Abnormally large and/or present in unusual places bruising and bleeding are common. It is inherited as an autosomal dominant transmission. [accessanesthesiology.mhmedical.com]

From the age of 68 she began presenting Raynaud's phenomenon in the hands and feet without digital ulcers, xerostomia and xerophthalmia. [reumatologiaclinica.org]

Acronym REYNS Synonyms Primary biliary cirrhosis scleroderma Raynaud disease and telangiectasia Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. [uniprot.org]

The patient presented with fatigue, pruritus and dyspnea on exertion complaints. Liver function tests showed elevation of alkaline phosphatase and gamma-glutamyl transpeptidase. [journalmc.org]

Case Presentation: This paper reports the case of a 75-year-old woman who presented with some of the features mentioned above, severe PAH, dyspnea for one month and two weeks of purulent expectoration, as well as generalized pruritus, nasal telangiectasias [scielo.org.co]

• Pain

  Intensity of pain can vary from a dull minor pain, to intense sharp pain possibly causing momentary vision loss/blurriness and often loss of breath. [en.wikipedia.org]

  The nipple pain is so severe that it causes most women to stop breastfeeding. One of our mothers described her pain as a “vice clamped on my nipples.” [pediatrics.aappublications.org]

  It is important that you let your health visitor or breastfeeding counsellor know if you are experiencing severe pain. [netmums.com]

  Pain medication was discontinued, swelling and cramping was reduced and she had better function of both hands as well as improved sensitivity in both hands and feet. [baromedical.ca]

• Chills

  It has not returned this cold season yet, even tho I have chilled my fingers to an icy severe pain breaking up frozen hamburger. [mpkb.org]

  Winter weather brings cold temperatures, but some people feel the chill more than others. If you suffer from Raynaud's syndrome - also known as Raynaud’s phenomenon - your hands and feet can feel like blocks of ice. [express.co.uk]

  Be careful not to get chilled getting in and out of the tub or shower. If possible, have someone start your car and turn on the heater a few minutes before you leave the house. [healthnavigator.org.nz]

  But she sympathises when I describe feeling chilled to the bone, and seems rather interested when we put my hands in cold water and three fingertips blanch white. [telegraph.co.uk]

  Keep warm It is important not only to keep the extremities warm but also to avoid chilling any part of the body. In cold weather, people with Raynaud's must pay particular attention to dressing. [medic8.com]

• Finger Pain

  In acute situations in a patient with severe finger pain and bluish fingers, one may apply nitroglycerin gel (the same paste that is used for angina ). The effects are immediate, and most patients are relieved of the attack. [emedicinehealth.com]

• Weight Gain

  It will also help stabilize your moods during pregnancy, provide you with extra energy, and keep your weight gain in check. Manage Stress Raynaud's attacks can be brought about by stress. Try to reduce stress as much as you can to prevent attacks. [thebabycorner.com]

• Asymptomatic

  […] previously shown dermatologic and respiratory symptoms related to scleroderma, and laboratory findings were associated with the mitochondrial pattern of antinuclear antibodies 18; increased phosphatase alkaline without a high level of bilirubin suggests an asymptomatic [scielo.org.co]

• Splenomegaly

  Other features include relative macrocephaly, micrognathia, high-arched palate, splenomegaly, hypotonia, hypertonia, hydrocephalus and raised intracranial pressure, and brainstem atrophy (gait ataxia). [accessanesthesiology.mhmedical.com]

  […] transaminase High liver enzymes 0002910 Gastrointestinal hemorrhage Gastrointestinal bleeding 0002239 Hyperbilirubinemia High blood bilirubin levels 0002904 Lip telangiectasia 0000214 Palmar telangiectasia 0100869 Raynaud phenomenon 0030880 Scleroderma 0100324 Splenomegaly [rarediseases.info.nih.gov]

  Examine any joints that are sore, palpate the abdomen to exclude hepato/splenomegaly and check the lymph fields to detect any evidence of malignancy. [patient.info]

• Dyspnea

  The patient presented with fatigue, pruritus and dyspnea on exertion complaints. Liver function tests showed elevation of alkaline phosphatase and gamma-glutamyl transpeptidase. [journalmc.org]

  Consequently, RS was diagnosed and phosphodiesterase type-5 inhibitors were started for PAH treatment resulting in the improvement of dyspnea. [scielo.org.co]

• Abdominal Pain

  In 2008 the patient was admitted to the hospital with anorexia, dyspepsia, ascites, abdominal pain and weight loss. Endoscopy showed esophageal varices and abdominal computed tomography revealed cirrhotic liver. [journalmc.org]

• Pyrosis

  Further investigation revealed that the patient had a previous history of Raynaud's phenomenon and pyrosis. [scielo.org.co]

• Flushing

  With vasospasm, the fingers turn white and cold then blue with dilated veins followed by relaxation of the vessel and normal blood flow causing a red 'flushing'. [jointhealth.org]

