Presentation
A very rare variant of lobular panniculitis, presenting with numerous large subcutaneous lesions, affecting children and occurring within the first 12 months of age. Lipogranulomatosis Subcutanea. First described by M. [accessanesthesiology.mhmedical.com]
Alpha1-antitrypsin deficiency panniculitis – tends to involve proximal extremities, ulceration and drainage of oily brown exudate is frequently observed, associated systemic manifestations (emphysema and cirrhosis) are usually present, and serum alpha1 [visualdx.com]
Keywords: Panniculitis; Lipogranulomatosis subcutanea; Granulomatous disorders; Treatment Case Report A 70-year-old female patient presented with a 10 week history of subcutaneous nodules on trunk and extremities. [symbiosisonlinepublishing.com]
Neither necrosis nor vasculitis is present [19]. [encyclopedia.pub]
This volume includes the reports of several hundreds of speakers from all over the world as presented during the congress or delivered 6 weeks later. [books.google.it]
Entire Body System
- Candidiasis
Functional asplenia has complicated the course of autoimmune diseases other than SLE, such as candidiasis endocrinopathy syndrome and alopecia areata [5]. [academic.oup.com]
Functional asplenia has complicated the course of autoimmune diseases other than SLE, such as candidiasis endocrinopathy syndrome and alopecia areata [ 5 ]. [rheumatology.oxfordjournals.org]
Chronic muco-cutaneous candidiasis and oral neoplasia. J Laryng Otol 1988; 102: 643-645. 4. Perheentupa J. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab 2006; 91: 2843-2850. [ncbi.nlm.nih.gov]
Childhood, Bullous Diabeticorum, Bullous Disorders, Bullous Pemphigoid, Burn, Buruli Ulcer, Buschke-Ollendorff Syndrome, Cafe-Au-Lait Spots, Caffey's Syndrome, Calcifying Epithelioma, Calcinosis Cutis And Osteoma Cutis, Callus, Campbell De'morgan Spot, Candidiasis [google.com]
Eyes
- Roth's Spots
▲ Rotavirus Infections rotavirus vaccine live oral rotavirus vaccine, live, oral rotaviruses Rotch Rotch sign Rotch, Thomas M. rote learning rotenone Roth Roth spot Roth spots Roth, Moritz Roth, Vladimir K. Roth, W. [medical-dictionary.thefreedictionary.com]
Roth's spots In bacterial endocarditis and other retinal hemorrhagic conditions, a round white spot surrounded by hemorrhage (secondary to microemboli in endocarditis). [wikem.org]
Skin
- Subcutaneous Nodule
On admission, subcutaneous nodules were recognized on bilateral upper arms, abdomen, gluteal regions and thighs. None of these nodules were associated with local heat or pain. [unboundmedicine.com]
On examination we observed multiple painless subcutaneous nodules on her back, right breast, left arm and shoulder and left thigh. These nodules were initially skin-colored, later bluish with some telangiectasias and skin atrophy (Figure1). [symbiosisonlinepublishing.com]
Erythema nodosum Erythematous condition (disorder) Inflammatory disease of subcutaneous fat including noninfectious granuloma (disorder) Subcutaneous nodule Vasculitis of the skin Name: Lipogranulomatosis subcutanea of Rothmann and Makai (disorder) See [snomedbrowser.com]
Definition / general Subcutaneous nodules on the trunk and extremities which undergo spontaneous involution, and are not associated with systemic symptoms Microscopic (histologic) description Lipogranulomas of subcutis, but not in crops Differential diagnosis [pathologyoutlines.com]
- Skin Lesion
Steroid treatment was effective on both skin lesions and mononeuropathy. Steroid treatment was effective on both skin lesions and mononeuropathy. [unboundmedicine.com]
Vascular access placement and fixation can be very difficult because of skin lesions. [accessanesthesiology.mhmedical.com]
Other skin manifestations include nodules, EN–like lesions, purpura, leg ulcers, and Raynaud symptoms [27][28]. [encyclopedia.pub]
Breast
- Nipple Retraction
[…] and Areola 197 Inflammatory Carcinoma 199 Skin and Nipple Retraction 203 Ulceration 206 Cutaneous Metastases 207 Lesions That Arise Outside the Ducts and Lobules 213 Skin Tumors 218 Calcifications of the Epidermis and Subcutaneous Tissue 222 Nipple Changes [books.google.es]
Neurologic
- Mononeuropathy
By those findings, she was diagnosed as Rothmann-Makai syndrome associated with mononeuropathy. Steroid treatment was effective on both skin lesions and mononeuropathy. Steroid treatment was effective on both skin lesions and mononeuropathy. [unboundmedicine.com]
Archives Belges de Dermatologie et de Syphiligraphie 24(4): 311-319, 1968 A case of Rothmann-Makai syndrome associated with mononeuropathy. Rinsho Shinkeigaku 31(10): 1107-1109, 1991 Spontaneous panniculitis (Rothmann-Makai syndrome) in athletes. [eurekamag.com]
Workup
Serum
- Thrombocytosis
Economopoulos Accepted: 02 September 2005 Published: 18 October 2005 Sir, A 27-yr-old woman was referred for evaluation of mild anaemia, leucocytosis and thrombocytosis. [academic.oup.com]
Economopoulos Published: 18 October 2005 Accepted: 02 September 2005 S ir, A 27-yr-old woman was referred for evaluation of mild anaemia, leucocytosis and thrombocytosis. [rheumatology.oxfordjournals.org]
- Anisopoikilocytosis
A peripheral blood smear revealed anisopoikilocytosis and numerous Howell–Jolly bodies, indicating functional hyposplenism. [academic.oup.com]
- Howell-Jolly Bodies
A peripheral blood smear revealed anisopoikilocytosis and numerous Howell–Jolly bodies, indicating functional hyposplenism. [academic.oup.com]
- Angiotensin Converting Enzyme Decreased
Angiotensin-converting enzyme decreased with 5.8 U/l (normal range: 20-70 U/l). Alpha -1-antitrypsin and syphilis serology normal or negative. Microbiological swabs were taken from the right breast wound and the right upper arm. [symbiosisonlinepublishing.com]
