Presentation
In a patient presenting with hematuria and proteinuria (albuminuria), bladder biopsy demonstrated Schistosoma hematobium infection and renal biopsy showed a minimal change glomerulonephritis. [ncbi.nlm.nih.gov]
With urogenital schistosomiasis, the most common presentations are dysuria, frequency and haematuria [ 10 ]. [omicsonline.org]
Snapshot A 29-year-old woman presents to the emergency department with 2 weeks of fever and abdominal pain. She denies any sick contacts but did recently return from Kenya. [medbullets.com]
Material And Methods We present a review of 32 cases of Chronic schistosomiasis presenting over a span of 4 years (2001 to 2005) at King Faisal Hospital, Taif, Kingdom of Saudi Arabia. [community.vanguardngr.com]
Presented in part: 11th International Congress of Parasitological Associations, Glasgow, Scotland, 6–11 August 2006. [academic.oup.com]
Entire Body System
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Lymphadenopathy
Four to 8 weeks after exposure, an acute illness can develop, manifested by fever, malaise, cough, rash, abdominal pain, diarrhea, nausea, lymphadenopathy, and eosinophilia (Katayama fever). [meddean.luc.edu]
Gastrointestinal
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Suprapubic Pain
pain, microscopic hematuria and frequency Complications include hydroureter, hydronephrosis, bladder ulcer, polyposis, bacterial urinary tract infection, renal failure, bladder cancer (squamous cell carcinoma, adenocarcinoma and rarely urothelial carcinoma [pathologyoutlines.com]
Liver, Gall & Pancreas
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Hepatomegaly
Physical examination is notable for hepatomegaly, most prominent in the left hepatic lobe. She also has an urticarial rash in her left foot. [medbullets.com]
In acute infections with heavy infection due to Schistosoma mansoni or Schistosoma japonicum, a mucoid bloody diarrhea accompanied by tender hepatomegaly occurs. [meddean.luc.edu]
Ultrasound examination showed hepatomegaly and portal fibrosis. Microscopic examination revealed round or oval eggs embedded in the parenchyma of liver along with periportal fibrosis. [community.vanguardngr.com]
Complications (for example, hepatomegaly or enlarged liver and bladder cancer) related to the disease are thought to occur due to long-term exposure to the highly antigenic eggs. [medicinenet.com]
Gong YY, Wilson S, Mwatha JK, Routledge MN, Castelino JM, et al. (2012) Aflatoxin exposure may contribute to chronic hepatomegaly in Kenyan school children. Environ Health Perspect 120: 893–896. View Article Google Scholar 76. [journals.plos.org]
Skin
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Urticaria
[…] mansoni and S. japonicum ) Prognosis treatment may decrease organ pathology Presentation Symptoms pruritus after swimming ("swimmer's itch") suggestive of larval penetration fever chills myalgias and arthralgias headache abdominal pain Physical exam urticaria [medbullets.com]
SIDE EFFECTS OF PRAZIQUANTEL More common Drowsiness Increased sweating General feeling of discomfort or illness Nausea or vomiting Less common Hives or Urticaria 21. [fr.slideshare.net]
Musculoskeletal
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Arthralgia
[…] cancer ( S. haematobium ) portal hypertension ( S. mansoni and S. japonicum ) Prognosis treatment may decrease organ pathology Presentation Symptoms pruritus after swimming ("swimmer's itch") suggestive of larval penetration fever chills myalgias and arthralgias [medbullets.com]
Neurologic
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Dizziness
Splitting praziquantel 40 mg/kg into two doses over 12 hours probably has no benefits over a single dose, and in a single trial of 220 participants the split dose caused more vomiting ( RR 0.5, 95% CI 0.29 to 0.86) and dizziness ( RR 0.39, 95% CI 0.16 [cochrane.org]
Urogenital
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Hematuria
The hematuria and proteinuria resolved following praziquantel therapy. The pathogenesis of glomerulonephritis in association with Schistosoma infection is discussed. [ncbi.nlm.nih.gov]
The total absence of hematuria, proteinuria and leukocyturia, however, may be used to rule out heavy infections in community surveys. [brightresearch.org]
Pupils with hematuria were more likely to have S. haematobium infection (P S. haematobium -infected participants had hematuria and vice versa. [parasitesandvectors.biomedcentral.com]
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Dysuria
[…] after their death, large numbers of calcified eggs can be found in bladder wall Diagrams / tables Images hosted on other servers: Life cycle Clinical features May clinically simulate urothelial carcinoma Symptoms are nonspecific; common symptoms are dysuria [pathologyoutlines.com]
Urinary symptoms may include frequent urination, painful urination (dysuria), and blood in the urine (hematuria). 13. [fr.slideshare.net]
With urogenital schistosomiasis, the most common presentations are dysuria, frequency and haematuria [ 10 ]. [omicsonline.org]
Symptoms and signs include dysuria, urgency, terminal microscopic and gross hematuria, secondary urinary tract infections, and nonspecific pelvic pain. Chronic urinary carriage and bacteremia with salmonella can occur. [meddean.luc.edu]
The common presenting symptoms of carcinoma ol the bladder were haematuria, pyuria, hypogastric pain, dysuria and frequency. More than a third of the patients had palpable suprapubic masses on admission. The tumours were often large and sessile. [erepository.uonbi.ac.ke]
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Macroscopic Hematuria
