The aim of this study was to investigate the presentation and complications of rotavirus compared to non-rotavirus gastroenteritis in UK children. [ncbi.nlm.nih.gov]

We excluded articles that did not present overall impact estimates, including those that compared subnational populations or those that presented rotavirus strain–specific impact. [doi.org]

• Fever

  The typical course for cases of bacterial superinfection involves a second peak of high fever; other clinical signs are variable. Septicemia after rotavirus gastroenteritis is a rare but dangerous entity. [ncbi.nlm.nih.gov]

  Or a fever that lasts for 3 days in a child 2 years or older. [saintlukeskc.org]

  Symptoms include: vomiting fever watery diarrhoea. The onset is sudden and symptoms last for an average of 3 to 7 days. The illness may cause severe dehydration and require treatment in hospital. [sahealth.sa.gov.au]

  Rotavirus infection is characterized by the abrupt onset of fever and vomiting followed by watery diarrhea. [doi.org]

• Pain

  Abdominal pain Severe vomiting and diarrhoea Dehydration Death from untreated dehydration Common responses Mild diarrhoea or vomiting Abdominal pain Rare response Intussusception (bowel obstruction) [immune.org.nz]

  The most common symptoms of rotavirus are severe watery diarrhea, vomiting, fever, and/or abdominal pain. Symptoms usually start about 2 days after a person is exposed to rotavirus. Vomiting and watery diarrhea can last 3 to 8 days. [cdc.gov]

  Symptoms include: • Fever • Vomiting • Diarrhea • Abdominal pain Vomiting and watery diarrhea may last from 3 to 8 days in a child who is infected with rotavirus. [stopfoodborneillness.org]

  The infection can cause abdominal pain as well. In healthy adults, a rotavirus infection may cause only mild signs and symptoms or none at all. [mayoclinic.org]

  Caring for Your Child After Rotavirus Immunization For pain and fever, check with your doctor to see if you can give either acetaminophen or ibuprofen, and to find out the appropriate dose. [kidshealth.org]

• Inflammation

  Rotavirus can cause gastrointestinal infections (inflammation of the stomach and intestines). It is most common in very young children. This infectious disease leads to inflammation of the stomach and intestines. [rivm.nl]

  Rotavirus, a common cause of viral diarrhea, causes an inflammation of the stomach and intestines known as gastroenteritis. Besides severe watery diarrhea, rotavirus causes vomiting and can lead to dehydration and even death. [livestrong.com]

  Rotavirus is a contagious virus that can cause gastroenteritis (inflammation of the stomach and intestines). Symptoms include severe watery diarrhea, vomiting, fever, and abdominal pain. [cdc.gov]

  Rotavirus is the leading cause of deadly diarrhoea in children worldwide DISEASE BURDEN Rotavirus is a virus that can cause inflammation of the stomach and intestines. [gavi.org]

• High Fever

  The illness is usually associated with high fever, severe vomiting and diarrhoea which frequently lead to dehydration and hospital admission. The illness can last 6 to 9 days. [stagnessurgery.com.au]

  The typical course for cases of bacterial superinfection involves a second peak of high fever; other clinical signs are variable. Septicemia after rotavirus gastroenteritis is a rare but dangerous entity. [ncbi.nlm.nih.gov]

  Children can also experience: vomiting severe fatigue a high fever irritability dehydration abdominal pain Dehydration is the greatest concern in children. [healthline.com]

  fever has blood in their poop or vomit is vomiting for more than 24 hours or diarrhea is not getting better after several days [kidshealth.org]

• Swelling

  The hallmark sign of mumps is swelling of the salivary glands. [+] more Rubella Rubella Rubella (German measles) is a contagious viral disease that can cause fever, rash, swollen glands and arthritis. [immunizeforgood.com]

  If you see signs of a severe allergic reaction (hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness), call 9-1-1 and get the person to the nearest hospital. [cdc.gov]

  Sometimes in late stages the macula, the area of the retina responsible for central vision, swells. This swelling is called macular edema and affects central vision. [merckmanuals.com]

  This may include hives, difficulty breathing, or swelling of the throat, tongue, or lips. The chance of true anaphylaxis is about 1 in 1 million vaccine doses. Should this reaction occur, your health care provider is prepared to treat it. [immunizebc.ca]

  Make regular visits to an eye care specialist, who can detect cataracts or retinal swelling. Both of these problems can be treated. The disorder will continue to progress slowly. Complete blindness is uncommon. [medlineplus.gov]

