Presentation
The spotted fever rickettsia, Rickettsia helvetica, is mostly reported to present a flu-like self-limiting disease. [ncbi.nlm.nih.gov]
Entire Body System
- Fever
PATHOGENESIS: Typhus, spotted fever and trench fever are transmitted via arthropod vectors; Q fever is acquired via inhalation or ingestion of contaminated milk or food. [myplace.frontier.com]
A 17-year-old otherwise healthy girl was admitted to Department of Zoonotic and Tropical Diseases because of fever, eschar and rash. [ncbi.nlm.nih.gov]
On day 7 after the second onset of fever, the patient was able to work but still felt ill and had a slight fever (37.6°C). [doi.org]
- Anemia
[…] ovejas), Ixodes scapularis (garrapatas de ciervos) Síntomas (tiempo de incubación: de 5-7 días): Fiebre, linfadenitis, exantema Complicaciones (aprox. 13%): peri y miocarditis, insuficiencia renal, neumonía, encefalitis, sangrados gastrointestinales, anemia [arminlabs.com]
Bartonella bacilliformis transmitted by the sandfly in certain regions of Western South America invades human red blood cells, causing acute, often severe, hemolytic anemia. [ncbi.nlm.nih.gov]
- El Salvador
Regarding the typhus group rickettsioses, there is clinical or serological evidence of Rickettsia prowazekii in Guatemala, Rickettsia typhi in Panama, Guatemala, and Costa Rica and unidentified species of the typhus group in El Salvador. [dovepress.com]
Gastrointestinal
- Vomiting
Tabs Content Clinical Overview Diagnosis Indications for Testing Tick bite exposure and relevant epidemiologic setting Fever, headache, myalgia, nausea, vomiting; rash 2-5 days after fever Laboratory Testing Diagnosis and laboratory confirmation recommendations [arupconsult.com]
Other symptoms are general symptoms common with other types of infections such as vomiting, diarrhea, and abdominal pain. [web.uconn.edu]
Symptoms (incubation time: 5-7 days): Fever, nausea, vomiting, severe headache, lymphadenitis, exanthema. [arminlabs.com]
Patients infected with R. rickettsii generally have nonspecific symptoms including fever, nausea, vomiting, muscle pain, lack of appetite, and severe headache after an incubation period about 5-10 days following an infected tick bite. [microbewiki.kenyon.edu]
Patient 2: A 20-year-old male in contact with a dog presented with a 6-day history of fever up to 39.5°C, dry cough, arthralgias, myalgias, headache, sweating and vomiting. He showed a macular rash on the trunk and upper limbs without itching. [elsevier.es]
- Nausea
Tabs Content Clinical Overview Diagnosis Indications for Testing Tick bite exposure and relevant epidemiologic setting Fever, headache, myalgia, nausea, vomiting; rash 2-5 days after fever Laboratory Testing Diagnosis and laboratory confirmation recommendations [arupconsult.com]
Symptoms (incubation time: 5-7 days): Fever, nausea, vomiting, severe headache, lymphadenitis, exanthema. [arminlabs.com]
Experience of the self-reported symptoms nausea (p = 0.006) and radiating pain (p = 0.041) was more common among those with recent, current or probable infection compared to those who did not seroconvert. [ncbi.nlm.nih.gov]
She returned four days later with persistent fever, anorexia, irritability, photophobia, cough, diffuse myalgias, nausea, vomiting, and a rash. [web.uconn.edu]
Patients infected with R. rickettsii generally have nonspecific symptoms including fever, nausea, vomiting, muscle pain, lack of appetite, and severe headache after an incubation period about 5-10 days following an infected tick bite. [microbewiki.kenyon.edu]
Skin
- Skin Rash
Most rickettisal species produce a constellation of high fever, headaches, and skin rash. Most Rickettsial species are transmitted by arthropod vectors during blood meals. Treatment for all Rickettsial diseases is doxycycline or chloramphenicol. [pathwaymedicine.org]
This is followed by dissemination via the vascular system producing vasculitis and a skin rash. These lesions may become necrotic. [myplace.frontier.com]
Rash (small, tiny bumps on the skin) normally starts on the limbs and may eventually involve the whole body. [tickbites.net]
Some other conditions that may be confused with tick bite fever are infection with Neisseria meningitidis (the meningococcus, which causes meningitis and a skin rash), measles and German measles. [health24.com]
- Eruptions