  Once the area is warmed and blood flow returns, a tingling sensation may accompany a red flush and, possibly, swelling. There may also be a painful, throbbing sensation. [medicalnewstoday.com]

  The arteries dilate again, increasing blood flow and causing the affected fingers and toes to flush bright red. They may also feel warm and may throb painfully. [southerncross.co.nz]

  Heat is lost through the skin and we may look flushed. When we are cold, these same blood vessels allow less blood to flow through them, so less heat reaches the skin surface. [healthnavigator.org.nz]

  Patients with persistent or bothersome symptoms may be helped by taking oral medications to open (dilate) blood vessels,including calcium channel blockers - a modified release of this preparation reduces the common side effects of headache and flushing [familydoctor.co.nz]

• Tingling

  Raynaud’s syndrome, also called Raynaud’s disease or Raynaud’s phenomenon, is a disease that causes the blood vessels in the body to spasm during a change to cold temperature, which causes numbness, throbbing, tingling and pain in the fingers and toes [healio.com]

  When blood flow returns, these areas may turn red, throb, tingle and burn. Raynaud’s attacks can last from a few seconds to several hours. Their occurrence can range from daily to weekly. [aurorahealthcare.org]

  Numbness or tingling most frequently occurs in the toes or fingers but in some cases numbness in the earlobes, nose, or lips can also be experienced. Cold weather and stress may intensify numbness and tingling caused by Raynaud’s disease. [nativeremedies.com]

  Warmth, tingling and throbbing. The quick return of blood to the fingers triggers these feelings. Skin ulcers and gangrene. [arthritis.org]

  When the blood flow returns, the skin turns red and throbs or tingles. In severe cases, loss of blood flow can cause sores or tissue death. Primary Raynaud's happens on its own. The cause is unknown. [medlineplus.gov]

• Stroke

  Stress in general can also play a role in strokes. The hormones from stress can cause plaque that is already in the artery to rupture. Dr. Wittstein explains that there is a way for broken heart syndrome to cause a stroke. [nbcnews.com]

  Infant stroke and beta-2-glycoprotein 1 antibodies: Six cases. Eur J Pediatr 2003; 162: 678-681. [journals.sagepub.com]

  Just a day after Carrie Fisher passed away, her mother, legendary actress Debbie Reynolds, also died at the age of 84, reportedly from a stroke. [refinery29.com]

  Doubles Risk of Coronary Artery Disease and Stroke A 1998 study indicated that people who have Raynaud's may have double the risk of coronary artery disease and stroke. "Hopkins: Is Raynaud's a Predictor of Heart Disease?" by Fredrick M. [sclero.org]

  These include herniated discs in the spine, strokes, tumors within the spinal cord, polio, and carpal tunnel syndrome. Other blood disorders. Trauma. [encyclopedia.com]

• Seizure

  […] orthopedic deformations (hyperextensible fingers, multiple palmar creases, multiple plantar creases), cutaneous lesions (severe atopic dermatitis, ichthyosis, hyperkeratosis, hypohidrosis), and neurological disturbance (mild to moderate mental retardation, seizures [accessanesthesiology.mhmedical.com]

  […] syndrome ハーラー症候群 GertrudHurler（1889-1965） Germanpediatrician Hutchinson ハッチンソン Hutchinson's teeth ハッチンソン歯 Hutchinson-Gilford ハッチンソン・ギルフォード Hutchinson-Gilford syndrome ハッチンソン・ギルフォード症候群 Ivemark イヴェマルク Ivemark syndrome イヴェマルク症候群 Jackson ジャクソン jacksonian seizure [jams.med.or.jp]

• Hypercholesterolemia

  Hyperlipidemia and hypercholesterolemia are common (22) – use of medication to lower such as statins do not yet have an established role in CNS. [dovepress.com]

• Alkaline Phosphatase Increased

  phosphatase Greatly elevated alkaline phosphatase High serum alkaline phosphatase Increased alkaline phosphatase Increased serum alkaline phosphatase [ more ] 0003155 Elevated hepatic transaminase High liver enzymes 0002910 Gastrointestinal hemorrhage [rarediseases.info.nih.gov]

Patients were seen after two and four weeks of treatment and at the end of the 10-week treatment phase. Blood samples pre- and post-treatment were taken for haemorrheology. [raysahelian.com]

The effects of each treatment are accumulative, and therefore a course of treatments will be recommended. [healthrenewal.co.za]

As with any alternative treatment option, or taking any supplement, be sure to talk to your doctor before adding it to your treatment plan. [mollysfund.org]

Are There Alternative Medicine Treatments for Raynaud's Phenomenon? Many alternative care products and health supplements are sold for the treatment of Raynaud's phenomenon. [emedicinehealth.com]