• Pneumonia

  KEYWORDS: Rotavirus; Sentinel surveillance; Streptococcus pneumoniae; Vaccination [ncbi.nlm.nih.gov]

  Pneumonia severity index in viral community acquired pneumonia in adults. PLoS One. 2019. 14 (3):e0210102. [Medline]. [Full Text]. McLaren SH, Mistry RD, Neuman MI, Florin TA, Dayan PS. [medscape.com]

  Flu may be complicated by other risk factors, including pneumonia. [+] more Hepatitis B Hepatitis B Hepatitis B virus (HBV) affects the liver and is primarily spread through blood and bodily fluids. [immunizeforgood.com]

  The alliance says that this is “a major step towards protecting children against severe diarrhoea and pneumonia—the two leading child killers.” [doi.org]

• Cough

  Prevention includes observing good respiratory-hygiene (cough and sneeze etiquette) and hand-hygiene (frequent, thorough handwashing) measures. [tripprep.com]

  [+] more Pertussis (Whooping Cough) Pertussis (Whooping Cough) Pertussis (Whooping Cough) is a highly contagious bacterial respiratory disease. [immunizeforgood.com]

  Adverse Reactions: Reactions to the vaccine are uncommon – some children developed diarrhoea, vomiting, fever, runny nose, cough or wheeze and ear infection in the period after vaccination but the incidence was around the same as children not vaccinated [stagnessurgery.com.au]

  Occasionally it can be passed on through droplets coughed or sneezed into the air. Older children and adults can be infected without showing the usual symptoms. This can help rotavirus infections to be passed on in a community. [vk.ovg.ox.ac.uk]

• Diarrhea

  Diarrhea-Related Deaths Figure 1. Figure 1. Number of Diarrhea-Related Deaths among Children 59 Months of Age or Younger from July 2002 through May 2009 in Mexico, According to Age Group. [doi.org]

  001.0–005.9 (excluding 003.2) and 008.0–008.5; parasitic intestinal disease, 006.0–007.9 (excluding 006.3–006.6); presumed infectious diarrhea, 009.0–009.3; presumed noninfectious diarrhea, 558.9; and diarrhea not otherwise specified, 787.91. [pediatrics.aappublications.org]

• Vomiting

  Infectious gastroenteritis (vomiting and diarrhea ) may be caused (in order of frequency) either by viral, bacterial, or fungal agents. There are four viral families that cause the bulk of gastroenteritis. [emedicinehealth.com]

  Children with diarrhoea or vomiting should not attend school or childcare centres until diarrhoea or vomiting has stopped for at least 48 hours. [immune.org.nz]

  Rotavirus gastroenteritis is characterized by fever, vomiting, and diarrhea, with vomiting particularly prominent. Dehydration is a frequent complication because of the severity of the diarrhea and the associated vomiting. [ncbi.nlm.nih.gov]

  The vaccine will not stop diarrhea or vomiting caused by other germs, though. [dph.illinois.gov]

• Acute Diarrhea

  For centuries, acute diarrhea has been a major worldwide cause of death in young children, and until 1973, no infectious agents could be identified in about 80% of patients admitted to hospital with severe dehydrating diarrhea. [ncbi.nlm.nih.gov]

  Abstract For centuries, acute diarrhea has been a major worldwide cause of death in young children, and until 1973, no infectious agents could be identified in about 80% of patients admitted to hospital with severe dehydrating diarrhea. [doi.org]

• Abdominal Cramps

  The affected person may also have headache, fever and abdominal cramps (“stomach ache”). [certest.es]

  Spread by faecal-oral transmission, rotavirus infection in adults typically manifests with nausea, malaise, headache, abdominal cramping, diarrhoea, and fever. Infection can also be symptomless. [ncbi.nlm.nih.gov]

  Signs and Symptoms Kids with a rotavirus infection have fever, nausea, and vomiting, often followed by abdominal cramps and frequent, watery diarrhea. Kids may also have a cough and runny nose. [kidshealth.org]

• Failure to Thrive

  We describe three infants, two with failure to thrive, who had dehydration and diarrhea within 1 month after their first or second rotavirus immunization and subsequently received a diagnosis of severe combined immunodeficiency. [ncbi.nlm.nih.gov]