Several days after an eschar appears, the following can develop: Fever Headache Rash (sparse maculopapular or papulovesicular eruptions on the trunk and extremities) Muscle aches NOTE: R. parkeri rickettsiosis can be difficult to distinguish from RMSF [cdc.gov]
The infection tends to be moderate to severe and a generalised maculopapular eruption is seen. The systemic features of epidemic louse-borne typhus include neurological symptoms (eg, deafness and delirium) and abdominal pain. [dermnetnz.org]
The rash is a diffuse macular (featuring elevated discoloration) rash, is most prominent on wrists and ankles, which will usually erupt three or four days after the onset of fever. [web.uconn.edu]
Cutaneous eruptions in Indian tick typhus. Int J Dermatol. In article [7] Current medical diagnosis and treatment-2015. Chapter 32-rickettsial disease. [pubs.sciepub.com]
She had a temperature of 39°C and a widespread macular, blanching eruption over her trunk and limbs, including the palms and soles. [mja.com.au]
Psychiatrical
- Suggestibility
These data suggest that NLRP3 inflammasome plays a role in host control of bacteria in vivo in a tissue-specific manner. [ncbi.nlm.nih.gov]
Neurologic
- Headache
Clinical features are generally mild, characterized by eschar, fever, headache, malaise and lymphadenopathy. Antigenic similarity among rickettsiae leads to cross-reactive antibody responses; definitive diagnosis requires molecular methods. [ncbi.nlm.nih.gov]
She was febrile (38.5°C) and reported headache, nausea, and abdominal pain. She had no eschar or rash. [doi.org]
Usually a fever accompanies the appearance of the eschar along with other discomforts such as headache. Lymph nodes near the site usually swell. [tickbites.net]
Workup
Microbiology
- Rickettsia Typhi
Vectors for rickettsia typhi Classification of rickettsia typhi Epidemic louse-borne typhus Epidemic louse-borne typhus is distributed worldwide but is associated with emergency situations. [dermnetnz.org]
KEYWORDS: California; Ctenocephalides felis; Rickettsia felis; Rickettsia typhi; cat flea [ncbi.nlm.nih.gov]
References for Rickettsia typhi Complete Genome Sequence of Rickettsia typhi and Comparison with Sequences of Other Rickettsiae. McLeod, M.P. et al. J. Bacteriol. 2004 186: 5842-5855. [hgsc.bcm.edu]
- Rickettsia Prowazekii
prowazekii/genetics* Rickettsia prowazekii/pathogenicity Transcription, Genetic Virulence/genetics Substances DNA, Bacterial DNA, Mitochondrial Membrane Proteins Secondary source ID GENBANK/AJ235270 GENBANK/AJ235271 GENBANK/AJ235272 GENBANK/AJ235273 [ncbi.nlm.nih.gov]
Affiliations PMID: 9823893 DOI: 10.1038/24094 The genome sequence of Rickettsia prowazekii and the origin of mitochondria S G Andersson et al. Nature. 1998. [pubmed.ncbi.nlm.nih.gov]
Genome information T number T00018 Org code rpr Aliases RICPR, 272947 Full name Rickettsia prowazekii Madrid E Definition Rickettsia prowazekii Madrid E Annotation manual Taxonomy TAX: 272947 Lineage Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales [genome.jp]
Other Rickettsia include Rickettsia prowazekii, which causes typhus, R. rickettsii, which causes Rocky Mountain spotted fever, and Rickettsia akari, which causes rickettsialpox. [microbewiki.kenyon.edu]
- Rickettsia Rickettsii
R. rickettsii is the only Rickettsia species that utilizes ABM. [web.uconn.edu]
Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa. Infect Immun 76(2):542-50. Fournier PE, et al., 2009. [mgc.ac.cn]
Key Words: Rickettsia rickettsii, Brazilian spotted fever, sepsis, ARDS. Rickettsia rickettsii infections can cause a wide range of clinical manifestations, ranging from asymptomatic or mild febrile illness to overwhelming and fatal disease [1-6]. [scielo.br]
Serological antibody-absorption tests with purified antigens of R. parkeri and Rickettsia rickettsii, associated with immunofluorescence assay indicated that the patients in two cases were infected by R. parkeri. [ncbi.nlm.nih.gov]
What are Rickettsia rickettsii (Rocky Mountain spotted fever) and other Rickettsia species? The Rickettsiae are a genus of Gram-negative coccobacilli, which includes two major groups of bacteria. [youtube.com]
- Rickettsia Conorii
[…] infection.tif 2.216 × 1.784; 825 KB Rickettsia conorii in cytoplasm.gif 600 × 480; 265 KB Rickettsia conorii in Vero.gif 600 × 450; 138 KB Rickettsia rickettsii.jpg 297 × 278; 17 KB Rickettsia rpsL leader.pdf 1.275 × 1.650; 8 KB Rickettsia rpsL leader.png [commons.wikimedia.org]
