Presentation
The retroviral RNA presents the same structural phenotype than cellular mRNAs. [gydb.org]
He has earned two awards for presentations explaining his Cornell work. [owu.edu]
Here we present several examples of retroviruses for which envelope capture has been identified. Indeed, capture may explain the notable conservation of env sequences among otherwise phylogenetically distant retroviruses. [ncbi.nlm.nih.gov]
Cancer-Causing Viruses and Their Inhibitors presents a plethora of research from internationally reputed contributors who discuss different types of oncoviruses, their mechanisms of invasion and growth, and their life cycles. [data.bnf.fr]
Gastrointestinal
- Gagging
The gag gene codifies for a gag polyprotein containing the matrix (MA), capsid (CA) and the nucleocapsid (NC) domains which, in the maturation process, are spliced into independent peptides. [gydb.org]
The arrow between gag-pro indicates a ribosomal readthrough site. Figure 7 Lentivirus genome expression. [talk.ictvonline.org]
Another variant, Phoenix-gp, contains only Gag-Pol and enables additional flexibility in pseudotyping. [addgene.org]
This gives rise to the unspliced full length mRNA that will serve as genomic RNA to be packaged into virions or used as a template for translation of gag(pro) and gag(pro)-pol (1 ribosomal frameshift) polyproteins. [viralzone.expasy.org]
- Nausea
Symptoms of ATL include: Feeling tired Swollen lymph nodes Excess thirst Fever Frequent infections and illnesses Nausea and vomiting Skin problems Bone problems Swollen or enlarged liver Swollen or enlarged spleen Around 2% of those with HTLV type I [webmd.com]
- Vomiting
Symptoms of ATL include: Feeling tired Swollen lymph nodes Excess thirst Fever Frequent infections and illnesses Nausea and vomiting Skin problems Bone problems Swollen or enlarged liver Swollen or enlarged spleen Around 2% of those with HTLV type I [webmd.com]
Musculoskeletal
- Arthritis
Associated with a variety of diseases including immunodeficiencies, neurological disorders, arthritis and others. No oncogene-containing members of this group have been isolated. (B72) [wildpro.twycrosszoo.org]
[…] though, you may develop neurological symptoms including: Erectile dysfunction Problems walking Sensory changes Cognitive impairment Incontinence Loss of muscle control Some doctors believe this condition is also associated with chronic lung infections, arthritis [webmd.com]
Bovine leukemia virus) Epsilonretrovirus (Walleye epidermal hyperplasia virus) Lentivirus (human immunodeficiency virus (HIV), simian immunodeficiency viruses (SIV), feline immunodeficiency virus, puma lentiviruses, bovine immunodeficiency virus, caprine arthritis [thenativeantigencompany.com]
[…] lentivirus group N/A bovine immunodeficiency virus Subgenus: Equine lentivirus group N/A Equine infectious anemia virus Subgenus: Feline lentivirus group N/A feline immunodeficiency virus Petuluma Subgenus: Ovine/caprine lentivirus group N/A caprine arthritis [virology.net]
[…] shown in comparison to representative genome organizations of other lentiviral subgroups: equine (equine infectious anemia virus, EIAV), feline (feline immunodeficiency virus, FIV), bovine (bovine immunodeficiency virus, BIV), caprine/ovine (caprine arthritis–encephalitis [pnas.org]
Workup
Microbiology
- Human T-Lymphotropic Virus-2
HIV-2, SIV, BIV, FIV) Subfamily: Foamy- or Spumaretroviruses (Spumaretrovirinae) 5 species of retroviruses are known to be human pathogens: In the genus Deltavirus: Human T-lymphotropic virus 1 (HTLV-1) Human T-lymphotropic virus 2 (HTLV-2) In the genus [altmeyers.org]
Treatment
More about Retroviruses STD Treatment Guidelines (CDC) CDC’s latest treatment guidelines for STDs. [health.state.mn.us]
There is no recommended treatment for people with asymptomatic HTLV-1 infection. If adult T-cell leukemia-lymphoma (ATL) develops, treatment may include a combination of the antiretroviral drugs Retrovir (zidovudine) and interferon-alpha. [verywellhealth.com]
