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Sarcomatoid Mesothelioma


Presentation

  • In the present study we included nine sarcomatoid carcinomas of the lung.[onlinelibrary.wiley.com]
  • A recently diagnosed case of sarcomatoid malignant pleural mesothelioma presented in a middle-aged man experiencing a cough, fever and chest pain.[mesotheliomadiagnosis.com]
  • We found that cytoplasmic podoplanin staining was present in sarcomatoid mesotheliomas, and wanted to explore the reproducibility and specificity of this staining pattern.[insights.ovid.com]
  • The most common presenting symptom was abdominal pain, and 3 of 4 women were suspected to have cholecystitis/cholelithiasis. All cases stained positive for cytokeratins, and 2 contained heterologous elements.[journals.lww.com]
  • […] fibrous tumor. ( 27293862 ) Kim KC...Vo HP 2016 10 Connective tissue growth factor and β-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma. ( 24839947 ) Jiang L...Toyokuni S 2014 11 Phrenic nerve paralysis as the initial presentation[malacards.org]
Weakness
  • With antipodoplanin antibody, no staining was seen in the pulmonary adenocarcinomas (0/80, 0%) or the synovial sarcomas (0/8, 0%), and weak cytoplasmic staining was seen in only 1 sarcomatoid carcinoma (1/15, 7%).[insights.ovid.com]
  • In sarcomatoid mesothelioma, positive staining for desmin was observed only in three cases (8%), but the reaction was focal (1 or 2 ) and weak.[onlinelibrary.wiley.com]
Fishing
  • […] activation in rat sarcomatoid mesothelioma. ( 24839947 ) Jiang L...Toyokuni S 2014 11 Phrenic nerve paralysis as the initial presentation in pleural sarcomatoid mesothelioma. ( 25076889 ) Makimoto G...Kishimoto T 2014 12 Diagnostic usefulness of p16/CDKN2A FISH[malacards.org]
  • A renal epithelioid angiomyolipoma/perivascular epithelioid cell tumor with TFE3 gene break visualized by FISH. Medical molecular morphology, 45, 234-237, 2012.[sikluv-ustav-patologie.patologie.cz]
Pathologist
  • Email: koinai@hiroshima‐u.ac.jp Abstract Differentiation of sarcomatoid mesothelioma from other sarcomatoid tumors involving the pleura and other structures by light microscopy remains an important diagnostic challenge for surgical pathologists.[onlinelibrary.wiley.com]
Fatigue
  • These inflammatory cells form dense bundles that form tumors solely in the lining of the lungs, causing symptoms of chest pain, fatigue, and weight loss.Treatments for lymphohistiocytic mesothelioma are standard for other cancers, but this unique type[mesowatch.com]
Physician
  • If a patient comes in with symptoms of mesothelioma, a history of asbestos exposure is a huge signal to physicians that they may have the rare cancer.[mesotheliomadiagnosis.com]
Pneumonia
  • Pinpoint cell type and stage of cancer Develop an understanding of the most effective treatment plan If sarcomatoid mesothelioma is suspected, seeking a mesothelioma specialist is often the best option to avoid common misdiagnoses, such as ovarian cancer, pneumonia[mesotheliomadiagnosis.com]
Cough
  • A recently diagnosed case of sarcomatoid malignant pleural mesothelioma presented in a middle-aged man experiencing a cough, fever and chest pain.[mesotheliomadiagnosis.com]
Abdominal Pain
  • The most common presenting symptom was abdominal pain, and 3 of 4 women were suspected to have cholecystitis/cholelithiasis. All cases stained positive for cytokeratins, and 2 contained heterologous elements.[journals.lww.com]
Suggestibility
  • These findings suggest that cytoplasmic podoplanin expression may be useful in the diagnosis of sarcomatoid mesothelioma, although it should be used with caution on biopsy material.[insights.ovid.com]
  • Rather, studies suggest it develops in response to female hormones, prior surgery, endometriosis or foreign fibers.[mesowatch.com]
  • Therefore, CAM5.2 is suggested to be the most useful positive marker for differentiating sarcomatoid mesothelioma from true sarcoma.[onlinelibrary.wiley.com]
  • The diagnosis is usually suggested by imaging studies (unilateral pleural thickening; pleural effusion). An occupational history must be obtained. Cytological examination of the effusion can be diagnostic, but often shows equivocal results.[academic.oup.com]
  • Report of a case suggesting perineurial cell differentiation. Pathology Research and Practice, 198, 767-74, 2002. Michal M. Sklerotizující perineuriom. Česko-slovenská Patologie, 39, 5-35, 2003. Zámečník M., Michal M.[sikluv-ustav-patologie.patologie.cz]

Treatment

  • Palliative Treatments for Sarcomatoid Mesothelioma Sarcomatoid mesothelioma patients are often left with palliative treatments as their only option.[mesotheliomadiagnosis.com]
  • Cancer treatments are most effective when tailored to the particular type of cancerous cell, so misdiagnosing biphasic mesothelioma can lead to insufficient treatment.[mesowatch.com]
  • […] carcinomas of the lung: evidence-based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center. ( 28782639 ) Marchevsky AM...Galateau-Salle F 2017 7 Evaluation of intracavitary administration of curcumin for the treatment[malacards.org]
  • The updated ESMO Clinical Practice Guidelines provide clear recommendations for management of this disease from diagnosis through treatment (medical, radiotherapy and surgery) to follow up. Download the PDF from Annals of Oncology[esmo.org]
  • The use of PET scan to rule out extra-thoracic metastasis in patients considered for radical treatment is under investigation and findings seem promising. treatment surgery Various surgical procedures have been studied with varying degrees of success.[academic.oup.com]

Prognosis

  • This form of cancer is aggressive with limited treatment options and a poor prognosis.[mesotheliomadiagnosis.com]
  • Patients with more epithelial cells generally receive a better prognosis, while patients with more sarcomatoid cells receive a poorer prognosis.[mesowatch.com]
  • Clinicopathological characteristics and prognosis of malignant pleural mesothelioma. Zhonghua Jie He He Hu Xi Za Zhi. 2013; 36(11):825-828. Tegeltija D, Samardžija G, Lovrenski A, Eri Ž, Popović M.[md-medicaldata.com]
  • A distinct entity with favourable prognosis. Histopathology, 39, 14-24, 2001 Michal M., Zámečník M., Chlumská A. Nové jednotky a úskalí diagnostiky nádorů měkkých tkání.[sikluv-ustav-patologie.patologie.cz]

Prevention

  • In the palliative setting, radiotherapy can be delivered locally in view of pain control or prevention of obstructive symptoms [IV, C].[academic.oup.com]

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