BACKGROUND: Schistosoma japonicum causes marked liver fibrosis, while lethal syndromes present in advanced schistosomiasis patients. Its management depends on the degree of fibrosis present. [ncbi.nlm.nih.gov]

• Splenomegaly

  Usually, these patients will present with portal hypertension signs and symptoms, including splenomegaly, gastroesophageal varices, hematemesis, and ascites. Hepatic function is commonly preserved until late stages 2. [radiopaedia.org]

  Hepatomegaly was found in 76.3% (1082/1419); hepatic fibrosis was found in 73.3% (1040/1419); and splenomegaly was found in 18.6% (264/1419). [ncbi.nlm.nih.gov]

• Fever

  (inanition) (of unknown origin) (persistent) (with chills) (with rigor) R50.9 ICD-10-CM Diagnosis Code R50.9 Fever, unspecified 2016 2017 2018 2019 Billable/Specific Code Applicable To Fever NOS Fever of unknown origin [FUO] Fever with chills Fever with [icd10data.com]

  Föredragen term Schistosomiasis Hänvisningstermer Bilharziases Bilharziasis Fever, Katayama Infection, Schistoma Infections, Schistoma Katayama Fever Schistoma Infection Schistoma Infections Anmärkning general or unspecified; prefer specifics; coordinate [finto.fi]

  A 28-year-old Marine Corps officer developed Katayama fever with central nervous system (CNS) manifestations 6 weeks after swimming on Leyte Island in the Philippines. [ncbi.nlm.nih.gov]

  Bilharziasis, bilharzia, bilharziosis, and snail fever or, in the acute form, Katayama fever are alternate names for schistosomiasis. Theodore Bilharz identified the parasite Schistosoma hematobium in Egypt in 1851. [medicinenet.com]

  Kin Kiang fever. Egyptian splenomegaly. Cercarial dermatitis. Swimmer's itch. Collector's itch. Dew itch. Sawah itch. Snail fever. Yangtze fever. Koganbyo. Clam digger's itch. Kichocho. Haemic distomiasis. [isradiology.org]

• Pain

  More than half of the respondents reported impairments in at least one dimension of the EQ-5D plus questionnaire, particularly pain or discomfort (47.9%; 675/1410) and anxiety or depression (39.4%; 555/1410). [ncbi.nlm.nih.gov]

  […] schis·to·so·mi·a·sis ja·pon·i·ca, Japanese schistosomiasis infection with Schistosoma japonicum, characterized by dysenteric symptoms, painful enlargement of the liver and spleen, dropsy, urticaria, and progressive anemia. schis·to·so·mi·a·sis ja·pon· [medical-dictionary.thefreedictionary.com]

  Schistosomiasis Symptom Abdominal Pain Abdominal (belly) pain is pain or discomfort that is felt in the part of the trunk below the ribs and above the pelvis. It comes from organs within the abdomen or organs adjacent to the belly. [medicinenet.com]

  The infection leads to anaemia, chronic fatigue and painful urination/defaecation during childhood, later developing into severe organ problems such as liver and spleen damages, bladder cancer, genital lesions and infertility. [eliminateschisto.org]

• Anemia

  Alternatively, anemia may result from cytokine-mediated dyserythropoiesis, as seen in anemia of inflammation. [ncbi.nlm.nih.gov]

  […] schis·to·so·mi·a·sis ja·pon·i·ca, Japanese schistosomiasis infection with Schistosoma japonicum, characterized by dysenteric symptoms, painful enlargement of the liver and spleen, dropsy, urticaria, and progressive anemia. schis·to·so·mi·a·sis ja·pon· [medical-dictionary.thefreedictionary.com]

  Exploration of the mechanisms of S. japonicum –associated anemia suggests that processes other than extracorporeal blood loss, such as anemia or inflammation, may be involved. [ajtmh.org]

• Fishing

  Cercariae are infective to the second host in the life cycle, and infection may occur passively (e.g., a fish consumes a cercaria) or actively (the cercaria penetrates the fish). [bionity.com]

  When a person enters the water to wash clothes, fish, bathe or play, the cercarie will swim to the person and pierce through their exposed skin. Being microscopic, the person is unaware that they have just been infected by a schistosome worm. [eliminateschisto.org]

  […] guineensis and related S. intercalatum Rain forest areas of central Africa Urogenital schistosomiasis Schistosoma haematobium Africa, the Middle East, Corsica (France) Schistosomiasis mostly affects poor and rural communities, particularly agricultural and fishing [who.int]

