Presentation
A very rare variant of lobular panniculitis, presenting with numerous large subcutaneous lesions, affecting children and occurring within the first 12 months of age. Lipogranulomatosis Subcutanea. First described by M. [accessanesthesiology.mhmedical.com]
Alpha1-antitrypsin deficiency panniculitis – tends to involve proximal extremities, ulceration and drainage of oily brown exudate is frequently observed, associated systemic manifestations (emphysema and cirrhosis) are usually present, and serum alpha1 [visualdx.com]
Neither necrosis nor vasculitis is present [19]. [encyclopedia.pub]
This volume includes the reports of several hundreds of speakers from all over the world as presented during the congress or delivered 6 weeks later. [books.google.it]
This summarical article presents inflammatory diseases of the subcutis in a systematic fashion, based on whether they are centered on fibrovascular septa or the adipose lobules, and whether morphologic vasculitis is present or not. [unboundmedicine.com]
Entire Body System
- Inflammation
Les Panniculites sont un groupe de maladie caractérisées par une inflammation de la couche graisseuse sous-cutanée (dite pannicule ou panniculus adiposus). [fr.dbpedia.org]
Select ↓ Attribute Value Relationship 1 Associated morphology (attribute) Lipogranuloma (morphologic abnormality) Relationship 2 Associated morphology (attribute) Focal inflammation (morphologic abnormality) Relationship 3 Associated morphology (attribute [vtsl.vetmed.vt.edu]
The panniculitis is an inflammation of subcutaneous fat responsible for fairly uniform clinical features including nodules and plaques, or swelling located in the subcutaneous tissue, occasionally progressing to atrophy of subcutaneous fat. [accessanesthesiology.mhmedical.com]
In reality, most types of panniculitis have both lobular and septal inflammation. Further classification is based on whether or not there is inflammation involving the blood vessels of the fat, i.e. vasculitis. [lymphedemapeople.com]
(Hrsg) Springer Verlag S 1465 Rothmann M (1894) On inflammation and atrophy of the subcutaneous fatty tissue. [altmeyers.org]
- Anemia
Term translation Owner English to German Medical Anton-Babinski syndrome Anton*-Babinski* Syndrom Siegfried Armbruster English to Chinese medicine Robert\'s syndrome 罗伯特(氏)综合征:裂唇,裂腭,晶体混浊,先天性心脏病,多囊肾等多发性畸形症 Han Li English to German Medical Benjamin\'s (anemia [proz.com]
The CD4 countwas unchanged (436/mL), the HIV viral load was non-detectable, and the anemia and thrombocytopenia hadresolved. [documents.tips]
[…] dysplastic nevus syndrome ectodermal dysplasia (hidrotic) ectodermal dysplasia (hypohidrotic) Ehlers-Danlos syndrome (EDS) eosinophilia-myalgia syndrome (EMS) epidermodysplasia verruciformis (EV) Fabry's disease familial Mediterranean fever (FMF) Fanconi's anemia [rr2.nakayamashoten.co.jp]
Laboratory findings may include a raised erythrocyte sedimentation rate (ESR), leukocytosis, and mild anemia. 3 Two clinical variants have been described. [basicmedicalkey.com]
Although it is often associated with hematological abnormalities such as anemia and hypercalcemia, SCFN in this patient presented with hyperbilirubinemia. [unboundmedicine.com]
- Weight Loss
Symptoms include tender skin nodules, and systemic signs such as weight loss and fatigue.Restated, an inflammatory disorder primarily localized in the subcutaneous fat is termed a "panniculitis," a group of disorders that may be challenging both for the [fr.dbpedia.org]
It predominantly affects middle age men of mediterranean origin A systemic disease, often associated with arthritis, fever, and weight loss. The cutaneous lesions consist of histiocytes, which are usually confined to the dermis. [icd9data.com]
Lupus erythematosus, sarcoidosis, granuloma annulare, Sweet's disease, acute sudden weight loss from gastrointestinal surgery, and infections including deep fungi and pyogens may present as lobular parmiculitis. [lymphedemapeople.com]
Nonpharmacological Recommendations Weight Loss Weight loss, although not specifically evaluated in patients with resistant hypertension, has a clear benefit in terms of reducing blood pressure and often allows for reduction in the number of prescribed [ahajournals.org]
AEs related to weight loss (decreased weight, anorexia and decreased appetite) were reported in 43 (7.7%) patients. [arthritis-research.biomedcentral.com]
