery The best chance for resection with curative intent is at the time of primary presentation.[bccancer.bc.ca]
  • Workup Liposarcoma. Contrast-enhanced axial CT shows large right retroperitoneal liposarcoma (arrow) composed predominantly of fat but also has areas of soft tissue density and calcific components. 10.[slideshare.net]

Treatment

  • The 2 objectives of this review were: 1) to determine the benefit of RT in terms of local control and/or survival in the treatment of retroperitoneal sarcomas and 2) to discover the optimal timing of RT in the treatment sequence.[ncbi.nlm.nih.gov]

Prognosis

  • Based on scientific literature and clinical expertise, clinicopathological data were analyzed using both a supervised and an unsupervised classification method to predict the prognosis, with similar sample sizes (66 and 65, resp., in casewise approach[ncbi.nlm.nih.gov]
  • The future of RPS prognosis prediction The development of robust, externally validated nomograms provides clinicians with a tool, which allows prediction of individual prognosis in RPS patients.[cco.amegroups.com]

Etiology

  • The findings of positive blood cultures in patient A indicate an infectious etiology, most likely secondary to her intestinal perforation, may underlie her leukocytosis.[jscr.oxfordjournals.org]
  • They have assembled expert authors to review the following topics: Epidemiology and Etiology of Sarcomas; Management of Extremity Sarcomas; Management of Retroperitoneal Sarcomas; Management of Dermatofibrosarcoma Protuberans; Management of Desmoids;[books.google.ro]
  • […] neoplasms arise from outside the major organs, and are divided according to histological types: mesenchymal origin : skeletal muscle, fat, peripheral nerve, vessels, fibrous tissue extragonadal germ cell tumors primary retroperitoneal adenocarcinoma Etiology[radiopaedia.org]

Epidemiology

  • In this report, we describe the first case, to our knowledge, in the medical literature and discuss epidemiology, diagnosis, and management.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Prevention

  • If possible, every spilled gallstone during surgery should be retrieved to prevent this rare complication.[ncbi.nlm.nih.gov]
  • The aim of non-surgical follow up treatment is to prevent the sarcoma coming back. Even if the cancer is in remission, regular check ups will be arranged so that the whole of the abdomen can be monitored closely.[chelseasurgeonsclinic.com]

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