  Bugajska–Schretter A, Elfman L, Fuschs T, Kapiotis S, Rumpold H, Valenta R, Spitzauer S: Parvalbumin, a cross–reactive fish allergen, contains IgE–binding epitopes sensitive to periodate treatment and Ca 2+ depletion. [karger.com]

• Malnutrition

  Full-Text Figures & Tables References (52) Cited By Supplements Metrics Related Content Abstract The objectives of this study were 1) to provide more accurate estimates of the relationship between Schistosoma japonicum infection and both protein energy malnutrition [ajtmh.org]

  Many current studies are now focusing on these aspects of disease, including performance-related impacts such as chronic anemia, malnutrition, cognitive impairment, and physical endurance. [journals.plos.org]

  Children who are repeatedly infected with schistosomiasis (due to constant exposure to contaminated water) can develop anaemia, malnutrition and learning disabilities. [yourgenome.org]

  Finally, the Global Burden of Disease study did not consider other effects associated with schistosomiasis, such as anaemia, malnutrition, cognitive impairment and growth retardation. [who.int]

• Cough

  wheezing, shortness of breath and coughing up blood nervous system or brain can cause seizures (fits), headaches, weakness and numbness in your legs, and dizziness Without treatment, affected organs can become permanently damaged. [nhs.uk]

  […] intravascular infection caused by parasitic Schistosoma trematode worms It is prevalent in Africa, the Middle East, South America, and Asia Acute schistosomiasis, or Katayama syndrome, can present as fever, malaise, myalgia, fatigue, non-productive cough [bmj.com]

  Then, fever, chills, cough, and muscle aches can begin within one to two months of infection. However, most people have no symptoms at this early phase of infection. [medicinenet.com]

  Symptoms may include inflammation, cough, late-afternoon fever, skin eruption (giant urticaria), and swelling and tenderness of the liver. There may then be blood in the stools and urine in the more acute stage. [britannica.com]

  “dead-end” host for nonhuman-pathogenic schistosomes Acute schistosomiasis (also known as schistosomiasis japonica or Katayama syndrome or fever) Systemic hypersensitivity reaction – may occur 2-8 weeks after infection Fever, myalgia, nonproductive cough [arupconsult.com]

• Diarrhea

  diarrheal (disease) (infantile) (inflammatory) R19.7 ICD-10-CM Diagnosis Code R19.7 Diarrhea, unspecified 2016 2017 2018 2019 Billable/Specific Code Applicable To Diarrhea NOS Type 1 Excludes functional diarrhea ( K59.1 ) neonatal diarrhea ( P78.3 ) [icd10data.com]

  In acute infections with heavy infection due to Schistosoma mansoni or Schistosoma japonicum, a mucoid bloody diarrhea accompanied by tender hepatomegaly occurs. [meddean.luc.edu]

  […] active infection and past exposure Generally negative at onset of clinical symptoms Seroconversion occurs ~30 days after symptoms and ~6 weeks after contact with contaminated water Differential Diagnosis Acute Entamoeba histolytica Rickettsia typhi Diarrhea [arupconsult.com]

  Those with diagnosed chronic schistosomiasis should seek medical care if their chronic symptoms increase (especially abdominal pain, shortness of breath, bloody diarrhea or bloody urine, seizures, or mental-status changes). [medicinenet.com]

  Manifestations include fever, cough, abdominal pain, diarrhea, hepatospenomegaly, and eosinophilia. Occasionally central nervous system lesions occur. [atlas.or.kr]

• Right Upper Quadrant Pain

  upper quadrant pain Chronic and advanced disease results from the host’s immune response to schistosome eggs deposited in tissues and the granulomatous reaction evoked by the antigens they secrete S mansoni, S japonicum, S intercalatum, and S mekongi [bmj.com]

  Right upper quadrant pain and bloody diarrhea may also occur. [36] These symptoms mimic any acute viral, bacterial, or malarial illness. [emedicine.medscape.com]

• Intestinal Disease

  […] results from the host’s immune response to schistosome eggs deposited in tissues and the granulomatous reaction evoked by the antigens they secrete S mansoni, S japonicum, S intercalatum, and S mekongi cause intestinal disease; S haematobium causes urinary [bmj.com]

• Hypertension

  The primary goal of this monograph, to provide a framework of patho physiology of portal hypertension with authoritative descriptions of the clinical and laboratory manifestations of various portal hypertensive dis orders, has clearly been achieved by [books.google.de]

  Intrahepatic portal fibrosis causes portal hypertension. Esophageal varices complicate the picture of portal hypertension. Death in patients with hepatosplenic involvement is usually due to rupture of these varices. [histopathology-india.net]

  Chronic infection with S. japonicum may lead to the development of liver fibrosis, calcification and portal hypertension. [ncbi.nlm.nih.gov]