- Candidiasis
Functional asplenia has complicated the course of autoimmune diseases other than SLE, such as candidiasis endocrinopathy syndrome and alopecia areata [5]. [tropicalmedandhygienejrnl.net]
Functional asplenia has complicated the course of autoimmune diseases other than SLE, such as candidiasis endocrinopathy syndrome and alopecia areata [ 5 ]. [rheumatology.oxfordjournals.org]
Chronic muco-cutaneous candidiasis and oral neoplasia. J Laryng Otol 1988; 102: 643-645. 4. Perheentupa J. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab 2006; 91: 2843-2850. [ncbi.nlm.nih.gov]
Childhood, Bullous Diabeticorum, Bullous Disorders, Bullous Pemphigoid, Burn, Buruli Ulcer, Buschke-Ollendorff Syndrome, Cafe-Au-Lait Spots, Caffey's Syndrome, Calcifying Epithelioma, Calcinosis Cutis And Osteoma Cutis, Callus, Campbell De'morgan Spot, Candidiasis [google.com]
- Pathologist
Look at other dictionaries: Rothmann-Makai syndrome — Roth·mann Ma·kai syndrome (rotґmahn mawґkoi) [Max Rothmann, German pathologist, 1868–1915; Endre Makai, Hungarian surgeon, 20th century] see under syndrome … Medical dictionary Liste der Hauterkrankungen [medicine.academic.ru]
Roth·mann-Ma·kai syndrome (rotґmahn mawґkoi) [Max Rothmann, German pathologist, 1868–1915; Endre Makai, Hungarian surgeon, 20th century] see under syndrome. Medical dictionary. 2011. [medicine.enacademic.com]
Rothman, a German pathologist, and E. Makai, a Hungarian surgeon, in 1900. Very rare. Belongs to the group of panniculitis. [accessanesthesiology.mhmedical.com]
[Review] Semin Diagn Pathol. 2017 May; 34(3):261-272.Wick MR SD The diagnosis of panniculitis is felt to be a confusing topic by some pathologists. [unboundmedicine.com]
Musculoskeletal
- Arthritis
From the reviews of the first edition: "The section on the differential diagnosis of arthritis is the most comprehensive treatise of the subject that I have seen." # New England Journal of Medicine# 1 "This is a book that one can pick up and read sections [books.google.es]
Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. [books.google.de]
Arthritis Rheum. 1990, 33: 160-172. [arthritis-research.biomedcentral.com]
- Fracture
Salter-Harris fracture Fracture involving growth plate. [wikem.org]
At that time the patient had presented with a minor fracture of the left ankle, and when the plaster was removed she was found to have irregular red discoloration on the outer part of the ankle. This subsequently spread to involve both shins. [tropicalmedandhygienejrnl.net]
Fibromyalgia as a predictor of complex regional pain syndrome after distal radius fracture. Hand (N Y) 2019;14:516–22. Cited Here [53]. Loftus AM, Nicholls MER, Mattingley JB, Bradshaw JL. [journals.lww.com]
Skin
- Erythema
Clinical variants of erythema nodosum have been described mainly in adults, including chronic erythema nodosum, erythema nodosum migrans, and subacute nodular migratory panniculitis. [plasticsurgerykey.com]
Histologically, erythema nodosum represents the prototype of septal panniculitis. [basicmedicalkey.com]
Erythema induratum of Bazin – occurs on the posterior aspects of the lower extremities, and ulceration is frequent; an etiologic relationship with tuberculosis is often demonstrated; histopathology reveals lobular panniculitis with vasculitis involving [visualdx.com]
Erythema Nodosum Support Group http://health.groups.yahoo.com/group/er ... sum_Group/ The website for the group Is Erythema Nodosum http://www.geocities.com/erythema_nodos ... _Page.html ............ [lymphedemapeople.com]
Erythema nodosum Erythematous condition (disorder) Inflammatory disease of subcutaneous fat including noninfectious granuloma (disorder) Subcutaneous nodule Vasculitis of the skin Name: Lipogranulomatosis subcutanea of Rothmann and Makai (disorder) See [snomedbrowser.com]
- Subcutaneous Nodule
Definition / general Subcutaneous nodules on the trunk and extremities which undergo spontaneous involution, and are not associated with systemic symptoms Microscopic (histologic) description Lipogranulomas of subcutis, but not in crops Differential diagnosis [pathologyoutlines.com]
On admission, subcutaneous nodules were recognized on bilateral upper arms, abdomen, gluteal regions and thighs. None of these nodules were associated with local heat or pain. [unboundmedicine.com]