It was the first year in his young life he didn’t have to be admitted into a hospital –not that he didn’t have a few medical scares that required treatment. [my.clevelandclinic.org]

Prognosis - Reynolds syndrome Not supplied. Treatment - Reynolds syndrome Not supplied. Resources - Reynolds syndrome Not supplied. [checkorphan.org]

Expected results The prognosis for most people with Raynaud's disease is very good. In general, primary Raynaud's disease has the best prognosis, with a relatively small chance for serious complications (1%). [encyclopedia.com]

Scleroderma should be considered and, additionally, PAH should be investigated since it is present in up to 10% of patients, conferring a worse prognosis. [scielo.org.co]

“This is all in the hopes of being able to offer better care and prognosis information to families, and potentially, to study the impact of future treatments.” [my.clevelandclinic.org]

What is the prognosis and treatment for this disease? The condition you are describing in your mother's fingers is compatible with Raynaud's phenomenon. [medicinenet.com]

Ascherman et al propose an autoimmune etiology, with cytokeratin 10 (K10) as a candidate autoantigen; their study in mice showed that anti-K10 antibodies can mediate ischemia similar to that seen in Raynaud phenomenon. [17] Possible causes for secondary [emedicine.medscape.com]

^ "Raynaud Phenomenon: Practice Essentials, Pathophysiology, Etiology". 6 December 2017. [en.wikipedia.org]

The etiology of congenital nephrotic syndrome: current status and challenges. World J Pediatr. 2016;12(2):149–158. doi:10.1007/s12519-016-0009-y 8. Wiggins RC. The spectrum of podocytopathies: a unifying view of glomerular diseases. [dovepress.com]

Objectives: To determine the epidemiological, clinical, paraclinical and evolutionary features of Reynolds syndrome Methods: We report 7 cases of Reynolds syndrome collected in the our department between 1996 and 2014 Results: There were 7 middle-aged [ard.bmj.com]

Epidemiology Affects 3-4% of U.S. adult population Predominately affects women by 3 to 1 ratio Onset from Puberty to age 30 years Family History responsible in 20-30% of patients III. [fpnotebook.com]

[…] to interact and contribute. [ 1 ] Note that Raynaud also has a type of gangrene (symmetrical gangrene of the extremities) and a sign (symmetrical, mottled cyanosis of extremities with patches of erythema and excessive sweating) named after him. [ 2 ] Epidemiology [patient.info]

Hematologic Collagen-vascular (autoimmune) Medication-induced (eg, cisplatin, bleomycin, beta-blockers) [18] Miscellaneous syndromes such as Fabry disease, [19] pheochromocytoma, lung adenocarcinoma, acromegaly, carpal tunnel syndrome, and myxedema Epidemiology [emedicine.medscape.com]

By epidemiological nexus with Chagas disease, a Chaga test was requested, but it reported a negative result. Source: Own elaboration based on the data obtained in the study. Fig 3 12-lead electrocardiogram. [scielo.org.co]

S2CID 8696332. ^ "Raynaud Phenomenon: Practice Essentials, Pathophysiology, Etiology". 6 December 2017. [en.wikipedia.org]

Pathophysiology Exaggerated response to cold Temperature s Increased Alpha Adrenergic Receptor responsiveness May be primary idiopathic or secondary cause IV. Causes: Secondary Causes of Raynaud's Phenomenon V. Causes: Provocative Factors VI. [fpnotebook.com]

Disease “recurrence” following transplant has been reported, though in truth it is the development of a different pathophysiology. [dovepress.com]

Pathophysiology In individuals with Raynaud phenomenon, one or more body parts experience intense vasospasm with associated color change and subsequent hyperemia. [emedicine.medscape.com]

Pathophysiology and recent findings of primary biliary cirrhosis complicated by systemic sclerosis. Hepatol Res. 2014;44(4): 377-83. http://doi.org/bzfw. [ Links ] 18. Muratori L, Granito A, Muratori P, Pappas G, Bianchi FB. [scielo.org.co]

Prevention and care Prevention measures are important in primary and secondary Raynaud's syndrome regardless of the severity. Initial simple care: Keep the body warm, especially the extremities. Wear warm clothing in colder environments. [familydoctor.co.nz]

The goal is to prevent and manage symptoms, adopt a healthy lifestyle and improve blood circulation. [thebabycorner.com]

Is it possible to prevent Raynaud's phenomenon? Raynaud's phenomenon can be prevented by avoiding the precipitating factors, such as cold or heat exposure, smoking, etc. Certain medications should be avoided. [medicinenet.com]

Getting medical help may prevent a worsening of symptoms and serious complications. [medicalnewstoday.com]

Can One Prevent Raynaud's Phenomenon? Preventing the arteries from narrowing is the key to living successfully with Raynaud's phenomenon. Avoid cold weather. Dress in warm, loose-fitted layers of clothing. [emedicinehealth.com]