Presentation
Abstract The present study evaluated rickettsial infection in Amblyomma spp. ticks collected in a farm in Coronel Pacheco, a Brazilian spotted fever (BSF) endemic area. [ncbi.nlm.nih.gov]
The present study evaluated rickettsial infection in Amblyomma spp. ticks collected in a farm in Coronel Pacheco, a Brazilian spotted fever (BSF) endemic area. [scielo.br]
It presents high mortality rates in Brazil, with transmission to humans or animals through the bite of infected ticks. [uel.br]
There are 680 hypothetical proteins (HPs) present in the genome of R. rickettsii. [eurekaselect.com]
Cardiovascular
- Thrombosis
The skin rash consists of hemorrhagic macules as well as petechiae caused by inflammation, occlusive thrombosis, and micro-hemorrhages from capillaries due to R. rickettsii infection of endothelial cells. Treatment Doxycycline or chloramphenicol [pathwaymedicine.org]
Skin
- Formication
High-performance LC–MS/MS and data analysis The desalting peptides were suspended in 0.1% formic acid and submitted to LC-MS/MS analysis. [parasitesandvectors.biomedcentral.com]
Neurologic
- Excitement
Forty-eight hours after exposure, the enzymatic activity was determined by measuring the release of the AMC fluorescent cleavage product from the synthetic fluorogenic substrate Ac-DEVD-AMC (emission excitation: 380–460 nm). [parasitesandvectors.biomedcentral.com]
Workup
Microbiology
- Leptospira Interrogans
Abstract Five serovars of Leptospira interrogans, Leptospira biflexa, Leptonema illini, and Rickettsia rickettsii were examined and found not to contain the 39-kDa antigen (P39) of Borrelia burgdorferi, the Lyme disease spirochete. [ncbi.nlm.nih.gov]
Lo M, Bulach DM, Powell DR, Haake DA, Matsunaga J, et al. (2006) Effects of temperature on gene expression patterns in Leptospira interrogans serovar Lai as assessed by whole-genome microarrays. Infect Immun 74: 5848–5859. [journals.plos.org]
Treatment
However, under all treatment conditions, a significant number of rickettsiae could be detected microscopically. [ncbi.nlm.nih.gov]
Prognosis
Identification of specific etiology is important for appropriate treatment in order to optimize prognosis. [n.neurology.org]
Predictors of prognosis and risk of acute renal failure in patients with Rocky Mountain spotted fever. 1996. [qmrawiki.canr.msu.edu]
Etiology
The present study confirms for the first time R. rickettsii as the etiological agent of a lethal spotted fever group rickettsiosis in human patients from Espírito Santo state. [ncbi.nlm.nih.gov]
Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group Data source GenBank (Assembly: GCA_000018225.1) BioProject: 9636 Keywords Human pathogen Disease H00323 Spotted fever Comment Etiologic [genome.jp]
Identification of specific etiology is important for appropriate treatment in order to optimize prognosis. [n.neurology.org]
Epidemiology
Web. 23 May 2012. ↑ Helmick CG, Bernard KW, D’Angelo LJ (1984) Rocky Mountain spotted fever: clinical, laboratory, and epidemiological features of 262 cases. [qmrawiki.canr.msu.edu]
Diagnosis Indications for Testing Tick bite exposure and relevant epidemiologic setting Fever, headache, myalgia, nausea, vomiting; rash 2-5 days after fever Laboratory Testing Diagnosis and laboratory confirmation recommendations (CDC) Antibiotic therapy [arupconsult.com]
Abstract Rickettsial diseases except those belonging to spotted fever group rickettsioses are poorly studied in South America particularly in Brazil where few epidemiological reports have been published. [ncbi.nlm.nih.gov]
To report a case, health care providers/facilities should call OCHCA Epidemiology at 714-834-8180, fax reports to 714-560-4050, or mail to P.O. Box 6128, Santa Ana, CA 92706-0128. [ochealthinfo.com]
We present here an overview of the various tick- and flea-borne rickettsial zoonoses described in the last 20 years, focusing on the ecological, epidemiological and clinical aspects. [doi.org]
Pathophysiology
Abstract Rickettsiae are arthropod-borne intracellular bacterial pathogens that primarily infect the microvascular endothelium leading to systemic spread of the organisms and the major pathophysiological effect, increased microvascular permeability, and [ncbi.nlm.nih.gov]
Prevention
Furthermore, treatment with 500 microM alpha-lipoic acid for 72 h p.i. completely prevented ultrastructural changes in infected cells. [ncbi.nlm.nih.gov]