On examination we observed multiple painless subcutaneous nodules on her back, right breast, left arm and shoulder and left thigh. These nodules were initially skin-colored, later bluish with some telangiectasias and skin atrophy (Figure1). [symbiosisonlinepublishing.com]
- Skin Lesion
Steroid treatment was effective on both skin lesions and mononeuropathy. Steroid treatment was effective on both skin lesions and mononeuropathy. [unboundmedicine.com]
Vascular access placement and fixation can be very difficult because of skin lesions. [accessanesthesiology.mhmedical.com]
Other skin manifestations include nodules, EN–like lesions, purpura, leg ulcers, and Raynaud symptoms [27][28]. [encyclopedia.pub]
- Alopecia
History also revealed Hashimoto's thyroiditis diagnosed at the age of 14 yr and the onset of alopecia areata at the age of 20 yr. [tropicalmedandhygienejrnl.net]
Areata, Alopecia Mucinosa, Alopecia Totalis, Alopecia Universalis, Androgenetic Alopecia, Scarring Alopecia, Amebiasis, Amputation Stump Dermatitis, Amyloidosis, Anagen Effluvium, Anaphylactoid Purpura, Anderson-Fabry Disease, Anemia, Anetoderma, Angiitis [google.com]
GENERALIZZATA B LICHEN PLANUS ATROFICO C LICHEN PLANUS ATROFICO DIFFUSO O ERITRODERMIA B LICHEN PLANUS BOLLOSO C LICHEN PLANUS BOLLOSO DIFFUSO O ERITRODERMIA B LICHEN PLANUS E ACUMINATO ATROFIZZANTE DIFFUSO-ERITRODERMIA B LICHEN PLANUS E ACUMINATO ATROFIZZANTE(ALOPECIA [yumpu.com]
- Skin Atrophy
These nodules were initially skin-colored, later bluish with some telangiectasias and skin atrophy (Figure1). Histology We took two biopsies from the shoulder and the back. [symbiosisonlinepublishing.com]
Workup
Serum
- Anisopoikilocytosis
A peripheral blood smear revealed anisopoikilocytosis and numerous Howell–Jolly bodies, indicating functional hyposplenism. [tropicalmedandhygienejrnl.net]
- Thrombocytosis
Economopoulos Accepted: 02 September 2005 Published: 18 October 2005 Sir, A 27-yr-old woman was referred for evaluation of mild anaemia, leucocytosis and thrombocytosis. [tropicalmedandhygienejrnl.net]
Economopoulos Published: 18 October 2005 Accepted: 02 September 2005 S ir, A 27-yr-old woman was referred for evaluation of mild anaemia, leucocytosis and thrombocytosis. [rheumatology.oxfordjournals.org]
- Howell-Jolly Bodies
A peripheral blood smear revealed anisopoikilocytosis and numerous Howell–Jolly bodies, indicating functional hyposplenism. [tropicalmedandhygienejrnl.net]
Other Pathologies
- Lymphocytic Infiltrate
Microscopic examination of skin biopsy showed lipolysis and diffuse lymphocyte infiltration (panniculitis) and perivascular lymphocyte infiltration was also observed. [unboundmedicine.com]
In the first stage, there is acute inflammation of the fat lobules with fat cell degeneration accompanied by an infiltrate of neutrophils, lymphocytes and macrophages. [tropicalmedandhygienejrnl.net]
Biopsy
- Foam Cell
Lobular panniculitis, focal granulomatous infiltrates, foam cells, giant cells, micropseudocysts. Differential diagnosis This section has been translated automatically. Internal therapy This section has been translated automatically. [altmeyers.org]
Finally, the foam cells are replaced by fibroblasts. The first two histological stages correspond to clinically apparent induration, while in the third stage atrophy of the skin may develop. There are no diagnostic laboratory findings. [tropicalmedandhygienejrnl.net]
Laboratory
- Leukocytosis
Laboratory findings may include a raised erythrocyte sedimentation rate (ESR), leukocytosis, and mild anemia. 3 Two clinical variants have been described. [basicmedicalkey.com]
Involvement of the bone marrow may produce anemia, leukocytosis or leukopenia, and bone pain. Hepatomegaly, steatorrhea, and intestinal perforation have also been reported. [lymphedemapeople.com]
Expressed prostatic fluid leukocytosis was not associated with prostatic tenderness. Conclusion Men with CP/CPPS have more tenderness compared to men without CPPS. [springermedizin.de]
Treatment
Rothmann-Makai syndrome Rothmund Rothmund syndrome Rothmund, August von Rothmund's syndrome Rothmund-Thomson syndrome Roth's spots Rothschild, Henri Jacques Nathanial Charles de rotifer rotigotine rotigotine transdermal system rotoblation Rotokinetic treatment [medical-dictionary.thefreedictionary.com]
Lindsley discuss recent developments in diagnosis, treatment, genetics, immunology, imaging, and more. [books.google.es]
