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Rubella Virus


Presentation

  • A disseminated relapsing neurological disorder presented simultaneously in two sisters. Encephalitic features were present in one case. The illness was associated with a significant increase in rubella specific IgM in both sisters.[ncbi.nlm.nih.gov]
  • In case 3 a boy of 9 presented with an illness indistinguishable from the systemic variety of juvenile chronic arthritis (Still's disease).[ncbi.nlm.nih.gov]
  • A 7-month-old boy presented with generalized brownish macules, indurated erythemas, papules, and pigmentation. They first appeared at around 3 months of age. His mother had contracted rubella during the 14th gestational week.[ncbi.nlm.nih.gov]
  • RESULTS: Patients with Rubella virus-associated uveitis were younger at time of initial ophthalmologic presentation (P .014).[ncbi.nlm.nih.gov]
  • Rubella virus AU was characterized by younger age at onset and chronic course and typically was associated with cataract at presentation. Heterochromia was present in 23% of RV AU patients.[ncbi.nlm.nih.gov]
Liver Dysfunction
  • Blood tests revealed thrombocytopenia, liver dysfunction, coagulopathy, and hyperferritinemia. Bone marrow examination revealed many atypical lymphocytes and some histiocytes with hemophagocytosis.[ncbi.nlm.nih.gov]
Oligoarthritis
  • In this report we present 21 instances in which live rubella virus was isolated from synovial fluid obtained from 6 cases of inflammatory oligoarthritis or polyarthritis over a period of 2 years in the absence of firm clinical evidence of rubella.[ncbi.nlm.nih.gov]
Cutaneous Manifestation
  • The cutaneous manifestations of our patient were extraordinary and informative. These prominent skin lesions should be recognized as cutaneous markers of CRS.[ncbi.nlm.nih.gov]
Anterior Uveitis
  • […] of 13 patients with chronic anterior uveitis of undetermined origin.[ncbi.nlm.nih.gov]
  • Anterior uveitis associated with HSV or VZV occurred characteristically in older patients and frequently followed an acute course.[ncbi.nlm.nih.gov]
  • Awareness of rubella associated anterior uveitis should remain also in vaccinated patients, especially those without a fully competent immune system.[ncbi.nlm.nih.gov]
  • We examined a 13-year-old boy with chronic anterior uveitis complicated by mature cataract.[ncbi.nlm.nih.gov]
  • uveitis (AU) without clinical features of FHUS.[ncbi.nlm.nih.gov]
Corneal Edema
  • Clinical features associated with herpetic AU included conjunctival redness, corneal edema, history of keratitis, and development of posterior synechiae.[ncbi.nlm.nih.gov]
Polyradiculoneuropathy
  • Electrophysiologic studies showed peripheral polyradiculoneuropathy with multifocal conduction block.[ncbi.nlm.nih.gov]

Workup

Toxoplasma Gondii
  • METHODS: Using the Goldmann-Witmer coefficient technique, intraocular synthesis of specific antibodies against RV, herpes simplex virus, varicella-zoster virus, cytomegalovirus (CMV) and Toxoplasma gondii-specific immunoglobulin G antibodies was performed[ncbi.nlm.nih.gov]
  • In addition, intraocular immunoglobulin G production against herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV) and toxoplasma gondii was determined.[ncbi.nlm.nih.gov]
  • Product Order number Anti-Rubella Virus IIFT (IgG / avidity test) FI 2590-G / X Indications: infections with Toxoplasma gondii, rubella virus, cytomegalovirus (CMV), herpes simplex virus (HSV-1 and HSV-2).[euroimmun.com]
  • OBJECTIVES: To determine the seroprevalence of Toxoplasma gondii (T. gondii), Rubella virus, and Cytomegalovirus (CMV) among pregnant women in Izmir, Turkey.[ncbi.nlm.nih.gov]
  • RESULTS: Inverse associations of cord blood IgE to seasonal allergens with positive maternal records for Toxoplasma gondii (adjusted odds ratio 0.37 [0.17-0.81]) and rubella virus (adjusted odds ratio 0.35 [0.13-0.96]) were found.[ncbi.nlm.nih.gov]

