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Salzmann's Nodular Dystrophy

Dystrophy Salzmann's Nodular Corneal


Presentation

  • This book presents a brief survey on the bacteriology and parasitology of the eye. Organized into three parts encompassing 20 chapters, this book begins with an overview of the normal histology of the eye.[books.google.com]
  • It is our ambition to present a complete survey of all medical phenomena named for a person, with a biography of that person. Disclaimer: Whonamedit? does not give medical advice.[whonamedit.com]
  • Carlson Today’s patient presentation has Fuchs’ Corneal Dystrophy, a visually significant nuclear sclerotic cataract, an elevated Salzmann’s Nodule , and only has one eye.[alancarlsonmd.com]
  • 62-year-old woman presents with 3 years of progressive decrease in vision September 9, 2013 Chief Complaint A 62-year-old woman presents with a 3-year history of painless, progressive loss of vision in both eyes.[webeye.ophth.uiowa.edu]
  • Case presentation: A 61-year-old patient presented with a history of cataract in both eyes, reducing vision to 20/60 OD and 20/50 OS. The exam revealed white discrete nodules on the anterior corneal surface causing negative fluorescein staining.[healio.com]
Weakness
  • Dystrophies Figure Star shaped and breadcrumb like opacities in the eyes of a patient with Granular Corneal Dystrophy Type Photos courtesy of Jason Jedlicka Recurrent Erosion Syndrome Valerie Saw It can also occur spontaneously or in patients with a weakness[threepanelopera.com]
Flushing
  • […] dysfunction and acne rosacea was seen in patients with recalcitrant RCE. 6 This was in the form of inspissation of meibomian glands, reduced tear film break-up time, conjunctival injection, and accompanying facial cutaneous changes such as facial erythema, flushes[nature.com]
Contusion
  • This book discusses as well the physical injuries in the eye brought about by contusion.[books.google.com]
  • […] disorder due to contact lens H18.831 - H18.839 Recurrent erosion of cornea Q13.3 Corneal corneal opacities Q13.4 Other congenital corneal malformations S05.00x - S05.02x Injury of conjunctiva and corneal abrasion without foreign body S05.10x - S05.12x Contusion[aetna.com]
Neglect
  • In rare cases of neglected nodules within the visual axis, anterior stromal haze may compromise the final visual results.[webeye.ophth.uiowa.edu]

Workup

  • Clinical examination: A general medical workup is advisable in patients with systemic association of the disease. Examination of eyes should be carried out under slit lamp (bio-microscopy) by an eye specialist.[aimu.us]

Treatment

  • In these eyes recurrences seem to occur more frequently after treatment. Of 35 eyes documented to have Salzmann's nodular degeneration during the last 15 years in our department, 22 needed PTK treatment.[ncbi.nlm.nih.gov]
  • Ideal for ophthalmic practitioners and allied health professionals alike, this indispensable resource is your comprehensive guide for the speedy diagnosis and treatment of the most common eye disorders.[books.google.com]
  • Figure 2: Topography before treatment.[webeye.ophth.uiowa.edu]
  • Treatment: Medical therapy consists of lubrication, warm compresses, lid hygiene, topical steroids, and/or oral doxycycline and has been successful in over half of the patients in some series.[missionforvisionusa.org]
  • How Much Does a Superficial Keratectomy Treatment Cost in Nashville? The cost of your superficial keratectomy treatment may be covered by your vision and medical insurance.[bestvisionforlife.com]

Prognosis

  • This reduces the healing time and improves visual prognosis post-operatively. DSEKs can be used as treatment for conditions such as Fuch’s Endothelial Dystrophy.[lincolneyelaser.com]
  • Salzmann's nodular corneal degeneration (SNCD): Clinical findings, risk factors, prognosis and the role of previous contact lens wear. Contact Lens and Anterior Eye. 2011;34(4):173-178.[webeye.ophth.uiowa.edu]
  • Salzmann’s nodular corneal degeneration (SNCD): Clinical findings, risk factors, prognosis and the role of previous contact lens wear. Cont Lens Anterior Eye. 2011 Aug;34(4):173-8. 4. Fario AA, Halperin GI, Sved N, et al.[reviewofoptometry.com]
  • Salzmann’s Nodular Corneal Degeneration: Clinical Findings, Risk Factors, Prognosis and the Role of Previous Contact Lens Wear.[eyewiki.aao.org]
  • The authors concluded that the Boston KPro-1 had an excellent prognosis for retention in eyes with congenital glaucoma.[aetna.com]