Other ECG Findings
- Ischemic Changes
We concluded that this mononeuropathy may be induced by a ischemic change which may be caused by panniculitis. [unboundmedicine.com]
We concluded that this mononeuropathy may be induced by a ischemic change which may be caused by panniculitis. Similar articles A case of Rothmann-Makai panniculitis successfully treated with tetracycline. Asano Y, Idezuki T, Igarashi A. [pubmed.ncbi.nlm.nih.gov]
Biopsy
- Foam Cell
Lobular panniculitis, focal granulomatous infiltrates, foam cells, giant cells, micropseudocysts. Differential diagnosis This section has been translated automatically. Internal therapy This section has been translated automatically. [altmeyers.org]
Finally, the foam cells are replaced by fibroblasts. The first two histological stages correspond to clinically apparent induration, while in the third stage atrophy of the skin may develop. There are no diagnostic laboratory findings. [academic.oup.com]
Treatment
Oral treatment with non-steroidal ibuprofen, short course of prednisolone (80 mg/d) tapered down, and pantoprazole was initiated with rapid improvement. [symbiosisonlinepublishing.com]
Steroid treatment was effective on both skin lesions and mononeuropathy. Steroid treatment was effective on both skin lesions and mononeuropathy. [unboundmedicine.com]
Lindsley discuss recent developments in diagnosis, treatment, genetics, immunology, imaging, and more. [books.google.es]
[…] assessments (PA treatment = 23 and sham treatment = 26). [journals.lww.com]
Complementary treatments can help people cope throughout treatment and beyond. [everydayhealth.com]
Prognosis
Textbook of Pediatric Rheumatology examines the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents, detailing the presentation, differential diagnosis, course, management, and prognosis [books.google.es]
The prognosis of SN is generally very poor, with a high fatality rate. We report the case of a full-term infant with delayed onset of SN showing good prognosis. [unboundmedicine.com]
The prognosis depends upon the severity of the renal disease http://www.geocities.com/SoHo/Gallery/6 ... ulitis.htm ............ [lymphedemapeople.com]
The prognosis is excellent, and the disorder resolves spontaneously over a period of weeks to months. A biopsy is not usually required if the history of a cold exposure is reported. [encyclopedia.pub]
The patients described had developed subcutaneous nodular lesions that progressed to necrosis, and the prognosis was very poor. [actasdermo.org]
Etiology
Erythema induratum of Bazin – occurs on the posterior aspects of the lower extremities, and ulceration is frequent; an etiologic relationship with tuberculosis is often demonstrated; histopathology reveals lobular panniculitis with vasculitis involving [visualdx.com]
Journal of the European Academy of Dermatology and Venereology: JEADV 17(4): 479-480, 2003 Lipo granulomatosis rothmann makai individual disease or poly etiological syndrome. [eurekamag.com]
Pathogenesis and histological features The etiology and pathogenesis of erythema nodosum are unknown. [basicmedicalkey.com]
DOI: http://dx.doi.org/10.15226/2378-1726/3/3/00129 Abstract Lipogranulomatosis subcutaneous (Rothmann-Makai) is a rare localized non-infectious panniculitis of unknown etiology. [symbiosisonlinepublishing.com]
[…] their high frequency in patients with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy.9 However, vascular dementia is not per se a marker of small vessel disease, and a control group with stroke of a different etiology [ahajournals.org]
Epidemiology
Epidemiological studies have shown that MS and its components may independently or combined increase PC risk [64]. [mdpi.com]
Descriptive epidemiology of low-back pain and its related medical care in the United States. Spine 1987 Apr;12(3):264-8. 60. Gran JT. An epidemiological survey of the signs and symptoms of ankylosing spondylitis. [iqb.es]
Epidemiology 2000; 11: 309-314. [ncbi.nlm.nih.gov]
Cancer Epidemiology, Biomarkers & Prevention 2001, 10(12), 1307-1308. [ncl.ac.uk]
Pathophysiology
We assessed EPVS in the basal ganglia and centrum semiovale separately because it is possible that due to their different locations and features, they may have distinct pathophysiologies. [ahajournals.org]
The pathophysiology of CP/CPPS involves the entire pelvis and not only the prostate. [springermedizin.de]
Saint's triad The coexistence of hiatal hernia, gallbladder disease, and diverticulosis in a patient; named after Saint, a South African surgeon; no pathophysiologic basis for the coexistence of all three processes, emphasizing that more than one disease [wikem.org]
The microbiome may be involved in a number of pathophysiological pathways. [mdpi.com]
Prevention
0% Emergent - ED Care Needed - Preventable/Avoidable - 0% Emergent - ED Care Needed - Not Preventable/Avoidable - 0% Primary diagnosis of injury 0% Primary diagnosis of mental health problems 0% Primary diagnosis of substance abuse 0% Primary diagnosis [codelay.com]
Prevention and management of infection in children with sickle cell anaemia. Paediatr Drugs 2001 ; 3 : 793 –801. 4 Kalhs P, Panzer S, Kletter K et al. Functional asplenia after bone marrow transplantation. [academic.oup.com]
The reduction in hyperalgesia produced by morphine and DAMGO was prevented byH-d-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2(CTAP) and that of SNC80 was prevented by naltrindole. U50,488 had no effect on the decreased mechanical withdrawal thresholds. [jpet.aspetjournals.org]