We also present a review of the literature in order to present the most recent and relevant information regarding neurosarcoidosis. [onlinelibrary.wiley.com]

Cryptococcal meningitis in sarcoid patients often presents clinically with non-specific features, and should be excluded in patients with sarcoidosis and neurological disturbances. [tandfonline.com]

Presentations and outcomes of neurosarcoidosis: a study of 54 cases. [scielo.br]

The study, “Not everything is as it seems: neurosarcoidosis presenting as leptomeningitis,” was published in the journal Clinical Case Reports. [sarcoidosisnews.com]

• Intermittent Fever

  Case Report A 39‐year‐old woman without relevant medical history prior to admission presented to the emergency room with a 2‐week gradual onset of frontal headache, intermittent fever, nausea, vomiting, disorientation, and incoherent language. [onlinelibrary.wiley.com]

• Dysarthria

  Lower cranial nerves may also be involved, causing dysarthria or dysphagia 2, 4, 9. Sarcoidosis may cause involvement of peripheral nerves in up to 20% of patients. [onlinelibrary.wiley.com]

• Frontal Headache

  Case Report A 39‐year‐old woman without relevant medical history prior to admission presented to the emergency room with a 2‐week gradual onset of frontal headache, intermittent fever, nausea, vomiting, disorientation, and incoherent language. [onlinelibrary.wiley.com]

Due to the multiple clinical manifestations that patients with neurosarcoidosis may have, the diagnostic workup should be complete and multidisciplinary. [onlinelibrary.wiley.com]

The treatment will differ depending on the clinical manifestations, but the most common treatment is the use of steroids and other immunosuppressive drugs. [onlinelibrary.wiley.com]

Still, the woman responded well to the treatment, and her symptoms improved. She was discharged three weeks later and told to continue a gradually lessening routine of steroids. A month later, the patient relapsed. [sarcoidosisnews.com]

There are no randomized trials defining the optimal treatment for NS. [scielo.br]

PROGNOSIS Although treatment with steroids can improve MRI, clinical responses may not correlate with radiological improvement36. [scielo.br]

More research needs to be performed to better comprehend the etiology and pathophysiology of sarcoidosis. [onlinelibrary.wiley.com]

Since sarcoidosis is a disease, or a group of diseases, of unknown etiology,2 it is best recognized by its clinicopathological features. [jamanetwork.com]

Research into specific microbial etiologies showed that mycobacterial DNA and protein antigens are present in sarcoidosis tissues and are the target of T and B cell responses, suggesting some important etiologic factors18. [scielo.br]

More research needs to be performed to better comprehend the etiology and pathophysiology of sarcoidosis. [onlinelibrary.wiley.com]

PATHOPHYSIOLOGY The etiology of NS is multifactor, involving genetic predisposition, environmental and individual factors. [scielo.br]

Radiotherapy is effective in the prevention of progression of local symptoms of neurosarcoidosis and for sarcoid meningitis 2. [onlinelibrary.wiley.com]