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Rofecoxib

4 [4' (methylsulfonyl)phenyl] 3 Phenyl 2(5H) Furanone


Presentation

  • We present three cases of oral lesions caused by rofecoxib. Extensive erosions appeared, which in all cases resolved on withdrawal of the drug.[ncbi.nlm.nih.gov]
  • Consequently, the company will not update the information contained in the website and investors should not rely upon the information as current or accurate after the presentation date.[vioxx.com]
Italian
  • CONCLUSION: Rofecoxib withdrawal has markedly changed the prescribing pattern of drugs that are used in OA-related pain treatment, with a striking decrease of coxib use in Italian general practice.[ncbi.nlm.nih.gov]
  • Paola Giordano, Massimo Franchini, Giuseppe Lassandro, Maria Faienza, Roberto Valente and Angelo Molinari, Issues in pediatric haemophilia care, Italian Journal of Pediatrics, 39, 1, (24), (2013).[doi.org]
  • ., Inc’s Motion to Dismiss the Foreign Class Actions, as it relates to the Italian and French class action complaints, under the doctrine of forum non conveniens. Order & Reasons dated August 30, 2006.[laed.uscourts.gov]
Hunting
  • Hunt R, Bowen B, James C, et al. COX-2 specific inhibition with MK-0966 25 or 50 mg q.d. over 4 weeks does not increase fecal blood loss: a controlled study with placebo and ibuprofen 800 mg t.i.d [abstract 247].[doi.org]
  • Google Scholar 9 Hunt RH, Bowen B, Mortensen ER, et al. Fecal blood loss after specific inhibition of cyclo-oxygenase-2: treatment with rofecoxib compared with ibuprofen and placebo in healthy subjects. Am J Med. In press.[ahajournals.org]
Intermittent Claudication
  • claudication. 17 In contrast to naproxen and indobufen, the NSAID comparators used in the rofecoxib osteoarthritis phase IIb/III clinical trials program (ibuprofen, diclofenac, and nabumetone) all have less pronounced and/or less sustained antiplatelet[doi.org]
Hypothermia
  • Hypothermia significantly reduced neuronal damage in both transgenic mice and wild type controls to the same extent, suggesting that the aggravating effect of COX-2 could be largely eliminated by hypothermia.[ncbi.nlm.nih.gov]
Flame-shaped Hemorrhage
  • A 68-year-old female with severe osteoporosis developed a BRVO with flame-shaped hemorrhages in the superior hemisphere OS 1 day after taking rofecoxib (25 mg) daily.[ncbi.nlm.nih.gov]
Leg Pain
  • A 68-year-old woman with bipolar disorder under long-term treatment with lithium, carbamazepine, pipamperon, and mirtazapine was prescribed rofecoxib 25 mg twice daily for the treatment of leg pain.[ncbi.nlm.nih.gov]
Severe Osteoporosis
  • A 68-year-old female with severe osteoporosis developed a BRVO with flame-shaped hemorrhages in the superior hemisphere OS 1 day after taking rofecoxib (25 mg) daily.[ncbi.nlm.nih.gov]
Hip Pain
  • A 47-year-old American male took Vioxx for 1 week to relieve hip pain and noticed temporarily decreased vision OD. A month later, he resumed taking Vioxx and noticed a progressive decline in his VA with persistent cloudiness.[ncbi.nlm.nih.gov]

Workup

Dyslipidemia
  • Coxib-induced infarctions apparently have been considered to be "special" infarctions because they generally are attributed to thromboxane rather than to dyslipidemia.[ncbi.nlm.nih.gov]

Treatment

  • However, after early termination of treatment because of cardiovascular toxicity, we attempted to follow up all randomised patients for at least 1 year after stopping study treatment.[ncbi.nlm.nih.gov]

Prognosis

  • In addition, COX-2 expression did not correlate with prognosis overall or predict effectiveness of COX-2 inhibitors.[ncbi.nlm.nih.gov]
  • Points: Least Squares Mean (Standard Error) Scores with Difference and 95% Confidence Interval The post hoc analysis comparing test scores in overlapping subgroups of patients with MMSE scores of 24–26 in the present study (the subgroup with the worst prognosis[nature.com]

Etiology

  • Several secondary causes are implicated in the etiology of idiopathic intracranial hypertension.[ncbi.nlm.nih.gov]
  • This PHI assessment goes far beyond single endpoints as is the case in trials and classical epidemiologic (etiologic) research.[bmj.com]
  • […] that the MCI concept was relatively new at the time the study was initiated, along with the source of the patients (advertising campaigns as well as direct clinical referrals), may have also resulted in greater heterogeneity with regard to underlying etiology[nature.com]

Epidemiology

  • Evidence that inflammatory mechanisms contribute to neuronal injury in Alzheimer's disease along with a number of epidemiological studies suggests that non-steroidal anti-inflammatory drugs (NSAIDs) may slow the rate of cognitive deterioration.[clinicaltrials.gov]
  • The FDA also sponsored one of the large epidemiologic studies performed in a cohort of Kaiser Permanente patients. Risk of Myocardial Infarction (MI) or Stroke Associated with Rofecoxib Use.[nejm.org]
  • Finally, a series of epidemiologic analyses have also raised questions about the cardiovascular safety of the coxibs.[doi.org]
  • This PHI assessment goes far beyond single endpoints as is the case in trials and classical epidemiologic (etiologic) research.[bmj.com]
Sex distribution
Age distribution

Pathophysiology

  • A causal relationship between the start of rofecoxib treatment and the colon ischemia cannot be definitely established on the basis of the evidence, but the temporal relationship is striking and the pathophysiological rationale could be founded.[ncbi.nlm.nih.gov]
  • The pathophysiology of joint damage in such patients involves inflammation and angiogenesis.[bloodjournal.org]
  • Rofecoxib effectively treated primary dysmenorrhea, and cyclooxygenase-2–derived prostanoids play a role in the pathophysiology of primary dysmenorrhea.[journals.lww.com]
  • Rofecoxib was associated with a greater risk for MI , but the exact significance and pathophysiology of this possible relationship is unclear. Rofecoxib was voluntarily withdrawn from global markets in October 2004.[cochrane.org]
  • Sleisenger and Fordtran's gastrointestinal and liver disease: pathophysiology/diagnosis/management. 6th ed. Vol. 1. Philadelphia: W.B. Saunders, 1998:343-57. 6. Meade EA, Smith WL, DeWitt DL.[doi.org]

Prevention

  • PATIENTS AND METHODS: A prospective two-stage study design for phase 2 clinical trials with 42 patients was used to determine if rofecoxib (a COX-2 inhibitor) 50 mg oral for 7 days prevents heterotopic ossification.[ncbi.nlm.nih.gov]

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