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2.1
Rubella-Associated Arthritis
Joint Inflammation in Rubella

Presentation

The arthritis occurred after natural infection (one case) or immunisation with HPV 77 DES vaccine (six cases) and had been present for up to 6 years. [ncbi.nlm.nih.gov]

Clinical presentations of viral arthritis Virus Frequency of arthritis Typical presenting features Likelihood of presenting with arthritis Duration of arthritis Comments EBV Very low Pharyngitis, cervical lymphadenopathy Fevers Very low Days Often have [racgp.org.au]

Hepatitis C arthropathy may be present in 2 to 20 percent of patients with HCV. It generally presents as a rheumatoid-like arthritis, or as an oligoarthritis. [rheumatology.org]

Snapshot A 30-year-old woman presents to the emergency room. She is a tourist from Southeast Asia and reports having a low-grade fever for several days. She also reports having arthralgias, especially in her wrists and knees. [medbullets.com]

The present issue is a com pilation of essays reflecting some of the facets of this particular diamond and I am especially grateful to authors and publishers alike in the unusual and tragic circumstances which attended its preparation. [books.google.de]

Entire Body System

  • Malaise

    Nonspecific constitutional symptoms may briefly antedate the rash and include malaise, fever, anorexia, upper respiratory tract infection, lymphadenopathy, and eye pain. [rheumaknowledgy.com]

    […] surveillance study of measles/mumps/rubella vaccine in Finland during 1982 to 1993 with 1.5 million pediatric and adult vaccinees reported no deaths or permanent sequelae. [ Ref ] Other side effects have included fever, syncope, headache, dizziness, malaise [drugs.com]

    It is characterized by anorexia (loss of appetite), malaise, conjunctivitis, headache, and minimal respiratory symptoms. Enlarged tender lymph nodes four-ten days before rash. Viremia is evident. 3. Exanthem. [atsu.edu]

    Supportive care with acetaminophen for fever and malaise is suggested. IVIG use during pregnancy for this condition is controversial. Prevention of rubella is important. [clinicaladvisor.com]

    […] have been reported during clinical trials, with use of the marketed vaccine, or with use of monovalent or bivalent vaccine containing measles, mumps, or rubella : Body As A Whole Panniculitis; atypical measles; fever; syncope ; headache; dizziness; malaise [rxlist.com]

Musculoskeletal

  • Arthritis

    These data do not support a direct role for raised CIC levels in the pathogenesis of rubella-associated arthritis or arthralgia. [ncbi.nlm.nih.gov]

    Arthritis Foundation. Juvenile Arthritis. Available online at http://www.arthritis.org/conditions-treatments/disease-center/juvenile--arthritis/. Accessed Sept 2013. Arthritis Foundation. Rheumatoid Arthritis. [labtestsonline.it]

Workup

Workup Laboratory Studies Parvovirus B19 The incubation period for parvovirus B19 is 7-18 days, and the state of viremia lasts 5-6 days. [emedicine.medscape.com]

The family history, after a very extensive workup, on both sides is totally negative for autism and the mother's chromosomal studies were normal." In the following case, Dr. [forums.prohealth.com]

HLA Type

  • HLA-B27

    Connective tissue disease, especially SLE Seronegative arthritis, especially Ankylosing spondylitis Rheumatoid factor-negative spondylo-arthropathies associated with HLA-B27. [rcpa.edu.au]

    The role of HLA-B27 in this process has been discussed, and the favorite hypothesis is a cross-reaction between microbial structures and HLA-B27, or that HLA-B27 itself might be a target of immune response. [antimicrobe.org]

    Individuals genetically prone to develop autoimmune illness (namely carriers of HLA-DR1, DR4, DR6, or HLA-B27) are more likely to contract post-immunization arthritis. [encognitive.com]

Treatment

A similar approach is taken to the treatment of bacterial infection. Discussions of pathophysiology are intertwined with discussions of diag nostic techniques, prevention techniques and treatment of bacterial in fections. [books.google.de]

Evans J, et al: Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. ‏ الصفحة 173 - Dalakas MC, Illa I, Dambrosia JM et al. [books.google.com]

Available online at http://www.arthritis.org/conditions-treatments/disease-center/osteoarthritis/. Accessed Sept 2013. [labtestsonline.it]

Treatment of Viral Arthritis Viral arthritis is mild and requires only symptomatic treatment. NSAIDs, low dose steroids are mostly used. Antiviral drugs are used when indicated. [boneandspine.com]

Intravenous treatment for two weeks to one month is the CDC’s recommended treatment duration References and further reading: Eugene D. Shapiro, M.D. Lyme Disease; N Engl J Med 2014; 370:1724-1731 http://www.cdc.gov/lyme 6) The correct answer is C. [rheumatology.org]