Steroid treatment was effective on both skin lesions and mononeuropathy. Steroid treatment was effective on both skin lesions and mononeuropathy. [unboundmedicine.com]
Oral treatment with non-steroidal ibuprofen, short course of prednisolone (80 mg/d) tapered down, and pantoprazole was initiated with rapid improvement. [symbiosisonlinepublishing.com]
Prognosis
Textbook of Pediatric Rheumatology examines the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents, detailing the presentation, differential diagnosis, course, management, and prognosis [books.google.es]
The prognosis of SN is generally very poor, with a high fatality rate. We report the case of a full-term infant with delayed onset of SN showing good prognosis. [unboundmedicine.com]
The prognosis is excellent, and the disorder resolves spontaneously over a period of weeks to months. A biopsy is not usually required if the history of a cold exposure is reported. [encyclopedia.pub]
The prognosis depends upon the severity of the renal disease http://www.geocities.com/SoHo/Gallery/6 ... ulitis.htm ............ [lymphedemapeople.com]
The patients described had developed subcutaneous nodular lesions that progressed to necrosis, and the prognosis was very poor. [actasdermo.org]
Etiology
Erythema induratum of Bazin – occurs on the posterior aspects of the lower extremities, and ulceration is frequent; an etiologic relationship with tuberculosis is often demonstrated; histopathology reveals lobular panniculitis with vasculitis involving [visualdx.com]
Journal of the European Academy of Dermatology and Venereology: JEADV 17(4): 479-480, 2003 Lipo granulomatosis rothmann makai individual disease or poly etiological syndrome. [eurekamag.com]
Pathogenesis and histological features The etiology and pathogenesis of erythema nodosum are unknown. [basicmedicalkey.com]
DOI: http://dx.doi.org/10.15226/2378-1726/3/3/00129 Abstract Lipogranulomatosis subcutaneous (Rothmann-Makai) is a rare localized non-infectious panniculitis of unknown etiology. [symbiosisonlinepublishing.com]
[…] their high frequency in patients with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy.9 However, vascular dementia is not per se a marker of small vessel disease, and a control group with stroke of a different etiology [ahajournals.org]
Epidemiology
Epidemiological studies have shown that MS and its components may independently or combined increase PC risk [64]. [mdpi.com]
Descriptive epidemiology of low-back pain and its related medical care in the United States. Spine 1987 Apr;12(3):264-8. 60. Gran JT. An epidemiological survey of the signs and symptoms of ankylosing spondylitis. [iqb.es]
Epidemiology 2000; 11: 309-314. [ncbi.nlm.nih.gov]
Cancer Epidemiology Biomarkers and Prevention 1999, 8(4), 289-292. Chen G-F, Tang Y-M, Green B, Lin D-X, Guengerich FP, Daly AK, Caporaso NE, Kadlubar FF. [ncl.ac.uk]
Pathophysiology
We assessed EPVS in the basal ganglia and centrum semiovale separately because it is possible that due to their different locations and features, they may have distinct pathophysiologies. [ahajournals.org]
The pathophysiology of CP/CPPS involves the entire pelvis and not only the prostate. [springermedizin.de]
Saint's triad The coexistence of hiatal hernia, gallbladder disease, and diverticulosis in a patient; named after Saint, a South African surgeon; no pathophysiologic basis for the coexistence of all three processes, emphasizing that more than one disease [wikem.org]
The microbiome may be involved in a number of pathophysiological pathways. [mdpi.com]
Prevention
Prevention and management of infection in children with sickle cell anaemia. Paediatr Drugs 2001 ; 3 : 793 –801. 4 Kalhs P, Panzer S, Kletter K et al. Functional asplenia after bone marrow transplantation. [tropicalmedandhygienejrnl.net]
0% Emergent - ED Care Needed - Preventable/Avoidable - 0% Emergent - ED Care Needed - Not Preventable/Avoidable - 0% Primary diagnosis of injury 0% Primary diagnosis of mental health problems 0% Primary diagnosis of substance abuse 0% Primary diagnosis [codelay.com]
The reduction in hyperalgesia produced by morphine and DAMGO was prevented byH-d-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2(CTAP) and that of SNC80 was prevented by naltrindole. U50,488 had no effect on the decreased mechanical withdrawal thresholds. [jpet.aspetjournals.org]