Figure 1 An eight-year-old boy was referred to the nephrology clinic with a two-year history of painless, gross macroscopic hematuria. [nejm.org]
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Abdominal Pain with Urination
Information on health of the children and schistosomiasis infection Cough, abdominal pain, bloody urine (red urine), history of schistosomiasis, worm infestation, and abdominal problems had significantly higher odds of schistosomiasis infection than other [mmj.mw]
Workup
Urine
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Albuminuria
In a patient presenting with hematuria and proteinuria (albuminuria), bladder biopsy demonstrated Schistosoma hematobium infection and renal biopsy showed a minimal change glomerulonephritis. [ncbi.nlm.nih.gov]
Treatment
[…] weeks after treatment). [bmcinfectdis.biomedcentral.com]
Four weeks after treatment, the participants will be assessed for cure and egg reduction. The study may provide an alternative drug treatment for S. haematobium. [clinicaltrials.gov]
Praziquantel is the treatment of choice for Schistosoma haematobium infection in the United States. However, trichlorfon may be the preferred treatment in areas of endemic disease where praziquantel is too expensive. [nejm.org]
Control is reliant on annual mass-treatment programmes, with little prospect of an anti-infection vaccine. [findaphd.com]
Estimates show that at least 220.8 million people required preventive treatment in 2017. Preventive treatment, which should be repeated over a number of years, will reduce and prevent morbidity. [who.int]
Prognosis
S. mansoni and S. japonicum ) or the bladder ( S. haematobium ) causes an immune response leading to inflammation and fibrosis Associated conditions squamous cell bladder cancer ( S. haematobium ) portal hypertension ( S. mansoni and S. japonicum ) Prognosis [medbullets.com]
The prognosis of schistosomiasisassociated PAH is not well understood and is likely very similar to that of idiopathic PAH. [phassociation.org]
What is the prognosis (outcome) for schistosomiasis? Early antiparasitic treatment, especially with acute schistosomiasis, may allow people to recover completely without developing chronic disease. [medicinenet.com]
If someone is also infected with malaria, HIV, or hepatitis, there is a worse prognosis. Can schistosomiasis be prevented? People who travel to areas affected by schistosomiasis should avoid exposure to fresh water that is likely to be contaminated. [patient.info]
Etiology
Schistosoma haematobiumis the etiologic agent for urogenital schistosomiasis, a major source of morbidity and mortality for more than 112 million people worldwide. [bio-protocol.org]
The results of this thesis provide new leads for further research on disease etiology and underlying mechanisms in Schistosoma co-infections. [openaccess.leidenuniv.nl]
[…] necrosis and ulceration, followed by fibrosis with chronic inflammatory infiltrate Epidemiology Schistosoma haematobium infection is common in Africa and the Middle East, and is the world's leading cause of hematuria Uncommon in US, except in immigrants Etiology [pathologyoutlines.com]
Etiology: The trematodes (flukes). Schistosomes are flukes that inhabit the portal vascular system. All species have similar life cycles. [meddean.luc.edu]
A Study on the etiological factors of bilharzial bladder cancer in Egyt.6. The possible role of urinary bacteria. Tumori 1982; 64: 23-28. 32. Hicks RM, Ismail MM, Walters CL, Beecham MT, EL-Alamy MA. [ispub.com]
Epidemiology
A community-wide study was carried out in a co-endemic focus in the north of Senegal, combining epidemiological, ecological, immunological, and geographical analyses. This multidisciplinary approach led to several new insights. [openaccess.leidenuniv.nl]
Epidemiological studies have suggested that host immunological factors may play an important role in co-endemic areas. [research.vu.nl]
EPIDEMIOLOGY S. Haematobium is found in the Middle East, India, Portugal and Africa. [flipper.diff.org]
Chan MS, Bradley M, Bundy DAP (1997) Transmission patterns and the epidemiology of hookworm infection. International Journal of Epidemiology 26: 1392–1400. View Article Google Scholar 28. [journals.plos.org]
Methodology: A Community based cross sectional epidemiological survey on urinary Schistosomiasis was undertaken between November 2011 and September, 2012. [scopemed.org]
Pathophysiology
Each disease-oriented section begins with an up-to-date review of pathophysiology and then focuses on specific diseases. [books.google.de]
I: pathophysiology and diagnostic techniques. Neph Dial Transp 1999; 14: 2746-2753. 9. Latif, A.S. Urinogenital Infections in the Tropics (pp. 8.1–8.10). The Australasian College of Tropical medicine. 2004. [ispub.com]
Prevention
[…] updated information on the extent of disease burden, communities at risk and factors associated with infection at the district and sub-district level to facilitate effective prioritization and monitoring while ensuring ownership and sustainability of prevention [ncbi.nlm.nih.gov]
Estimates show that at least 220.8 million people required preventive treatment in 2017. Preventive treatment, which should be repeated over a number of years, will reduce and prevent morbidity. [who.int]
Mass therapy which prevents SCC in schistosomiasis patients would than cost 17.92 million USD per year and a chronic often incurable disease like SCC would be not only “treated” but safely prevented (34). [intjcancermanag.com]
The diagnosis, treatment, and prevention of schistosomiasis are discussed separately. (See "Diagnosis of schistosomiasis" and "Treatment and prevention of schistosomiasis" .) MICROBIOLOGY Five schistosome species can cause infection in humans. [uptodate.com]