Presentation
She presented a full recovery and options for future reproduction are under evaluation. [ncbi.nlm.nih.gov]
Entire Body System
- Inflammation
Thus T2-weighted spin echo sequences should be performed and may be helpful to assess activity of periportal inflammation. [ncbi.nlm.nih.gov]
While S. mansoni does not directly infect the genital tract, we hypothesize that the inflammation it causes in the gut may be associated with mucosal inflammation at other sites through activation of common mucosal homing integrins such as a4b7. [clinicaltrials.gov]
This damage may be due to schistosome eggs migrating to these organs and causing inflammation. [yourgenome.org]
- Asymptomatic
Chronic asymptomatic patients and those with incipient fibrosis expressed very high levels of heterogeneity of their antibody responses. [ncbi.nlm.nih.gov]
In 5 patients, the schistosomiasis was asymptomatic and had been diagnosed by routine examinations and had no relationship to nephropathy. In 4 patients, the nephropathy was suggestive of being of schistosomal origin. [journals.lww.com]
Asymptomatic cases have been detected serologically. [viceprovost.tufts.edu]
Gastrointestinal
- Abdominal Pain
Here, we describe the case of a 31-year-old woman with lower abdominal pain who was diagnosed as presenting a fallopian tube tumor caused by Manson's schistosomiasis. The diagnosis was delayed because her symptoms were considered nonspecific. [ncbi.nlm.nih.gov]
All patients reported non-specific abdominal symptoms, such as diarrhea (six patients), abdominal pain (seven patients), and blood in the stool (five patients), as well as weight loss (two patients). [idpjournal.biomedcentral.com]
Long-term involvement of the colon produces abdominal pain and bloody diarrhea. Recurrent Salmonella bacteremia is related to parasitization of the schistosome gut by Salmonella. [meddean.luc.edu]
pain with dizziness for 12 h. [wjgnet.com]
Liver, Gall & Pancreas
- Hepatosplenomegaly
On physical examination he had jaundice and hepatosplenomegaly. Diagnosis of S. marcescens bacteremia was made by isolation of the bacterium in blood culture, and schistosomiasis was diagnosed by rectal and liver biopsies. [ncbi.nlm.nih.gov]
Overall presence of hepatomegaly was 24.2%, splenomegaly 4.9% and hepatosplenomegaly 30.3%. [journals.plos.org]
In addition to its antiparasite action, CsA reduced hepatosplenomegaly due to schistosomiasis and diminished the granulomatous inflammatory response of mice to parasite eggs in the liver. [karger.com]
There may be generalized lymphadenopathy, hepatosplenomegaly, urticaria and leukocytosis with marked eosinophilia. [jotscroll.com]
Cardiovascular
- Hypertension
Portopulmonary hypertension syndrome (PPHS) is a complication of portal hypertension where the substrate is micro-vessel lesions which are indicative of plexogenic arteriopathy. PPHS has not been linked to pulmonary schistosomiasis. [ncbi.nlm.nih.gov]
However no study investigated its role in portal hypertension. [atlasofscience.org]
Skin
- Ulcer
Ova are mainly seen in the loose submucosa of large intestine, usually with formation of granulomas and infiltration by eosinophils and inflammatory cells Later the muscularis mucosa becomes involved and the overlying mucosa shows small superficial ulcers [pathologyoutlines.com]
Garlic also resulted in various ultrastructural alterations in the tegument of the surviving worms including tubercular disruption, oedema, blebbing, ulcers, and vacuolization of other tegumental structures. [ncbi.nlm.nih.gov]
Only mature eggs are capable of crossing into the digestive tract, possibly through the release of proteolytic enzymes, but also as a function of host immune response, which fosters local tissue ulceration. [wikidoc.org]
Bowel S. mansoni and japonicum produce congestion and ulceration of the bowel wall. Long-term involvement of the colon produces abdominal pain and bloody diarrhea. [meddean.luc.edu]
Urogenital
- Hematuria
In this case, a 48-year-old woman with macroscopic hematuria, dysuria and a palpable abdominal mass was investigated. Ultrasound showed a large exophytic mass in the bladder. [ncbi.nlm.nih.gov]