Your life expectancy with HIV can be long if you received treatment soon after becoming infected and are diligent about sticking to your treatments. [webmd.com]
But a variety of treatments can help to keep them managed. HIV treatment Specific antiviral medications, called antiretroviral therapy (ART), are available for the management of HIV. ART can help to reduce viral load in a person with HIV. [healthline.com]
The main objective is to determine whether treatment at primary infection for a limited duration delays damage to the immune system and prolongs time to initiation of long-term anti-HIV therapy. [sanger.ac.uk]
Prognosis
For seropositive individuals with mild or no signs of disease, including those in whom the virus can be demonstrated, the prognosis remains uncertain. [cdc.gov]
Etiology
HIV causes AIDS while HTLV-1 is the etiological agent for adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. Retrovirology aims to cover comprehensively all aspects of human and animal retrovirus research. [retrovirology.com]
Evidence implicates a retrovirus as the etiologic agent of acquired immunodeficiency syndrome (AIDS). Two prototype isolates have been described. [cdc.gov]
The observation that RNA was the source of genetic information in the causative agents of certain animal tumors led to a number of paradigm-shifting biologic insights regarding not only the direction of genetic information passage but also the viral etiology [accessmedicine.mhmedical.com]
Etiologic Agents Cellular Targets of Infection Course of Infection with HIV and SIV Immunopathogenic Mechanisms of HIV Infection Role of Lymphoid Organs in Immunopathogenesis Pathogenesis of Kaposi's Sarcoma and Other Opportunistic Neoplasms Tissue-Specific [ncbi.nlm.nih.gov]
Epidemiology
NHLBI Retrovirus Epidemiology Donor Study (REDS). Hepatology. 2000 Mar;31(3):756-62. doi: 10.1002/hep.510310329. [clinicaltrials.gov]
Growth and Assay of Pathogenic Retroviruses Oncogenesis Neurological Diseases Retrovirus-Induced Immunodeficiencies Other Retrovirus-Induced Diseases Host Genes that Influence Pathogenesis Transmission and Epidemiology Conclusion References Pathogenesis [ncbi.nlm.nih.gov]
Published Genome Data The reference sequence for the Human immunodeficiency virus 1 can be found here Studies Influenza sequencing HIV genome sequencing Viral Illumina Pilot (NoroVirus HIV AnyVirus) Bridging the Evolution and Epidemiology of HIV in Europe [sanger.ac.uk]
Affiliations and Expertise Vice Dean for Research & Graduate Studies Associate Vice President for Health Sciences Research Co-Director, Medical Scientist Training Program Professor of Medicine and Microbiology & Immunology, Division of Infectious Diseases and Epidemiology [elsevier.com]
Pathophysiology
Our current understanding of the pathophysiology of HIV infection suggests that prolonged ‐‐ and possibily life‐long ‐‐ therapy will be required to maintain suppression of HIV ( Havlir 1996 ). [doi.org]
Prevention
Minnesota Family Planning and STD Hotline Toll-free hotline for confidential information about the prevention, testing locations and treatment of STDs in Minnesota (1-800-78-FACTS). Last Updated: 10/19/2022 [health.state.mn.us]
Her research focuses on sexually transmitted infections, reproductive health and HIV prevention, care and treatment. Elizabeth Anne Bukusi Research Highlights | 23 February 2021 Mirella Bucci [nature.com]
Human Immunodeficiency Virus Transmission & Prevention The source of infection is from bodily fluids of the carrier such as semen or blood. [tolweb.org]
The Center focuses on the prevention and eradication of human retroviruses, the latency of which has made it a challenging global health problem. [ewww.kumamoto-u.ac.jp]
Abstention from IV drug usage and reduction of needle-sharing and other use of contaminated needles by IV drug users should also be effective in preventing transmission of the virus and of AIDS. [cdc.gov]