  Early hepatic involvement with portal hypertension: Study of 5 cases " " Schistosomiase intestinale. [agris.fao.org]

• Liver Fibrosis

  BACKGROUND: Schistosoma japonicum causes marked liver fibrosis, while lethal syndromes present in advanced schistosomiasis patients. Its management depends on the degree of fibrosis present. [ncbi.nlm.nih.gov]

• Hepatosplenomegaly

  Each lesion represents a cercarial invasion site. 25 A boy with swollen abdomen due to schistosomiasis (bilharziasis) with hepatosplenomegaly. 26 Schistosomiasis (Bilharziasis). [slideplayer.com]

  Portal hypertension can develop and cause hepatosplenomegaly, ascites, and esophageal varices. [meddean.luc.edu]

  Some patients may also present with hepatosplenomegaly. The clinical signs are more pronounced when the infection is caused by S. mansoni and S. japonicum. [therapeutique-dermatologique.org]

  […] with abdominal distention, hepatosplenomegaly, pedal edema, pallor, distended abdominal veins, and ascites Intestinal polyposis with heme-positive stool, pallor, and signs of malnutrition CNS symptoms, including focal neurologic findings, seizures, and [emedicine.medscape.com]

  The severity of S. japonicum arises in 60% of all neurological diseases in schistosomes due to the migration of schistosome eggs to the brain.[5] Symptoms an infected person might experience include: fever, cough, abdominal pain, diarrhea, hepatosplenomegaly [en.wikipedia.org]

• Hepatomegaly

  Hepatomegaly was found in 76.3% (1082/1419); hepatic fibrosis was found in 73.3% (1040/1419); and splenomegaly was found in 18.6% (264/1419). [ncbi.nlm.nih.gov]

  Hepatomegaly rapidly developed in acutely infected persons, with 82% of subjects developing hepatic enlargement within 2 years of reinfection. [academic.oup.com]

• Myalgia

  Schistosomiasis, or bilharzia, is a common intravascular infection caused by parasitic Schistosoma trematode worms It is prevalent in Africa, the Middle East, South America, and Asia Acute schistosomiasis, or Katayama syndrome, can present as fever, malaise, myalgia [bmj.com]

  Self-limited – humans are a “dead-end” host for nonhuman-pathogenic schistosomes Acute schistosomiasis (also known as schistosomiasis japonica or Katayama syndrome or fever) Systemic hypersensitivity reaction – may occur 2-8 weeks after infection Fever, myalgia [arupconsult.com]

  A fever is ubiquitous (safari fever, Katayama fever ) and an infected person may also experience prostration, headache, myalgia and night sweats. A variable set of skin symptoms may also be present, including rash, urticaria and facial oedema. [therapeutique-dermatologique.org]

  The infected patients present a serious syndrome including: fever, weakness, loss of weight, diarrhoea, abdominal pain, cough, myalgia, arthralgia, urticaria, edema and enlargement of the liver and spleen (Neves 1965, Lambertucci 1993), which are markedly [scielo.br]

  Fever, lethargy, malaise, and myalgia are the most common symptoms of Katayama syndrome. Less common symptoms include cough, headache, anorexia, and rash (urticarial or papular). [emedicine.medscape.com]

• Urticaria

  […] schis·to·so·mi·a·sis ja·pon·i·ca, Japanese schistosomiasis infection with Schistosoma japonicum, characterized by dysenteric symptoms, painful enlargement of the liver and spleen, dropsy, urticaria, and progressive anemia. schis·to·so·mi·a·sis ja·pon· [medical-dictionary.thefreedictionary.com]

  LAMBERT AC: Fevers with urticaria and eosinophilia, and their relationship to infection with Schistosomum japonicum, Trans. Soc. Trop. Med. and Hyg., 1911, v, 38-45. CrossrefGoogle Scholar 16. [acpjournals.org]

  Symptoms may include inflammation, cough, late-afternoon fever, skin eruption (giant urticaria), and swelling and tenderness of the liver. There may then be blood in the stools and urine in the more acute stage. [britannica.com]

  A variable set of skin symptoms may also be present, including rash, urticaria and facial oedema. Some patients may also present with hepatosplenomegaly. [therapeutique-dermatologique.org]

• Headache

  Their clinical symptoms varied, such as headache, dizziness, seizures, and others. Studies in blood were normal except for eosinophilia. [ncbi.nlm.nih.gov]

  Nieva 3 described the case of a patient from Samar who experienced epilepsy, headaches and sensory changes. The ova of S. japonicum were found in the feces. The probable diagnosis [jamanetwork.com]

