The presentation in adulthood with rupture of the aneurysm and the successful surgical treatment of both abnormalities are unusual. [ncbi.nlm.nih.gov]

• Hyperlaxity

  Osteogenesis imperfecta (OI) is a heritable connective tissue disorder, caused by abnormalities in type 1 collagen, and is characterized by bone fragility and other extraskeletal features, including hearing loss, blue sclerae, dentinongenesis imperfecta and hyperlaxity [bmcneurol.biomedcentral.com]

• Blue Sclera

  She had blue sclerae, a history of several fractures of the extremities, and a family history of bone fragility and blue sclerae in her son. According to these findings, she was diagnosed with OI type 1. [bmcneurol.biomedcentral.com]

• Normal Hearing

  Completely normalized hearing was found in five patients at 3-6 months follow-up, whereas two cases noticed a partial loss and one made no recovery. [ncbi.nlm.nih.gov]

Workup for Patients with Suspected Nontraumatic SAH Figure 1. Algorithm for evaluating patients with suspected nontraumatic SAH. [aafp.org]

The workup may include: Physical exam - The physician checks blood pressure, feels the body for masses and listens to blood flow sounds. [innerbody.com]

See Workup for more detail. [emedicine.medscape.com]

• Macrocytic Anemia

  At a referring institution, he showed evidence of macrocytic anemia (white blood cell count, 9,000/μL; red blood cell count, 104×10(4)/μL; hemoglobin, 4.0 g/dL; hematocrit, 12.2%; and platelet count, 26.6×10(4)/μL). [ncbi.nlm.nih.gov]

BACKGROUND: Endovascular coil embolization and craniotomy with clip ligation are the 2 most commonly used treatments for ruptured cerebral aneurysm. [ncbi.nlm.nih.gov]

The rationale for treatment selection is not known, and no correction was made for associated biases of non-random assignment to treatment. [jnis.bmj.com]

Treatment of ruptured cerebral aneurysm is the primary concern in all patients after SAH. [surgicalneurologyint.com]

Abstract Subpial hematoma is a rare type of intracranial hemorrhage with a poor prognosis. [ncbi.nlm.nih.gov]

Therefore, early diagnosis and proper treatment are crucial for a good prognosis. [skullbaseinstitute.com]

Prognosis What is the prognosis? An un-ruptured aneurysm may go unnoticed throughout a person’s lifetime. Aburst brain aneurysm, however, may be fatal or cause permanent brain damage. [nni.com.sg]

The etiology may be of local, systemic, psychological, or occupational in nature. However, the major etiological factor is psychological. [ncbi.nlm.nih.gov]

The etiology of sleep bruxism seems to be centrally mediated (23). It occurs mostly during a switch from deep sleep to shallow sleep (24). [frontiersin.org]

Pathophysiology The pathogenesis of cerebral aneurysms is related inherently to structural aberrations of the cerebrovasculature, although the etiology of these abnormalities may be diverse. [emedicine.medscape.com]

Loculated intracranial aneurysms: angiography and possible etiology. Radiology 1974 ; 113 : 101 ↵ Gailloud P, Murphy KJ. Rupture of cerebral aneurysm during angiography. N Engl J Med 1999 ; 340 : 1442 ↵ Yousem DM, Trinh BC. [ajnr.org]

Size Small, < 15 mm Large, 15–25 mm Giant, 25–50 mm Supergiant, 50 mm Shape Berry: Most common (95%); berry-shaped aneurysm with a neck or stem Sacular: Any aneurysm with a sacular outpouching Fusiform: Outpouching of an arterial wall but with no stem Etiology [medical-dictionary.thefreedictionary.com]

BACKGROUND: To review the epidemiology of sporadic ruptured cerebral aneurysm. [ncbi.nlm.nih.gov]

Aneurysm subarachnoid hemorrhage outcomes epidemiology national inpatient sample unruptured aneurysm hemorrhage coil statistics Statistics from Altmetric.com Aneurysm subarachnoid hemorrhage outcomes epidemiology national inpatient sample unruptured aneurysm [jnis.bmj.com]

Epidemiology of subarachnoid hemorrhage in Finland from 1983 to 1985. Stroke. 1991. 22: 848-53 23. Szikora I, Berentei Z, Kulcsar Z, Marosfoi M, Vajda ZS, Lee W. [surgicalneurologyint.com]

Unruptured intracranial aneurysms: epidemiology, natural history, management options, and familial screening. Lancet Neurol. 13, 393–404 (2014). 8. Nieuwkamp, D. J. et al. [nature.com]

"Epidemiology and genetics of intracranial aneurysms". European Journal of Radiology. 82 (10): 1598–605. doi:10.1016/j.ejrad.2012.12.026. [en.wikipedia.org]

Factors predisposing to aneurysm rupture such as hemodynamic changes in the parent vessel, pathophysiology of the aneurysm wall, size and location of the aneurysm, age, sex aid blood pressure of the patient are thought to be important contributing factors [ir.ymlib.yonsei.ac.kr]

The incidence and pathophysiology of hyponatraemia after subarachnoid haemorrhage. Clin Endocrinol (Oxf). 2006 Mar. 64(3):250-4. [Medline]. Sluzewski M, van Rooij WJ. [emedicine.medscape.com]

Blister aneurysms were not considered in this series since they differ both morphologically and histologically from saccular aneurysms and likely represent a distinct pathophysiology. [surgicalneurologyint.com]

Recent genome-wide association studies (GWAS) provide molecular evidence for shared biological function and activities (pathophysiology) of these aneurysms. [ninds.nih.gov]

The rationale of this emergency procedure is to prevent early rerupture and also to prevent neurological ischaemic consequences of the subarachnoid haemorrhage likely to develop in the first week after a rupture. [ncbi.nlm.nih.gov]

Surgery and procedures If preventative treatment is recommended, the 2 main techniques used are called neurosurgical clipping and endovascular coiling. Both techniques help prevent ruptures by stopping blood flowing into the aneurysm. [nhs.uk]