Nine ticks tested positive for Ri. conorii subsp. caspia (marking the first documentation of this subspecies in France), 7 tested positive for Ri. massiliae, and 4 tested positive for both rickettsiae. [ncbi.nlm.nih.gov]
Pruebas disponibles para Rickettsia PCR Rickettsia-DNA-PCR en sangre (2x tubo EDTA) Bacteria Vectores Síntomas Complicaciones Bacteria: Rickettsia conorii, R. rickettsii, R. helvetica, R. slovaca, R. prowazekii (no reacciona a la tinción de gram, intracelular [arminlabs.com]
Philip, 1950 Species Rickettsia bellii Philip et al., 1983 Species Rickettsia canadensis McKiel et al., 1967 Species Rickettsia conorii Brumpt, 1932 Species Rickettsia felis Bouyer et al., 2001 emend. [itis.gov]
- Chlamydia
(Foggie, 1949) Dumler et al., 2001 Species Rickettsia psittaci Lillie, 1930 accepted as Chlamydophila psittaci (Lillie 1930) Everett et al., 1999 Species Rickettsia psittaci Lillie, 1930 accepted as Chlamydia psittaci (Lillie 1930) Page, 1968 Species [irmng.org]
Rickettsiae are, like chlamydia, compulsory intracellular parasite bacteria of small size (300 nm). They live in the cytoplasm of eukaryotic cells. [arminlabs.com]
Joseph T, Nano FE, Garon CF, Caldwell HD (1986) Molecular characterization of Chlamydia trachomatis and Chlamydia psittaci plasmids. Infect Immun 51: 699–703. View Article Google Scholar 33. [doi.org]
Immunofluorescence is still the gold standard technique for the serological diagnosis of some parameters such as Bartonella, Coxiella, Legionella, Chlamydia, Rickettsia, etc. [en.vircell.com]
Treatment
Increased recognition of QTT will enable consideration of and prompt treatment of R. australis infection by clinicians in Australia. [ncbi.nlm.nih.gov]
Treatment: Antimicrobial treatment as recommended by the doctor. Immunisation: None available. Case follow up: Is conducted by Public Health Units and the Communicable Disease Control Directorate. [ww2.health.wa.gov.au]
Treatment Treatment is usually with the tetracycline antibiotic doxycycline which reduces the duration and severity of infection. Prevention Exclusion of people with rickettsial infections from childcare, preschool, school and work is not necessary. [sahealth.sa.gov.au]
Treatment of RMSF Rocky Mountain spotted fever in pregnancy The most effective treatment is tetracycline. [babymed.com]
Prognosis
Identification of specific etiology is important for appropriate treatment in order to optimize prognosis. [n.neurology.org]
No influence of GB virus C replication on the prognosis in a cohort of HIV‐1‐infected patients, AIDS, 2002, vol. 16 (pg. 2482 - 5 ) 16. [doi.org]
Etiology
Rickettsia was suggested as one etiology of Buerger's disease long ago. We report a patient with Buerger's disease for whom a left below-knee amputation was done. [ncbi.nlm.nih.gov]
Identification of specific etiology is important for appropriate treatment in order to optimize prognosis. [n.neurology.org]
Rickettsia IFA IgM For the detection and semi-quantitation of IgM antibodies to R. rickettsii, the etiologic agent of Rocky Mountain spotted fever, and to R. typhi, the etiologic agent of murine typhus, in human serum. [focusdx.com]
Epidemiology
Epidemiological and clinical evidences, coupled with our serological analysis, suggest that R. parkeri is the etiological agent of human cases of spotted fever in Uruguay, a disease that has been recognized in that country as cutaneous-ganglionar rickettsiosis [ncbi.nlm.nih.gov]
Pathophysiology
His particular research focus encompasses the characterisation of an animal model for transmission and immuno-pathophysiology studies in scrub typhus, building towards vaccine development. [ndm.ox.ac.uk]
MORU also has ongoing studies to determine the pathophysiological mechanisms of scrub typhus infection. [tropmedres.ac]
Host- and microbe-related risk factors for and pathophysiology of fatal Rickettsia conorii infection in Portuguese patients. J Infect Dis 198 : 576 – 585. 49. Horney LF ,, Walker DH. 1988. [asmscience.org]
Prevention
Prevention Exclusion of people with rickettsial infections from childcare, preschool, school and work is not necessary. There is no vaccine available to prevent infection. [sahealth.sa.gov.au]
Prevention of rickettsia typhi There are no existing vaccines for rickettsial infections. Rickettsial infections can be prevented by taking measures to reduce exposure to lice and fleas. [dermnetnz.org]
That, together with it being treatable and as such preventable, makes a huge case. [ndm.ox.ac.uk]