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Samson-Gardner Syndrome


  • The first hit is a heterozygous MEN1 germline mutation, inherited from one parent (familial cases) or developed in an early embryonic stage (sporadic cases) and present in all cells at birth.[en.wikipedia.org]
  • In-Depth Information The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers.[rarediseases.info.nih.gov]


  • Pathophysiology [ edit ] MEN1 follows Knudson’s “two-hit” model for tumor suppressor gene carcinogenesis (30).[en.wikipedia.org]

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