Etiology

  • Therefore, although the etiology remains uncertain, it is thought that SND can be triggered by multiple events that lead to a non-specific corneal tissue reaction based on individual predisposition.[remedicajournals.com]
  • Etiology: Salzmann's nodular degeneration has been associated with trachoma, interstitial keratitis, vernal keratoconjunctivitis, phlyctenular keratoconjunctivitis, ocular trauma, measles, scarlet fever, and previous surgery.[missionforvisionusa.org]
  • Whereas subtle recurrences are common in most cases over a 5 to 15 year period, visually significant recurrences are uncommon (5 to 20%) and can be minimized with meticulous control of the etiology responsible for the condition [1, 2].[webeye.ophth.uiowa.edu]
  • DEPENDING UPON ETIOLOGY A] Age related degeneration:- Arcus senilis, Vogt’s white limbal girdle, Hassal-Henle bodies,Mosaic degeneration.[slideshare.net]
  • Etiology There has not been a specific causal etiology described to date.[eyewiki.aao.org]

Epidemiology

  • In terms of epidemiology, a wide age range in both men and women has been reported.[remedicajournals.com]
  • - metabolism Disease Progression Corneal Dystrophies, Hereditary - epidemiology Aged Gelsolin - genetics Mutation Finland - epidemiology Amyloidosis - metabolism Journal Article Details Digital rights Loading Rights Save Investigative ophthalmology &[query.library.utoronto.ca]
  • Table 2 Epidemiology Onset often around 50 years of age, but has been reported in ages 13-92 [2] Female patients account for 75-90% of all cases [1,2]. Often bilateral [1,2].[webeye.ophth.uiowa.edu]
  • Epidemiology 72%-88% of cases occur in females [10] . SND is more common in Caucasian women in the 6th decade of life but can be seen in both males and females of all ages beginning near adolescence [3] [7] .[eyewiki.aao.org]
  • Recurrent erosions of the cornea: epidemiology and treatment . Cornea 2000; 19 : 767–771. 13. Tabery HM . Corneal stromal infiltrates in patients with recurrent erosions . Acta Ophthalmol Scand 1998; 76 : 589–592. 14.[nature.com]
Sex distribution
Age distribution

Pathophysiology

  • Corneal dystrophy, Gelatinous drop-like Corneal dystrophy is a group of rare hereditary disorders characterised by bilateral abnormal deposition of substances in the transparent front part of the eye called the cornea . [1] [2] [3] Pathophysiology [ edit[en.wikipedia.org]
  • Pathophysiology One hypothesis suggests that enzymatic destruction of Bowman’s layer results in migration and proliferation of keratocytes from the posterior stroma, resulting in secondary deposition of extracellular matrix components in nodular areas[eyewiki.aao.org]
  • […] partial optic nerve crush Rejdak R. 1,2 , Schüttauf F. 2 , Lehaci C. 2 , Zagorski Z. 1 , Zarnowski T. 1 , Grieb P. 3 , Zrenner E. 2 1 Tadeusz Krwawicz Chair of Ophthalmology and 1 st Eye Hospital, Medical University, Lublin, Poland, 2 Department of Pathophysiology[dog2004.org]

Prevention

  • Avoidable - 0% Emergent - ED Care Needed - Not Preventable/Avoidable - 0% Primary diagnosis of injury 0% Primary diagnosis of mental health problems 0% Primary diagnosis of substance abuse 0% Primary diagnosis of Alcohol 0% Unclassified 100% We Could[medicbind.com]
  • Some have also advocated the concomitant use of mitomycin-C after surgery aimed at preventing an SND recurrence (Bowers et al, 2003).[clspectrum.com]
  • Ongoing treatment/prevention is aimed at controlling chronic irritation of the eye such as dry eye , blepharitis and meibomian gland dysfunction.[moyeseye.com]
  • “There are studies that show that MMC is probably safe to use, but there are not a lot of studies showing that it really works well for preventing recurrence of corneal dystrophies,” Dr. Ayres said.[eyeworld.org]

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