  It is well tolerated, with approximately 20% of treated patients experiencing adverse effects including abdominal pain, nausea, headaches, vertigo and somnolence. [therapeutique-dermatologique.org]

  […] irritation of the bladder (cystitis), pain when peeing, a frequent need to pee, and blood in your pee heart and lungs can cause a persistent cough, wheezing, shortness of breath and coughing up blood nervous system or brain can cause seizures (fits), headaches [nhs.uk]

• Seizure

  Of the 71 patients who had paroxysmal disease, 54 had convulsions, in 33 of which it was of the Jacksonian type, and 24 had psychomotor seizures and 1 autonomic seizures. [ncbi.nlm.nih.gov]

  […] system can cause irritation of the bladder (cystitis), pain when peeing, a frequent need to pee, and blood in your pee heart and lungs can cause a persistent cough, wheezing, shortness of breath and coughing up blood nervous system or brain can cause seizures [nhs.uk]

• Enlargement of the Liver

  […] schis·to·so·mi·a·sis ja·pon·i·ca, Japanese schistosomiasis infection with Schistosoma japonicum, characterized by dysenteric symptoms, painful enlargement of the liver and spleen, dropsy, urticaria, and progressive anemia. schis·to·so·mi·a·sis ja·pon· [medical-dictionary.thefreedictionary.com]

  Other symptoms can include cough, diarrhoea, weight loss, haematuria (blood in urine), headaches, joint and muscle pain, and enlargement of the liver and spleen. [travelhealthpro.org.uk]

A novel and effective hyperthermia method for Schistosomiasis japonica prevention and treatment. [pure.qub.ac.uk]

The administration of praziquantel and corticosteroid drugs in early stages is good for prognosis. [ncbi.nlm.nih.gov]

Prognosis If treated early, prognosis is very good and complete recovery is expected. The illness is treatable, but people can die from the effects of untreated schistomiasis. [encyclopedia.com]

What is the prognosis (outcome) for schistosomiasis? Early antiparasitic treatment, especially with acute schistosomiasis, may allow people to recover completely without developing chronic disease. [medicinenet.com]

Ten years after the etiology of the disease had been established, it was demonstrated that the life cycle of the parasite, like that of all other... Bibliography 1. FUJII Y: Katayama disease (with note), Internat. Med. [acpjournals.org]

Ten years after the etiology of the disease had been established, it was demonstrated that the life cycle of the parasite, like that of all other FULL TEXT [annals.org]

The etiologic relationship between Schistosomiasis japonica infection and the hepatocellular carcinoma is also discussed in this report. [ncbi.nlm.nih.gov]

The etiological and pathogenetic link between helminthiasis and carcinoma should be considered in the same way as for other related inflammatory large-bowel diseases. [deepdyve.com]

Whereas the etiological context between chronic infection by Schistosoma haematobium and endemic… CONTINUE READING [semanticscholar.org]

From the 1950s, massive epidemiological investigations and active control measures for schistosomiasis japonica have been carried out. [ncbi.nlm.nih.gov]

(Research in Filariasis and Schistosomiasis 2) University of Tokyo Press, Tokyo 1972 Works Epidemiological survey on schistosomiasis japonica in Bohol, Philippoines 1986 Epidemiological survey on schistosomiasis japonica in sulawesi, Indonesia 1990 Epidemiological [researchmap.jp]

Kunio Okuda, Jean-Pierre Benhamou Springer Science & Business Media, 09.11.2013 - 569 Seiten Portal hypertension is the abnormal pathophysiologic state that develops in liver cirrhosis and certain other disorders with characteristic clinical and hemodynamic [books.google.de]

[…] in Egypt, Mahgreb region of North Africa Found in areas of the Middle East Eggs hatch within 15 - 30 minutes S. japonicum: Indonesia and parts of China and Southeast Asia S. mekongi: Cambodia and Laos S. intercalatum: parts of Central and West Africa Pathophysiology [pathologyoutlines.com]

This review article describes the latest updates at the turn of the new millennium with an emphasis on the pathophysiology, diagnosis, genomics, host infection susceptibility, epidemiology, treatment, control and vaccine development for human schistosomiasis [nature.com]

A novel and effective hyperthermia method for Schistosomiasis japonica prevention and treatment. [pure.qub.ac.uk]

Author information 1 Department of Epidemiology and Biostatistics, School of Public Health, Biomedical Statistical Center, Fudan University, Shanghai, China; Shandong Institute of Prevention and Control for Endemic Disease, Jinan, China; Shanghai Institute [ncbi.nlm.nih.gov]

Jian Wang National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China. Tie-Wu Jia National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China. [geospatialhealth.net]