  A child with severe combined immunodeficiency (SCID), a group of rare, life-threatening genetic disorders that affect the body’s ability to fight infection and often result in chronic diarrhea and failure to thrive. [babycenter.com]

• Suggestibility

  Characterization of nucleotide substitutions among Bang373, CAL-1, and ADRV suggested that all the gene segments might have evolved neutrally at similar mutation rates, while some of the gene segments (e.g., VP2 gene) were suggested to be more conserved [ncbi.nlm.nih.gov]

• Convulsions

  In Taiwan, 8 (6.4%) of 125 patients with rotavirus gastroenteritis had convulsions [26]. However, 68% of all patients had a fever with the diarrhea. In Japan, 35 (2.6%) of 1200 patients with rotavirus gastroenteritis had convulsions [27]. [academic.oup.com]

  KEYWORDS: Convulsion; Rotavirus; Seizures; Vaccine [ncbi.nlm.nih.gov]

It was felt that the anemia was associated with the long-term use of NTZ, thus an anemia workup was not initiated but would have been considered if the blood count had not improved. [healio.com]

See Workup for more detail. Management In most cases, no medication is required for rotavirus infection. Instead, attention should be directed to appropriate fluid intake and other conservative measures. [emedicine.com]

Furthermore, ondansetron reduced diarrhea episodes, most pronounced in children that had been sick for more than 3 days before treatment (p = 0.028). CONCLUSION: Ondansetron may be a beneficial treatment for children with rotavirus gastroenteritis. [ncbi.nlm.nih.gov]

Treatment Gastroenteritis is a common illness which can be particularly serious in young children. No specific antiviral treatment is available and antibiotics are not effective. [sahealth.sa.gov.au]

Traditional treatments for a rotavirus infection If your child develops rotavirus, she may not be able to attend daycare or school while ill. [childrenshospital.org]

Diarrheal Disease Treatment "Oral rehydration therapy is the best." [biomedcentral.com]

Prognosis Except for mild cases or sectorial RP, most cases progress to legal blindness (visual acuity < 1/20 and visual field < 5 degrees). The documents contained in this web site are presented for information purposes only. [orpha.net]

What is the prognosis of a rotavirus infection? Rotavirus infection is a self-limited disease that resolves after three to nine days of symptoms. Rarely, severe dehydration accompanying rotavirus infection has led to death. [medicinenet.com]

Outlook / Prognosis What’s the outlook for children with rotavirus? Most children recover from rotavirus without long-term health effects. Symptoms last about a week. [my.clevelandclinic.org]

Rotaviruses are members of the Reoviridae family of non-enveloped viruses and important etiologic agents of acute gastroenteritis in infants and young children. [ncbi.nlm.nih.gov]

It is the most important etiologic agent globally of diarrhea in children under 5 years of age (2). Two globally licensed vaccines (Rotarix and RotaTeq) have been developed for the control of human RVA (3). [mra.asm.org]

To enable greater understanding of the overall epidemiologic situation, rotavirus types found in animals in Europe are described. In addition, rotavirus types occurring in children outside Europe are considered. [ncbi.nlm.nih.gov]

In this review we intend to familiarise clinicians who primarily provide care for adult patients with the salient features of rotavirus pathophysiology, clinical presentation, epidemiology, treatment, and prevention. [ncbi.nlm.nih.gov]

Pathophysiology is complex and not fully understood Enterocytes at villous tips are initially infected; the virus binds surface carbohydrates and penetrates the cell membrane leading to transcription of viral RNA Damage to the mucosa leads to malabsorption [pathologyoutlines.com]

The pathophysiology of rotavirus diarrhea is clearly multifactoral. [doi.org]

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Rotavirus is a major cause of nonbacterial gastroenteritis, especially in infants and very young children (6 months-2 years of [mayocliniclabs.com]

Evo﹠Evo) talk 06:22, 27 April 2017 (UTC) Review by anonymous peer reviewer This review was submitted on 27 Apr 2017, and refers to this previous version of the article Content: The content is accurate and reflects the current state of rotavirus from a pathophysiology [en.wikiversity.org]

OBJECTIVES: To evaluate rotavirus vaccines approved for use (RV1, RV5, and LLR) for preventing rotavirus diarrhoea. [ncbi.nlm.nih.gov]

PREVENTION Unlike other types of diarrhoea, improving hygiene does not prevent rotavirus infection. Also, antibiotics and other drugs cannot cure rotavirus. [gavi.org]