Pregnancy, in itself, leads to numerous anatomic and physiological changes including capillary engorgement and mucosal edema of the oropharynx, larynx and trachea leading to a more difficult airway. [oatext.com]

Ectropion of the eyelids, especially the upper eyelid with constant danger of keratoconjunctivitis, corneal ulceration, scarring or perforation with loss of vision Incapacitating contracture of the neck with inability to look forwards Severe microstomia [drnjithendran.com]

uncontrolled thyroid disease or Polycystic Ovary Syndrome), as per the Investigator's discretion Abnormal photosensitivity due to metabolic disorder or due to use of external agents, (drugs, herbs, etc.) within 2 weeks of initial treatment or during [clinicaltrials.gov]

sweats, fatigue, myalgia, and headache. [drsherris.com]