Urogenital schistosmiasis is characterized by hematuria. In chronic infections, damage to the urinary system can occur, such as fibrosis of the bladder and ureter, as well as kidney damage that may lead to kidney failure. [news-medical.net]
Symptoms and signs include dysuria, urgency, terminal microscopic and gross hematuria, secondary urinary tract infections, and nonspecific pelvic pain. Chronic urinary carriage and bacteremia with salmonella can occur. [meddean.luc.edu]
Granuloma formation in the bladder wall and at the ureterovesical junction results in the major disease manifestations of schistosomiasis haematobia (hematuria, dysuria, and obstructive uropathy). [wikidoc.org]
Workup
Biopsy
- Hepatocellular Carcinoma
carcinoma related to Schistosoma mansoni 07.11.2012 · Resources for Health Professionals. [zgfoxjzsuj.ddns.net]
Treatment
Treatment-related side effects observed were transient and tolerable. [ncbi.nlm.nih.gov]
Estimates show that at least 251.4 million people required preventive treatment in 2021. Preventive treatment, which should be repeated over a number of years, will reduce and prevent morbidity. [who.int]
Prognosis
Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Schistosomiasis from other Diseases Epidemiology and Demographics Risk Factors Screening Natural History, Complications and Prognosis [wikidoc.org]
Course and prognosis The prognosis of hepatic schistosomiasis is good in the acute and hepatointestinal forms. The prognosis of the hepatosplenic forms depends on whether the liver disease is compensated or decompensated. [elsevier.es]
Prognosis of schistosomiasis mansoni patients infected with hepatitis B virus. Memorias do Instituto Oswaldo Cruz. 1998;93 Suppl 1:255-8. Ghaffar YA, Fattah SA, Kamel M, Badr RM, Mahomed FF, Strickland GT. [sapd.es]
Etiology
Schistosomiasis is an important etiology to consider in the differential diagnosis of pulmonary hypertension. [ncbi.nlm.nih.gov]
Such classifications do not consider the mechanisms by which the etiologic agent provokes the lesion. [link.springer.com]
[…] association between Schistosoma This article reviews the literature to highlight the etiological relationship between Schistosoma haematobium infestation and the development of urinary bladder GO TO PAGE Neuroschistosomiasis mansoni: Literature Review [zgfoxjzsuj.ddns.net]
Epidemiology
Our objectives were to estimate the epidemiological burden and the costs of severe stages of S. mansoni in Brazil in 2010. METHODS: We conducted an epidemiologic descriptive study and a partial economic evaluation of cost-of-illness. [ncbi.nlm.nih.gov]
Pathophysiology
Trials.gov US National Guidelines Clearinghouse NICE Guidance FDA on Schistosomiasis pathophysiology CDC on Schistosomiasis pathophysiology Schistosomiasis pathophysiology in the news Blogs on Schistosomiasis pathophysiology Directions to Hospitals Treating [wikidoc.org]
The pathophysiology and morphologic features are discussed. Schistosomiasis is an important etiology to consider in the differential diagnosis of pulmonary hypertension. [ncbi.nlm.nih.gov]
Pathophysiology Infection with parasitic worms of the genus Schistosoma is responsible for causing schistosomiasis. [news-medical.net]
Pathophysiology and treatment.. Gastroenterol Clin North Am, 21 (1992), pp. 163-77 [20] Rezende SA, Lambertucci JR, Goes AM.. [elsevier.es]
Africa, South America, Middle East S. japonicum : Southeast Asia S. haematobium : Africa, Middle Eastern Sites Liver, intestine, bladder, lungs, spleen, brain or spinal cord; less common sites of embolization include the skin and peritoneal surfaces Pathophysiology [pathologyoutlines.com]
Prevention
The mainstay of control is preventive chemotherapy with praziquantel. In Africa, an estimated 230 million people require preventive chemotherapy. In western Côte d'Ivoire, infections with Schistosoma mansoni are widespread. [ncbi.nlm.nih.gov]
Estimates show that at least 220.8 million people required preventive treatment in 2017. Preventive treatment, which should be repeated over a number of years, will reduce and prevent morbidity. [who.int]
The narrator sums up the information given in the film and repeats that hopefully new research will lead to a vaccine preventing schistosomiasis. Time start: 00:18:07:20 Time end: 00:27:43:18 Length: 00:09:35:23 [wellcomecollection.org]