Treatment

  • These results suggest a potential application of NTZ for the treatment of persistent rubella infections, but more studies are required.[ncbi.nlm.nih.gov]
  • Management approach mainstay of treatment is supportive care and prevention with vaccines Conservative supportive care indication all patients modalities anti-pyretics analgesics hydration Complications Vertical transmission to fetus congenital rubella[medbullets.com]
  • FIRST AID/TREATMENT: Treatment for rubella is supportive(1). There have been no reports of successful treatment with antiviral drugs.[msdsonline.com]

Prognosis

  • Visual prognosis was favorable for all 3 groups.[ncbi.nlm.nih.gov]
  • Postnatal Infection: Patients with rubella infection have an excellent prognosis. Exceptions include patients with encephalitis in which prognosis is related to the severity and extent of encephalitis.[renalandurologynews.com]
  • […] rubella syndrome blueberry muffin appearance dermal extramedullary hematopoiesis cataracts deafness congenital heart disease (pulmonary artery stenosis or patent ductus arteriosus) Prevention measles, mumps, and rubella (MMR) vaccine given over 2 doses Prognosis[medbullets.com]

Etiology

  • Acute liver failure is a syndrome with a wide range of etiologic possibilities in children, but in up to 50% of the cases in the literature no diagnosis is established.[ncbi.nlm.nih.gov]
  • In patients with multiphasic ADEM of unknown etiology, clinicians should also consider the possibility of preceding infection with rubella virus.[ncbi.nlm.nih.gov]
  • Abstract Rubella virus (RV) isolation is recommended by the WHO Measles and Rubella Labnet for studying the etiology and epidemiology of rubella.[ncbi.nlm.nih.gov]
  • A great variety of viruses which cause exanthema share other clinical manifestations, making the etiologic identification a very difficult task, relying exclusively on the clinical examination.[ncbi.nlm.nih.gov]
  • INTRODUCTION: Fuchs' heterochromic cyclitis (FHC) is a common intraocular disease of uncertain etiology that has recently been related to rubella virus (RV) infection.[ncbi.nlm.nih.gov]

Epidemiology

  • Strengthening rubella surveillance, including the integration of epidemiologic information and laboratory data, is a vital strategy for rubella control and elimination.[ncbi.nlm.nih.gov]
  • KEYWORDS: Epidemiological surveillance; Measles; Population surveys; Rubella; Seroprevalence [Indexed for MEDLINE] Free full text[ncbi.nlm.nih.gov]
  • Rubella is not a reportable disease in Nigeria and data of its epidemiology are extremely rare. In this study, we estimate the burden of acute rubella virus infection among pregnant women during their first trimester in Makurdi-Benue State-Nigeria.[ncbi.nlm.nih.gov]
  • The information reported in this paper will contribute to understanding the molecular epidemiology of RV in São Paulo, Brazil. Copyright 2012 Wiley Periodicals, Inc.[ncbi.nlm.nih.gov]
  • Thereafter, in late 2007, the epidemiological conditions changed, resulting in a large RV outbreak with the clear dominance of genotype 2B.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Considering the involvement of the central nerve as well as the peripheral nerve in an adult patient, this case is thought to be valuable in view of the pathophysiology of neurologic complication in rubella virus infection.[ncbi.nlm.nih.gov]

Prevention

  • Author information 1 WHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing[ncbi.nlm.nih.gov]
  • Consequently, the primary objective of global rubella control programs is prevention of congenital rubella infection and associated birth defects.[ncbi.nlm.nih.gov]
  • An effective surveillance system, which could be achieved and maintained by using an external quality assessment program, is critical for prevention and control of this disease.[ncbi.nlm.nih.gov]
  • Author information 1 Health Department of the Community of Madrid, Subdirectorate General of Health Promotion and Prevention, Madrid, Spain.[ncbi.nlm.nih.gov]
  • The main mechanism of action was specific for Bax as capsid bound Bax and prevented Bax-induced apoptosis but did not bind Bak nor inhibit Bak-induced apoptosis.[ncbi.nlm.nih.gov]

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