Prognosis

Postnatal Infection: Patients with rubella infection have an excellent prognosis. Exceptions include patients with encephalitis in which prognosis is related to the severity and extent of encephalitis. [infectiousdiseaseadvisor.com]

The long-term prognosis for recovery is poor, meaning, the damage can be permanent. Subscribe to the NewsWithViews Daily News Alerts! As stated by Dr. [newswithviews.com]

[…] congenital rubella syndrome Associated conditions congenital rubella syndrome blueberry muffin appearance dermal extramedullary hematopoiesis cataracts deafness congenital heart disease Prevention measles, mumps, and rubella (MMR) vaccine given over 2 doses Prognosis [medbullets.com]

Prognosis and outcome Maternal outcome is routinely uncomplicated. However, CRS can lead to significant morbidity in the fetus. The sequelae associated with CRS most commonly are associated with hearing loss (67%). [clinicaladvisor.com]

Interpersonal And Communication Skills Explain the evaluation, diagnosis, treatment and prognosis clearly to patient and family, using a patient-centered approach. [rheumatology.org]

Etiology

In this analysis, etiologic mechanisms for chronic arthritis following adult rubella and Hepatitis B vaccines were also explored. [vaccines.me]

Persistence of rubella virus in lymphoreticular cells in 35 per cent of these cases of juvenile arthritis supports the view that the virus may be an etiologic agent in chronic human joint disease, but further work will be required to support this suggestion [nejm.org]

Etiology: Chronic rubella arthritis is caused by infection with an RNA virus. The rubella virus has been isolated from synovial fluid and peripheral blood. [rheumaknowledgy.com]

MM 499-502; ID 903-911 NAME OF DISEASE : Rubella German measles Three-day measles ETIOLOGICAL AGENT : The rubella virus (a togavirus), contains RNA and an envelope. It replicates in the cytoplasm. EPIDEMIOLOGY : Man is only host. [atsu.edu]

PMCID: PMC111599 Rubella virus (RV), the etiologic agent of German measles, belongs to the family Togaviridae and is the only member of the genus Rubivirus. [explorevaccines.wordpress.com]

Epidemiology

The volume includes a remarkably fresh and interesting discussion of viral diseases as they affect the nervous system, including conventional and unconventional virus agents, and in addition, discussions of path ophysiology and epidemiology and postinfectious [books.google.de]

Annual updates on rubella incidence are published in ECDC’s Annual epidemiological report on communicable diseases in Europe. The 2013 report is available here. [ecdc.europa.eu]

Rubella vaccination and epidemiology : Cherry, J.D. “The ‘new’ epidemiology of measles and rubella.” Hospital Practice (July 1980), p. 55. CDC. “Rubella and congenital rubella syndrome—United States, 1985-1988. MMWR 1989; 38:173-178. CDC. [vaccineinjury.info]

Epidemiology and Prevention of Vaccine-Preventable Diseases (12 ed.). Public Health Foundation. pp. 301–323. ISBN 9780983263135. Archived from the original on 2017-05-01. [en.wikipedia.org]

Molecular epidemiological study of rubella virus genotype could reveal the transportation of rubella virus from a country to another country. [explorevaccines.wordpress.com]

Pathophysiology

Discussions of pathophysiology are intertwined with discussions of diag nostic techniques, prevention techniques and treatment of bacterial in fections. [books.google.de]

Epstein-Barr virus Usually polyarthralgia but may cause arthritis Varicella-zoster virus Mumps virus Adenovirus or coxsackieviruses A9, B2, B3, B4, and B6 Cause polyarthritis, pleuritis, myocarditis Echovirus Pathophysiology Viral infection is dependent [boneandspine.com]

Here, we review the epidemiology, the pathophysiological mechanisms, the pertinent clinical and laboratory findings as well as the principles of therapy of the most common virus-associated arthritides. [arthritis-research.biomedcentral.com]

Prevention

Additional surgical problems are discussed regarding prevention and management of peri operative infection and brain abscess. [books.google.de]

Special attention is given to the prevention and treatment of these diseases found in developing countries as well as the latest findings about new antimicrobial agents, gram-negative infections and their management, and recommendations for immunization [books.google.com]

Centers for Disease Control and Prevention. Arthritis Types. Available online at http://www.cdc.gov/arthritis/basics/types.htm. Accessed Sept 2013. Centers for Disease Control and Prevention. Childhood Arthritis. [labtestsonline.it]

Epidemiology and Prevention of Vaccine-Preventable Diseases (10th ed.). Centers for Disease Control and Prevention. Archived from the original on 2007-06-20. Retrieved 2007-07-03. ^ a b c d "Chapter 11 — Rubella" (PDF). Immunisation Handbook 2006. [en.wikipedia.org]

The MMR vaccine, introduced in the United States in 1971, helps prevent the measles, the mumps, and rubella (German measles). This vaccine was a huge development in the battle to prevent these dangerous diseases. [healthline.com]

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